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A NEW METHOD TO ASSESS PRESENCE OF SV40 IN MALIGNANT
MESOTHELIOMA
by
Vanina Tomasian
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
December 2006
Copyright 2006 Vanina Tomasian
Object Description
| Title | A new method to assess presence of SV40 in malignant mesothelioma |
| Author | Tomasian, Vanina |
| Author email | tomasian@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2006-08-21 |
| Date submitted | 2006 |
| Restricted until | Unrestricted |
| Date published | 2006-11-06 |
| Advisor (committee chair) | Laird-Offringa, Ite A. |
| Abstract | Malignant mesothelioma, a tumor of the serosal lining of the pleura, pericardium and peritoneum, is a worldwide problem. Simian virus 40 (SV40) has been implicated as a potential co-factor in the etiology of this disease, but despite many studies, its presence is still controversial. To address this controversy, we studied SV40 DNA presence in 52 pleural malignant mesotheliomas using real time PCR (Q-PCR) and Digital PCR. Digital PCR is a new method developed to address the potential problem of low SV40 copy numbers in tumors by improving SV40 DNA. The SV40 positivity rate with these assays was 25-35%, indicating that SV40 is present in some malignant mesotheliomas. Additionally, our Digital PCR results indicate that this new method is useful to study SV40 presence in different human tumors as it is more sensitive, allowing detection of low SV40 copy numbers. |
| Keyword | malignant mesothelioma |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m125 |
| Rights | Tomasian, Vanina |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Tomasian-20061106 |
| Archival file | uscthesesreloadpub_Volume35/etd-Tomasian-20061106.pdf |
Description
| Title | Page 1 |
| Full text | A NEW METHOD TO ASSESS PRESENCE OF SV40 IN MALIGNANT MESOTHELIOMA by Vanina Tomasian A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) December 2006 Copyright 2006 Vanina Tomasian |
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