Close
About
FAQ
Home
Collections
Login
USC Login
Register
0
Selected
Invert selection
Deselect all
Deselect all
Click here to refresh results
Click here to refresh results
USC
/
Digital Library
/
University of Southern California Dissertations and Theses
/
Enhancing chimeric antigen receptor-engineered immune cell therapy with synthetic biology and nanomedicine
(USC Thesis Other)
Enhancing chimeric antigen receptor-engineered immune cell therapy with synthetic biology and nanomedicine
PDF
Download
Share
Open document
Flip pages
Download a page range
Contact Us
Contact Us
Copy asset link
Request this asset
Abstract (if available)
Abstract
Chimeric antigen receptor (CAR)-engineered adoptive cell therapy has garnered much attention as it has been used in conjunction with or as a replacement for traditional cancer treatments. However, its uses, particularly in solid tumors, have been tempered by serious adverse side effects and lackluster clinical results. The following chapters will focus on improving CAR-based therapy with antibody mimetic proteins in place of scFvs (Chapter 1), CAR-NK cells conjugated to chemotherapy-loaded liposomes (Chapter 2), and CAR-NK cells with additional cytokine and suicide switch transgenes (Chapter 3). Synthetic biology and nanomedicine are two areas of biomedical research which can synergize with CAR-related treatments to create safer, more effective cancer therapies.
Linked assets
University of Southern California Dissertations and Theses
Conceptually similar
PDF
Improving antitumor efficacy of chimeric antigen receptor-engineered immune cell therapy with synthetic biology and combination therapy approaches
PDF
Engineering chimeric antigen receptor-directed immune cells for enhanced antitumor efficacy in solid tumors
PDF
Novel design and combinatory therapy to enhance chimeric antigen receptor engineered T cells (CAR-T) efficacy against solid tumor
PDF
Mechanistic model of chimeric antigen receptor T cell activation
PDF
Engineering therapeutics for the improved antitumor efficacy of chimeric antigen receptor T cell therapy
PDF
Engineering chimeric antigen receptor (CAR) -modified T cells for enhanced cancer immunotherapy
PDF
Enhancing the specificity and cytotoxicity of chimeric antigen receptor Natural Killer cells
PDF
Optimization of nanomedicine based drug delivery systems for the treatment of solid tumors
PDF
Generation and characterization of anti-CD138 chimeric antigen receptor T (CAR-T) cells for the treatment of hematologic malignancies
PDF
Self-secretion of checkpoint blockade enhances antitumor immunity by murine chimeric antigen receptor-engineered T cells
PDF
Lym-1 epitope targeted chimeric antigen receptor (CAR) T cells for the immunotherapy of cancer
PDF
Development of TCR-like antibody and novel chimeric antigen receptor for cancer immunotherapy
PDF
Engineered control of the CAR-T-tumor synapse using customized DNA linkers
PDF
Chimeric Antigen Receptor targeting Prostate Specific Membrane Antigen (PSMA)
PDF
Generation and characterization of humanized anti-CD19 chimeric antigen receptor T (CAR-T) cells for the treatment of hematologic malignancies
PDF
Comparative analysis of scFv and non-scFv based chimeric antigen receptors (CARs) against B cell maturation antigen (BCMA)
PDF
Engineering immunotoxin and viral vectors for cancer therapy
PDF
Phospho-proteomic analysis of immune cell activation
PDF
Therapeutic resistance in acute lymphoblastic leukemia: cIAP2 inhibition sensitizes B cell acute lymphoblastic leukemia to anti-CD19 chimeric antigen receptor T cell
PDF
Generation and characterization of fully human anti-CD19 chimeric antigen receptor T (CAR-T) cells for the treatment of hematologic malignancies
Asset Metadata
Creator
Siegler, Elizabeth Louise
(author)
Core Title
Enhancing chimeric antigen receptor-engineered immune cell therapy with synthetic biology and nanomedicine
School
Viterbi School of Engineering
Degree
Doctor of Philosophy
Degree Program
Biomedical Engineering
Publication Date
04/26/2019
Defense Date
03/18/2019
Publisher
University of Southern California
(original),
University of Southern California. Libraries
(digital)
Tag
cancer immunotherapy,cellular therapy,chimeric antigen receptor,nanomedicine,OAI-PMH Harvest,synthetic biology
Format
application/pdf
(imt)
Language
English
Contributor
Electronically uploaded by the author
(provenance)
Advisor
Wang, Pin (
committee chair
)
Creator Email
elsiegler14@gmail.com,horcher@usc.edu
Permanent Link (DOI)
https://doi.org/10.25549/usctheses-c89-151579
Unique identifier
UC11660961
Identifier
etd-SieglerEli-7297.pdf (filename),usctheses-c89-151579 (legacy record id)
Legacy Identifier
etd-SieglerEli-7297.pdf
Dmrecord
151579
Document Type
Dissertation
Format
application/pdf (imt)
Rights
Siegler, Elizabeth Louise
Type
texts
Source
University of Southern California
(contributing entity),
University of Southern California Dissertations and Theses
(collection)
Access Conditions
The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the a...
Repository Name
University of Southern California Digital Library
Repository Location
USC Digital Library, University of Southern California, University Park Campus MC 2810, 3434 South Grand Avenue, 2nd Floor, Los Angeles, California 90089-2810, USA
Tags
cancer immunotherapy
cellular therapy
chimeric antigen receptor
nanomedicine
synthetic biology