University of Southern California Dissertations and Theses

Development of a multi-mode optical imaging system for preclinical applications in vivo

Development of a multi-mode optical imaging system for preclinical applications in vivo [program]

(USC Thesis Other)

Development of a multi-mode optical imaging system for preclinical applications in vivo [program]

ZIP

Transcript (if available)

Content 3D_Joystick/3D-MIP reconstruction/3D_reconstruction.exe
3D_Joystick/3D-MIP reconstruction/communication.c
3D_Joystick/3D-MIP reconstruction/communication.h
3D_Joystick/3D-MIP reconstruction/hamamatstu
3D_Joystick/3D-MIP reconstruction/MIP_3D_reconstruction.c
3D_Joystick/3D-MIP reconstruction/MIP_3D_reconstruction.cws
3D_Joystick/3D-MIP reconstruction/MIP_3D_reconstruction.h
3D_Joystick/3D-MIP reconstruction/MIP_3D_reconstruction.prj
3D_Joystick/3D-MIP reconstruction/MIP_3D_reconstruction.uir
3D_Joystick/3D-MIP reconstruction/MIP_3D_reconstruction_dbg.cdb
3D_Joystick/3D-MIP reconstruction/Snap1394 without IMAQ Vision.cws
3D_Joystick/3D-MIP reconstruction/temp.tif
3D_Joystick/3D-MIP reconstruction/test_1.tif
3D_Joystick/3D-MIP reconstruction/test_hamamatsu
3D_Joystick/joystick-cvi_FLIM/communication.c
3D_Joystick/joystick-cvi_FLIM/communication.h
3D_Joystick/joystick-cvi_FLIM/joystick.c
3D_Joystick/joystick-cvi_FLIM/joystick.cdb
3D_Joystick/joystick-cvi_FLIM/joystick.cws
3D_Joystick/joystick-cvi_FLIM/joystick.exe
3D_Joystick/joystick-cvi_FLIM/joystick.h
3D_Joystick/joystick-cvi_FLIM/joystick.prj
3D_Joystick/joystick-cvi_FLIM/joystick.uir
3D_Joystick/joystick-cvi_FLIM/cvibuild.joystick/build.ini
3D_Joystick/joystick-cvi_FLIM/cvibuild.joystick/dependencies.bri
3D_Joystick/joystick-cvi_FLIM/cvibuild.joystick/joystick.nidobj
3D_Joystick/joystick-cvi_FLIM/cvibuild.joystick/joystick.niobj
3D_Joystick/joystick-cvi_FLIM/cvibuild.joystick/resources.res
System Control_Two_photon/System Control_multimode/command.c
System Control_Two_photon/System Control_multimode/command.h
System Control_Two_photon/System Control_multimode/communication.c
System Control_Two_photon/System Control_multimode/communication.h
System Control_Two_photon/System Control_multimode/motorControlServer.cws
System Control_Two_photon/System Control_multimode/motorControlServer.prj
System Control_Two_photon/System Control_multimode/motorControlServer_dbg.cdb
System Control_Two_photon/System Control_multimode/motorControlServer_dbg.exe
System Control_Two_photon/System Control_multimode/nmccom.h
System Control_Two_photon/System Control_multimode/nmccom.lib
System Control_Two_photon/System Control_multimode/NMCLIB04.dll
System Control_Two_photon/System Control_multimode/nmclib04.lib
System Control_Two_photon/System Control_multimode/picio.h
System Control_Two_photon/System Control_multimode/picservo.h
System Control_Two_photon/System Control_multimode/picservo.lib
System Control_Two_photon/System Control_multimode/picstep.h
System Control_Two_photon/System Control_multimode/picstep.lib
System Control_Two_photon/System Control_multimode/server.c
System Control_Two_photon/System Control_multimode/server.h
System Control_Two_photon/System Control_multimode/server.uir
System Control_Two_photon/System Control_multimode/server_dbg.cdb
System Control_Two_photon/System Control_multimode/server_dbg.exe
System Control_Two_photon/System Control_multimode/sever2.c
System Control_Two_photon/System Control_multimode/sio_util.h
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/build.ini
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/command.nidobj
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/communication.nidobj
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/daqmxioctrl.nidobj
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/dependencies.bri
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/resources.res
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/server.nidobj
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/server.niobj
System Control_Two_photon/System Control_multimode/cvibuild.motorControlServer/Shortcut to Motor control.lnk
System Control_Two_photon/System Control_multimode/cvidistkit.motorControlServer/DistFile.cab
System Control_Two_photon/System Control_multimode/cvidistkit.motorControlServer/instmsi.exe
System Control_Two_photon/System Control_multimode/cvidistkit.motorControlServer/instmsiw.exe
System Control_Two_photon/System Control_multimode/cvidistkit.motorControlServer/MotorControlServer.msi
System Control_Two_photon/System Control_multimode/cvidistkit.motorControlServer/setup.exe
System Control_Two_photon/System Control_multimode/cvidistkit.motorControlServer/setup.ini
System Control_Two_photon/two_photon/communication.c
System Control_Two_photon/two_photon/communication.h
System Control_Two_photon/two_photon/test.jpg
System Control_Two_photon/two_photon/Thumbs.db
System Control_Two_photon/two_photon/two-photon.exe
System Control_Two_photon/two_photon/two_photon reconstruction.c
System Control_Two_photon/two_photon/two_photon reconstruction.cws
System Control_Two_photon/two_photon/two_photon reconstruction.h
System Control_Two_photon/two_photon/two_photon reconstruction.prj
System Control_Two_photon/two_photon/two_photon reconstruction.uir
System Control_Two_photon/two_photon/two_photon reconstruction_dbg.cdb
System Control_Two_photon/two_photon/two_photon reconstruction_dbg.exe
System Control_Two_photon/two_photon/cvibuild.two_photon reconstruction/build.ini
System Control_Two_photon/two_photon/cvibuild.two_photon reconstruction/communication.nidobj
System Control_Two_photon/two_photon/cvibuild.two_photon reconstruction/daqmxioctrl.nidobj
System Control_Two_photon/two_photon/cvibuild.two_photon reconstruction/dependencies.bri
System Control_Two_photon/two_photon/cvibuild.two_photon reconstruction/resources.res
System Control_Two_photon/two_photon/cvibuild.two_photon reconstruction/two_photon reconstruction.nidobj

Abstract (if available)

Abstract This thesis reports advanced optical imaging technology in a stand-alone system that enables functional mesoscopic imaging (whole-body or endoscopic imaging with microscopic resolution) of small animals in vivo, and provides for quantitative, dynamic, and functional monitoring of chemo- and nanoconstruct therapy. Many currently available imaging approaches have been applied to preclinical studies of cancer, stem cells, and pharmaceutical outcomes. Moreover, useful in vivo imaging may require several, preferably combined, and advanced imaging modalities to examine different but complementary characteristics of molecules, cells, or tissues. Although commercial systems perform well for standard imaging of small animals, they have limitations stemming from being single-modality instruments. Thus, a new multimode optical imaging system that is designed to be application-optimizable, with higher sensitivity and specificity has been developed here in order to overcome these limitations. The instrument combines various in vivo imaging modes, including fluorescence intensity, spectral, lifetime, intra-vital confocal, two-photon excited fluorescence, and bioluminescence imaging. Also this system is a unique and comprehensive imaging platform for analyzing kinetic, quantitative, environmental, and other highly-relevant information with macro- to micro-scopic resolution. This system can be optimized for various applications, and the combination of multiple imaging modes for increased contrast and complementary/synergetic information in chemotherapy assessment and cancer detection is emphasized here.

Linked assets

Development of a multi-mode optical imaging system for preclinical applications in vivo

Conceptually similar

PDF

Development of a multi-mode optical imaging system for preclinical applications in vivo

PDF

Analysis and visualization of multi-mode optical spectral-signature bioimaging data for in vivo applications

PDF

Development of back-end processing system for high frequency ultrasound b-mode imaging

Asset Metadata

Creator Hwang, Jae Youn (author)

Core Title Development of a multi-mode optical imaging system for preclinical applications in vivo [program]

School Viterbi School of Engineering

Degree Doctor of Philosophy

Degree Program Biomedical Engineering

Degree Conferral Date 2009-08

Publication Date 08/06/2009

Defense Date 06/22/2009

Publisher University of Southern California (original), University of Southern California. Libraries (digital)

Tag cancer detection,chemotherapy assessment,corrole,functional mesoscopic imaging,multimode optical imaging,nanoconstruct,OAI-PMH Harvest

Format 85 files (extent)

Language English

Contributor Electronically uploaded by the author (provenance)

Advisor Farkas, Daniel L. (committee chair), Khoo, Michael C.K. (committee chair), Feinberg, Jack (committee member), Gray, Harry B. (committee member), Shung, Kirk K. (committee member)

Creator Email jaeyhwan@usc.edu,jaeyoun.hwang@gmail.com

Permanent Link (DOI) https://doi.org/10.25549/usctheses-c127-15521

Unique identifier UC181282

Identifier usctheses-c127-15521 (legacy record id)

Legacy Identifier etd-Hwang-3117

Dmrecord 15521

Document Type Dissertation

Format 85 files (extent)

Rights Hwang, Jae Youn

Internet Media Type application/zip

Type texts

Source University of Southern California (contributing entity), University of Southern California Dissertations and Theses (collection)

Repository Name Libraries, University of Southern California

Repository Location Los Angeles, California

Repository Email cisadmin@lib.usc.edu