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The role of alcohol and alcohol-related risk factors in population health using a multi-level approach

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The role of alcohol and alcohol-related risk factors in population health using a multi-level approach

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Content The Role of Alcohol and Alcohol-Related Risk Factors in Population Health Using a Multi-Level
Approach
by
Nicholas Sebastian Acuna
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(EPIDEMIOLOGY)
August 2024
Copyright 2024 Nicholas Sebastian Acuna

ii
Acknowledgments
The work of this dissertation could not have been possible without the unwavering support
of my family, friends, faculty, and staff members.
I stand on the shoulder of trailblazers in the fields of public health, epidemiology, and
biostatistics. My committee members are scientists who are positively impacting human health, and I
cannot be more thankful that I had the opportunity to learn from them. I would like to extend my
deepest gratitude and appreciation to my chair, Dr. Veronica Wendy Setiawan, for taking a chance
on me and shaping me to being the epidemiologist I am today. Your keen attention to detail and
thought-provoking conversations about science have challenged me to be a better writer, critical
thinker, data analyst, and overall scientist. To Dr. Anna Wu thank you for always providing me
thorough feedback on all my papers and results. You brought extensive epidemiology expertise in
my projects that allowed me to grow as a researcher. To Dr. Mariana Stern thank you for your
academic advising, foundational knowledge on epidemiology, understanding health disparities, and
reminding me that no matter how many bumps are along on the road that I will make it. To Dr.
David Conti thank you for your insights in molecular and genetic epidemiology and biostatistics. I
appreciated how you reminded me to think of the public health relevance when it came to answering
my research questions. To Dr. Iona Cheng thank you for making me critically think about the multilevel drivers to health and your deep understanding in neighborhood health. I have truly enjoyed
learning how Geographic Information Systems (GIS) positions itself in epidemiology from you and
everyone at UCSF.
Most importantly to my parents, Edith and Pablo R. Acuña, my brother, Pablo A. Acuña,
and grandparents, Hilda and Hernando Tatis – los quiero mucho y sin su apoyo nunca podría
lograrlo. It was such a difficult journey to leave New Jersey to pursue this degree and I couldn’t have
made it without your messages and FaceTime calls to make it to the finish line. To my partner, Vic

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Dela Cruz, thank you for always listening to me, taking an interest in my work, being my biggest
supporter even when I didn’t believe in myself at times, and showing me the beauty of life outside of
school – mahal kita. And finally, to my college and hometown friends, you have always brought a
smile to my face with our conversations about life, family, relationships, or our nostalgic times
together. I could always count on all of you for a good laugh and catching up.

iv
Table of Contents
Acknowledgments .............................................................................................................................................. i
List of Tables ................................................................................................................................................... vii
List of Figures ................................................................................................................................................ viii
Abstract ............................................................................................................................................................. ix
Chapter One: Introduction to Alcohol and Health ..................................................................................... 1
I. Multilevel Approach in Population Health ....................................................................... 1
II. Alcohol & Trends in the United States .............................................................................. 2
III. Alcohol Metabolism and Alcoholic Product Components ............................................. 6
IV. Neighborhood Health and Alcohol .................................................................................. 10
V. Epidemiology and Risk Factors of Alcohol-Associated Liver Disease ...................... 12
VI. Aims of Dissertation ........................................................................................................... 18
Chapter Two: The Association of Alcohol Outlet Density with Alcohol Intake: The Multiethnic
Cohort .............................................................................................................................................................. 21
Introduction ....................................................................................................................................... 22
Methods .............................................................................................................................................. 24
Results ................................................................................................................................................. 29
Discussion .......................................................................................................................................... 30
Tables .................................................................................................................................................. 35
Chapter Three: Circulating microRNAs and Alcohol Consumption in the Multiethnic Cohort
Study ................................................................................................................................................................. 41
Introduction ....................................................................................................................................... 42
Methods .............................................................................................................................................. 43
Results ................................................................................................................................................. 47
Discussion .......................................................................................................................................... 48
Tables .................................................................................................................................................. 51
Figures ................................................................................................................................................. 53
Chapter Four: Replication and Polygenic Risk Score Analysis for Alcohol-Associated Liver
Disease in the Multiethnic Cohort Study .................................................................................................... 53
Introduction ....................................................................................................................................... 54
Methods .............................................................................................................................................. 56
Results ................................................................................................................................................. 60
Discussion .......................................................................................................................................... 61
Tables .................................................................................................................................................. 64
Figures ................................................................................................................................................. 68
Chapter Five: Public Health Significance & Future Directions .............................................................. 71
Public Health Significance ............................................................................................................... 71
Future Directions .............................................................................................................................. 72
Conclusion ......................................................................................................................................... 74
References ........................................................................................................................................................ 75
Appendices ...................................................................................................................................................... 87
Appendix A: Multinomial logistic regression model of alcohol outlet area-based density
and self-reported alcohol intake by location ................................................................................. 87
Appendix B: Association between alcohol outlet area-based density and self-reported
alcohol intake stratified by gender .................................................................................................. 88
Appendix C: Association of population-based alcohol outlet density and self-reported
alcohol intake by racial/ethnic groups in Los Angeles County, CA ......................................... 89

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Appendix D: Association between alcohol outlet area-based density and alcohol intake
stratified by race/ethnicity for Hawaii MEC participants .......................................................... 90
Appendix E: Multinomial logistic regression model of alcohol outlet population-based
density and alcohol intake by location using follow-up questionnaire ..................................... 91
Appendix F: The association of alcohol intake (continuous per drink) and circulating
microRNA adjusted for age at biospecimen draw, sex, race/ethnicity, body mass index
(kg/m2), smoking status, batch, time in years between baseline questionnaire and
biospecimen draw, and case-control status ................................................................................... 92
Appendix G: The association of alcohol intake (categorical) and circulating microRNA
adjusted for age at biospecimen draw, sex, race/ethnicity, body mass index (kg/m2),
smoking status, batch, time in years between baseline questionnaire and biospecimen
draw, and case-control status ........................................................................................................ 106
Appendix H: Heterogeneity by sex for the association of alcohol intake (continuous per
drink) and circulating microRNA adjusted for age at biospecimen draw, race/ethnicity,
body mass index (kg/m2), smoking status, batch, time in years between baseline
questionnaire and biospecimen draw, and case-control status ................................................ 130
Appendix I: Heterogeneity by race/ethnicity for the association of alcohol intake
(continuous per drink) and circulating microRNA adjusted for age at biospecimen draw,
sex, body mass index (kg/m2), smoking status, batch, time in years between baseline
questionnaire and biospecimen draw, and case-control status ................................................ 154
Appendix J: Heterogeneity by body mass index (kg/m2) for the association of alcohol
intake (continuous per drink) and circulating microRNA adjusted for age at
biospecimen draw, sex, race/ethnicity, smoking status, batch, time in years between
baseline questionnaire and biospecimen draw, and case-control status ................................. 179
Appendix K: Heterogeneity by smoking status for the association of alcohol intake
(continuous per drink) and circulating microRNA adjusted for age at biospecimen draw,
sex, race/ethnicity, body mass index (kg/m2), batch, time in years between baseline
questionnaire and biospecimen draw, and case-control status ................................................ 203
Appendix L: Study characteristics of analytic sample by case-control status ........................ 238
Appendix M: Heterogeneity by case-control status for replicating main findings ............... 239
Appendix N: Association from the replication analysis of alcohol-related liver cirrhosis
among MEC participants by the combined and self-identified race and ethnicity ............... 241
Appendix O: Association from the replication analysis of alcohol-associated liver
disease among MEC participants by the combined and self-identified race and ethnicity
adjusting for alcohol intake ........................................................................................................... 245
Appendix P: Association from the replication analysis of alcohol-associated liver disease
among MEC participants with 12 or more months of continuous FFS coverage by the
combined and self-identified race and ethnicity ......................................................................... 249
Appendix Q: Association from the replication analysis of alcohol-associated liver disease
among MEC participants without existing chronic conditions impacting the liver by the
combined and self-identified race and ethnicity ......................................................................... 253
Appendix R: Polygenic risk score, per standard deviation increase, and its association
with alcohol-related liver cirrhosis in the MEC ......................................................................... 257
Appendix S: Polygenic risk score, per standard deviation increase, and its association with
alcohol-associated liver in the MEC adjusting for alcohol intake ........................................... 257
Appendix T: Polygenic risk score, per standard deviation increase, and its association
with alcohol-associated liver in the MEC among those with 12 months or more
continuous coverage of Medicare Fee-For-Service ................................................................... 258

vi
Appendix U: Polygenic risk score, per standard deviation increase, and its association
with alcohol-associated liver in the MEC among those without chronic conditions
impacting the liver .......................................................................................................................... 258
Appendix V: On- and off-premise population-based alcohol outlets in Hawaii (a and b),
and Los Angeles County, California (c and d) by census block group ................................... 259

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List of Tables
Table 1: Existing genetic studies assessing the association of single nucleotide polymorphisms
and alcohol-related liver disease ................................................................................................................... 15
Table 2: Demographic characteristics by alcohol outlet for MEC participants in Los Angeles
County, California (n=93,467) ...................................................................................................................... 35
Table 3: Demographic characteristics by alcohol outlet for MEC participants in Hawaii
(n=85,510) ....................................................................................................................................................... 36
Table 4: Multinomial logistic regression model of alcohol outlet population-based density and
alcohol intake by location .............................................................................................................................. 38
Table 5: Association between alcohol outlet population-based density and alcohol intake
stratified by gender ......................................................................................................................................... 39
Table 6: Association between alcohol outlet population-based density and alcohol intake
Stratified by race/ethnicity for Hawaii MEC participants ........................................................................ 40
Table 7: Characteristics of study sample (N=917) .................................................................................... 51
Table 8: miRNAs associated with alcohol consumption modelled as categorical (nondrinkers,
light drinkers, and heavy drinkers) and continuous (per standard drink) variables .............................. 52
Table 9: Study characteristics of participants by case-control status ...................................................... 64
Table 10: Association from replication analysis in the MEC by self-identified race and ethnicity .... 65
Table 11: Polygenic risk score, per standard deviation increase, and its association with alcoholAssociated liver disease in the MEC ............................................................................................................ 68

viii
List of Figures
Figure 1: Adapted from Warnecke et al. a conceptual framework of proximal, intermediate, and
distal factors influencing health disparities in population health .............................................................. 2
Figure 2: Behavioral Risk Factor Surveillance System data of California and Hawai’i between
2011 through 2021, on self-reported a) any alcohol consumption and b) heavy drinking (over
14 drinks per week for males and 7 or more drinks a week for females) within the past-month ........ 4
Figure 3: Behavioral Risk Factor Surveillance System data of California and Hawai’i between
2011 through 2021, by sex on self-reported a) any alcohol consumption and b) heavy drinking
(over 17 drinks per week for males and 7 or more drinks a week for females) within the
past-month ......................................................................................................................................................... 5
Figure 4: Behavioral Risk Factor Surveillance System data of California and Hawai’i between
2011 through 2021, by race and ethnicity on self-reported a) any alcohol consumption and b)
heavy drinking (over 7 drinks per week for males and 7 or more drinks a week for females)
within the past-month ...................................................................................................................................... 5
Figure 5: Main oxidative pathway that decomposes ethanol in the liver ................................................. 7
Figure 6: Diagram depicting the three projects proposed in this dissertation using the Multiethnic
Cohort as the data source. Assessing the association of alcohol outlet density and alcohol intake
(Project 1), self-reported alcohol consumption on circulating miRNA levels (Project 2), and a
replication analysis and constructing a polygenic risk score of alcohol-related liver disease
(Project 3) ......................................................................................................................................................... 18
Figure 7: Volcano plot of miRNAs associated with alcohol consumption using nominal
p-values ............................................................................................................................................................. 53
Figure 8: Flowchart of final analytic sample ............................................................................................... 68
Figure 9: Principal components (1-10) for MEC participants ................................................................. 69
Figure 10: Correlation analysis among genome-wide significant SNPs across self-identified racial
and ethnic groups (A: Combined, B: White participants, C: African American/Black
participants, D: Latino participants, E: Japanese American participants, F: Native Hawaiian
participants) ..................................................................................................................................................... 69
Figure 11: Performance of unweighted polygenic risk score, in quintiles, for alcohol-associated
liver disease for combined and by self-identified race and ethnicity ...................................................... 70
Figure 12: Performance of internal, multiethnic weight polygenic risk score, in quintiles, for
alcohol-associated liver disease for combined and by self-identified race and ethnicity ..................... 70

ix
Abstract
Despite the relative stability of alcohol consumption over time, the harms associated with
alcohol use have escalated. Employing a multi-level approach in population health research provides
insights into how factors ranging from the proximal (e.g., genetics) to the distal (e.g., neighborhood
environments and policy) can influence health outcomes and disparities. This dissertation leverages
multi-level data within a multiethnic population, with alcohol consumption serving as the unifying
theme across three distinct projects.
The first project examines the relationship between alcohol consumption and the density of
on- and off-premise alcohol outlets—retail locations where alcohol is sold—while exploring
potential differences by sex and race/ethnicity. The second project investigates circulating
microRNAs at the molecular level to determine their association with alcohol consumption, as well
as the potential modification of these effects by various demographic and lifestyle factors. The third
project focuses on existing genome-wide association studies (GWAS) related to alcohol-associated
liver disease, replicating and validating these findings within a multiethnic cohort. The final chapter
synthesizes the main findings from each project, discusses their public health significance, and
outlines directions for future research.

1
Chapter One: Introduction to Alcohol and Health
I. Multilevel Approach in Population Health
The field of epidemiology and population health have long studied exposures and its
association to health outcomes, including but not limited to, incidence, mortality, and prevalence in
populations. Within epidemiology, experts have focused on particular areas including
genetic/molecular epidemiology, social epidemiology, behavioral epidemiology, nutritional
epidemiology, and environmental epidemiology to name a few. Researchers in these areas have
shown relationships that certain exposures are known as risk factors for diseases. That is to say,
individuals possessing or being exposed to a risk factor face a higher risk of disease. While the
literature and scientific discovery increases every day, we are able to further increase our
understanding with a multilevel approach. Using a multilevel approach, we can step away from a
singular topical area and look at all the levels, including social determinants of health, health
behaviors, and genetic/molecular factors, to have a better understanding of influences on health
behaviors and outcomes. In a seminal paper published in the American Journal of Public Health,
Warnecke and colleagues comprehensively illustrate how these drivers influence health and more
specifically can lead to health disparities (Figure 1).1 Starting from what is known as proximal factors
these encompass genetic and molecular pathways which can lead to susceptibility to phenotypes and
complex diseases. In this category demographic and lifestyle information and such as their sex, race
and ethnicity, education as well as alcohol use, smoking behaviors, and dietary intake are included.
Finally, the distal factors include those at the policy and institutional level that influence systems and
social conditions.

2
Figure 1. Adapted from Warnecke et al.1 a conceptual framework of proximal, intermediate, and
distal factors influencing health disparities in population health.
It is rare that a disease has a single causal factor. In many cases, there are several risk factors
that work synergistically leading to a symptomatic disease. However, we cannot solely focus on just
genetics or lifestyle factors or neighborhood attributes. Rather, we must look at a variety of different
levels as these all may play a role in the development of a disease or increase risk of mortality for
certain populations. Therefore, the subsequent chapters of this dissertation will examine multiple
levels of exposure on health behaviors and diseases in a racially and diverse population with a
unifying theme of alcohol.
II. Alcohol & Trends in the United States
The most recent National Survey on Drug Use and Health (NSDUH) report shows that
over 85% of adults reported ever consuming alcohol.2 A meta-analysis combining survey responses
from 6 nationally represented data sources showed that between 2000 to 2016, there was a 0.3%

3
increase per year in prevalence of alcohol consumption and 0.7% increase per year in binge
drinking.3 Additionally, from 2019 through 2020 using NSDUH, there was an increase (men: 8.1%
to 9% and women: 4.0% to 4.7%) in self-reports of heavy alcohol use, defined as binge drinking (5
drinks per day for men and more than 4 drinks per day for women) on five or more days within the
past month among adults.2 The COVID-19 pandemic introduced greater stress and boredom, due to
lockdowns, thus leading to increase in alcohol consumption4 and alcohol-related mortality.5 Current
guidelines from the Dietary Guidelines for Americans 2020-2025 recommend no more than 2 drinks per
day for men and no more than 1 drink per day for women,
6 whereas the World Cancer Research
Fund recommends avoiding alcohol altogether.7 The most common type of alcoholic drinks among
US adults have remained relatively stable throughout the years with beer being consumed the most
followed by wine and distilled spirits.8 With these trends and high consumption of alcohol it is
critical to continue understand what may be driving these current patterns and identifying methods
to mitigate excessive consumption. Using longitudinal data from the National Health and Nutrition
Examination Survey (NHANES I), baseline questionnaire administered between 1971 through 1974,
and NHANES I Epidemiologic Follow-Up Survey (NHEFS), administered between 1982 through
1984, 1986, 1987, and 1992, investigators found that predictors for consistent alcohol consumption
included being male, self-identify as White, having a high school education or higher, being a
smoker, not married, and earning over $7000 annually.
9 These same factors are associated with the
prevalence of binge drinking in the Behavioral Risk Factor Surveillance System (BRFSS), defined as
consuming five or more drinks for men and four or more drinks for women, being highest among
college educated, male, self-identify as non-Hispanic White, having higher income, and unmarried.10
BRFSS data showed alcohol consumption differences in California and Hawai’i , the two
locations of the data source of this dissertation, the Multiethnic Cohort (MEC) Study. Between

4
2001 to 2011, California had a slightly higher prevalence of consuming alcohol within the past
month compared to Hawai’i (Figure 2a), but among drinkers Hawai’i had a higher prevalence of
heavy drinking (14 or more drinks a week for men and 7 or more drinks a week for women) (Figure
2b). When stratified by sex, males in both Hawai’i and California had higher self-reported any
alcohol consumption (Figure 3a) and heavy alcohol consumption (Figure 3b). However, Hawai’i
males had the highest reported heavy alcohol consumption. Additionally, stratification by race and
ethnicity (Figure 4) by both locations revealed that White individuals had the highest reported
consuming alcohol in the past month and Native Hawaiian and White individuals had the highest
reported heavy consumption of alcohol.
Figure 2. Behavioral Risk Factor Surveillance System data of California and Hawai’i between 2011
through 2021, on self-reported a) any alcohol consumption and b) heavy drinking (over 14 drinks per
week for males and 7 or more drinks a week for females) within the past-month.

5
Figure 3. Behavioral Risk Factor Surveillance System data of California and Hawai’i between 2011
through 2021, by sex on self-reported a) any alcohol consumption and b) heavy drinking (over 17
drinks per week for males and 7 or more drinks a week for females) within the past-month.
Figure 4. Behavioral Risk Factor Surveillance System data of California and Hawai’i between 2011
through 2021, by race and ethnicity on self-reported a) any alcohol consumption and b) heavy

6
drinking (over 7 drinks per week for males and 7 or more drinks a week for females) within the pastmonth.
III. Alcohol Metabolism and Alcoholic Product Components
i. Alcohol Metabolism
There are two main pathways in the metabolism of alcohol: oxidative and non-oxidative
pathways. This section will focus on oxidative pathways as it is the most common way by which
alcohol is metabolized in the body. After alcohol is swallowed, it is first absorbed in the small
intestine and then goes into the veins where it finally is led into the liver.11 Once in the liver,
enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) begin to
break down the composition of ethanol (Figure 5). In the oxidative pathway, ADH takes ethanol
and produces acetaldehyde in the cytosol. Acetaldehyde is a highly toxic byproduct in the liver but is
rapidly converted to acetate by ALDH.12 Both reactions require nicotinamide adenine dinucleotide
(NAD+) and is reduced to NADH as a result. The increase of NADH inhibits important biological
pathways such as gluconeogenesis, glycolysis, pyruvate dehydrogenase, and fatty acid oxidation that
ultimately reduce the power of the cell.13,14
Another pathway which ethanol is metabolized in the liver is by the enzyme cytochrome
P450, which has over 100 different genes that encode for it. Specifically, CYP2E1 has the highest
activity of the P450s of converting ethanol into acetaldehyde.13 CYP2E1 normally converts ethanol
into acetaldehyde at higher blood alcohol concentration levels.11 Of concern, is through this
oxidative process reactive oxygen species (ROS) such as hydroxyethyl, superoxide anion, and
hydroxyl radicals are produced.11 These ROS can contribute to DNA damage, tissue injury, and
potentially carcinogenesis.11,15

7
Though a minor process which ethanol is oxidized occurs in the peroxisomes of the cells
from catalase.11 It requires hydrogen peroxide (H2O2) to bind to ethanol and produces water as a byproduct.11
Figure 5. Main oxidative pathway that decomposes ethanol in the liver.
ii. Alcohol Product Definition, Production, & Chemical Components
There are three main alcoholic beverages used in the Standard International Trading
Classification (SITC) which include beer, wine from fresh grapes, and distilled spirits. Each contain
slightly different ingredients and processes in which they are made, but the focus in the proceeding
sections will be on ethanol intake from alcoholic beverages. However, we cannot overlook that there
may be other components within alcohol that may impact biological processes and thus are
discussed briefly in this section.
a. Beer

8
The conventional process of making beer, which remains relatively the same to this day,
includes malted barley, water, hops, and yeast. The seeds of the barley plant, otherwise known as
kernels or grains, are used for the malting process.16 The process consists of leaving these kernels in
optimal temperature and moisture to allow for germination that can last up to 10 days.16 Malt is
enriched with many enzymes including -amylase, -amylase, -glucosidase, and limit dextrinase.17
The malt is then added to hot water with hops and then transferred to a vial to ferment with yeast.
Through cellular metabolism, yeast with sugar produces ethanol, carbon dioxide, and esters.16 On
average, a single serving of beer (12 ounces) in the US contain about 5% of ethanol.18
b. Wine
The core ingredient for wine making is either red or white grapes. These grapes are collected,
and the juice is extracted by crushing them. Grapes have various components in it including
phenolics, terpenoids, fats, carbohydrates, acids, and nitrogenous compounds.19 After the juice has
been extracted it gets filtered and sulfur dioxide (SO2) is added to control the yeast in the
fermentation process.19 During the fermentation process, yeast uses the sugar to produce ethanol
and the exact level of ethanol produce can vary depending on the temperature of the fermentation.19
A majority of wine is water (86%) followed by alcohol (3%) and the remaining consists of various
compounds such as glycerol, organic acids, sugars, phenols, sorbitol, and minerals.20 A single serving
of wine (5 ounces) has about 12% of ethanol.18
c. Distilled Spirits
Similar to wines and beers, distilled spirits begin with a base that needs to undergo the
fermentation process. This base can include grains, grapes or other fruits, molasses, cane sugar, or
potatoes.21 However, what makes these products different is that they undergo a distillation process.

9
Distillation ultimately separates the water from the alcohol via evaporation and condensation.22 This
process can be repeated to remove any unwanted volatile compounds such as methanol, ethyl
acetate, and n-propanol, which are produced during the fermentation process.23 The final product
after distillation contains a concentrated liquid of ethanol and, on average, 1.5 ounces of a distilled
spirit contains about 40% of ethanol.18

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IV. Neighborhood Health and Alcohol
There is a growing understanding that health is not only shaped by individual-level factors, but
also coalescing social and neighborhood-level factors as well.24,25 Studies have shown that
neighborhood features such as access to sidewalks26 and parks,27 and availability of grocery stores28
can have positive impacts on an individual’s health such as lower body mass index and risk of
obesity, and lower incidence of diabetes and cardiovascular disease.29
Neighborhood-levels have profound effects on an individual’s health. A conceptual framework
from Diez Roux and colleagues illustrate how neighborhood characteristics, both physical and
social, are derived from residential segregation and influence these lifestyle behaviors.25 Furthermore,
a comprehensive review demonstrated how both the social and built environment plays an
important role across the cancer continuum.30 Therefore, understanding and researching areas how
neighborhoods are drivers for health are critical and needed in public health and epidemiology.31
One built environment attribute that has been studied extensively in relationship to lifestyle and
other neighborhood characteristics are alcohol outlets. Such that alcohol outlets have been shown to
also be associated with binge drinking. Binge drinking classified as drinking more than 4 drinks for
women and 5 drinks for men can have deleterious health impacts such as addiction, poor mental
health outcomes, and mortality.32 Off-premise alcohol outlets, defined as liquor stores and
convenience stores selling alcoholic products, in New York City have a nonlinear relationship with
binge drinking. Residing in an area with more than 80 off-premise alcohol outlets per square mile
had the strongest associations.33 Thereby suggesting that targeting areas in New York City with the
highest density of alcohol outlets may be the best approach at potentially reducing binge drinking. In
another study, using data from the Stanford Heart Disease Prevention Program from 1979 to 1990,

11
a neighborhood deprivation score was used to assess its association with self-reported alcohol intake
and potential mediating effects with alcohol outlet density.34 The neighborhood deprivation score
was constructed using the Townsend Material Deprivation Index which uses four census variables:
proportion of crowded occupied housing units, unemployed individuals, rented units in the area, and
housing units without a car.35 They concluded that individuals residing in the least deprived
neighborhoods was associated with an increase in alcohol intake after adjusting for demographic
information and individual-level socioeconomic status. They also assessed the mediating role of
alcohol outlet density on alcohol intake but did not find evidence of this.34
Slutske et al., investigated the association between neighborhood contextual factors (alcohol
outlet density, urbanicity, and neighborhood disadvantage), at the census tract level in the United
States, with alcohol consumption on a sample of 15,197 participants.
36 They only found a positive
association (OR=1.19, 95% CI: 1.08,1.31) with increasing on-premise alcohol outlet density, defined
as bars and restaurants, and reporting using alcohol in the past year. However, there was an inverse
association (OR=0.90, 95% CI: 0.82,0.99) with increasing off-premise alcohol outlet density and
reported alcohol intake in the past year. No associations were found with how frequently
participants were drinking or the quantity. In a second study, these investigators leveraged genetic
information from their sample and performed a gene-environment interaction study to see if there
findings would be consistent.37 They used 2,434 sibling pairs and revealed that residing in
neighborhoods with high densities of alcohol outlets (both on- and off-premises) and participants
who were more genetically susceptible to drink more were more like to consume more alcohol.37
While the literature has published various studies on alcohol outlets and both harms and association
with lifestyle behaviors a critical review of the literature demonstrates that findings are mixed
particularly due to differences in study methodologies.38

12
V. Epidemiology and Risk Factors of Alcohol-Associated Liver Disease
i. Trends in US incidence and mortality
There was a total of 425,045 alcohol-induced deaths in the United States between 2000 to
2016.39 Of these deaths, 60.1% and 69.1% were due to ALD among males and females, respectively
underscoring the importance of ALD as the leading cause-specific for alcohol-induced deaths. Data
from NHANES (2001-2002 to 2015-2016) suggest that ALD prevalence has remained stable in the
US around 9% and 7% among males and females, respectively.40 Additionally, investigators from the
same study used the Nationwide Inpatient Sample (NIS) data and showed that hospitalizations from
alcohol-related cirrhosis increased by almost 20% from 2007 to 2014.40 Therefore, indicating that
while prevalence of disease is stable the burden on the healthcare system is increasing. In the
Multiethnic Cohort Study, etiology of liver disease was characterized among the five major racial and
ethnic groups that were linked to Medicare Fee-For-Service.41 Across each of the racial and ethnic
groups, non-alcoholic fatty liver disease was the leading etiology for liver disease followed by ALD.
Among ALD cases (n=1,195) identified in this population between 1999 to 2012, Latino (29.0%),
White (28.9%), and Japanese American (23.1%) participants had the greatest proportion of ALD
cases.
Investigators used data from the Centers for Disease Control and Prevention Wide-Ranging
Online Data for Epidemiologic Research (CDC WONDER) to investigate trends on alcoholassociated liver disease mortality between 1999 to 2022.42 The age-adjusted mortality rates for ALD
in 1999 was 6.6 deaths per 100,000 people and in 2022 this rate increased to 13.5 deaths per 100,000
people. While the mortality rate was higher for males compared to females, females had a higher
mortality average annual percent change (males AAPC: 2.5% and females AAPC: 4.5%) increase
during this time period. When stratified by race and ethnicity, White (AAPC = 3.6%) , Asian and

13
Pacific Islander (AAPC = 0.3%), and American Indian or Alaskan Natives (4.3%) had increasing
ALD mortality rates.
ii. Risk Factors of Alcohol-Associated Liver Disease
a. Alcohol
Progression of ALD is primarily driven by alcohol consumption. Heavy and chronic
consumption of alcohol can lead to injury of the liver due to acetaldehyde and other metabolic
products.43 As described in the section, Alcohol Metabolism, these by-products are harmful to the liver.
As the liver accumulates injury it progresses to a state known as steatosis and continued injury leads
20-40% of people to develop fibrosis and later on 8-20% develop a severe stage known as alcoholassociated cirhossis.44 Alcohol-associated cirrhosis is a more severe stage of ALD and outcomes are
based on if a patient is able to abstain from alcohol consumption in order to slow down fibrosis
progression.44 Therefore, the chronic and heavy consumption of alcohol leads to liver injury and
thus progression of alcohol-associated liver diseases.
b. Obesity and Body Mass Index
In a study from France 1,604 individuals with either alcohol use disorder or alcohol liver
disease were analyzed to determine if excess weight, defined as over 10-years being overweight by
BMI, was independently associated with the presence of alcoholic cirrhosis, acute alcoholic hepatitis,
and steatosis.
45 After adjusting for important covariates such as age, sex, alcohol consumption within
the past 5-years, and alcohol misuse, investigators found a positive association with being
overweight and alcoholic cirrhosis (OR=2.15, 95% CI: 1.5-3.0) and acute alcoholic hepatitis
(OR=3.0, 95% CI: 1.0-9.0). Thus, demonstrating that independent of alcohol and other important
confounders, being overweight for 10-years is independently associated with various alcohol liver
diseases. In another study based out of California demonstrated both the independent and

14
synergistic effects of alcohol and obesity on serum alanine (ALT) and aspartate (AST)
aminotransferase levels.46 Elevated levels of ALT and AST indicate acute and chronic liver injury
including alcohol-associated liver disease.47 While the study was not able to show an association an
association specifically with ALD, it did show that the joint effects of obesity and alcohol have a
positive association with liver damage, as measured by elevated ALT and AST levels.
c. Diabetes
Diabetes is characterized by the body’s inability to respond and secrete insulin.48 One of the
functions of the liver is to release glucose when the body is fasting.49 Interestingly, a review compiled
literature on diabetes and liver diseases and report that diabetes can not only serve as a risk factor
for liver diseases, but also can be a consequence from liver diseases known as “hepatogenous
diabetes.”50 Previous studies have shown that diabetes has been shown to have a high prevalence
(19%) and risk of development (males: HR=1.69[95% CI: 1.46-1.96] and females: HR= 1.72[95%
CI: 1.11,2.65]) among those with alcohol-associated liver disease.51,52 A possible pathophysiology
mechanism whereby diabetes can lead to liver injury is through excess free fatty acids can increase
oxidative stress and ultimately leading to fibrosis.50
d. Aging
As one ages, the liver’s functions begin to change such as reduction in liver volume, increase
in lipofuscin, differences in expression of proteins, and reduced hepatobiliary function.53,54
Ultimately these changes in the liver function deviate from homeostasis and can lead to abnormal
health outcomes. In mouse models and human participants, studies have shown that aging reduced
SIRT1 and miR-233 levels.55,56 As a result, this led to increasing inflammatory mediators and reactive
oxygen species, which lead to liver injury.

15
e. Sex
Descriptive epidemiology studies, using population-level data from the National Health and
Nutrition Examination Survey, have demonstrated that males have higher prevalence of ALD
compared to females.40 Specifically, from 2001 to 2016 the national prevalence of ALD for males
was between 9% to 10% and for females between 7% to 8%.40 This concords with alcohol
consumption trends that males tend to drink alcohol at both higher frequency (times per week) and
intensity (drinks during ) compared to females.57
f. Genetic Susceptibility
A complete list of current literature on GWAS and case-control studies for ALD are
reported in Table 1. Genome wide association studies (GWAS) have identified single nucleotide
polymorphisms (SNPs) associated with ALD in predominantly in European ancestry populations58–60
and one in an East Asian ancestral study.61 Majority of the cases of ALD consisted of males.
Important genes that were associated with those SNPs include PNPLA3, MBOAT3, TM6SF2, and
ZNF827. In the study by Innes and colleagues, they did not define ALD in their study, but rather
used high levels of ALT and AST as proxies to identify cases of ALD.62 In one study conducted in
Mexico City, Mexico sampled a population of mestizo individuals (European and Ameri indigenous
ancestry) with ALD to assess variations of PNPLA3 and the disease and found consistently that it
was associated with ALD despite the SNP originally being identified in an European ancestry
population.63
Table 1. Existing genetic studies assessing the association of single nucleotide polymorphisms and
alcohol-related liver disease.
Study
Author
Year Case
definition
Study
Design
Sample Size Population Significant SNPs

16
Genome-wide association studies
Buch et al. 2015 alcoholrelated
cirrhosis
GWAS
(discovery &
validation)
Discovery:
2138 (86.2%
males)
Validation:
2070 (75.2%
males)
European
ancestry
rs738409 (PNPLA3)
rs641738 (MBOAT7)
rs10401969 (TM6SF2)
rs58542926 (TM6SF2)
Beaudoin
et al.
2017 Alcoholic
hepatitis
GWAS 183 (61.2%
males)
European
ancestry
Nothing reached statistical
significance.
However, strongest signals
detected were rs2294915,
rs3747207, and rs738409
(PNPLA3)
Innes et al. 2020 Alcoholrelated
cirrhosis
using
surrogate
liver
phenotypes
GWAS
(Discovery
analysis,
phase 1
replication,
phase 2
replication)
Discovery:
35839 (63%
males)
Phase I:
300564
(45.3%
males)
Phase II:
2399 (80.7%
males)
European
ancestry
(UK
Biobank)
rs2642438 (MARC1)
rs15052 (HNRNPUL1)
Kim et al. 2020 Alcoholassociated
liver disease
GWAS Nondrinkers:
18840
Light
drinkers:
14511
Heavy
drinkers:
3431
Korean
(East
Asian)
Nondrinkers:
rs2006227 (GGT1)
rs1183910 (HNF1A)
rs4835265 (ZNF827)
Light drinkers:
rs2006227 (GGT1)
rs1183910 (HNF1A)
rs4835265 (ZNF827)
Heavy drinkers:
rs2006227 (GGT1)
rs1183910 (HNF1A)
rs4835265 (ZNF827)
SchwantesAn &
Darlay et
al.
2021 alcoholassociated
cirrhosis
GWAS
(replication
and metaanalysis)
GenomeALC
1,128 cases
(75.2%
males)
614 controls
(73.1%
males)
UK BioBank
(replication):
European
ancestry
Meta analysis:
rs10433937 (HSD17B13)
rs11134977 (FAF2)
rs28929474 (SERPINA1)
rs10401969
(SUGP1/TM6SF2)
rs2294915 (PNPLA3)

17
439 cases
(80.6%
males)
8,364
controls
(76.2%
males)
Heavy
drinkers no
cirrhosis:
160 (68.1%
males)
Case-control studies / replication analyses
Tian et al. 2010 alcoholic
liver disease
(ALD) and
alcoholic
cirrhosis
Replication
analysis /
case-controls
ALD:
434 (85%
males)
Cirrhosis:
482 (85%
males)
Controls:
305 (84%
males)
European
& Native
American
ancestry
rs738409 (PNPLA3)
Stickel et
al.
2011 (1)
alcoholic
liver
cirrhosis
(ALC), (2)
alcoholics
with liver
steatosis on
ultrasound
and
elevation of
ALT
(alcoholic
liver
damage
[ALD]), (3)
alcoholic
liver
steatosis
and normal
liver
enzyme
Case-control
comparing
genotype
frequencies
Cases:
873 (91.0%
males)
Controls:
708 (98.0%
males)
European
ancestry
rs738409(GG) (PNPLA3)

18
levels
(alcoholic
fatty liver
[AFL])
Kolla et al. 2018 Alcoholassociated
liver disease
Case-control
(replication
study)
428 (76.9%) European
ancestry
rs738409 (PNPLA3)
VI. Aims of Dissertation
The three projects outlined for the dissertation are described below. Figure 6 illustrates the
three projects and the unifying connections each contribute to each other.
Figure 6. Diagram depicting the three projects proposed in this dissertation using the Multiethnic
Cohort as the data source. Assessing the association of alcohol outlet density and alcohol intake
(Project 1), self-reported alcohol consumption on circulating miRNA levels (Project 2), and a
replication analysis and constructing a polygenic risk score of alcohol-related liver disease (Project 3).
Project 1
We hypothesized that participants residing in neighborhoods with high density of on- and
off-premise alcohol outlets will have an increased odds of consuming alcohol. This hypothesis is
based on previous studies have shown the impacts alcohol outlets have been associated with

19
alcohol-related outcomes such as car accidents64, violent crimes65,66, and binge drinking.33 We tested
this hypothesis leveraging data on alcohol outlet density in the MEC, geocoding baseline addresses
for MEC participants for their census block group. We first characterized alcohol outlet density by
individual and neighborhood-level factors among MEC participants. Afterwards, we assessed the
association of the alcohol outlet density with alcohol consumption. We also evaluated if there was
any heterogeneity in association by sex or race/ethnicity. We hypothesize that participants residing
in neighborhoods with high density of on- and off-premise alcohol outlets will have an increased
odds of consuming alcohol.
Project 2
We hypothesized that we would find differential expression levels based on participants’ selfreported alcohol intake on circulating miRNAs and differences by subgroups. We based our
hypothesis on the literature whereby lifestyle exposures such as smoking, physical activity, and food
intake can alter the levels of the circulating miRNAs found in our bodies.67,68 microRNAs are noncoding segments in our genes that have the capabilities of silencing or enhancing gene functions.
There are few studies that have looked at circulating miRNA levels being influenced by alcohol
consumption in healthy human participants.69–71 Project 2 will investigate how self-reported alcohol
intake is associated with circulating miRNA levels in MEC participants.
Project 3
The third and final project will examine whether genetic variants that were associated with
alcohol-related liver diseases from genome wide association studies (GWAS) conducted in largely
European ancestry population replicate associations in a multiethnic population. Many previous
studies have used individuals of European ancestry58–60 and relatively few have replicated findings

20
from these GWAS among racially and ethnically diverse populations.61 The MEC has the
opportunity to expand findings from previous GWAS and replicate previous findings associated
with alcohol-related liver disease among those with varying ancestry. Additionally, we constructed a
polygenic risk score to stratify participants and identify those who may be at low and high risk of
ALD.

21
Chapter Two: The Association of Alcohol Outlet Density with
Alcohol Intake: The Multiethnic Cohort
Abstract
Objective. Neighborhood characteristics have been shown to influence lifestyle behaviors.
Here we characterized alcohol outlet density in Los Angeles County, California, and Hawaii and
assessed the association of alcohol outlet density with self-reported alcohol intake in the Multiethnic
Cohort.
Method. Participants (n=178,977) had their addresses geocoded, at cohort entry (1993-
1996), and appended to block group-level alcohol outlet densities (on- and off-premises).
Multinomial logistic regression was performed to assess the association between self-reported
alcohol intake and on- and off-premise alcohol outlet densities by each state. Stratified analysis was
conducted by sex, race, and ethnicity.
Results. Overall, we did not find associations between alcohol outlet density and selfreported alcohol intake in Los Angeles County, but we found that on-premise alcohol outlets were
associated with 59% (OR=1.59, 95% CI:1.29,1.96) increased odds of consuming >2 drinks per day
in Hawaii. Women living in neighborhoods with high density of on-premise alcohol outlets (Los
Angeles County OR=1.15, 95% CI: 0.95,1.40) and (Hawaii OR=2.07, 95% CI: 1.43,3.01) had an
increased odds of >2 drinks per day.
Conclusion. This study suggests that neighborhood factors are associated with individual
level behaviors and that there may be a need for multilevel interventions.

22
Introduction
In 2019, over 85% of U.S. adults reported ever drinking alcohol and over 25% reported
binge drinking in the past month.
72 From 1999 to 2017, the rate of alcohol-related deaths increased
by over 50%.
73 This causes great concern as high consumption of alcoholic products has detrimental
health consequences such as increasing the risk of liver diseases, cancer, mental health problems, and
heart disease.
74 In addition, alcohol drinking increases the risk of fatal injuries from motor vehicle
accidents75, of committing sexual assaults76, and of other unsafe sexual risk behaviors.
77
There is a growing understanding that health is not only shaped by individual-level factors, but also
coalescing social and neighborhood-level factors as well.
24,25 An important neighborhood feature that
has been shown to be associated with alcohol intake is the availability of alcohol outlets.
33,78–82
Alcohol outlet density is defined as licensed locations where alcoholic products are served or
purchased and can be characterized as either an on-premise or off-premise site.
83 On-premise
alcohol outlet density are those locations where alcohol is served with consumption at that site,
which can include bars, restaurants, and concession stands. Off-premise alcohol outlet density are
locations where alcohol products are purchased but not consumed such as liquor stores,
convenience stores, or grocery stores. Both operate slightly differently in neighborhoods where onpremises have been thought to be tied to public drunkenness, driving under the influence, and
increase in violence whereas off-premises with civil disorder.
84
The Task Force on Community Preventive Services released a report emphasizing the
importance of limiting alcohol outlet density to reduce excessive alcohol consumption.
85 Moreover,
Campbell and colleagues developed an analytic framework whereby reducing the number of alcohol
outlets, increasing prices of alcoholic products, limiting alcohol advertising, or changing social
norms surrounding drinking can have positive effects on both alcohol consumption and alcoholrelated health and social problems.
86 The framework shows that access to alcohol outlets has been

23
associated with excessive alcohol consumption and alcohol-related health problems. Gruenewald
and colleagues introduced the concept of an ecologic approach for understanding drivers and
constraints in individuals to drink in the early 1990s and showed that increasing the physical
availability of alcohol led to both greater alcohol consumption and alcohol-related problems.
87 This
was later expanded to include more specific drivers at both the community and individual level, but
more specifically social drivers.
78 Nested within community level drinking environments and social
disorganization, both demographic measures (e.g., gender, race/ethnicity, education, etc.) and
psychological/social measures (e.g., impulsivity, tolerance of deviance, etc.) influence drinking
patterns and behaviors.
78 Statistically, investigators were able to demonstrate from their conceptual
framework that both community and individual level factors influence alcohol consumption thus
underscoring the importance of considering a social ecological framework.
Previous studies on alcohol outlet density and alcohol intake have mixed findings such that
there are positive and null associations.
38 While the literature on alcohol outlet densities is large,
there remains gaps as to whether certain racial/ethnic populations or if a particular sex is at risk of
consuming more alcohol because of greater alcohol outlet densities in their neighborhood. The
current study can add to the literature by studying how this particular neighborhood attribute may
influence individual health behaviors for specific race/ethnicities or sex in two different locations.
Specifically, we characterized alcohol outlet density in the Multiethnic Cohort Study (MEC), a large
racially and ethnically diverse cohort from Los Angeles County, California and Hawaii, and assessed
the association between the neighborhood alcohol outlet density and self-reported alcohol intake.
We hypothesized that residing in neighborhoods with high on- and off-premise alcohol outlet
density would be associated with increased alcohol intake.

24
Methods
Study Population
The MEC is a prospective cohort of over 215,000 individuals residing predominantly in Los
Angeles County, California, and Hawaii. The cohort consists of five major racial/ethnic groups
(African American/Black, Japanese American, Latino, Native Hawaiian, and White). Participants
were ages 45 to 75 at the time of recruitment in 1993-1996. Recruitment details and procedures have
been published previously.
88 There were 195,566 participants (105,220 in Los Angeles County and
90,346 in Hawaii) who completed the baseline questionnaire with a geocoded residential address
(geocoded using ArcGIS Pro 2.8.2 and ESRI StreetMap Premium version 2020 R4 as described in
‘Address and Geocoding’). We excluded participants who were not part of the five main
racial/ethnic groups (n=161), or with missing information on body mass index (n=2,066), smoking
status (n=2,895), alcohol intake (n=4,418), mortality information (n=2,276), education (n=866), and
pack-years of cigarette smoking (n=3,907). After these exclusions, the final analytic sample for this
study was 178,977 (93,467 in Los Angeles County and 85,510 in Hawaii). The study received
Institutional Review Board approval from University of Southern California, University of Hawaii
and University California, San Francisco.
Measurement of Alcohol Consumption
At baseline, participants were mailed a 26-page questionnaire which included a quantitative
food frequency questionnaire (QFFQ). The QFFQ asked over 180 food items, which also included
questions on consumption of alcoholic beverages.
88 Participants were asked, on average, if they
consumed regular or draft beer, light beer, white or pink wine, red wine, and hard liquor in the past
year. Frequency of each of the alcoholic products was scored on a 9-point scale ranging from “never
or hardly ever” to “4 or more times a day.” Serving sizes were measured on a 4-point scale: ≤1,2,3,

25
or ≥4 cans/bottle/glasses/drinks. Daily ethanol intake (g/day) was calculated using the following
conversions: 1 can of regular/draft beer, 13.0 g of ethanol; 1 can of light beer, 11.5 g; 1 glass of
white/pink wine, 11.3 g; 1 glass of red wine, 11.2 g; and 1 drink of hard liquor, 15.4 g. We estimated
overall ethanol intake measured as grams per day for each participant. In the MEC, a large
proportion of participants did not alcohol drinkers (approximately 40%) and thus the distribution
was highly right skewed. We categorized alcohol intake into a 4-level categorical variable (0 g/day =
0 drinks per day , >0 and <12g/day = less than 1 drink per day, 12-24g/day = 1 to 2 drinks per day,
>24g/day = >2 drinks per day). Hereafter we present results as number of drinks per day. A
calibration study in the cohort showed satisfactory correlations between the QFFQ and 24-hour diet
recall for all sex and racial/ethnic groups with the correlations for alcohol intake ranged from 0.56
to 0.88.
89
Address and Geocoding
The MEC maintained up-to-date addresses on all participants through mailings and linkages
with secondary data sources such as the U.S. Postal Service. Residential addresses were geocoded
using ArcGIS Pro 2.8.2 and ESRI StreetMap Premium version 2020 R4 to latitude and longitude
coordinates to rooftop or parcel centroid, and otherwise to street centerline as described
previously.
90
Alcohol Outlet Density
Alcohol outlet density was calculated at the block group level, representing our
neighborhood unit, using Dun and Bradstreet business data to identify alcohol outlets.
91,92 We use
census block groups, a smaller area geography that represent less heterogeneity, as they are useful
administrative geographies for proxying neighborhoods in large population-based studies.
93 Standard

26
Industrial Classification System (SIC) codes were used to identify on-site/premise vs. offsite/premise outlets. On-premise included restaurants (5813), bars, (8641) and concession stands
(58120201); off-premise included grocery stores (54110000, 54110100, 54110101, 54110102,
54110103, 54110104, 54110105, 54119904, 54119905), convenience stores (54110200, 54110201,
54110202), and liquor stores (592).
34,81,86,94 Grocery stores were included as off-premise outlets as
both California and Hawaii allowed alcoholic beverages to be sold in grocery stores during the study
period following the methodology of Campbell and colleagues.
86 While off-premise can be
disaggregated by specific venue type, given they may operate under varying mechanisms, we were
unable to disaggregate with our current data and report our findings as overall off-premise outlets in
a participant’s block group. Alcohol outlet counts for a 3-year window, 1990-1992, were used to
provide an average count for the 1990 block groups characterizing baseline neighborhoods for MEC
participants. Alcohol outlet population-based density was calculated by dividing the averaged 3-year
count by the population of each block group per 1,000 people.
83 In addition, alcohol outlet areabased density was calculated by dividing the averaged 3-year count by the area of each block group
in square kilometers.
83 We presented the population-based density analyses as the main results. The
area-based density results are presented in the Appendix. Alcohol outlets were categorized into a
three-level variable. Participants that did not have any alcohol outlets in their block group were
categorized into “none.” Similar to Pollack and colleagues,
34 remaining participants were categorized
into “low” alcohol outlet density if they were in the 75th percentile or lower and categorized as
“high” if they were in the upper 25th percentile. Data were prepared using R 4.0.3 and R Studio
2022.07.0. Alcohol outlet density was mapped to block groups using ArcGIS Pro 2.8.2 and census
geographic data from the National Historical Geographic Information System (NHGIS).
95
Neighborhood Socioeconomic Status

27
Geocodes for analytic sample baseline addresses were linked to 7,606 unique 1990 U.S.
Census block groups for California, and 507 for Hawaii. From the Census data, we ascertained
neighborhood socioeconomic status (nSES), which is an established composite measure assessed by
principal component analysis on education, occupation, unemployment, household income, poverty,
rent, and house values.
96 As in a previous MEC study, nSES was categorized into quintiles based on
their distributions across block groups separately for each state.
97
Covariate Data
In the 26-page mail baseline questionnaire between 1993 to 1996, MEC participants were
asked questions on date of birth, their sex (men, women), and to self-report their race and ethnicity.
Participants were also asked their educational attainment, and this was categorized into a three-level
variable (high school degree or less, vocational school/some college, college degree or higher). We
collected information on participants’ smoking status (never, former, current). Former and current
smokers had additional questions regarding how many years they smoked cigarettes and number of
cigarettes, on average, they smoked a day. Pack-years was calculated as number of packs of cigarettes
smoked per day times the number of years smoked. Additionally, participants were asked about their
current height in feet and inches and about their weight in pounds and body mass index (BMI,
kg/m2
) was computed using this information.
Statistical Analyses
We performed a cross-sectional analysis separately for Los Angeles County, CA, and Hawaii
given both alcohol outlet density and alcohol consumption were captured at the same time.
Descriptive statistics were computed for demographics, smoking behaviors, alcohol drinking, and
nSES by on- and off-premise alcohol outlet densities. Categorical variables were reported by

28
frequency distribution (n [%]) and continuous variables by mean and standard deviation (mean
[SD]). We performed multinomial (generalized odds) logistic regression, using marginal models, of
self-reported alcohol intake as the 3-factor outcome variable, using 0 drinks as the reference
category. On-premise and off-premise alcohol outlet densities were mutually adjusted in our models
as we hypothesized on- and off-premise outlet densities do not exist in isolation from each other.
We believe this is a reasonable approach as similarly conducted in a prior study.
98 Sensitivity analyses
where the on-premise and off-premise alcohol outlet densities variables were entered in separate
models did not change effect estimates substantially and thus were not reported. We ran bivariate
analyses for each potential confounder, and they were all associated with at least one of the
exposures (on- or off-premises) and with self-reported alcohol intake. Odds ratios with 95%
confidence intervals were adjusted for age at cohort entry, education status, nSES (quintiles), BMI
(continuous, kg/m2
), smoking status, pack-years of cigarettes smoking (continuous), with sex and
race/ethnicity as strata variables, and clustering by census block group to deattenuate the variance
estimates. Linear trends were computed by examining the alcohol outlet density as ordinal variables
(1,2,3) in their corresponding model. We assessed heterogeneity in associations by sex and
race/ethnicity for each state by treating the categorical alcohol outlet density as an ordinal variable in
its corresponding model using a 3-degree of freedom test. We conducted a longitudinal analysis in a
subset of participants (n=81,252) with follow up alcohol data collected on average of 11 years after
baseline and found similar findings to the full cohort analysis using baseline data (Appendix E). We
did not have information on participants’ alcohol outlet density at follow up, and therefore were
unable to perform an analysis incorporating this information. All analyses were two-tailed and done
using SAS version 9.4 (SAS Institute, Inc., Cary, North Carolina).

29
Results
The demographic characteristics by alcohol outlet for MEC participants in Los Angeles
County and Hawaii are shown in Table 2 and 3, respectively. In Los Angeles County, those with a
graduate degree or higher were more likely to be residing in neighborhoods with a high density of
on-premise alcohol outlets (Table 2). In Hawaii, participants living in the lowest quintile of nSES
status had decreasing proportions of on-premise alcohol outlets and increasing off-premise alcohol
outlets in their neighborhoods (Table 3). In addition, participants in Hawaii who resided in
neighborhoods with high densities of on- and off-premise alcohol outlets tended to be current
smokers. The distribution of on- and off-premise alcohol outlet densities in our study population are
presented for Hawaii and Los Angeles County (Appendix V).
In Los Angeles County, there were no statistically significant associations for both onpremise and off-premise alcohol outlet densities and self-reported alcohol intake (Table 4). In
Hawaii, residing in neighborhoods with high on-premise alcohol outlet density was associated with
an increased odds of consuming alcohol: 28% (OR=1.28, 95% CI: 1.13,1.45) for <1 drink per day,
47% (OR=1.47, 95% CI: 1.23,1.75) for 1-2 drinks/day, and 59% (OR=1.59, 95% CI: 1.29,1.96) for
>2 drinks per day. In addition, there was a significant increasing trend for each alcohol intake
category from neighborhoods with no on-premise alcohol outlet density to high on-premise alcohol
outlet density (Ptrend<0.01). We observed similar results for the area-based alcohol outlet density
variable (Appendix A).
Test for heterogeneity in associations by sex revealed a difference between men and women
for on-premise alcohol outlets in both Los Angeles County (Pheterogeneity<0.01) and Hawaii
(Pheterogeneity=0.01) (Table 5). Additionally, in Los Angeles County we observed heterogeneity for offpremise alcohol outlet densities between the two sexes (Pheterogeneity=0.03), though we did not observe
any significant associations nor any clear trends for both men and women. Women residing in Los

30
Angeles County neighborhoods with high on-premise alcohol outlet density had an increased odds
of alcohol drinking: 10% (OR=1.10, 95% CI: 1.00,1.20) for <1 drink, 22% (OR=1.22, 95% CI:
1.02,1.46) for 1-2 drinks per day and 15% (OR=1.15, 95% CI: 0.95,1.40) for >2 drinks. Similarly,
women living in Hawaii neighborhoods with high on-premise alcohol density had an increased odds
of drinking: 50% (OR=1.50, 95% CI: 1.23,1.83) for <1 drink, 90% (OR=1.90, 95% CI: 1.40,2.58)
for 1-2 drinks per day and 107% (OR=2.07, 95% CI: 1.43,3.01) for >2 drinks. Men in Hawaii had a
24% (OR=1.24, 95% CI:1.06,1.46) increased odds of consuming 1-2 drinks in neighborhoods with
high on-premise alcohol outlets, and a 41% (OR=1.41, 95% CI: 1.16,1.71) increased odds of
consuming >2 drinks in neighborhoods with high off-premise alcohol outlets. Slightly attenuated
effect estimates were seen in the area-based alcohol outlet density variables compared to the
population-based alcohol outlet density results (Appendix B).
We observed significant heterogeneity in associations by race/ethnicity in Hawaii (Table 6),
but not for Los Angeles County (Appendix C). On-premise alcohol density was associated with
higher alcohol consumption among Native Hawaiian and White participants in Hawaii. The largest
effect estimate was found in Native Hawaiian participants, with a 33% (95% CI: 1.00,1.76) increased
odds of consuming 1-2 drinks per day compared to nondrinkers in neighborhoods with high onpremise alcohol outlets. In addition, we observed that White participants in Hawaii had a 22% (95%
CI: 1.01,1.47) increased odds of consuming >2 drinks per day compared to nondrinkers in
neighborhoods with high on-premise alcohol outlet density. Racial and ethnic differences were
observed with the area-based alcohol outlet density for Hawaii (Appendix D).
Discussion
In this large multiethnic population, we found that on-premise alcohol outlet density was
associated with self-reported alcohol intake among MEC participants residing in Hawaii. For Los

31
Angeles County, we did not find an overall association between on- and off-premise alcohol outlet
densities and self-report alcohol intake. However, we did find differences by sex where women, in
Los Angeles County and Hawaii, residing in neighborhoods with high on-premise alcohol outlets
were more likely to consume alcohol and similarly for men in Hawaii. For Hawaii, residing in
neighborhoods with high on-premise alcohol outlets was associated with alcohol intake independent
of residing in neighborhoods with high off-premise alcohol outlet. In addition, we observed a linear
trend where participants residing in neighborhoods with increasing on-premise alcohol outlet density
was associated with a higher odds of self-reported drinking.
A previous study investigated the association between off-premise alcohol outlets and
alcohol intake in Los Angeles and Louisiana.
79 Similar to our results, there was no association in Los
Angeles but there was a positive association in Louisiana. In Louisiana, for each additional offpremise alcohol outlet within one mile of a participant’s home there was a 0.9% increase in alcohol
consumption over the past 12 months. In the Schonlau et al. study, investigators only looked at offpremise alcohol outlet density without mutually adjusting for on-premise alcohol outlet.
79 Therefore,
we ran a sensitivity analysis to see if the effect estimates between on- and off-premise alcohol outlet
densities changed when we ran the on-premise and off-premise alcohol outlet variables in separate
models and we did not see any significant changes in the odds ratios (data not shown). The authors
stated that the landscape in Louisiana differs from Los Angeles, and we believe this may be the case
for our study, where the consumption of alcohol in Los Angeles County may be influenced less by
outlet density in an individual’s block group.
79 Within the MEC, a notable difference was observed
between Hawaii and Los Angeles County in terms of participant distribution across neighborhoods
with high and low on-premise alcohol outlets—10.1% and 29.2%, respectively, in Hawaii, versus
6.4% and 19.3%, respectively, in Los Angeles County (p<0.001). Furthermore, a higher proportion
of participants in Hawaii, 18.8% and 13.9%, respectively, resided in neighborhoods with high and

32
low on-premise alcohol outlets, compared to participants in Los Angeles County, where 9.4% and
9.5%, respectively, consumed >2 drinks per day (p<0.001). These differences in the distribution of
alcohol consumption and alcohol outlets may contribute to the observed differences in our results.
To contextualize our findings based on evidence-based recommendations, the Dietary
Guidelines for Americans 2020-2025, recommend that men should limit alcohol intake to no more than
2 drinks per day and for women no more than 1 drink per day.
6 Here we show that women in
Hawaii who reside in neighborhoods with high on-premise alcohol outlet density had a higher odds
of drinking (>2 drinks per day), which is higher than the recommended amount. The pattern holds
for women in Los Angeles County where there is also an increased odds of consuming 1-2 drinks
per day in neighborhoods with high on-premise alcohol outlet density. This is also true for men in
Hawaii, though the effect estimate not at the same magnitude, where we see increased odds of
drinking >2 drinks a day. These results suggest that there is an association where high on-premise
alcohol outlet density and alcohol intake especially to levels above than the recommended amount.
One hypothesis, discussed in a previous MEC paper,
90 potentially explaining why the effect
estimates are larger in women than in men, is that we are better capturing a women’s neighborhood
associations given they may be spending more time in their neighborhood.
Native Hawaiian and White participants had an elevated odds of consuming alcohol in
neighborhoods with low or high on-premise alcohol outlets. This coincides with data from the
Department of Health, Mental Health Division, of the State of Hawaii showing that White and
Native Hawaiian adults had the highest prevalence rates of drinking alcohol when compared to
Japanese and Filipino residents.
99 Our results may complement these aggregated data from the
Hawaii Department of Health and show from a neighborhood-level why there are racial/ethnic
differences in alcohol consumption.

33
There are some notable strengths in this study. The analytic sample had over 90,000
participants based in Los Angeles County and over 85,000 participants in Hawaii. This provided us
with a large sample to examine sex and racial/ethnic differences across the two states. Our results
add to the scarce data describing racial/ethnic differences as to whether alcohol outlets influence
self-reported alcohol intake. Further research is warranted to examine how alcohol outlet density
affects alcohol intake across racial/ethnic groups to implement culturally appropriate interventions
in reducing alcohol intake. We were also able to geocode participants’ address and create variables
(alcohol outlet density and neighborhood socioeconomic status) that further describe the
participants’ social and built environments. From there, we adjusted for both individual-level and
neighborhood-level factors to inform how this may influence a lifestyle behavior—alcohol
consumption. This approach is more comprehensive as health is not only shaped by an individual’s
lifestyle choices but is also jointly influenced by their social and built environments.
24 Additionally,
we performed further analyses to ensure our results were consistent such as using follow-up alcohol
intake data and running our analyses using self-reported alcohol intake as a continuous variable. We
found that our results from these additional analyses were consistent (data not shown).
While there are strengths in this study, we must address the limitations as well. Both on- and
off-premise alcohol outlet densities were computed using container-based methods.
83 This method
counts the number of alcohol outlets in a predetermined area. The count can then be converted into
a rate by dividing the number of alcohol outlets by the total population in the area (populationbased) or by the size of the area (area-based). However, this method is subject to border issues,
where a specific block group may not have any alcohol outlets, but in the neighboring block group
may have many alcohol outlets. As a result, we cannot rule out the possibility where in block groups
categorized as “none” that participants went to the neighboring block-group, categorized as “high”,
to obtain alcohol. Another limitation is the possibility of increasing alcohol outlets in each area that

34
has a growing population. If the number of alcohol outlets increases proportional to the population,
then the density will be the same even though the availability of alcohol increased in the area.
However, we saw similar results when we looked at the alcohol outlet density counts (data not
shown). Additionally, we were unable to disaggregate venues by specific venue types (bars and
nightclubs vs. restaurants) in our analyses. Further studies are needed to distinguish types of venues
when examining the association with alcohol intake as they may operate with different mechanisms
influencing alcohol consumption. We did not adjust for income, given it is known that individuals
with higher income have the ability to purchase more alcoholic product thus from an economics
perspective would increase alcohol retail demand.
100 Our cross-sectional study design limits making
causal inferences and temporal relationships between alcohol outlets and alcohol consumption.
However, the longitudinal analysis in a subset of MEC participants with follow up data collected on
average of 11 years after baseline showed similar findings to the full cohort analysis using baseline
data. Finally, even though our data on alcohol consumption and alcohol outlets are from the 1990s,
our findings align with studies conducted in more contemporary periods.
98,101
The findings from this study have important health implications for both Los Angeles
County and Hawaii. In CDC’s Guide for Measuring Alcohol Outlet Density, they emphasize the
importance of surveillance of these outlets and consequently health outcomes to guide prevention
strategies to reduce excessive alcohol intake.
83 While we were unable to detect an overall association
in Los Angeles County for alcohol outlet density and alcohol intake, we did find that women in
block groups with high on-premise alcohol outlets had an increased odds of alcohol consumption.
In Hawaii, we found that with increasing on-premise alcohol outlets there is an association with
alcohol intake. We observed that Native Hawaiians and White participants in Hawaii living in block
groups with high on-premise alcohol outlets had an increased odds of consuming alcohol.

35
Neighborhood attributes such as alcohol outlet density is associated with self-reported alcohol intake
and there may be a need for multilevel interventions to reduce alcohol intake.
Tables
Table 2. Demographic characteristics by alcohol outlet for MEC participants in Los Angeles
County, California (n=93,467).a
On-Premises Population-Based Density Off-Premises Population-Based Density
Variable
None
(N=69,457)
Low
(N=18,007)
High
(N=6,003)
None
(N=39,179)
Low
(N=40,788)
High
(N=13,500)
Age at cohort entry, years 61.14±8.35 61.35±8.36 62.11±8.42 61.32±8.35 61.08±8.33 61.54±8.43
Alcohol intake
0 drinks per day 36,645(52.8) 9,258(51.4) 3,036(50.6) 19,956(50.9) 21,607(53.0) 7,376(54.6)
< 1 drink per day 22,147(31.9) 5,858(32.5) 1,983(33.0) 12,877(32.9) 13,022(31.9) 4,089(30.3)
1-2 drinks per day 4,489(6.5) 1,188(6.6) 421(7.0) 2,730(7.0) 2,543(6.2) 825(6.1)
>2 drinks per day 6,176(8.9) 1,703(9.5) 563(9.4) 3,616(9.2) 3,616(8.9) 1,210(9.0)
Body Mass Index (kg/m2
)
< 25 23,357(33.6) 6,658(37.0) 2,221(37.0) 14,006(35.8) 13,950(34.2) 4,280(31.7)
25-30 29,038(41.8) 7,254(40.3) 2,524(42.1) 16,278(41.6) 16,938(41.5) 5,600(41.5)
> 30 17,062(24.6) 4,095(22.7) 1,258(21.0) 8,895(22.7) 9,900(24.3) 3,620(26.8)
Education
High school degree or less 35,693(51.4) 8,783(48.8) 2,696(44.9) 18,180(46.4) 21,534(52.8) 7,458(55.2)
Vocational school/some
college 20,466(29.5) 5,257(29.2) 1,924(32.1) 12,083(30.8) 11,617(28.5) 3,947(29.2)
College degree or higher 13,298(19.2) 3,967(22.0) 1,383(23.0) 8,916(22.8) 7,637(18.7) 2,095(15.5)
Gender
Men 29,521(42.5) 7,903(43.9) 2,602(43.3) 16,662(42.5) 17,715(43.4) 5,649(41.8)
Women 39,936(57.5) 10,104(56.1) 3,401(56.7) 22,517(57.5) 23,073(56.6) 7,851(58.2)
Neighborhood SES
Quintile 1 21,637(31.2) 4,605(25.6) 1,254(20.9) 7,423(19.0) 14,096(34.6) 5,977(44.3)
Quintile 2 15,245(22.0) 3,616(20.1) 1,061(17.7) 8,756(22.4) 8,338(20.4) 2,828(21.0)
Quintile 3 12,656(18.2) 3,256(18.1) 1,714(28.6) 7,667(19.6) 7,111(17.4) 2,848(21.1)
Quintile 4 11,061(15.9) 3,495(19.4) 1,145(19.1) 8,184(20.9) 6,425(15.8) 1,092(8.1)
Quintile 5 8,858(12.8) 3,035(16.9) 829(13.8) 7,149(18.3) 4,818(11.8) 755(5.6)
Pack-years among ever smokers 15.90±14.69 16.58±15.38 16.41±15.08 16.06±14.82 16.13±15.03 15.91±14.39
Race/Ethnicity
White 9,045(13.0) 3,102(17.2) 919(15.3) 5,867(15.0) 5,813(14.3) 1,386(10.3)
African American/Black 22,726(32.7) 4,365(24.2) 2,010(33.5) 12,903(32.9) 10,782(26.4) 5,416(40.1)

36
Latino 29,736(42.8) 7,886(43.8) 2,122(35.4) 15,347(39.2) 18,974(46.5) 5,423(40.2)
Japanese American 7,950(11.5) 2,654(14.7) 952(15.9) 5,062(12.9) 5,219(12.8) 1,275(9.4)
Smoking Status
Never 31,551(45.4) 8,247(45.8) 2,677(44.6) 17,960(45.8) 18,511(45.4) 6,004(44.5)
Former 26,087(37.6) 6,894(38.3) 2,310(38.5) 14,892(38.0) 15,407(37.8) 4,992(37.0)
Current 11,819(17.0) 2,866(15.9) 1,016(16.9) 6,327(16.2) 6,870(16.8) 2,504(18.6)
aCategorical variables are presented as frequencies and continuous variables as mean±standard deviation.
Table 3. Demographic characteristics by alcohol outlet for MEC participants in Hawaii (n=85,510).a
On-Premises Population-Based Density Off-Premises Population-Based Density
Variable
None
(N=51,907)
Low
(N=24,954)
High
(N=8,649)
None
(N=49,124)
Low
(N=27,111)
High
(N=9,275)
Age at cohort entry, years 59.51±9.23 59.29±9.16 60.65±9.34 59.54±9.20 59.19±9.20 60.72±9.34
Alcohol intake
0 drinks per day 26,919(51.9) 12,082(48.4) 3,670(42.4) 24,898(50.7) 13,402(49.4) 4,371(47.1)
< 1 drink per day 14,059(27.1) 7,239(29.0) 2,500(28.9) 13,550(27.6) 7,654(28.2) 2,594(28.0)
1-2 drinks per day 4,149(8.0) 2,164(8.7) 854(9.9) 4,142(8.4) 2,221(8.2) 804(8.7)
>2 drinks per day 6,780(13.1) 3,469(13.9) 1,625(18.8) 6,534(13.3) 3,834(14.1) 1,506(16.2)
Body Mass Index (kg/m2)
< 25 25,520(49.2) 12,663(50.8) 4,371(50.5) 24,678(50.2) 13,061(48.2) 4,815(51.9)
25-30 18,257(35.2) 8,671(34.8) 2,992(34.6) 17,156(34.9) 9,631(35.5) 3,133(33.8)
> 30 8,130(15.7) 3,620(14.5) 1,286(14.9) 7,290(14.8) 4,419(16.3) 1,327(14.3)
Education
High school degree or less 19,888(38.3) 8,387(33.6) 2,899(33.5) 17,849(36.3) 9,851(36.3) 2,474(37.5)
Vocational school/some
college 14,975(28.9) 7,484(30.0) 2,678(31.0) 14,222(29.0) 8,141(30.0) 2,774(29.9)
College degree or higher 17,044(32.8) 9,083(36.4) 3,072(35.5) 17,053(34.7) 9,119(33.6) 3,027(32.6)
Gender
Men 24,847(47.9) 11,819(47.4) 4,209(48.7) 23,289(47.4) 13,037(48.1) 4,549(49.1)
Women 27,060(52.1) 13,135(52.6) 4,440(51.3) 25,835(52.6) 14,074(51.9) 4,726(51.9)
Neighborhood SES
Quintile 1 5,978(11.5) 2,026(8.1) 748(8.7) 5,136(10.5) 1,953(7.2) 1,663(17.9)
Quintile 2 8,108(15.6) 2,334(9.4) 1,304(15.1) 6,785(13.8) 3,706(13.7) 1,255(13.5)
Quintile 3 8,785(16.9) 4,466(17.9) 2,524(29.2) 7,352(15.0) 5,194(19.2) 3,229(34.8)
Quintile 4 11,281(21.7) 4,126(16.5) 2,142(24.8) 9,468(19.3) 5,735(21.2) 2,346(25.3)
Quintile 5 17,755(34.2) 12,002(48.1) 1,931(22.3) 20,383(41.5) 10,523(38.8) 782(8.4)
Pack-years among ever
smokers 20.71±16.51 21.27±16.83 22.44±17.23 20.77±16.57 21.15±16.75 22.23±17.13
Race/Ethnicity
White 17,660(34.0) 9,556(38.3) 4,712(54.5) 17,542(35.7) 10,460(38.6) 3,926(42.3)
Japanese American 25,890(49.9) 11,941(47.9) 2,864(33.1) 24,314(49.5) 12,118(44.7) 4,263(46.0)
Native Hawaiian 8,357(16.1) 3,457(13.9) 1,073(12.4) 7,268(14.8) 4,533(16.7) 1,086(11.7)
Smoking Status

37
Never 23,575(45.4) 11,059(44.3) 3,489(40.3) 22,343(45.5) 11,868(43.8) 3,912(42.2)
Former 20,625(39.7) 10,107(40.5) 3,749(43.4) 19,616(39.9) 11,032(40.7) 3,833(41.3)
Current 7,707(14.9) 3,788(15.2) 1,411(16.3) 7,165(14.6) 4,211(15.5) 1,530(16.5)
aCategorical variables are presented as frequencies and continuous variables as mean±standard deviation.

38
Table 4. Multinomial logistic regression model of alcohol outlet population-based density and alcohol intake by location.a,b
aModel mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status, neighborhood socioeconomic status, body
mass index (BMI), smoking status, pack-years of cigarettes smoking among ever smokers, with gender and race/ethnicity as strata variables, and
clustering by block group.
bBoldface indicates statistical significance (p<0.05).
Los Angeles (n=93,467) Hawaii (n=85,510)
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI)
Onpremises
None 22,147 1.00 (Ref) 4,489 1.00 (Ref) 6,176 1.00 (Ref) 14,059 1.00 (Ref) 4,149 1.00 (Ref) 6,780 1.00 (Ref)
Low 5,858 1.01(0.96,1.06) 1,188 1.00(0.92,1.09) 1,703 1.05(0.96,1.14) 7,239 1.07(0.97,1.18) 2,164 1.08(0.93,1.26) 3,469 1.05(0.90,1.22)
High 1,983 1.04(0.97,1.11) 421 1.06(0.94,1.19) 563 1.03(0.92,1.17) 2,500 1.28(1.13,1.45) 854 1.47(1.23,1.75) 1,625 1.59(1.29,1.96)
P-trend 0.31 0.44 0.30 <0.01 <0.01 <0.01
Offpremises
None 12,877 1.00 (Ref) 2,730 1.00 (Ref) 3,616 1.00 (Ref) 13,550 1.00 (Ref) 4,142 1.00 (Ref) 6,534 1.00 (Ref)
Low 13,022 1.01(0.97,1.05) 2,543 0.95(0.88,1.02) 3,616 0.99(0.92,1.06) 7,654 1.04(0.95,1.14) 2,221 0.98(0.86,1.13) 3,834 1.07(0.92,1.24)
High 4,089 1.00(0.95,1.05) 825 0.99(0.90,1.09) 1,210 1.04(0.95,1.14) 2,594 1.10(0.97,1.24) 804 1.05(0.87,1.27) 1,506 1.12(0.91,1.37)
P-trend 0.94 0.44 0.60 0.14 0.73 0.15

39
Table 5. Association between alcohol outlet population-based density and alcohol intake stratified by gender.a,b
aModel mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status, neighborhood socioeconomic status, body
mass index (BMI), smoking status, pack-years of cigarettes smoking among ever smokers, with race/ethnicity as a strata variable, and clustering by
block group.
bBoldface indicates statistical significance (p<0.05).
Men Women Pheterogeneity
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
Los Angeles
County
On-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 0.99(0.93,1.06) 0.98(0.89,1.08) 1.02(0.93,1.11) 1.01(0.95,1.08) 1.01(0.89,1.16) 1.08(0.93,1.24)
High 0.97(0.88,1.07) 0.97(0.83,1.12) 0.97(0.85,1.10) 1.10(1.00,1.20) 1.22(1.02,1.46) 1.15(0.95,1.40)
p-trend 0.51 0.59 0.89 0.09 0.09 0.11 <0.01
Off-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 1.02(0.97,1.08) 0.94(0.86,1.02) 0.95(0.88,1.02) 0.99(0.94,1.03) 0.93(0.83,1.04) 1.02(0.90,1.15)
High 1.00(0.92,1.08) 1.03(0.92,1.16) 1.04(0.94,1.15) 0.99(0.93,1.06) 0.91(0.78,1.06) 1.05(0.90,1.22)
p-trend 0.76 0.86 0.92 0.68 0.14 0.55 0.03
Hawaii
On-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 1.07(0.99,1.15) 1.08(0.97,1.20) 1.04(0.91,1.19) 1.09(0.94,1.27) 1.13(0.86,1.48) 1.13(0.86,1.49)
High 1.08(0.97,1.20) 1.24(1.06,1.46) 1.41(1.16,1.71) 1.50(1.23,1.83) 1.90(1.40,2.58) 2.07(1.43,3.01)
p-trend 0.03 <0.01 <0.01 <0.01 <0.01 <0.01 0.01
Off-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 1.02(0.95,1.09) 0.96(0.87,1.06) 1.06(0.94,1.20) 1.05(0.91,1.22) 1.00(0.78,1.29) 1.06(0.82,1.37)
High 1.14(1.01,1.30) 1.05(0.88,1.24) 1.14(0.94,1.38) 1.05(0.88,1.27) 1.05(0.76,1.45) 1.04(0.72,1.51)
p-trend 0.07 0.96 0.11 0.38 0.73 0.58 0.84

40
Table 6. Association between alcohol outlet population-based density and alcohol intake stratified by race/ethnicity for Hawaii MEC
participants.a,b
aModel mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status, neighborhood socioeconomic status, body
mass index (BMI), smoking status, pack-years of cigarette smoking among ever smokers, with gender as a strata variable, and clustering by block group.
bBoldface indicates statistical significance (p≤0.05).
White Japanese American Native Hawaiian
<1 drink/day
vs. 0
drinks/day
1-2
drinks/day vs.
0 drinks/day
>2 drinks/day
vs. 0
drinks/day
<1 drink/day
vs. 0
drinks/day
1-2
drinks/day vs.
0 drinks/day
>2 drinks/day
vs. 0
drinks/day
<1 drink/day
vs. 0
drinks/day
1-2
drinks/day vs.
0 drinks/day
>2
drinks/day vs.
0 drinks/day
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) Pheterogeneity
Onpremises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low
1.06(0.98,1.14
)
1.06(0.95,1.19
)
1.03(0.89,1.20
)
1.05(0.93,1.19
)
0.95(0.74,1.21
)
0.96(0.77,1.20
)
1.06(0.95,1.18
)
1.33(1.08,1.64
)
1.05(0.84,1.33
)
High
1.05(0.95,1.16
)
1.15(1.00,1.33
)
1.22(1.01,1.47
)
1.13(0.96,1.33
)
1.02(0.76,1.37
)
1.24(0.94,1.65
)
1.06(0.90,1.25
)
1.33(1.00,1.76
)
1.10(0.77,1.56
)
p-trend 0.10 0.02 0.04 0.15 0.94 0.47 0.25 <0.01 0.56 0.04
Offpremises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low
1.00(0.93,1.08
)
0.93(0.83,1.03
)
0.98(0.85,1.13
)
1.02(0.91,1.14
)
0.95(0.76,1.18
)
1.07(0.86,1.32
)
0.99(0.89,1.10
)
0.95(0.77,1.17
)
1.01(0.81,1.25
)
High
1.16(1.03,1.30
)
1.12(0.94,1.32
)
1.16(0.93,1.43
)
1.10(0.96,1.27
)
1.09(0.83,1.44
)
1.24(0.96,1.61
)
1.10(0.93,1.30
)
0.98(0.74,1.31
)
0.93(0.66,1.33
)
p-trend 0.09 0.74 0.31 0.31 0.93 0.14 0.50 0.72 0.83 0.46

41
Chapter Three: Circulating microRNAs and alcohol consumption in
the Multiethnic Cohort Study
Abstract
Background. Excessive alcohol consumption is a significant public health concern and
contributes to liver diseases and cancer. Modifiable lifestyle factors including alcohol consumption
can influence circulating microRNAs (miRNAs), which may impact gene expression. Smoking and
other lifestyle factors have been found to influence miRNAs levels but studies on the associations
between miRNAs and alcohol intake are sparse, particularly in multiethnic populations.
Objective. To assess the association of alcohol consumption and circulating miRNAs in the
Multiethnic Cohort Study.
Methods. Participants (N = 917) had alcohol consumption data collected at baseline and
miRNA data collected at later blood draw. Multivariable adjusted negative binomial models were
used to assess the association between alcohol consumption (continuous and categorical) and
miRNAs. Stratified analyses were conducted by sex, race/ethnicity, smoking status, and body mass
index.
Results. We did not detect an association of miRNAs with alcohol intake in continuous
models after correcting for multiple comparisons. However, we did find an inverse association for
light drinkers with miR-451a [incidence rate ratio (IRR) = 0.59, p = 8.21E-04] and heavy drinkers
(IRR = 0.44, p = 1.47E-03) compared to nondrinkers. Additionally, miR-320e (IRR = 0.63, p =
1.61E-03) was associated with alcohol intake for light drinkers compared to nondrinkers.
Conclusions. We identified an association for light and heavy drinkers with miR-451a and
mir-320e, miRNAs previously associated with cancers and liver diseases, in comparison to
nondrinkers.

42
Introduction
Excessive alcohol consumption accounts for more than $259 billion in annual healthcare
costs in the United States.
102 Mortality due to alcohol consumption increased by 50% from 1999 to
2017.
73 Alcohol is classified as a group I carcinogen by the International Agency for Research on
Cancer 21, with sufficient evidence for seven cancer sites, and excessive, chronic consumption can
lead to alcohol-associated liver diseases.
44 Thus, research on the interconnecting biological pathways
of alcohol carcinogenesis is critical to inform lifestyle interventions and potential targeted
therapeutics to minimize risk and manage disease associated with alcohol consumption.
microRNAs (miRNAs) are 21–22-nucleotide-long sequences in the non-coding regions of
RNA that influence gene expression. miRNAs also have recently been used as biomarkers for early
detection of chronic diseases such as cancer103, liver disease104, and cardiovascular disease.
105 Previous
reviews have demonstrated that modifiable lifestyle factors such as smoking, physical activity, and
diet are associated with circulating miRNAs.
67,106 In addition, a recent cross-sectional study using
data from the population-based Rotterdam Study identified four signature miRNAs (miR-193b-3p,
miR-122-5p, miR-3937, and miR-4507) to be associated with increased alcohol consumption.
107
Mediation analysis further showed that these microRNAs partially explained the relationship of
alcohol intake with liver disease and liver-related traits, including fatty liver disease, liver enzyme γglutamyl transferase, and steatosis. A study of 16 university-aged students compared miRNA levels
before alcohol was consumed and 3–5 hours after alcohol consumption, showing that miRNA
expression changed, both increasing and decreasing, significantly following alcohol intake.
69
However, the small sample size of this study was limited to categorizing crudely alcohol levels
among participants. Additional studies of alcohol consumption and miRNAs and their downstream
consequences may help identify early strategies to intervene before individuals develop alcoholinduced chronic diseases.

43
Given the few studies on alcohol intake and circulating miRNAs among adults, we leveraged
the racially and ethnically diverse Multiethnic Cohort Study (MEC) to: 1) assess the association of
self-reported alcohol intake with circulating miRNAs, and 2) assess if sex, race/ethnicity, smoking
status, and body mass index (BMI) modified the alcohol consumption–miRNA association, given
previous literature showing these factors are associated with alcohol intake108,109 and miRNA
expression levels.
67,106
Methods
Study Population
The MEC is a prospective cohort that recruited participants 45–75 years of age
predominantly in Los Angeles County, California, and Hawai’i in 1993–1996. Detailed recruitment
information has been described previously.
88 Briefly, >215,000 participants who self-identified from
five major racial/ethnic groups (African American/Black, Japanese American, Latino, Native
Hawaiian, and White) were mailed a 26-page questionnaire covering sociodemographic, lifestyle
behaviors including habitual eating, and medical history. In 2001–2006, ~70,000 MEC participants
provided blood samples.
The sample for this study comes from an existing nested case–control study of pancreatic
cancer with 477 incident pancreatic cancer cases and 477 controls within MEC.
110 Pancreatic cancer
cases were defined as newly diagnosed cases (ICD-O-3 C25.0–C25.3, C25.7–C25.9) who provided a
pre-diagnostic blood sample. Controls were randomly selected from participants who were cancerfree at the time of blood collection, except from non-melanoma skin cancer, and were matched 1:1
to cases based on age at blood collection (±2 years), sex, race/ethnicity, and date of baseline blood
collection (±90 days). We excluded participants who had missing information on self-reported

44
baseline alcohol intake (n = 22), smoking status (n = 9), and BMI (n = 6). A total of 917 participants
were included in the final sample.
miRNA Expression Profiling
RNA was extracted and purified from pre-diagnostic plasma samples using an miRNeasy
plasma kit (Qiagen, Valencia, CA, USA), following the manufacturer’s instructions. Cell-free
circulating miRNA levels were evaluated using the nCounter Human v3 miRNA Expression Assay
(Nanostring Technologies Inc., Seattle, WA, USA), including CodeSets of probes for 798 common
human miRNAs, according to the manufacturer’s instructions. To minimize technical variation,
samples of each case–control pair were processed in the same batch for RNA isolation and assayed
on the same cartridge for miRNA expression. NanoString Reporter Code Counts files were
imported into nSolver Analysis software v3.0 (Nanostring Technologies) for data quality check and
analysis. We followed NanoString quality control guidelines to ensure assays had optimal ligation,
hybridization, and imaging scanning. Any samples that did not meet quality control metrics (e.g., low
field of view counted, unusual binding density) were repeated.
To normalize miRNA data, a background correction was first applied to remove any nonspecific binding. Using seven negative control probes with no target transcript, background level was
calculated for each sample and was subtracted from the adjusted probe. Normalization of miRNA
counts used the mean counts of three spike-in synthetic control miRNAs (ath-miR159a, cel-miR248, and osa-miR414) to control for variance in starting material and miRNA purification efficiency.
Sample content normalization used geometric mean counts of the top 50 miRNAs expressed,
excludinghasa-miR-32has hsa-miR-16-5hasand hsa-miR-451a because these miRNAs may be related
to red blood cell contamination or hemolysis.
111 After these steps, expression level of each miRNA
was calculated.

45
Self-Reported Alcohol Intake
Participants completed a quantitative food frequency questionnaire at baseline. The
questionnaire assessed the frequency of intake of ~180 food items and alcoholic beverages.
88
Participants were asked how often and how much they consumed regular or draft beer, light beer,
white or pink wine, red wine, and hard liquor on average in the past year. Frequency of consuming
each alcoholic product included nine options (“never or hardly ever”, “once a month”, “2 to 3 times
a month”, “once a week”, “2 to 3 times a week”, “4 to 6 times a week”, “once a day”, “2 to 3 times a
day”, and “4 or more times a day”) and serving size included four options (≤1, 2, 3, or ≥4
cans/bottles/glasses/drinks). Daily ethanol intake (g/day) was calculated using the following
conversions: 1 can of regular/draft beer, 13.0 g of ethanol; 1 can of light beer, 11.5 g of ethanol; 1
glass of white/pink wine, 11.3 g of ethanol; 1 glass of red wine, 11.2 g of ethanol; and 1 drink of
hard liquor, 15.4 g of ethanol. A previous calibration study in MEC showed that the 24-hour recall
for sex and all ethnic groups showed satisfactory correlation89, specifically for alcohol intake of 0.56–
0.88.
112 We analyzed ethanol intake as a continuous measure of standard drinks per day and
categorized it using sex-specific cut-off points. According to the National Institute on Alcohol
Abuse and Alcoholism a standard drink is ~14 g of ethanol18, and Dietary Guidelines for Americans
2020–2025 recommend that men drink no more than 2 drinks per day and women no more than 1
drink per day.
6 Therefore, we categorized alcohol intake as nondrinkers (0 g of ethanol/day), light
drinkers (<28 g of ethanol/day for men and <14 g of ethanol/day for women), and heavy drinkers
(≥28 g of ethanol/day for men and ≥14 g of ethanol/day for women).
Statistical Analysis

46
Demographic and lifestyle information of the analytic sample are reported with categorical
variables summarized using count and frequency (n [%]), and continuous variables using mean and
standard deviation (mean [SD]). We ran negative binomial models with alcohol intake (continuous)
as the main exposure of interest and circulating miRNAs as the outcome adjusted for age at blood
collection (continuous), sex (male, female), race/ethnicity (African American/Black, Japanese
American, Latino, Native Hawaiian, White), BMI (<25, 25–29.9, ≥30 kg/m2
), smoking status (never,
former, current), batch, and case–control status. Sensitivity analysis was performed using a model
with circulating miRNA adjusting for batch and using Pearson residuals as an outcome for analysis
with the above models. P-values from two analyses were compared with Q-Q plots. The model with
batch adjustment showed no systematic overdispersion of p-values and thus was used in our main
analysis.
Participants in MEC were followed-up with every ~5 years, and alcohol consumption was
collected in a follow-up questionnaire administered in 2003–2008. A total of 137 participants
completed the questionnaire prior to blood collection, with an average time of 10.3 years between
baseline and the follow-up questionnaire. Of these participants, 82.5% did not change their alcohol
intake compared to baseline. Therefore, we reported results using baseline data. To account for
change in alcohol intake from cohort entry to blood collection, we included a time variable (in years)
from baseline to blood collection in our models.
We additionally repeated main models using alcohol intake as a categorical variable
(nondrinker, light drinker, and heavy drinker). To assess potential heterogeneity for all miRNAs by
sex, race/ethnicity, smoking status, and BMI, we included an interaction term of each variable with
alcohol intake (continuous) and used the likelihood ratio test to compare to the model without an
interaction term. Given our sample comes from a nested case–control study of pancreatic cancer, we
additionally ran a sensitivity analysis by case–control status among miRNAs that were significant

47
from our main results and assessed if there was heterogeneity in associations. A nominal p < 0.05
for the product term of alcohol intake and variable of interest was considered as significant
heterogeneity. All analyses were conducted in R (version 4.1.2). For multiple comparisons, a false
discovery rate (FDR) using the Benjamini-Hochberg method113 was used for two-sided p < 0.05
considered statistically significant for our main models, and nominal p-values for stratified analyses
given the smaller sample size per group.
Results
Demographic characteristics of participants are presented in Table 7. A majority of the study
population was Japanese American (36.0%), female (54.6%), never smokers (51.1%), and
nondrinkers (52.3%). On average participants were ~69 years old at blood collection. The average
time between baseline questionnaire and blood collection was 9 years (SD = 2.2).
We found 29 miRNAs associated with alcohol consumption using nominal p < 0.05 (Figure
7, Appendix F). Of these, 7 were positively and 22 were negatively associated with alcohol intake.
However, when corrected for multiple comparison using FDR, we did not find any statistically
significant associations. When we used alcohol intake as a categorical variable in the models (Table
8, Appendix G), we detected an inverse association for light drinkers with miR-451a [incidence rate
ratio (IRR) = 0.59, p = 8.21E-04] and heavy drinkers (IRR = 0.44, p = 1.47E-03) compared to
nondrinkers. Additionally, miR-320e (IRR = 0.63, p = 1.61E-03) was associated with alcohol intake
for light drinkers compared to nondrinkers.
We report in the main text significant results from our main analysis by subgroups.
However, heterogeneity results for all miRNAs by sex, race/ethnicity, BMI, and smoking status are
in Appendices H-K. Briefly, we did not detect significant heterogeneity by sex for either miR-320e
(p = 0.42) or miR-451a (p = 0.24). However, in stratified results among females, alcohol intake was

48
associated with miR-451a (p = 0.04). We detected significant heterogeneity by race/ethnicity for
miR-451a (p = 0.01), but no alcohol–miRNA association was significant in individual racial/ethnic
groups. Among Latino (IRR = 0.94, p = 0.17), African American/Black (IRR = 0.96, p = 0.26), and
White (IRR = 0.99, p = 0.85) participants there was an inverse association of alcohol intake with
miR-451a, whereas among Japanese American (IRR = 1.03, p = 0.38) and Native Hawaiian (IRR =
1.03, p = 0.52) participants there was a positive association. We did not detect significant
heterogeneity by BMI for either miR-320e (p = 0.25) or miR-451a (p = 0.66). Similarly, there was no
significant heterogeneity by smoking status for miR-451a (p = 0.83). We did observe significant
heterogeneity for miR-320e (p = 0.04), but when stratified by smoking status no individual group
was significant.
Characteristics by case–control status are in Appendix L. In sensitivity analysis by case–
control status, we observed no significant heterogeneity for miR-451a (p = 0.15) or miR-320e (p =
0.07) (Appendix M). When we stratified main findings by case–control status, among controls both
heavy drinkers (p < 0.01) and light drinkers (p < 0.01) were associated with miR-451a. However,
among cases only light drinkers (p = 0.01) were associated with miR-451a, while heavy drinkers were
borderline significant (p = 0.05). For miR-320e, there was a significant association with light
drinkers (p < 0.01) and heavy drinkers (p = 0.01) who were cases but not for controls.
Discussion
In a multiethnic population, two of 517 miRNAs, miR-451a and miR-320e, were associated
with alcohol intake after correcting for multiple comparisons. Alcohol intake was inversely
associated with miR-451a among women, but we did not observe significant heterogeneity by sex.
Additionally, we observed suggestive heterogeneity (p= 0.02) for miR-451a among different

49
racial/ethnic groups, although results did not reach statistical significance in any of the race/ethnic
groups. We additionally found significant heterogeneity for miR-320e (p = 0.04) by smoking status,
but none of the individual groups reached statistical significance.
miRNA-451a is an important regulator of programmed cell death and angiogenesis for
hepatocellular carcinoma.
114 miRNA-451a targets LPIN1 to inhibit apoptosis. Given that miR-451a
was associated with alcohol intake in the MEC population and alcohol intake is a known risk factor
for hepatocellular carcinoma115, miR-451a may mediate this relationship. Another study examining
participants with end-stage hepatocellular carcinoma found lower levels of miR-451a in bile
extracellular vesicles compared to participants with healthy livers.
116 Thus, our results support these
published findings as increasing alcohol intake had an inverse association with miR-451a levels,
suggesting a similar direction of association.
Previous studies show that miR-320e may discriminate between esophageal adenocarcinoma
and Barrett’s esophagus117, and downregulation of miR-320e may lead to tumor proliferation among
colorectal cancer patients.
118 Drahos et al. used pathway analysis to reveal that predicted pathways
for miR-320e include prostate cancer, glioma, HIF1 signaling, hepatitis B, and other cancer-related
pathways.
117 Future studies should not only replicate our findings of miR-451a and miR-320e
associated with alcohol intake but also investigate if other alcohol-related diseases are associated
with miR-320e.
Cross-sectional analysis of the Rotterdam Study cohort shows that miR-193b-3p, miR-122-
5p, miR-3937, and miR-4507 are associated with alcohol consumption.
107 We were unable to
replicate these findings in our study, which may be attributed to differences in study designs and a
large proportion of nondrinkers in our population (52.3%) compared to the Rotterdam Study
(15.9% nondrinkers). That study also used a cross-sectional design, while we used a prospective
design in which we collected alcohol intake information prior to blood collection. In another study,

50
ten Berg and colleagues investigated differences in miRNA levels before and after participants
attended a social event where alcohol was consumed.
69 They identified 265 miRNAs with
significantly altered expression levels following alcohol consumption with FDR correction, with only
one miRNA (miR-185-5p) decreased following alcohol consumption. Interestingly, that study also
reported increased miR-122 levels after alcohol consumption69, similar to previous studies.
107,119 miR122 is an important factor for liver development and homeostasis.
120 In our study, alcohol intake was
associated with miR-122-5p in a similar direction, but the association was not statistically significant.
Our study had notable strengths that allowed us to investigate the association between
alcohol intake and circulating miRNAs. First, we had a large sample of >900 participants in which
we could assess heterogeneity by sex, race/ethnicity, BMI, and smoking status to identify miRNAspecific associations with alcohol intake by subgroup. Additionally, we had a racially and ethnically
diverse sample where a majority of participants were Japanese American, Latino, and African
American, whereas previous studies used predominantly White populations.
Despite these strengths, there are limitations that we must address in our study. First, this
analysis leveraged data from a nested case–control study examining miRNA levels and pancreatic
cancer risk. While blood samples were collected prior to cancer diagnosis, we cannot rule out the
possibility that disease progression, even before diagnosis, influenced miRNA levels. The average
time between blood collection and pancreatic cancer diagnosis among cases was ~8 years. Our
sensitivity analysis replicated that among cases and controls, miR-451a was associated with light
drinkers and was borderline significant among cases for heavy drinkers. For miR-320e, there was an
association with light and heavy drinking among cases but not controls. Another limitation was that
we had a small proportion (14.9%) of participants with available follow-up data prior to blood
collection. Thus, we were unable to model with repeated data on alcohol intake for all participants.
However, when examining participants with both baseline and follow-up data, the majority did not

51
change their alcohol intake over time. Another limitation is that self-reported alcohol intake can be
subject to potential misclassification because people tend to underreport alcohol consumption. We
believe this is not a major concern as misclassification for alcohol intake is most prevalent in
younger populations (18–39 years old)121 and those with high alcohol intake.
122 Additionally, we
collected alcohol intake information at baseline and microRNA levels at blood collection, which was
on average about 9 years apart. There is limited literature regarding on how transient miRNAs are to
environmental exposure specifically focusing on alcohol. However, in an animal study that measured
miRNAs in striatal neurons, investigators saw that short-term exposure to alcohol increased
expression of miR-9-3p followed by a decreased to levels observed prior to exposure of alcohol
within 24 hours.123 This may suggest that alcohol has short-term effects on miRNAs and may be
biasing our results towards the null due to non-differential misclassification. Future longitudinal
studies are needed in order to examine the short- and long-term effects alcohol consumption has on
miRNAs.
In conclusion, we detected significant associations after correcting for multiple comparisons
when examining light and heavy alcohol drinkers with circulating miRNAs within the MEC. These
miRNAs are associated with cancers and liver diseases related to alcohol intake. We also identified
miRNAs associated with alcohol intake in subgroup analysis, suggesting there are differences by
subgroups and underscoring that miRNAs used to detect chronic diseases may need to be subgroup
specific. Overall, associating alcohol intake with circulating miRNAs is important given that many
miRNAs are being identified and used as biomarkers for various health outcomes.
Tables
Table 7. Characteristics of study sample (N = 917).
Characteristic n (%) or mean (SD)

52
Age at blood collection, mean (SD) 69.6 (8.1)
Sex, n (%)
Male 416 (45.4)
Female 501 (54.6)
Self-identified race/ethnicity, n (%)
African American/Black 171 (18.6)
Japanese American 330 (36.0)
Native Hawaiian 94 (10.3)
Latino 177 (19.3)
White 145 (15.8)
Smoking status, n (%)
Never 469 (51.1)
Former 352 (38.4)
Current 96 (10.5)
Alcohol consumption, grams/day, mean (SD) 7.4 (18.8)
Alcohol consumption using sex-specific cut-off points*,
n (%)
Nondrinker 480 (52.3)
Light drinker 340 (37.1)
Heavy drinker 97 (10.6)
Body mass index, kg/m2
, n (%)
<25 365 (39.8)
25.0–29.9 373 (40.7)
≥30 179 (19.5)
Time between cohort entry and blood collection, years,
mean (SD)
9.0 (2.2)
Case–control status
Case 459 (50.1)
Control 458 (49.9)
Table 8. miRNAs associated with alcohol consumption modelled as categorical (nondrinkers, light
drinkers, and heavy drinkers) and continuous (per standard drink) variables*
Nondrinker
(n = 480)
Light drinker
(n = 340)
Heavy drinker
(n = 97)
Per standard drink
increase
IRR FDR
p-value
IRR FDR
p-value
IRR FDR
p-value
miR451a
1.00 (Ref) 0.59 8.21E-04 0.44 1.47E-03 0.91 0.84
miR320e
1.00 (Ref) 0.63 1.61E-03 0.65 0.82 0.94 0.98
* Models adjusted for sex, self-identified race/ethnicity, body mass index, and smoking status.
IRR, incidence rate ratio; FDR, false discovery rate.

53
Figures
Figure 7. Volcano plot of miRNAs associated with alcohol consumption using nominal p-values.
Chapter Four: Replication and Polygenic Risk Score Analysis for
Alcohol-Associated Liver Disease in the Multiethnic Cohort Study
Abstract
Objective. To replicate existing single nucleotide polymorphisms (SNPs) association from
genome-wide association studies (GWAS) and construct a polygenic risk score (PRS) for alcoholassociated liver disease in a multiethnic population.
Methods. A matched case-control study was conducted in the Multiethnic Cohort Study
(MEC). Cases and controls were derived from MEC participants enrolled in Medicare Fee-ForService between 1999 to 2019. Cases were defined as having alcohol-associated liver disease (ALD)
and controls were not diagnosed with ALD and matched on age of blood drawn (+/- 5 years), sex,
and self-identified race and ethnicity. Conditional logistic regression models were utilized to examine
the associations of single nucleotide polymorphisms from previous GWAS and a polygenic risk
score (PRS) with ALD. PRS was computed using unweighted and internal, multiethnic weights.
hsa−miR−19b−3p hsa−miR−95−3p
hsa−miR−107
hsa−miR−10b−5p
hsa−miR−128−3p
hsa−miR−149−5p
hsa−miR−186−5p hsa−miR−188−5p
hsa−miR−302b−3p
hsa−miR−324−3p
hsa−miR−448
hsa−miR−451a hsa−miR−575 hsa−miR−627−5p
hsa−miR−28−3p hsa−miR−140−3p
hsa−miR−188−3p
hsa−miR−888−5p
hsa−miR−744−5p
hsa−miR−1262
hsa−miR−3144−3p hsa−miR−1537−3p
hsa−miR−514b−3p
hsa−miR−548y
hsa−miR−4451
hsa−miR−4536−5p
hsa−miR−1285−5p
hsa−miR−365b−5p
hsa−miR−503−3p
0.0
0.5
1.0
1.5
2.0
0.8 0.9 1.0 1.1
IRR estimate of alcohol intake per drink
−log10(Nominal p−value)
diffexpressed
a
a
a
DOWN
NO
UP

54
Results. There was a total of 321 ALD cases and 3,210 matched controls. Majority of cases
were self-identified Latino individuals (38.8%) and predominantly males (72.6%). In the replication
analysis for the combined group, the following SNPs were replicated: rs13147616 on ZNF827
(OR=0.82, p=0.046), rs10024759 on ZNF827 (OR=0.84, p=0.04), rs2294915 on PNPLA3
(OR=1.23, p=0.02), and rs738409 on PNPLA3 (OR=1.25, p=0.01). With increasing standard
deviation of the unweighted PRS there was a 18% (OR=1.18, 95% CI: 1.05,1.32) increased risk of
ALD among combined participants. Using internal, multiethnic weights for the PRS there was a
40% (OR=1.40, 95% CI: 1.11,1.77) increased risk of ALD for self-identified White individuals and
29% (OR= 1.29, 95% CI: 1.06,1.55) increased risk for self-identified Latino per standard deviation
increase of PRS.
Conclusions. In a multiethnic population, we replicated four SNPs from previous GWAS
and found significant association between PRS and ALD among self-identified White and Latino
individuals.
Introduction
Alcohol-associated liver disease (ALD) is a chronic condition defined by the scarring of the
liver and long-term consumption of alcohol. ALD encompasses a spectrum of diseases such as
steatosis, fibrosis, cirrhosis, alcoholic hepatitis, and hepatocellular carcinoma (HCC).
124 Heavy longterm alcohol consumption increases the amount of fat in the liver and roughly 95% of heavy
drinkers will develop a fatty liver.124 However, only 35% of these heavy drinkers will go on to
develop severe forms of ALD (e.g., alcoholic hepatitis, cirrhosis, and HCC).124 This suggests that
there may be other risk factors, such as genetics, that may influence the development of both severe
forms and less severe forms.

55
The prevalence of ALD for adults the United States (US), using the National Health and
Nutrition Examination Survey, has remained stable at around 8%.
40 In an analysis of the Multiethnic
Cohort (MEC) linked with Medicare, between 1999 to 2012, ALD was the second most common
cause of chronic liver disease, accounting for 21%, following nonalcoholic fatty liver disease.41
When looking by racial and ethnic groups among ALD cases, Latino (29.0%), White (28.9%), and
Japanese American (23.1%) participants constituted a majority of cases identified.41 In a single
institution study, there were racial/ethnic differences in the age of diagnosis of ALD whereby Latino
patients with ALD were diagnosed at a younger age (alcoholic fatty liver: 41 vs 51, alcoholic
hepatitis: 41 vs 48, and alcoholic cirrhosis: 49 vs 53) compared to White patients.125
In terms of mortality, there has been over 400,000 deaths attributed to ALD in the US
between 1999 to 2022 with an increase of over 3% each year.42 Additionally, in 2021, of the over
100,000 deaths of liver disease, 47% of them involved alcohol.126 There are racial and ethnic
difference for mortality rates whereby African American adults had lower rates compared to White
adults and Asian American and Pacific Islander adults showed no difference in rates compared to
White adults.42
To date, four genome wide association studies (GWAS) have reported several ALDassociated single-nucleotide polymorphisms (SNPs) in participants of European ancestry.58,60,61,127
One of these studies included participants of East Asian ancestry and investigated associations by
current drinking behaviors (nondrinkers, light drinkers, and heavy drinkers).61 Overall, the top three
genes identified in the GWAS of East Asian ancestry remained the same across the stratified alcohol
drinking groups (gamma-glutamyl transferase 1 [GGT1], hepatocyte nuclear factor 1 homeobox A
[HNF1A], and zinc finger protein 827 [ZNF827]). Based on the existing GWAS there are 15 SNPs
that were statistically significantly associated with ALD.58,60,61,127

56
Three case-control studies have sought to replicate findings from GWAS.63,128–130 One of
these studies included participants of non-European ancestry, namely 1,221 Mestizo individuals
(those with European and Native American ancestry) from Mexico City, Mexico. Focusing on
rs738409 on PNPLA3, results showed a suggestive association (OR = 1.26, 95% CI: 1.00-1.58) with
ALD in their population compared to controls that had alcohol dependence.
63
Polygenic risk score (PRS), also known as genetic risk score, is often used to identify
individuals at high risk for a disease based on germline genetic susceptibility as part of precision
medicine.131 Previous studies have developed and examined the predictive performance of PRS for
alcohol-associated cirrhosis in European ancestry populations.62,132,133 In the largest PRS study that
included information from three cohorts (ALCGenom-1, ALCGenom-2, and UK Biobank),
Whitfield and colleagues found that three SNPs (rs73409[G] on PNPLA3, rs10401969[C] on
SUGP1-TM6SF2, and rs6834314[G] on HSD17B13) along with diabetes status best discriminated
alcohol-related cirrhosis.133 By leveraging both PRS and lifestyle behaviors, healthcare providers can
identify high-risk individuals and recommend tailored interventions.
There are limited GWAS focusing on multiethnic populations. Replicating SNP associations
and checking the transportability of polygenic risk scores in multiethnic populations is essential to
ensure accuracy so information can be applied to any individual regardless of their ancestry.
Therefore, we aimed to replicate SNP associations from existing GWAS in the Multiethnic Cohort
Study and construct a polygenic risk score to assess the association with ALD.
Methods
Study Population
The MEC consists of over 215,000 participants primarily from five self-identified racial and
ethnic groups (African American, Japanese American, Latino, Native Hawaiian, and White) from

57
California (mainly Los Angeles County) and Hawai`i between 1993 to 1996.
88 At baseline,
participants were mailed a 26-page questionnaire which contained information on demographic,
dietary intake anthropometrics, and other lifestyle factors. From 2001 through 2006, approximately
70,000 MEC participants provided blood, saliva, and urine biospecimen for biomarker and genetic
information. Additionally, MEC participants, over the age of 65, have been linked to the Centers for
Medicare & Medicaid Services claim files and 93% of participants have been linked.
134
Case Selection
A total of 124,646 MEC participants were enrolled in Medicare Fee for Service (FFS)
between 1999 to 2019. We excluded participants who did not have GWAS data (n=78,858), who
were not part of the five major racial/ethnic groups (n=353) and had missing age at blood drawn
(n=394). There were 44,829 MEC participants enrolled in Medicare FFS with available GWAS data
(Figure 8).
We followed the same methodology that was used to identify incident cases of alcoholassociated liver diseases among MEC participants enrolled in Medicare FFS.
41 Cases of alcoholassociated liver disease were identified using ICD-9 codes if a participant had one in-patient claim or
at least two outpatient claims: 571.0 (alcoholic fatty liver), 571.1 (acute alcoholic hepatitis), 571.2
(alcoholic cirrhosis of liver), 571.3 (alcoholic liver damage, unspecified); and ICD-10 codes: K700
(alcoholic fatty liver), K7010 (alcoholic hepatitis without ascites), K7011 (alcoholic hepatitis with
ascites), K7030 (alcoholic cirrhosis of liver without ascites), K7031 (alcoholic cirrhosis of liver with
ascites), and K709 (alcoholic liver disease, unspecified) between 1999 to 2019. Controls were
participants who were also enrolled in Medicare FFS and did not ALD during the same time period
(1999 to 2019). There were 321 cases identified with ALD and 44,508 eligible controls. We matched

58
each case with 10 controls based on age at blood drawn (± 5 years), sex, and self-identified race and
ethnicity.
This study received Institutional Board Review approval by the University of Southern of
California and the University of Hawai`i.
Genotyping, Quality Control, & Imputation
Blood and buccal samples from MEC participants were primarily genotyped using the MultiEthnic Genotyping Array chip (Illumina) as part of pooled data from 30 GWAS studies of cancer
and chronic diseases within the cohort. A quality control protocol was used which included SNP
call-rate filtering, sample call rate filtering, concordance checks of inter- and intraplate controls,
removal of redundant or discordant variants based on location and call rates, and removal of SNPs
with race-specific allele frequency differences over 25% in comparison with 1000G phase 3 racespecific estimates.
There were 91 SNPs associated with alcohol associated liver disease that were identified
from the NHGRI-EBI GWAS Catalog.
135 Of these, three were duplicates (rs1041969, rs738409, and
rs1183910) and seven were not genotyped in the MEC (rs5785315, rs141221896, rs149014510,
rs199606102, rs71189240, rs562581727, and rs201060650). 15 of these 81 SNPs reached genomewide significance (p<5x10-8
) from the previous studies.
Statistical Analysis
Conditional logistic regression models were used to examine the SNP and ALD association
(assuming an additive genetic model) overall and adjusting for population stratification using
principal components (PCs) 1-6 for the combined analysis and by each racial and ethnic group. Age
at blood draw (years), sex, and self-identified race and ethnicity were included as strata variables

59
since they were the matching variables. We chose PCs 1-6 as they best discriminated ancestral
groups in our population (Figure 9). PCs were calculated using PLINK with a set of more than
50,000 SNPs.136
A PRS was developed for each participant based on 15 SNPs that reached genome-wide
statistical significance (p<5x10-8
) from the GWAS catalog. We conducted a correlation analysis
among these 15 SNPs for the entire population and by self-identified racial and ethnic group. We
identified rs738409 and rs2294915, both on PNPLA3, consistent across all groups with a correlation
coefficient () >0.80 (Figure 10). Of these two SNPs, rs738409 was retained for the PRS given it
was more strongly associated with ALD from the replication analysis. We were left with 14 SNPs
that we used for both unweighted and internal, multiethnic weights. Log odds ratios were estimated
for each ALD SNP per risk allele (0, 1, or 2). The internal, multiethnic weight PRS was estimated for
each participant by multiplying the multiethnic log odds for each of the 14 SNPs by the number of
risk alleles at the given loci, then summing all values. We also constructed a PRS using an
unweighted approach where we added the dosage across all SNPs with no weights applied. We
conducted several sensitivity analyses where we subset cases to alcohol-related liver cirrhosis
(n=240) with their corresponding controls to capture if our results held up using a more severe form
of ALD. Additionally, we ran our models where we adjusted for alcohol intake, only included
participants with continuous coverage for FFS enrollment for 12-months or more (n=2,900), and
those who did not have existing liver chronic conditions (hepatitis B, hepatitis C, human
immunodeficiency virus, hemochromatosis, autoimmune liver disease, and chronic renal
insufficiency) (n=3,317). For the sensitivity analyses, we present the results of the PRS per standard
deviation increase and not by quintiles given the reduced number of cases. All analyses were
conducted using R statistical software version 4.4.0.

60
Results
This analysis included a total of 321 ALD cases and 3,210 matched controls (Table 9). The
average age of cases was 66.9 years old (standard deviation = 7.0), predominantly male (72.6%), and
self-identified as Latino (38.8%).
Table 10 shows the associations between the 15 SNPs that reached genome wide
significance from the literature and ALD in all subjects combined and each self-identified racial and
ethnic group. Four of the 15 SNPs were replicated in the overall analysis. These included
rs738409[G] on PNPLA3 (Risk allele frequency [RAF]=0.37, OR=1.25, p=0.01), rs2294915[T] on
PNPLA3 (RAF=0.38, OR=1.23, p=0.02), rs10024759[G] on ZNF827 (RAF=0.48, OR = 0.84,
p=0.04), and rs13147616[A] on ZNF827 (RAF=0.27, OR=0.82, p=0.046). Among White
participants SNPs rs738409[G] (RAF=0.23, OR=1.53, p=0.03), rs1183910[A] (RAF=0.34,
OR=0.67, p=0.04), rs28929474[T] (RAF=0.01, OR=3.02, p=0.04), and rs2294915[T] (RAF=0.25,
OR=1.46, p=0.049) were replicated. Among Latino participants only rs10024759[G] (RAF=0.56,
OR=0.75, p=0.04) was replicated. In the sensitivity analysis for alcohol-related liver cirrhosis cases,
we found that rs738409[G] (RAF=0.37, OR= 1.36, p<0.01) and rs2294915[T] (RAF=0.38,
OR=1.31, p=0.01) were statistically significant among the combined group (Appendix N).
Additionally, risk of alcohol-related liver cirrhosis was associated rs739409[G] (RAF=0.23,
OR=1.56, p=0.04) among White participants and with rs2294915[T] (RAF=0.48, OR=1.38, p=0.03)
among Latino participants.
Associations between PRS per standard deviation and ALD are reported in Table 11. Using
an unweighted score, there was a 18% (OR per standard deviation =1.18, 95% CI: 1.05,1.32)
increased risk of ALD among all participants. ORs across all racial and ethnic groups ranged from
0.99 to 1.32, and the 95% CI included the null except for Whites (OR=1.32, 95% CI: 1.05,1.68).
When we repeated these analyses using internal, multiethnic weights, we found an increased odds of

61
ALD across most racial and ethnic groups; the results were statistically significant for all ethnic
groups combined (OR=1.28, 95% CI: 1.13,1.44) and among White (OR=1.40, 95% CI: 1.11,1.77),
and Latinos (OR=1.29, 95% CI: 1.06,1.55) participants.
Unweighted polygenic risk score categorized into quintiles is reported in Figure 11. Overall,
we did not find an association between quintiles and development of ALD using the unweighted
PRS approach. Results for the internal, multiethnic weight approach for the PRS are shown in
Figure 12. Compared to participants in the middle quintile of PRS (40-60%), all subjects combined
and self-identified Latinos in the highest quintile, 80-100%, experienced a two-fold (OR=2.20, 95%
CI: 1.50,3.22) and three-fold (OR=3.02, 95% CI: 1.57,5.83) increased odds of developing ALD.
Additionally, among self-identified Japanese Americans we found a three-fold increased odds of
developing ALD for those in the 60-80% (OR=3.33, 95% CI:1.19,9.37) and 80-100% (OR=3.06,
95% CI:1.07,8.71) quintiles compared to 40-60% (reference category).
Results for unweighted and weighted PRS and alcohol-related liver cirrhosis are presented in
Appendix R. The odds of alcohol-related liver cirrhosis increased with increasing multiethnic PRS
standard deviation in all subjects combined (OR=1.30, 95% CI: 1.13,1.49), in Japanese American
(OR=1.48, 95% CI: 1.05,2.07), and Latino (OR=1.08, 95% CI:1.08,1.65) adults. When analysis was
adjusted for alcohol intake and restricted to participants with 12 or more months of FFS coverage,
the PRS results did not differ substantially from the main results (Appendix S and Appendix T).
Interestingly among African American/Black participants when other chronic liver conditions were
excluded, we observed a 94% (OR=1.94, 95% CI:1.29,2.92) and 70% (OR=1.70, 95% CI: 1.16,2.52)
increased odds of ALD per increasing standard deviation of the unweighted and multiethnic PRS,
respectively (Appendix U).
Discussion

62
In a racially and ethnically diverse population, we were able to replicate some of the SNPs
from previous GWAS obtained in populations of predominantly of European ancestry. Both
unweighted and internal, multiethnic weights showed that with each increasing standard deviation of
PRS, all participants combined, and self-identified White participants showed an increased odds of
ALD. This was also observed among self-identified Latino participants in the analysis using an
internal, multiethnic weight. Additionally, using the quintiles for the internal, multiethnic weights we
observed that self-identified Japanese Americans in the two highest quintiles had an increased odds
of developing ALD. Moreover, when other existing liver chronic conditions were excluded, we saw
an increased odds of developing ALD for self-identified African American/Black participants.
In the replication analysis among all participants, we found SNPs located on PNPLA3 to be
positively associated with ALD; this finding was consistent when we restricted cases to only alcoholrelated liver cirrhosis. Several studies focusing on non-alcoholic fatty liver disease also reported a
role of this SNP137 indicating that this gene may be important in understanding the etiology of liver
diseases. PNPLA3 helps with digestive enzymes break down of triglycerides and retinyl esters in
hepatocytes and the I148M change leads to a loss of function, thus leading to fat accumulation in
the liver.138 Not only were we able to replicate SNPs in this gene among White individuals in the
MEC, we also found consistent positive associations among Latino participants. A study of
participants from Mexico City, Mexico study of both Ameriindigenous and European ancestry
participants found similar findings between genetic variants within PNPLA3 and ALD.
63
A notable strength of this study was the inclusion of participants of non-European ancestry.
Much of the literature on genetics and ALD has included only European participants with only two
studies with data on East Asian and Ameriindigenous ancestry.61,63 Therefore, we sought to
determine whether previous findings could be replicated in a multiethnic population and the
performance of this PRS. Additionally, we used a well-established criterion to define ALD where

63
participants had either two outpatient claims or one inpatient claim with the corresponding ICD
codes that have been used in a previous MEC etiologic study of liver diseases among participants
enrolled in Medicare FFS.41
This current study also has some limitations. First, while MEC is a large cohort, we still have
relatively small number of ALD cases, particularly in certain ethnic groups. Studies with large
number of ALD cases among individuals from non-European ancestry are needed to replicate our
findings. Another limitation is that we investigated an early stage of ALD by including alcoholic fatty
liver disease and this may not develop into severe forms. While it is an early stage of ALD, its
importance cannot be minimized given it may provide opportunities for early interventions that
focus on reducing alcohol consumption.139 We conducted a sensitivity analysis restricting to alcoholrelated liver cirrhosis, a more severe form of ALD, and we observed consistent associations for all
subjects combined and among Japanese American and Latino participants. Another limitation is that
we may be underestimating ALD cases from potential underreporting alcohol use. In order for ALD
to be diagnosed a patient must disclose their alcohol intake to their clinician, but this may be a
challenge given the stigma surrounding alcohol use.140 Additionally, since our sample comes from
FFS, individuals are 65 years and older our replication and PRS results might be only generalizable
to an older population. We also constructed a PRS with one of the approaches using an internal,
multiethnic weight based on our sample and thus may introduce bias into our results and should be
interpreted cautiously. However, we still detected that in the combined analysis as well as among
White participants there was an increased risk of ALD per increasing PRS using the unweighted
approach. For African American/Black, Native Hawaiian, and Latino participants, while not
statistically significant, the direction of the effect was positive for the unweighted PRS per standard
deviation increase.

64
Future studies need to aggregate data across multiple data sources to collect a large,
representative sample of ALD across the US and conduct a GWAS to identify novel loci associated
with the phenotype. In this current study, we demonstrated that we were able to replicate some
SNPs based on mostly European ancestry GWAS and that PRS constructed using GWAS SNPs
may enhance our ability to identify-high risk groups for ALD.
Tables
Table 9. Study characteristics of participants by case-control status.
Variable Cases (n=321) Controls (n=3,210)
Age at blood collection, mean(SD) 66.9 (7.0) 66.9 (6.9)
Sex, n(%)
Male 233 (72.6) 2336 (72.8)
Female 88 (27.4) 874 (27.2)
Self-identified race and ethnicity, n(%)
White 77 (24.0) 770 (24.0)
African American/Black 43 (13.4) 424 (13.2)
Japanese American 59 (18.4) 596 (18.6)
Native Hawaiian 19 (5.9) 190 (5.9)
Latino 123 (38.3) 1,230 (38.3)

65
Table 10. Association from replication analysis in the MEC by self-identified race and ethnicity.
rsid
Chromosome
:Position Chromosome Position
Reference
Allele
Alternative
Allele Ethnicity1 Allele Frequency Coefficient Odds Ratio Standard Error P-value
rs10433937 4:88230100 4 88230100 T G C 0.219221 0.04 1.04 0.11 0.70
rs10433937 4:88230100 4 88230100 T G W 0.267039 0.18 1.20 0.19 0.33
rs10433937 4:88230100 4 88230100 T G B 0.089579 0.13 1.14 0.40 0.74
rs10433937 4:88230100 4 88230100 T G J 0.338394 -0.02 0.98 0.21 0.92
rs10433937 4:88230100 4 88230100 T G L 0.138747 -0.05 0.95 0.21 0.79
rs10433937 4:88230100 4 88230100 T G H 0.462581 -0.16 0.85 0.37 0.67
rs13147616 4:146791129 4 146791129 C A C 0.274324 -0.20 0.82 0.10 0.046
rs13147616 4:146791129 4 146791129 C A W 0.169091 -0.30 0.74 0.25 0.24
rs13147616 4:146791129 4 146791129 C A B 0.048827 -0.19 0.82 0.54 0.72
rs13147616 4:146791129 4 146791129 C A J 0.356694 -0.09 0.92 0.20 0.67
rs13147616 4:146791129 4 146791129 C A L 0.359591 -0.22 0.80 0.15 0.14
rs13147616 4:146791129 4 146791129 C A H 0.394522 -0.48 0.62 0.40 0.24
rs10024759 4:146797538 4 146797538 A G C 0.475065 -0.18 0.84 0.09 0.04
rs10024759 4:146797538 4 146797538 A G W 0.45446 0.06 1.06 0.17 0.72
rs10024759 4:146797538 4 146797538 A G B 0.420147 -0.35 0.70 0.25 0.17
rs10024759 4:146797538 4 146797538 A G J 0.362525 -0.11 0.90 0.20 0.60
rs10024759 4:146797538 4 146797538 A G L 0.556415 -0.29 0.75 0.14 0.04
rs10024759 4:146797538 4 146797538 A G H 0.507333 -0.39 0.68 0.36 0.28
rs1183910 12:121420807 12 121420807 G A C 0.336894 -0.09 0.91 0.09 0.29
rs1183910 12:121420807 12 121420807 G A W 0.343086 -0.40 0.67 0.19 0.04
rs1183910 12:121420807 12 121420807 G A B 0.11969 -0.52 0.60 0.42 0.22
rs1183910 12:121420807 12 121420807 G A J 0.479635 0.01 1.01 0.19 0.95
rs1183910 12:121420807 12 121420807 G A L 0.338199 0.03 1.03 0.14 0.83
rs1183910 12:121420807 12 121420807 G A H 0.34134 0.25 1.29 0.37 0.50
rs28929474 14:94844947 14 94844947 C T C 0.006562 0.61 1.84 0.42 0.15
rs28929474 14:94844947 14 94844947 C T W 0.01362 1.11 3.02 0.54 0.04
rs28929474 14:94844947 14 94844947 C T B 0.003214 1.60 4.98 1.25 0.20
rs28929474 14:94844947 14 94844947 C T J 1.37E-05 -797.96 0.00 209801.78 1.00

66
rs28929474 14:94844947 14 94844947
C
T
L 0.006373
-0.52 0.59 1.05 0.62
rs28929474 14:94844947 14 94844947
C
T
H 0.007182
-4637.40 0.00 229410.40 0.98
rs10401969 19:19407718 19 19407718
T
C
C 0.089784 0.12 1.12 0.14 0.41
rs10401969 19:19407718 19 19407718
T
C
W 0.073219
-0.52 0.59 0.40 0.19
rs10401969 19:19407718 19 19407718
T
C
B 0.186294 0.27 1.31 0.26 0.29
rs10401969 19:19407718 19 19407718
T
C
J 0.110979 0.22 1.25 0.30 0.45
rs10401969 19:19407718 19 19407718
T
C
L 0.047909 0.01 1.01 0.32 0.97
rs10401969 19:19407718 19 19407718
T
C
H 0.145933 0.78 2.18 0.48 0.10
rs3794991 19:19610596 19 19610596
C
T
C 0.080213 0.00 1.00 0.16 1.00
rs3794991 19:19610596 19 19610596
C
T
W 0.079855
-0.47 0.62 0.38 0.21
rs3794991 19:19610596 19 19610596
C
T
B 0.074928 0.04 1.04 0.44 0.93
rs3794991 19:19610596 19 19610596
C
T
J 0.119005 0.06 1.06 0.30 0.84
rs3794991 19:19610596 19 19610596
C
T
L 0.048535
-0.06 0.94 0.33 0.85
rs3794991 19:19610596 19 19610596
C
T
H 0.176967 0.71 2.03 0.44 0.11
rs73004967 19:19717056 19 19717056
A
G
C 0.027156
-0.32 0.72 0.30 0.28
rs73004967 19:19717056 19 19717056
A
G
W 0.059525
-0.52 0.60 0.43 0.23
rs73004967 19:19717056 19 19717056
A
G
B 0.024728
-0.88 0.41 1.05 0.40
rs73004967 19:19717056 19 19717056
A
G
J 0.003053
-6.11 0.00 13.93 0.66
rs73004967 19:19717056 19 19717056
A
G
L 0.020986
-0.53 0.59 0.61 0.38
rs73004967 19:19717056 19 19717056
A
G
H 0.016883 2.48 11.98 1.02 0.02
rs626283 19:54677001 19 54677001
G
C
C 0.343965
-0.01 0.99 0.09 0.95
rs626283 19:54677001 19 54677001
G
C
W 0.407384
-0.34 0.71 0.18 0.05
rs626283 19:54677001 19 54677001
G
C
B 0.346145
-0.20 0.82 0.26 0.45
rs626283 19:54677001 19 54677001
G
C
J 0.209917 0.23 1.26 0.23 0.33
rs626283 19:54677001 19 54677001
G
C
L 0.357324 0.23 1.25 0.14 0.11
rs626283 19:54677001 19 54677001
G
C
H 0.415696
-0.17 0.84 0.35 0.63
rs148417465 22:24665282 22 24665282
G
A
C 0.019043
-0.38 0.68 0.46 0.41
rs148417465 22:24665282 22 24665282
G
A
W 0.006018 1.31 3.71 2.04 0.52
rs148417465 22:24665282 22 24665282
G
A
B 0.005084 4.01 55.13 2.50 0.11
rs148417465 22:24665282 22 24665282
G
A
J 0.065358
-0.83 0.44 0.58 0.15
rs148417465 22:24665282 22 24665282
G
A
L 0.008214
-0.10 0.91 2.30 0.97

67
rs148417465 22:24665282 22 24665282
G
A
H 0.027971
-0.64 0.53 2.49 0.80
rs5760491 22:24995134 22 24995134
G
T
C 0.379138 0.08 1.08 0.09 0.40
rs5760491 22:24995134 22 24995134
G
T
W 0.366617 0.02 1.02 0.19 0.92
rs5760491 22:24995134 22 24995134
G
T
B 0.24503 0.27 1.30 0.26 0.31
rs5760491 22:24995134 22 24995134
G
T
J 0.336371
-0.24 0.78 0.23 0.29
rs5760491 22:24995134 22 24995134
G
T
L 0.451476 0.13 1.14 0.14 0.34
rs5760491 22:24995134 22 24995134
G
T
H 0.395282 0.56 1.75 0.40 0.16
rs2006094 22:24997086 22 24997086
G
A
C 0.430522 0.06 1.07 0.09 0.47
rs2006094 22:24997086 22 24997086
G
A
W 0.383253 0.06 1.06 0.18 0.74
rs2006094 22:24997086 22 24997086
G
A
B 0.503073 0.13 1.14 0.25 0.61
rs2006094 22:24997086 22 24997086
G
A
J 0.340998
-0.23 0.80 0.23 0.31
rs2006094 22:24997086 22 24997086
G
A
L 0.481531 0.12 1.12 0.14 0.40
rs2006094 22:24997086 22 24997086
G
A
H 0.410323 0.50 1.65 0.38 0.19
rs2330805 22:24998619 22 24998619
A
G
C 0.470364 0.00 1.00 0.09 0.98
rs2330805 22:24998619 22 24998619
A
G
W 0.391548 0.05 1.05 0.18 0.79
rs2330805 22:24998619 22 24998619
A
G
B 0.737471
-0.31 0.73 0.29 0.28
rs2330805 22:24998619 22 24998619
A
G
J 0.343164
-0.21 0.81 0.23 0.35
rs2330805 22:24998619 22 24998619
A
G
L 0.498369 0.07 1.07 0.14 0.61
rs2330805 22:24998619 22 24998619
A
G
H 0.410292 0.49 1.64 0.38 0.20
rs738409 22:44324727 22 44324727
C
G
C 0.366741 0.22 1.25 0.09 0.01
rs738409 22:44324727 22 44324727
C
G
W 0.234086 0.42 1.53 0.19 0.03
rs738409 22:44324727 22 44324727
C
G
B 0.145148
-0.13 0.88 0.35 0.71
rs738409 22:44324727 22 44324727
C
G
J 0.49455 0.26 1.29 0.20 0.20
rs738409 22:44324727 22 44324727
C
G
L 0.473436 0.24 1.27 0.14 0.08
rs738409 22:44324727 22 44324727
C
G
H 0.308232
-0.22 0.80 0.39 0.56
rs2294915 22:44340904 22 44340904
C
T
C 0.376114 0.21 1.23 0.09 0.02
rs2294915 22:44340904 22 44340904
C
T
W 0.246346 0.38 1.46 0.19 0.049
rs2294915 22:44340904 22 44340904
C
T
B 0.185368
-0.35 0.70 0.33 0.29
rs2294915 22:44340904 22 44340904
C
T
J 0.487897 0.27 1.30 0.20 0.19
rs2294915 22:44340904 22 44340904
C
T
L 0.47887 0.26 1.30 0.14 0.06
rs2294915 22:44340904 22 44340904
C
T
H 0.312694
-0.13 0.88 0.38 0.74

68
1
Refers to self-identified race and ethnicity: African American/Black (B), Combined (C), Japanese
American (J), Native Hawaiian (H), Latino (L), and White (W).
Table 11. Polygenic risk score, per standard deviation increase, and its association with alcoholassociated liver disease in the MEC.
Unweighted
Approach
Internal Multiethnic
Weights
Case/Control OR (95% CI) OR (95% CI)
Combined 321/3,210 1.18 (1.05,1.32) 1.28 (1.13,1.44)
White 77/770 1.32 (1.05,1.68) 1.40 (1.11,1.77)
African American/
Black
43/424 1.31 (0.94,1.82) 1.33(0.98,1.80)
Japanese American 59/596 0.99 (0.75,1.29) 1.20 (0.91,1.59)
Native Hawaiian 19/190 1.32 (0.80,2.16) 1.14 (0.69,1.87)
Latino 123/1,230 1.16 (0.96,1.40) 1.29 (1.06,1.55)
Figures
Figure 8. Flowchart of final analytic sample.
MEC participants enrolled in
Medicare Fee-For-Service
(N=124,646)
No GWAS
information available
(n=78,858);
Not part of the five
major racial/ethnic
groups (n=353);
Missing covariate
information (n=606) MEC participants with imputed
GWAS data (n=44,829)
Alcohol-associated liver
disease cases (n=321)
Matched controls (1:10) on age at
blood drawn (±5 years), sex, and
race/ethnicity (n=3,210)

69
Figure 9. Principal components (1-10) for MEC participants.
Figure 10. Correlation analysis among genome-wide significant SNPs across self-identified racial
and ethnic groups (A: Combined, B: White participants, C: African American/Black participants, D:
Latino participants, E: Japanese American participants, F: Native Hawaiian participants).
Self-Identified race/ethnicity

70
Figure 11. Performance of unweighted polygenic risk score, in quintiles, for alcohol-associated liver
disease for combined and by self-identified race and ethnicity.
Figure 12. Performance of internal, multiethnic weight polygenic risk score, in quintiles, for alcoholassociated liver disease for combined and by self-identified race and ethnicity.
0.0
2.5
5.0
7.5
10.0
1%−20% 20%−40% 40%−60% 60%−80% 80%−100%
PRS Quintile
Odds R
atio
Self−Identified Race
and Ethnicity
Combined
Black
Native Hawaiian
Japanese American
Latino
White
0.0
2.5
5.0
7.5
10.0
1%−20% 20%−40% 40%−60% 60%−80% 80%−100%
PRS Quintile
Odds R
atio
Self−Identified Race
and Ethnicity
Combined
Black
Native Hawaiian
Japanese American
Latino
White

71
Chapter Five: Public Health Significance & Future Directions
Public Health Significance
This dissertation has explored important aspects of alcohol consumption and its impact on
health, focusing on a multiethnic population. The findings from the three projects underscore the
intricate relationship between environmental, genetic, and molecular factors in understanding
alcohol use and outcomes.
Alcohol Outlet Density and Alcohol Intake
The first project demonstrated an association between on-premise alcohol outlet density and
alcohol intake in the Multiethnic Cohort. Higher on-premise alcohol outlet density was associated
with a higher odds of alcohol consumption, highlighting the significant role of the built environment
in shaping drinking behaviors. These findings suggest that public health multilevel interventions
aimed at regulating alcohol outlet density could reduce alcohol consumption at the community level,
thereby mitigating the risk of alcohol-related harms and diseases.
Influence of Alcohol Intake on Circulating MicroRNAs
The second project provided insights into the biological mechanisms underlying alcohol
consumption by investigating the association between alcohol intake and circulating microRNAs.
Specific microRNAs were found to be significantly associated with alcohol intake and we found
evidence of effect modification by subgroups (sex, race and ethnicity, body mass index, and smoking
status). This opens opportunities for early detection and personalized interventions for those at-risk
of alcohol-related health issues.

72
Replication Analysis and Polygenic Risk Score for Alcohol-Associated Liver Disease
The third project focused on the genetic underpinnings of alcohol-associated liver disease
(ALD) through replication analysis and the development of a polygenic risk score (PRS). We were
able to replicate a handful of SNPs identified in previous studies and the creation of a robust PRS
provide to identify individuals at high genetic risk for ALD. This genetic insight is critical for
identifying high risk populations for personalized medicine, especially within the context of a diverse
population given relatively few genetic studies have been done in these populations.
Future Directions
Increasing Research Needed in Diverse Populations
The three projects described in this dissertation leveraged data from the Multiethnic Cohort
Study. All projects evaluated potential differences by race and ethnicity and found clear differences
in the three projects. In the alcohol outlet and alcohol consumption analysis, White and Native
Hawaiian participants in Hawaii had an increased odds of consuming alcohol if they lived in a
neighborhood with high on-premise outlets. For the second project, there was evidence of effect
modification by race and ethnicity for miR-451a where Latino, White, and African American/Black
participants had an inverse association and Japanese American and Native Hawaiian participants had
a positive association. In the final project focusing on ALD, only one SNP was replicated in Latino
populations and another in the Native Hawaiian population. This underscores the importance that
more funding and research should focus on diverse populations to study unique genetic variants and
environmental interactions that contribute to alcohol-related health disparities.

73
Longitudinal Analysis on Alcohol Outlet Density
In the first project we detected an association with alcohol consumption and alcohol outlet
density using a cross-sectional study design. While we used follow-up data on alcohol consumption
for MEC participants, we did not have information on alcohol outlet density in their block group at
follow-up. Therefore, understanding the changes in a participant’s environment and capturing this
information can further support policy to limit alcohol outlets in a given area with the ultimate goal
of reducing excessive alcohol intake.
Alcohol-Associated MicroRNAs as Biomarkers for Disease
There is growing literature of studies investigating which miRNAs could serve as potential
biomarkers for a myriad of diseases. Two miRNAs were found to be associated with alcohol
consumption and there were differences by subgroups. Future studies should incorporate this
information and other miRNAs in the development of biomarkers used to detect alcohol-associated
health outcomes (e.g., liver diseases, alcohol-related cancers, and psychological disorders)
Gene-Environment Interactions & Personalized Medicine
It is clear from the third project that there are genetic variants that influence risk of ALD.
However, future studies should expand on this and perform gene-environment interactions with
alcohol intake to identify groups that would be at highest risk for developing the disease. This could
be informative for personalized medicine whereby clinicians could use this information for targeted
interventions.

74
Conclusion
This dissertation has contributed to the growing body of knowledge on the complex
interplay between environmental factors, genetic predisposition, and molecular mechanisms with a
unifying theme of alcohol. The public health significance of these findings lies in their potential to
inform targeted interventions, policy changes, and personalized approaches to mitigate the burden
of alcohol-related diseases. Future research should continue to build on these multilevel drivers to
address challenges posed by alcohol consumption in diverse populations.

75
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Appendices
Appendix A. Multinomial logistic regression model of alcohol outlet area-based density and self-reported alcohol intake by location.a
aModel mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status, neighborhood socioeconomic status, body
mass index (BMI), smoking status, pack-years of cigarettes smoking among ever smokers, with gender and race/ethnicity as strata variables, and
clustering by block group.
Los Angeles County (n=93,467) Hawaii (n=85,510)
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI)
On-premises
None 22,147 1.00 (Ref) 4,489 1.00 (Ref) 6,176 1.00 (Ref) 14,059 1.00 (Ref) 4,149 1.00 (Ref) 6,780 1.00 (Ref)
Low 6,007 1.03(0.98,1.07) 1,227 1.01(0.93,1.10) 1,753 1.07(0.98,1.16) 7,244 1.08(0.98,1.19) 2,257 1.14(0.98,1.31) 3,793 1.16(0.99,1.35)
High 1,834 0.99(0.93,1.07) 382 1.05(0.93,1.18) 513 0.98(0.87,1.11) 2,495 1.34(1.18,1.54) 761 1.44(1.18,1.77) 1,301 1.45(1.18,1.79)
p-trend 0.63 0.50 0.46 <0.01 <0.01 0.01
Off-premises
None 12,877 1.00 (Ref) 2,730 1.00 (Ref) 3,616 1.00 (Ref) 13,550 1.00 (Ref) 4,142 1.00 (Ref) 6,534 1.00 (Ref)
Low 13,201 1.01(0.97,1.05) 2,628 0.96(0.90,1.04) 3,697 1.00(0.93,1.07) 7,701 1.05(0.96,1.15) 2,295 1.02(0.89,1.17) 4,095 1.14(0.98,1.32)
High 3,910 0.99(0.93,1.04) 740 0.93(0.84,1.03) 1,129 0.99(0.90,1.10) 2,547 0.99(0.87,1.14) 730 0.89(0.72,1.09) 1,245 0.87(0.71,1.07)
p-trend 0.92 0.15 0.93 0.38 0.71 0.68

88
Appendix B. Association between alcohol outlet area-based density and self-reported alcohol intake stratified by gender.a
aModel mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status, neighborhood socioeconomic status, body mass index
(BMI), smoking status, pack-years of cigarettes smoking among ever smokers, with race/ethnicity as a strata variable, and clustering by block group.
Men Women
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
Pheterogeneity
Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI)
Los Angeles
County
On-premises
None 10,319 1.00 (Ref) 2,966 1.00 (Ref) 4,622 1.00 (Ref) 11,828 1.00 (Ref) 1,523 1.00 (Ref) 1,554 1.00 (Ref)
Low 2,794 1.00(0.93,1.07) 800 0.98(0.89,1.09) 1,297 1.05(0.96,1.15) 3,213 1.04(0.98,1.10) 427 1.04(0.91,1.18) 456 1.08(0.94,1.25)
High 871 0.95(0.86,1.05) 249 0.97(0.84,1.13) 373 0.89(0.78,1.02) 963 1.02(0.92,1.12) 133 1.15(0.96,1.38) 140 1.14(0.95,1.38)
p-trend 0.45 0.62 0.55 0.34 0.18 0.10 0.02
Off-premises
None 5,843 1.00 (Ref) 1,761 1.00 (Ref) 2,682 1.00 (Ref) 7,034 1.00 (Ref) 969 1.00 (Ref) 934 1.00 (Ref)
Low 6,314 1.03(0.97,1.09) 1,749 0.96(0.88,1.05) 2,745 0.97(0.90,1.04) 6,887 0.98(0.94,1.03) 879 0.93(0.84,1.04) 952 1.04(0.92,1.17)
High 1,827 0.97(0.89,1.05) 505 0.95(0.84,1.07) 865 0.99(0.89,1.10) 2,083 1.00(0.93,1.07) 235 0.88(0.75,1.04) 264 0.97(0.83,1.14)
p-trend 0.85 0.28 0.56 0.74 0.10 0.96
0.03
Hawaii
On-premises
None 7,178 1.00 (Ref) 2,839 1.00 (Ref) 5,235 1.00 (Ref) 6,881 1.00 (Ref) 1,310 1.00 (Ref) 1,545 1.00 (Ref)
Low 3,568 1.05(0.97,1.13) 1,474 1.11(0.99,1.23) 2,787 1.13(0.99,1.29) 3,676 1.12(0.96,1.30) 783 1.21(0.93,1.57) 1,006 1.29(0.98,1.70)
High 1,191 1.20(1.06,1.36) 460 1.20(1.00,1.44) 928 1.33(1.10,1.61) 1,304 1.51(1.23,1.86) 301 2.03(1.45,2.84) 373 1.85(1.29,2.66)
p-trend <0.01 0.01 0.02 <0.01 <0.01 0.01
0.02
Off-premises
None 6,789 1.00 (Ref) 2,769 1.00 (Ref) 4,927 1.00 (Ref) 6,761 1.00 (Ref) 1,373 1.00 (Ref) 1,607 1.00 (Ref)
Low 3,873 1.03(0.95,1.10) 1,510 0.98(0.88,1.08) 3,089 1.12(0.99,1.28) 3,828 1.06(0.92,1.23) 785 1.07(0.84,1.38) 1,006 1.15(0.88,1.49)
High 1,275 1.05(0.92,1.21) 494 1.00(0.85,1.18) 934 0.91(0.76,1.10) 1,272 0.94(0.77,1.14) 236 0.71(0.49,1.02) 311 0.77(0.52,1.13)
p-trend 0.23 0.70 0.54 0.65 0.65 0.91
0.79

89
Appendix C. Association of population-based alcohol outlet density and self-reported alcohol
intake by racial/ethnic groups in Los Angeles County, CA.a,b
a
On-premise alcohol outlet density Pheterogeneity=0.14 & off-premise alcohol outlet density Pheterogeneity= 0.51.
bModel mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status,
neighborhood socioeconomic status, body mass index (BMI), smoking status, pack-years of cigarette smoking
among ever smokers, with gender as a strata variable, and clustering by block group.
<1 drink/day vs.
0 drinks/day
1-2 drinks/day vs.
0 drinks/day
>2 drinks/day vs. 0
drinks/day
OR (95% CI) OR (95% CI) OR (95% CI)
White
On-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 1.09(0.99,1.20) 0.99(0.83,1.19) 1.20(0.98,1.46)
High 1.14(0.96,1.34) 1.01(0.76,1.33) 1.26(0.99,1.59)
P-trend 0.04 0.99 0.02
Off-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 1.02(0.93,1.11) 0.99(0.85,1.17) 1.00(0.84,1.19)
High 0.93(0.80,1.07) 1.07(0.85,1.35) 0.96(0.78,1.19)
P-trend 0.58 0.76 0.84
African American/Black
On-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 0.95(0.86,1.03) 0.82(0.69,0.98) 0.90(0.77,1.06)
High 1.10(0.98,1.24) 1.07(0.86,1.34) 1.03(0.81,1.31)
p-trend 0.47 0.577 0.68
Off-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 0.97(0.91,1.04) 0.90(0.79,1.03) 0.98(0.87,1.11)
High 1.05(0.97,1.14) 1.03(0.88,1.20) 1.12(0.96,1.30)
P-trend 0.36 0.89 0.23
Japanese American
On-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 0.95(0.85,1.06) 1.00(0.79,1.25) 1.04(0.83,1.29)
High 1.16(0.99,1.37) 1.44(1.09,1.90) 1.23(0.92,1.65)
p-trend 0.38 0.07 0.23
Off-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 0.95(0.86,1.06) 0.96(0.78,1.16) 1.04(0.86,1.26)
High 0.93(0.79,1.10) 0.95(0.70,1.29) 1.04(0.76,1.40)
P-trend 0.26 0.60 0.75
Latinos
On-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 1.02(0.96,1.09) 1.10(0.97,1.24) 1.06(0.94,1.19)
High 0.96(0.87,1.06) 1.01(0.84,1.22) 0.95(0.79,1.14)
P-trend 0.64 0.42 0.90
Off-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low 1.03(0.97,1.09) 0.94(0.85,1.05) 0.96(0.87,1.07)
High 1.02(0.94,1.11) 0.96(0.82,1.12) 1.04(0.90,1.20)
P-trend 0.33 0.40 0.73

90
Appendix D. Association between alcohol outlet area-based density and alcohol intake stratified by race/ethnicity for Hawaii MEC participants.a
a
Model mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status, neighborhood socioeconomic
status, body mass index (BMI), smoking status, pack-years of cigarette smoking among ever smokers, with gender as the strata variable, and
clustering by block group.
White Japanese American Native Hawaiian
<1
drinks/day
vs. 0
drinks/day
1-2
drinks/day
vs. 0
drinks/day
>2
drinks/day vs.
0 drinks/day
<1
drinks/day
vs. 0
drinks/day
1-2
drinks/day
vs. 0
drinks/day
>2
drinks/day vs.
0 drinks/day
<1 drink/day
vs. 0
drinks/day
1-2
drinks/day
vs. 0
drinks/day
>2
drinks/day
vs. 0
drinks/day
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
Pheterogeneit
y
On-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low
1.05(0.97,1.13
)
1.09(0.98,1.21
)
1.12(0.98,1.29
)
1.01(0.89,1.15
)
0.93(0.73,1.19
)
0.97(0.78,1.22
)
1.03(0.92,1.15
)
1.29(1.05,1.58
)
1.08(0.87,1.36
)
High
1.10(0.97,1.25
)
1.22(1.03,1.44
)
1.13(0.92,1.41
)
1.22(1.05,1.43
)
1.02(0.74,1.39
)
1.28(0.97,1.67
)
1.19(0.97,1.46
)
1.54(1.08,2.19
)
0.92(0.62,1.36
)
p-trend 0.04 0.02 0.19 0.06 0.99 0.49 0.10 <0.01 0.75 0.02
Off-premises
None 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
Low
1.01(0.94,1.09
)
0.98(0.88,1.09
)
1.06(0.92,1.22
)
1.00(0.89,1.12
)
0.93(0.75,1.16
)
1.10(0.89,1.36
)
0.98(0.89,1.10
)
0.94(0.77,1.15
)
0.99(0.80,1.24
)
High
1.09(0.95,1.27
)
0.91(0.75,1.10
)
0.94(0.74,1.18
)
1.10(0.95,1.27
)
1.11(0.82,1.50
)
1.04(0.80,1.36
)
1.07(0.88,1.29
)
0.96(0.67,1.37
)
1.06(0.74,1.51
)
p-trend 0.28 0.42 0.98 0.32 0.85 0.32 0.61 0.52 0.95 0.50

91
Appendix E. Multinomial logistic regression model of alcohol outlet population-based density and alcohol intake by location using follow-up
questionnaire.a,b
aModel mutually adjusted for on- and off-premises alcohol outlets, age at cohort entry, education status, neighborhood socioeconomic status, body
mass index (BMI), smoking status, pack-years of cigarettes smoking among ever smokers, with gender and race/ethnicity as strata variables, and
clustering by block group.
Los Angeles County (n=34,408) Hawaii (n=46,844)
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
<1 drink/day vs. 0
drinks/day
1-2 drinks/day vs. 0
drinks/day
>2 drinks/day vs. 0
drinks/day
Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI) Count OR (95% CI)
Onpremises
None 8,583 1.00 (Ref) 1,589 1.00 (Ref) 1,588 1.00 (Ref) 7,978 1.00 (Ref) 2,467 1.00 (Ref) 2,823 1.00 (Ref)
Low 2,255 0.97(0.91,1.04) 474 1.08(0.95,1.22) 452 1.03(0.89,1.18) 4,033 1.04(0.93,1.16) 1,281 1.05(0.88,1.24) 1,577 1.13(0.95,1.35)
High 758 0.95(0.86,1.05) 143 0.93(0.77,1.13) 145 0.95(0.78,1.16) 1,381 1.31(1.14,1.51) 526 1.58(1.31,1.91) 649 1.68(1.33,2.12)
P-trend 0.24 0.85 0.88 0.04 <0.01 <0.01
Offpremises
None 5,150 1.00 (Ref) 1,028 1.00 (Ref) 978 1.00 (Ref) 7,702 1.00 (Ref) 2,405 1.00 (Ref) 2,874 1.00 (Ref)
Low 4,980 1.02(0.96,1.07) 908 0.96(0.86,1.07) 944 1.03(0.91,1.16) 4,304 1.08(0.92,1.27) 1,404 1.01(0.86,1.20) 1,591 1.08(0.94,1.24)
High 1,466 1.03(0.95,1.11) 270 1.00(0.86,1.17) 263 1.03(0.88,1.21) 1,386 1.08(0.94,1.24) 465 1.05(0.84,1.32) 584 1.07(0.84,1.36)
P-trend 0.50 0.82 0.62 0.19 0.28 0.54

92
Appendix F. The association of alcohol intake (continuous per drink) and circulating microRNA adjusted
for age at biospecimen draw, sex, race/ethnicity, body mass index (kg/m2), smoking status, batch, time in
years between baseline questionnaire and biospecimen draw, and case-control status.
Accession miRNA
β ethanol intake
per drink
IRR ethanol
intake per
drink
Nominal pvalue
FDR
p-value
MIMAT0000062 hsa-let-7a-5p -3.32E-02 9.67E-01 5.99E-01 9.82E-01
MIMAT0000063 hsa-let-7b-5p -2.47E-02 9.76E-01 1.77E-01 9.82E-01
MIMAT0000064 hsa-let-7c-5p -5.65E-02 9.45E-01 2.63E-01 9.82E-01
MIMAT0000065 hsa-let-7d-5p 8.36E-03 1.01E+00 8.48E-01 9.88E-01
MIMAT0000067 hsa-let-7f-5p -1.62E-02 9.84E-01 7.56E-01 9.88E-01
MIMAT0000414 hsa-let-7g-5p -1.66E-02 9.84E-01 5.97E-01 9.82E-01
MIMAT0000098 hsa-miR-100-5p -2.68E-02 9.74E-01 4.86E-01 9.82E-01
MIMAT0000102 hsa-miR-105-5p 1.19E-02 1.01E+00 7.39E-01 9.88E-01
MIMAT0000680 hsa-miR-106b-5p 3.73E-02 1.04E+00 2.84E-01 9.82E-01
MIMAT0000104 hsa-miR-107 -2.15E-02 9.79E-01 2.06E-02 8.43E-01
MIMAT0000253 hsa-miR-10a-5p -1.72E-03 9.98E-01 8.96E-01 9.88E-01
MIMAT0000254 hsa-miR-10b-5p -2.26E-02 9.78E-01 3.80E-02 8.55E-01
MIMAT0005825 hsa-miR-1180-3p -6.74E-02 9.35E-01 2.32E-01 9.82E-01
MIMAT0005828 hsa-miR-1183 -6.53E-03 9.93E-01 8.67E-01 9.88E-01
MIMAT0022838 hsa-miR-1185-1-3p 7.77E-02 1.08E+00 3.38E-01 9.82E-01
MIMAT0022713 hsa-miR-1185-2-3p -1.17E-02 9.88E-01 3.35E-01 9.82E-01
MIMAT0005798 hsa-miR-1185-5p -9.78E-03 9.90E-01 3.23E-01 9.82E-01
MIMAT0015049 hsa-miR-1193 2.44E-02 1.02E+00 6.92E-01 9.82E-01
MIMAT0005955 hsa-miR-1197 9.07E-03 1.01E+00 5.08E-01 9.82E-01
MIMAT0005863 hsa-miR-1200 -3.48E-03 9.97E-01 9.45E-01 9.88E-01
MIMAT0005865 hsa-miR-1202 -6.64E-02 9.36E-01 2.82E-01 9.82E-01
MIMAT0005866 hsa-miR-1203 -5.73E-03 9.94E-01 8.69E-01 9.88E-01
MIMAT0005869 hsa-miR-1205 5.88E-03 1.01E+00 9.35E-01 9.88E-01
MIMAT0005870 hsa-miR-1206 -7.61E-03 9.92E-01 8.90E-01 9.88E-01
MIMAT0000421 hsa-miR-122-5p 3.25E-02 1.03E+00 2.95E-01 9.82E-01
MIMAT0005459 hsa-miR-1224-3p 5.11E-03 1.01E+00 8.60E-01 9.88E-01
MIMAT0005577 hsa-miR-1226-3p -2.14E-02 9.79E-01 6.69E-01 9.82E-01
MIMAT0005583 hsa-miR-1228-3p -1.21E-02 9.88E-01 3.49E-01 9.82E-01
MIMAT0005589 hsa-miR-1234-3p -1.24E-02 9.88E-01 4.25E-01 9.82E-01
MIMAT0005591 hsa-miR-1236-3p 1.63E-02 1.02E+00 5.34E-01 9.82E-01
MIMAT0005896 hsa-miR-1244 1.99E-03 1.00E+00 9.57E-01 9.88E-01
MIMAT0005897 hsa-miR-1245a 6.00E-03 1.01E+00 7.14E-01 9.82E-01
MIMAT0019950 hsa-miR-1245b-5p -9.65E-03 9.90E-01 9.07E-01 9.88E-01
MIMAT0005898 hsa-miR-1246 -7.30E-02 9.30E-01 9.47E-02 9.61E-01

93
MIMAT0005901 hsa-miR-1249-3p -2.81E-02 9.72E-01 1.44E-01 9.82E-01
MIMAT0005904 hsa-miR-1253 9.36E-03 1.01E+00 6.00E-01 9.82E-01
MIMAT0005905 hsa-miR-1254 2.20E-02 1.02E+00 7.83E-01 9.88E-01
MIMAT0005906 hsa-miR-1255a -2.07E-02 9.80E-01 6.76E-02 9.55E-01
MIMAT0005908 hsa-miR-1257 -4.88E-03 9.95E-01 8.73E-01 9.88E-01
MIMAT0005909 hsa-miR-1258 1.29E-02 1.01E+00 4.70E-01 9.82E-01
MIMAT0004602 hsa-miR-125a-3p -4.33E-03 9.96E-01 9.51E-01 9.88E-01
MIMAT0000423 hsa-miR-125b-5p -1.41E-02 9.86E-01 6.71E-01 9.82E-01
MIMAT0000445 hsa-miR-126-3p -5.39E-03 9.95E-01 5.19E-01 9.82E-01
MIMAT0005913 hsa-miR-1261 1.02E-02 1.01E+00 8.13E-01 9.88E-01
MIMAT0005914 hsa-miR-1262 -2.23E-02 9.78E-01 1.77E-02 8.43E-01
MIMAT0005791 hsa-miR-1264 -9.37E-02 9.11E-01 2.72E-01 9.82E-01
MIMAT0005920 hsa-miR-1266-5p 2.78E-02 1.03E+00 5.83E-01 9.82E-01
MIMAT0005922 hsa-miR-1268a 1.26E-02 1.01E+00 8.72E-01 9.88E-01
MIMAT0018925 hsa-miR-1268b -1.14E-02 9.89E-01 2.98E-01 9.82E-01
MIMAT0005923 hsa-miR-1269a 1.18E-02 1.01E+00 5.25E-01 9.82E-01
MIMAT0000446 hsa-miR-127-3p 1.78E-03 1.00E+00 9.17E-01 9.88E-01
MIMAT0004604 hsa-miR-127-5p -6.27E-02 9.39E-01 2.65E-01 9.82E-01
MIMAT0005924 hsa-miR-1270 -1.47E-02 9.85E-01 8.11E-01 9.88E-01
MIMAT0005796 hsa-miR-1271-5p 6.77E-02 1.07E+00 3.91E-01 9.82E-01
MIMAT0005925 hsa-miR-1272 -2.39E-03 9.98E-01 9.49E-01 9.88E-01
MIMAT0005933 hsa-miR-1277-3p 3.24E-03 1.00E+00 9.36E-01 9.88E-01
MIMAT0005936 hsa-miR-1278 6.01E-02 1.06E+00 6.59E-02 9.55E-01
MIMAT0005937 hsa-miR-1279 -2.53E-02 9.75E-01 5.23E-01 9.82E-01
MIMAT0000424 hsa-miR-128-3p -4.67E-02 9.54E-01 4.85E-02 8.64E-01
MIMAT0005939 hsa-miR-1281 -6.57E-02 9.36E-01 2.32E-01 9.82E-01
MIMAT0005876 hsa-miR-1285-3p 2.45E-02 1.02E+00 3.68E-01 9.82E-01
MIMAT0022719 hsa-miR-1285-5p -1.86E-02 9.82E-01 4.61E-02 8.64E-01
MIMAT0005877 hsa-miR-1286 -3.29E-02 9.68E-01 3.71E-01 9.82E-01
MIMAT0005878 hsa-miR-1287-5p 3.16E-02 1.03E+00 3.79E-01 9.82E-01
MIMAT0004605 hsa-miR-129-2-3p -7.44E-02 9.28E-01 8.59E-02 9.61E-01
MIMAT0005880 hsa-miR-1290 -1.80E-03 9.98E-01 8.39E-01 9.88E-01
MIMAT0005883 hsa-miR-1293 4.66E-02 1.05E+00 5.31E-01 9.82E-01
MIMAT0005885 hsa-miR-1295a -3.10E-03 9.97E-01 8.65E-01 9.88E-01
MIMAT0026637 hsa-miR-1296-3p -8.07E-03 9.92E-01 5.84E-01 9.82E-01
MIMAT0005886 hsa-miR-1297 5.02E-04 1.00E+00 9.91E-01 9.99E-01
MIMAT0005800 hsa-miR-1298-5p -7.21E-02 9.30E-01 8.31E-02 9.55E-01
MIMAT0005887 hsa-miR-1299 3.53E-02 1.04E+00 2.66E-01 9.82E-01
MIMAT0005890 hsa-miR-1302 -1.64E-02 9.84E-01 5.31E-01 9.82E-01

94
MIMAT0022720 hsa-miR-1304-3p 1.13E-02 1.01E+00 8.22E-01 9.88E-01
MIMAT0005892 hsa-miR-1304-5p 4.93E-02 1.05E+00 1.32E-01 9.82E-01
MIMAT0005893 hsa-miR-1305 -9.21E-03 9.91E-01 3.84E-01 9.82E-01
MIMAT0005950 hsa-miR-1306-3p -5.24E-03 9.95E-01 9.10E-01 9.88E-01
MIMAT0005951 hsa-miR-1307-3p -6.73E-02 9.35E-01 7.96E-02 9.55E-01
MIMAT0022727 hsa-miR-1307-5p -8.26E-03 9.92E-01 5.73E-01 9.82E-01
MIMAT0000425 hsa-miR-130a-3p -1.00E-01 9.04E-01 1.69E-01 9.82E-01
MIMAT0000426 hsa-miR-132-3p 7.97E-03 1.01E+00 5.85E-01 9.82E-01
MIMAT0005795 hsa-miR-1323 -8.22E-04 9.99E-01 9.40E-01 9.88E-01
MIMAT0000427 hsa-miR-133a-3p -1.85E-02 9.82E-01 4.64E-01 9.82E-01
MIMAT0026478 hsa-miR-133a-5p -1.60E-02 9.84E-01 4.58E-01 9.82E-01
MIMAT0026481 hsa-miR-134-3p -1.60E-02 9.84E-01 3.49E-01 9.82E-01
MIMAT0000448 hsa-miR-136-5p -1.53E-02 9.85E-01 7.04E-01 9.82E-01
MIMAT0000429 hsa-miR-137 8.10E-03 1.01E+00 6.56E-01 9.82E-01
MIMAT0000430 hsa-miR-138-5p -1.00E-02 9.90E-01 7.98E-01 9.88E-01
MIMAT0004552 hsa-miR-139-3p -1.86E-04 1.00E+00 9.96E-01 9.99E-01
MIMAT0004597 hsa-miR-140-3p 8.95E-02 1.09E+00 3.46E-02 8.43E-01
MIMAT0000431 hsa-miR-140-5p 4.38E-02 1.04E+00 3.11E-01 9.82E-01
MIMAT0000432 hsa-miR-141-3p 3.96E-02 1.04E+00 5.98E-01 9.82E-01
MIMAT0000434 hsa-miR-142-3p -3.10E-02 9.69E-01 2.36E-01 9.82E-01
MIMAT0000435 hsa-miR-143-3p 6.44E-02 1.07E+00 1.16E-01 9.82E-01
MIMAT0000449 hsa-miR-146a-5p 3.04E-03 1.00E+00 9.34E-01 9.88E-01
MIMAT0002809 hsa-miR-146b-5p 1.46E-02 1.01E+00 6.87E-01 9.82E-01
MIMAT0000251 hsa-miR-147a -1.52E-02 9.85E-01 6.43E-01 9.82E-01
MIMAT0004928 hsa-miR-147b 2.98E-02 1.03E+00 3.42E-01 9.82E-01
MIMAT0000243 hsa-miR-148a-3p 4.08E-02 1.04E+00 3.28E-01 9.82E-01
MIMAT0000759 hsa-miR-148b-3p -1.94E-02 9.81E-01 6.81E-01 9.82E-01
MIMAT0000450 hsa-miR-149-5p 8.47E-02 1.09E+00 9.34E-03 8.43E-01
MIMAT0000451 hsa-miR-150-5p 1.57E-02 1.02E+00 7.46E-01 9.88E-01
MIMAT0000757 hsa-miR-151a-3p 2.28E-02 1.02E+00 7.08E-01 9.82E-01
MIMAT0007399 hsa-miR-1537-3p 1.13E-01 1.12E+00 3.53E-02 8.43E-01
MIMAT0000646 hsa-miR-155-5p 3.11E-03 1.00E+00 8.64E-01 9.88E-01
MIMAT0000417 hsa-miR-15b-5p -4.66E-02 9.54E-01 4.65E-01 9.82E-01
MIMAT0000069 hsa-miR-16-5p -3.11E-02 9.69E-01 1.52E-01 9.82E-01
MIMAT0004558 hsa-miR-181a-2-3p -8.58E-03 9.91E-01 5.88E-01 9.82E-01
MIMAT0000270 hsa-miR-181a-3p -7.18E-03 9.93E-01 5.69E-01 9.82E-01
MIMAT0000256 hsa-miR-181a-5p -4.35E-02 9.57E-01 5.01E-01 9.82E-01
MIMAT0031893 hsa-miR-181b-2-3p 2.62E-02 1.03E+00 2.97E-01 9.82E-01

95
MIMAT0000257
hsa-miR-181b5p+hsa-miR-181d5p -4.56E-02 9.55E-01 5.33E-01 9.82E-01
MIMAT0000258 hsa-miR-181c-5p -9.07E-02 9.13E-01 2.61E-01 9.82E-01
MIMAT0026608 hsa-miR-181d-3p -1.07E-02 9.89E-01 5.82E-01 9.82E-01
MIMAT0000260 hsa-miR-182-3p 2.95E-03 1.00E+00 9.39E-01 9.88E-01
MIMAT0006767 hsa-miR-1827 2.88E-02 1.03E+00 6.42E-01 9.82E-01
MIMAT0000261 hsa-miR-183-5p -8.12E-03 9.92E-01 3.62E-01 9.82E-01
MIMAT0000454 hsa-miR-184 6.24E-04 1.00E+00 9.62E-01 9.88E-01
MIMAT0000455 hsa-miR-185-5p -8.23E-04 9.99E-01 9.44E-01 9.88E-01
MIMAT0000456 hsa-miR-186-5p -3.25E-02 9.68E-01 2.51E-02 8.43E-01
MIMAT0000262 hsa-miR-187-3p -1.72E-02 9.83E-01 1.73E-01 9.82E-01
MIMAT0004613 hsa-miR-188-3p -7.65E-02 9.26E-01 4.52E-02 8.64E-01
MIMAT0000457 hsa-miR-188-5p 2.75E-02 1.03E+00 2.45E-02 8.43E-01
MIMAT0000072 hsa-miR-18a-5p 2.31E-03 1.00E+00 8.76E-01 9.88E-01
MIMAT0001412 hsa-miR-18b-5p -3.24E-02 9.68E-01 6.15E-01 9.82E-01
MIMAT0026916 hsa-miR-1908-3p -6.43E-02 9.38E-01 3.56E-01 9.82E-01
MIMAT0026482 hsa-miR-190a-3p -1.42E-02 9.86E-01 7.77E-01 9.88E-01
MIMAT0000458 hsa-miR-190a-5p 1.15E-02 1.01E+00 8.58E-01 9.88E-01
MIMAT0000440 hsa-miR-191-5p 7.27E-03 1.01E+00 8.07E-01 9.88E-01
MIMAT0007884 hsa-miR-1910-5p -1.20E-01 8.87E-01 6.45E-02 9.55E-01
MIMAT0000222 hsa-miR-192-5p -1.33E-02 9.87E-01 7.89E-01 9.88E-01
MIMAT0000459 hsa-miR-193a-3p 1.12E-02 1.01E+00 5.00E-01 9.82E-01
MIMAT0002819 hsa-miR-193b-3p 5.12E-03 1.01E+00 9.46E-01 9.88E-01
MIMAT0000226 hsa-miR-196a-5p -6.09E-04 9.99E-01 9.69E-01 9.88E-01
MIMAT0000227 hsa-miR-197-3p 3.10E-02 1.03E+00 2.87E-01 9.82E-01
MIMAT0022691 hsa-miR-197-5p -1.06E-02 9.90E-01 5.54E-01 9.82E-01
MIMAT0009447 hsa-miR-1972 1.67E-02 1.02E+00 3.20E-01 9.82E-01
MIMAT0009448 hsa-miR-1973 -2.22E-02 9.78E-01 9.89E-02 9.61E-01
MIMAT0009451 hsa-miR-1976 2.82E-02 1.03E+00 2.54E-01 9.82E-01
MIMAT0000228 hsa-miR-198 -2.51E-03 9.97E-01 9.25E-01 9.88E-01
MIMAT0000232
hsa-miR-199a3p+hsa-miR-199b3p -1.66E-03 9.98E-01 8.91E-01 9.88E-01
MIMAT0000231 hsa-miR-199a-5p 1.17E-02 1.01E+00 3.63E-01 9.82E-01
MIMAT0000263 hsa-miR-199b-5p -6.48E-03 9.94E-01 6.62E-01 9.82E-01
MIMAT0000074 hsa-miR-19b-3p -1.56E-01 8.55E-01 2.86E-02 8.43E-01
MIMAT0000682 hsa-miR-200a-3p 6.25E-03 1.01E+00 5.86E-01 9.82E-01
MIMAT0000318 hsa-miR-200b-3p -7.50E-05 1.00E+00 9.96E-01 9.99E-01
MIMAT0000617 hsa-miR-200c-3p 3.12E-02 1.03E+00 3.45E-01 9.82E-01
MIMAT0000264 hsa-miR-203a-3p -3.21E-03 9.97E-01 9.56E-01 9.88E-01

96
MIMAT0031890 hsa-miR-203a-5p -1.04E-02 9.90E-01 3.57E-01 9.82E-01
MIMAT0000266 hsa-miR-205-5p 8.71E-03 1.01E+00 8.85E-01 9.88E-01
MIMAT0009978 hsa-miR-2053 -4.24E-03 9.96E-01 6.84E-01 9.82E-01
MIMAT0000241 hsa-miR-208a-3p 5.35E-03 1.01E+00 6.53E-01 9.82E-01
MIMAT0004960 hsa-miR-208b-3p -6.87E-03 9.93E-01 4.76E-01 9.82E-01
MIMAT0000076 hsa-miR-21-5p 7.08E-03 1.01E+00 8.39E-01 9.88E-01
MIMAT0000267 hsa-miR-210-3p -6.58E-03 9.93E-01 5.45E-01 9.82E-01
MIMAT0026475 hsa-miR-210-5p -6.21E-03 9.94E-01 5.82E-01 9.82E-01
MIMAT0000268 hsa-miR-211-5p -2.06E-02 9.80E-01 8.20E-02 9.55E-01
MIMAT0010133 hsa-miR-2110 -4.74E-02 9.54E-01 1.41E-01 9.82E-01
MIMAT0009206 hsa-miR-2113 3.04E-02 1.03E+00 6.44E-01 9.82E-01
MIMAT0000269 hsa-miR-212-3p -2.08E-02 9.79E-01 9.77E-02 9.61E-01
MIMAT0000272 hsa-miR-215-5p -1.25E-02 9.88E-01 5.56E-01 9.82E-01
MIMAT0000273 hsa-miR-216a-5p -3.68E-02 9.64E-01 2.64E-01 9.82E-01
MIMAT0004959 hsa-miR-216b-5p 3.00E-02 1.03E+00 1.88E-01 9.82E-01
MIMAT0000274 hsa-miR-217 4.58E-02 1.05E+00 2.34E-01 9.82E-01
MIMAT0000275 hsa-miR-218-5p 3.87E-03 1.00E+00 9.22E-01 9.88E-01
MIMAT0000276 hsa-miR-219a-5p -2.28E-02 9.77E-01 7.83E-01 9.88E-01
MIMAT0019748 hsa-miR-219b-3p 8.33E-03 1.01E+00 8.03E-01 9.88E-01
MIMAT0000278 hsa-miR-221-3p -1.13E-02 9.89E-01 7.65E-01 9.88E-01
MIMAT0000279 hsa-miR-222-3p -1.32E-02 9.87E-01 8.57E-01 9.88E-01
MIMAT0000280 hsa-miR-223-3p -3.43E-03 9.97E-01 9.06E-01 9.88E-01
MIMAT0000281 hsa-miR-224-5p -3.57E-02 9.65E-01 5.96E-01 9.82E-01
MIMAT0000078 hsa-miR-23a-3p -1.85E-03 9.98E-01 8.97E-01 9.88E-01
MIMAT0000418 hsa-miR-23b-3p -1.44E-02 9.86E-01 3.28E-01 9.82E-01
MIMAT0018000 hsa-miR-23c -3.57E-03 9.96E-01 8.60E-01 9.88E-01
MIMAT0000081 hsa-miR-25-3p -2.12E-03 9.98E-01 9.68E-01 9.88E-01
MIMAT0004498 hsa-miR-25-5p -2.21E-02 9.78E-01 2.25E-01 9.82E-01
MIMAT0000082 hsa-miR-26a-5p 3.57E-03 1.00E+00 7.98E-01 9.88E-01
MIMAT0000083 hsa-miR-26b-5p -1.93E-02 9.81E-01 1.04E-01 9.61E-01
MIMAT0000084 hsa-miR-27a-3p -3.25E-02 9.68E-01 1.93E-01 9.82E-01
MIMAT0004502 hsa-miR-28-3p -4.01E-02 9.61E-01 3.07E-02 8.43E-01
MIMAT0000085 hsa-miR-28-5p -1.65E-02 9.84E-01 4.42E-01 9.82E-01
MIMAT0004679 hsa-miR-296-3p -2.81E-02 9.72E-01 7.16E-01 9.82E-01
MIMAT0004901 hsa-miR-298 4.94E-03 1.00E+00 8.89E-01 9.88E-01
MIMAT0000687 hsa-miR-299-3p 2.31E-02 1.02E+00 4.53E-01 9.82E-01
MIMAT0002890 hsa-miR-299-5p 5.02E-03 1.01E+00 6.84E-01 9.82E-01
MIMAT0000086 hsa-miR-29a-3p -4.26E-02 9.58E-01 1.98E-01 9.82E-01
MIMAT0000100 hsa-miR-29b-3p 3.04E-02 1.03E+00 5.76E-01 9.82E-01

97
MIMAT0000681 hsa-miR-29c-3p -6.88E-02 9.33E-01 3.98E-01 9.82E-01
MIMAT0004903 hsa-miR-300 -9.12E-02 9.13E-01 2.40E-01 9.82E-01
MIMAT0000688 hsa-miR-301a-3p -2.48E-02 9.76E-01 1.89E-01 9.82E-01
MIMAT0022696 hsa-miR-301a-5p -2.25E-02 9.78E-01 2.00E-01 9.82E-01
MIMAT0004958 hsa-miR-301b-3p -7.34E-03 9.93E-01 8.05E-01 9.88E-01
MIMAT0032026 hsa-miR-301b-5p -9.38E-03 9.91E-01 4.21E-01 9.82E-01
MIMAT0000684 hsa-miR-302a-3p -3.52E-02 9.65E-01 2.04E-01 9.82E-01
MIMAT0000683 hsa-miR-302a-5p -7.60E-02 9.27E-01 1.49E-01 9.82E-01
MIMAT0000715 hsa-miR-302b-3p -4.05E-02 9.60E-01 1.59E-02 8.43E-01
MIMAT0000717 hsa-miR-302c-3p -5.64E-02 9.45E-01 2.73E-01 9.82E-01
MIMAT0000718 hsa-miR-302d-3p -5.19E-03 9.95E-01 6.94E-01 9.82E-01
MIMAT0005931 hsa-miR-302e 1.62E-02 1.02E+00 7.28E-01 9.88E-01
MIMAT0005932 hsa-miR-302f 4.80E-02 1.05E+00 4.50E-01 9.82E-01
MIMAT0015378 hsa-miR-3065-3p -2.12E-02 9.79E-01 1.50E-01 9.82E-01
MIMAT0015027 hsa-miR-3074-3p -6.43E-02 9.38E-01 4.87E-01 9.82E-01
MIMAT0000088 hsa-miR-30a-3p -1.60E-02 9.84E-01 2.59E-01 9.82E-01
MIMAT0000420 hsa-miR-30b-5p 1.40E-02 1.01E+00 7.08E-01 9.82E-01
MIMAT0000244 hsa-miR-30c-5p 4.43E-02 1.05E+00 3.83E-01 9.82E-01
MIMAT0000245 hsa-miR-30d-5p -5.08E-02 9.50E-01 1.92E-01 9.82E-01
MIMAT0000693 hsa-miR-30e-3p -1.95E-02 9.81E-01 2.66E-01 9.82E-01
MIMAT0000692 hsa-miR-30e-5p -1.16E-02 9.88E-01 3.91E-01 9.82E-01
MIMAT0014996 hsa-miR-3131 1.94E-02 1.02E+00 5.44E-01 9.82E-01
MIMAT0015015 hsa-miR-3144-3p -2.02E-02 9.80E-01 3.40E-02 8.43E-01
MIMAT0015014 hsa-miR-3144-5p -1.48E-02 9.85E-01 7.50E-01 9.88E-01
MIMAT0015019 hsa-miR-3147 -1.14E-02 9.89E-01 2.06E-01 9.82E-01
MIMAT0015024 hsa-miR-3151-5p -1.68E-02 9.83E-01 8.33E-01 9.88E-01
MIMAT0015035 hsa-miR-3161 -1.96E-03 9.98E-01 9.69E-01 9.88E-01
MIMAT0015043 hsa-miR-3168 -4.41E-03 9.96E-01 6.91E-01 9.82E-01
MIMAT0018178 hsa-miR-3180 1.22E-02 1.01E+00 6.97E-01 9.82E-01
MIMAT0015057 hsa-miR-3180-5p 8.65E-03 1.01E+00 8.75E-01 9.88E-01
MIMAT0015089 hsa-miR-3202 -1.84E-02 9.82E-01 6.79E-01 9.82E-01
MIMAT0000510 hsa-miR-320a 3.39E-02 1.03E+00 6.19E-01 9.82E-01
MIMAT0005793 hsa-miR-320c 1.86E-02 1.02E+00 7.76E-01 9.88E-01
MIMAT0015072 hsa-miR-320e -5.33E-02 9.48E-01 1.27E-01 9.82E-01
MIMAT0000755 hsa-miR-323a-3p -4.53E-03 9.95E-01 9.51E-01 9.88E-01
MIMAT0015050 hsa-miR-323b-3p 1.31E-02 1.01E+00 6.38E-01 9.82E-01
MIMAT0000762 hsa-miR-324-3p -2.09E-02 9.79E-01 3.02E-02 8.43E-01
MIMAT0000771 hsa-miR-325 -1.64E-02 9.84E-01 5.16E-01 9.82E-01
MIMAT0026486 hsa-miR-328-5p -1.45E-02 9.86E-01 6.53E-01 9.82E-01

98
MIMAT0001629 hsa-miR-329-3p 9.73E-02 1.10E+00 1.06E-01 9.61E-01
MIMAT0026555 hsa-miR-329-5p 1.12E-02 1.01E+00 7.13E-01 9.82E-01
MIMAT0004693 hsa-miR-330-5p -5.32E-02 9.48E-01 4.13E-01 9.82E-01
MIMAT0000765 hsa-miR-335-5p -2.13E-02 9.79E-01 2.02E-01 9.82E-01
MIMAT0000754 hsa-miR-337-3p -8.16E-03 9.92E-01 5.50E-01 9.82E-01
MIMAT0004695 hsa-miR-337-5p -5.52E-03 9.94E-01 6.51E-01 9.82E-01
MIMAT0004701 hsa-miR-338-5p -8.57E-03 9.91E-01 7.03E-01 9.82E-01
MIMAT0000091 hsa-miR-33a-5p -2.13E-02 9.79E-01 7.79E-01 9.88E-01
MIMAT0003301 hsa-miR-33b-5p -1.41E-02 9.86E-01 2.32E-01 9.82E-01
MIMAT0004692 hsa-miR-340-5p -3.63E-02 9.64E-01 1.57E-01 9.82E-01
MIMAT0000753 hsa-miR-342-3p 4.09E-02 1.04E+00 5.51E-01 9.82E-01
MIMAT0004694 hsa-miR-342-5p -5.40E-03 9.95E-01 9.03E-01 9.88E-01
MIMAT0022698 hsa-miR-345-3p -6.45E-03 9.94E-01 7.90E-01 9.88E-01
MIMAT0000773 hsa-miR-346 -2.68E-02 9.74E-01 9.19E-02 9.61E-01
MIMAT0000255 hsa-miR-34a-5p 7.04E-03 1.01E+00 4.94E-01 9.82E-01
MIMAT0004676 hsa-miR-34b-3p -1.20E-02 9.88E-01 6.13E-01 9.82E-01
MIMAT0004677 hsa-miR-34c-3p -1.29E-02 9.87E-01 7.97E-01 9.88E-01
MIMAT0000686 hsa-miR-34c-5p 3.52E-03 1.00E+00 9.43E-01 9.88E-01
MIMAT0017981 hsa-miR-3605-5p 4.74E-03 1.00E+00 8.30E-01 9.88E-01
MIMAT0000703 hsa-miR-361-5p 5.86E-02 1.06E+00 4.12E-01 9.82E-01
MIMAT0017991 hsa-miR-3613-3p -1.92E-02 9.81E-01 1.28E-01 9.82E-01
MIMAT0017992 hsa-miR-3614-5p 1.42E-02 1.01E+00 3.44E-01 9.82E-01
MIMAT0017994 hsa-miR-3615 -1.22E-01 8.85E-01 8.05E-02 9.55E-01
MIMAT0000705 hsa-miR-362-5p -1.88E-03 9.98E-01 9.06E-01 9.88E-01
MIMAT0000707 hsa-miR-363-3p -2.32E-02 9.77E-01 5.34E-02 8.68E-01
MIMAT0003385 hsa-miR-363-5p -7.81E-02 9.25E-01 1.84E-01 9.82E-01
MIMAT0000710
hsa-miR-365a3p+hsa-miR-365b3p -1.10E-02 9.89E-01 5.06E-01 9.82E-01
MIMAT0022833 hsa-miR-365b-5p -2.60E-01 7.71E-01 8.14E-03 8.43E-01
MIMAT0000719 hsa-miR-367-3p -9.94E-03 9.90E-01 9.07E-01 9.88E-01
MIMAT0000721 hsa-miR-369-3p -8.67E-03 9.91E-01 5.04E-01 9.82E-01
MIMAT0001621 hsa-miR-369-5p -3.16E-02 9.69E-01 3.26E-01 9.82E-01
MIMAT0018119 hsa-miR-3690 4.14E-02 1.04E+00 4.00E-01 9.82E-01
MIMAT0000722 hsa-miR-370-3p -2.85E-02 9.72E-01 1.54E-01 9.82E-01
MIMAT0004687 hsa-miR-371a-5p 6.80E-03 1.01E+00 7.91E-01 9.88E-01
MIMAT0019892 hsa-miR-371b-5p -3.16E-03 9.97E-01 9.29E-01 9.88E-01
MIMAT0004688 hsa-miR-374a-3p -4.46E-02 9.56E-01 5.67E-01 9.82E-01
MIMAT0000727 hsa-miR-374a-5p 3.90E-02 1.04E+00 3.91E-01 9.82E-01
MIMAT0022928 hsa-miR-376a-2-5p -9.14E-02 9.13E-01 7.94E-02 9.55E-01

99
MIMAT0000729 hsa-miR-376a-3p 4.09E-03 1.00E+00 6.98E-01 9.82E-01
MIMAT0000720 hsa-miR-376c-3p 7.50E-02 1.08E+00 3.24E-01 9.82E-01
MIMAT0022861 hsa-miR-376c-5p 2.14E-02 1.02E+00 6.48E-01 9.82E-01
MIMAT0000730 hsa-miR-377-3p 1.80E-02 1.02E+00 7.02E-01 9.82E-01
MIMAT0018926 hsa-miR-378d -1.70E-02 9.83E-01 1.04E-01 9.61E-01
MIMAT0018927 hsa-miR-378e -1.04E-02 9.90E-01 6.07E-01 9.82E-01
MIMAT0018932 hsa-miR-378f -2.89E-02 9.71E-01 2.73E-01 9.82E-01
MIMAT0018937 hsa-miR-378g -9.04E-03 9.91E-01 4.42E-01 9.82E-01
MIMAT0018984 hsa-miR-378h -1.96E-02 9.81E-01 3.09E-01 9.82E-01
MIMAT0019074 hsa-miR-378i -3.66E-03 9.96E-01 6.89E-01 9.82E-01
MIMAT0000733 hsa-miR-379-5p -4.98E-03 9.95E-01 7.90E-01 9.88E-01
MIMAT0000735 hsa-miR-380-3p -9.65E-02 9.08E-01 2.78E-01 9.82E-01
MIMAT0000736 hsa-miR-381-3p -6.56E-02 9.36E-01 9.03E-02 9.61E-01
MIMAT0022862 hsa-miR-381-5p -5.11E-02 9.50E-01 4.21E-01 9.82E-01
MIMAT0022697 hsa-miR-382-3p 9.30E-02 1.10E+00 1.48E-01 9.82E-01
MIMAT0000737 hsa-miR-382-5p 7.01E-02 1.07E+00 2.79E-01 9.82E-01
MIMAT0018205 hsa-miR-3928-3p -5.75E-02 9.44E-01 4.78E-01 9.82E-01
MIMAT0018349 hsa-miR-3934-5p -1.98E-02 9.80E-01 5.63E-01 9.82E-01
MIMAT0002171 hsa-miR-410-3p -4.52E-02 9.56E-01 3.85E-01 9.82E-01
MIMAT0002170 hsa-miR-412-3p -2.02E-02 9.80E-01 6.47E-01 9.82E-01
MIMAT0003339 hsa-miR-421 -7.90E-03 9.92E-01 5.43E-01 9.82E-01
MIMAT0001340 hsa-miR-423-3p -3.10E-02 9.70E-01 6.18E-01 9.82E-01
MIMAT0004748 hsa-miR-423-5p -1.42E-02 9.86E-01 7.66E-01 9.88E-01
MIMAT0016915 hsa-miR-4284 4.29E-05 1.00E+00 9.99E-01 9.99E-01
MIMAT0016916 hsa-miR-4286 -7.85E-03 9.92E-01 4.31E-01 9.82E-01
MIMAT0001625 hsa-miR-431-5p -4.85E-03 9.95E-01 9.34E-01 9.88E-01
MIMAT0002814 hsa-miR-432-5p 4.67E-02 1.05E+00 2.39E-01 9.82E-01
MIMAT0001627 hsa-miR-433-3p 3.67E-02 1.04E+00 6.43E-01 9.82E-01
MIMAT0026554 hsa-miR-433-5p 2.69E-02 1.03E+00 4.76E-01 9.82E-01
MIMAT0018934 hsa-miR-4421 2.02E-02 1.02E+00 6.36E-01 9.82E-01
MIMAT0018947 hsa-miR-4431 3.04E-02 1.03E+00 5.54E-01 9.82E-01
MIMAT0018961 hsa-miR-4443 -2.15E-02 9.79E-01 4.74E-01 9.82E-01
MIMAT0018973 hsa-miR-4451 -7.18E-02 9.31E-01 4.69E-02 8.64E-01
MIMAT0018976
hsa-miR-4454+hsamiR-7975 1.62E-02 1.02E+00 4.58E-01 9.82E-01
MIMAT0018977 hsa-miR-4455 -1.44E-02 9.86E-01 5.56E-01 9.82E-01
MIMAT0018983 hsa-miR-4461 -5.52E-03 9.94E-01 6.48E-01 9.82E-01
MIMAT0001532 hsa-miR-448 -2.28E-02 9.77E-01 1.66E-02 8.43E-01
MIMAT0019019 hsa-miR-4485-3p -2.03E-02 9.80E-01 4.21E-01 9.82E-01

100
MIMAT0019022 hsa-miR-4488 -1.90E-02 9.81E-01 2.78E-01 9.82E-01
MIMAT0001541 hsa-miR-449a 6.52E-02 1.07E+00 2.22E-01 9.82E-01
MIMAT0003327 hsa-miR-449b-5p -8.95E-03 9.91E-01 5.64E-01 9.82E-01
MIMAT0010251 hsa-miR-449c-5p 2.94E-02 1.03E+00 4.84E-01 9.82E-01
MIMAT0022700 hsa-miR-450a-1-3p -5.15E-02 9.50E-01 2.42E-01 9.82E-01
MIMAT0031074 hsa-miR-450a-2-3p -1.25E-02 9.88E-01 2.47E-01 9.82E-01
MIMAT0001545 hsa-miR-450a-5p -7.46E-02 9.28E-01 1.87E-01 9.82E-01
MIMAT0004910 hsa-miR-450b-3p -3.23E-02 9.68E-01 6.23E-01 9.82E-01
MIMAT0019053 hsa-miR-4516 -1.23E-03 9.99E-01 9.17E-01 9.88E-01
MIMAT0001631 hsa-miR-451a -8.47E-02 9.19E-01 2.62E-02 8.43E-01
MIMAT0019070 hsa-miR-4531 2.00E-02 1.02E+00 4.10E-01 9.82E-01
MIMAT0020959 hsa-miR-4536-3p -2.00E-03 9.98E-01 8.77E-01 9.88E-01
MIMAT0019078 hsa-miR-4536-5p 7.73E-02 1.08E+00 1.48E-02 8.43E-01
MIMAT0003885 hsa-miR-454-3p -6.38E-03 9.94E-01 6.00E-01 9.82E-01
MIMAT0004784 hsa-miR-455-3p -1.56E-01 8.56E-01 8.31E-02 9.55E-01
MIMAT0003150 hsa-miR-455-5p -9.08E-03 9.91E-01 5.94E-01 9.82E-01
MIMAT0019709 hsa-miR-4647 2.63E-02 1.03E+00 4.08E-01 9.82E-01
MIMAT0019808 hsa-miR-4707-3p -8.80E-02 9.16E-01 2.90E-01 9.82E-01
MIMAT0019807 hsa-miR-4707-5p -1.15E-02 9.89E-01 3.77E-01 9.82E-01
MIMAT0019895 hsa-miR-4755-5p 1.23E-02 1.01E+00 5.42E-01 9.82E-01
MIMAT0019956 hsa-miR-4787-5p -3.00E-02 9.70E-01 3.28E-01 9.82E-01
MIMAT0019964 hsa-miR-4792 -5.15E-02 9.50E-01 3.34E-01 9.82E-01
MIMAT0002176 hsa-miR-485-3p -4.73E-02 9.54E-01 4.86E-01 9.82E-01
MIMAT0002178 hsa-miR-487a-3p -1.38E-02 9.86E-01 4.27E-01 9.82E-01
MIMAT0003180 hsa-miR-487b-3p 2.79E-02 1.03E+00 4.73E-01 9.82E-01
MIMAT0026614 hsa-miR-487b-5p 1.21E-02 1.01E+00 6.16E-01 9.82E-01
MIMAT0004763 hsa-miR-488-3p -1.60E-02 9.84E-01 7.33E-01 9.88E-01
MIMAT0002806 hsa-miR-490-3p -1.89E-02 9.81E-01 7.98E-01 9.88E-01
MIMAT0002807 hsa-miR-491-5p 1.12E-04 1.00E+00 9.99E-01 9.99E-01
MIMAT0003161 hsa-miR-493-3p -2.39E-02 9.76E-01 6.69E-01 9.82E-01
MIMAT0002816 hsa-miR-494-3p 1.39E-02 1.01E+00 8.56E-01 9.88E-01
MIMAT0002817 hsa-miR-495-3p 1.21E-02 1.01E+00 3.76E-01 9.82E-01
MIMAT0022924 hsa-miR-495-5p -1.30E-02 9.87E-01 2.05E-01 9.82E-01
MIMAT0002820 hsa-miR-497-5p -6.09E-03 9.94E-01 7.04E-01 9.82E-01
MIMAT0002824 hsa-miR-498 -5.99E-03 9.94E-01 8.36E-01 9.88E-01
MIMAT0004772 hsa-miR-499a-3p -8.03E-03 9.92E-01 9.06E-01 9.88E-01
MIMAT0002870 hsa-miR-499a-5p 2.39E-02 1.02E+00 5.97E-01 9.82E-01
MIMAT0019897 hsa-miR-499b-5p 6.26E-02 1.06E+00 3.93E-01 9.82E-01
MIMAT0021021 hsa-miR-5001-5p -7.48E-03 9.93E-01 7.98E-01 9.88E-01

101
MIMAT0021044 hsa-miR-5010-3p -8.95E-03 9.91E-01 5.33E-01 9.82E-01
MIMAT0004775 hsa-miR-502-3p -6.75E-02 9.35E-01 4.44E-01 9.82E-01
MIMAT0002873 hsa-miR-502-5p -1.41E-02 9.86E-01 5.91E-01 9.82E-01
MIMAT0022925 hsa-miR-503-3p -6.64E-02 9.36E-01 4.63E-02 8.64E-01
MIMAT0002874 hsa-miR-503-5p 2.15E-03 1.00E+00 9.50E-01 9.88E-01
MIMAT0002878 hsa-miR-506-3p 3.28E-02 1.03E+00 3.30E-01 9.82E-01
MIMAT0022701 hsa-miR-506-5p 2.66E-04 1.00E+00 9.97E-01 9.99E-01
MIMAT0002879 hsa-miR-507 -3.98E-02 9.61E-01 6.44E-01 9.82E-01
MIMAT0004778 hsa-miR-508-5p -2.15E-02 9.79E-01 1.95E-01 9.82E-01
MIMAT0002881 hsa-miR-509-3p 2.81E-02 1.03E+00 6.25E-01 9.82E-01
MIMAT0004779 hsa-miR-509-5p -3.64E-02 9.64E-01 2.56E-01 9.82E-01
MIMAT0026613 hsa-miR-510-3p 8.08E-04 1.00E+00 9.55E-01 9.88E-01
MIMAT0002808 hsa-miR-511-5p -2.06E-02 9.80E-01 8.05E-01 9.88E-01
MIMAT0002822 hsa-miR-512-5p -1.13E-02 9.89E-01 4.35E-01 9.82E-01
MIMAT0004777 hsa-miR-513a-3p -2.00E-02 9.80E-01 2.11E-01 9.82E-01
MIMAT0002877 hsa-miR-513a-5p 1.69E-03 1.00E+00 9.76E-01 9.93E-01
MIMAT0005788 hsa-miR-513b-5p -3.91E-02 9.62E-01 2.86E-01 9.82E-01
MIMAT0005789 hsa-miR-513c-5p -2.49E-02 9.75E-01 6.96E-01 9.82E-01
MIMAT0002883 hsa-miR-514a-3p 3.33E-03 1.00E+00 8.14E-01 9.88E-01
MIMAT0022702 hsa-miR-514a-5p 8.45E-02 1.09E+00 1.20E-01 9.82E-01
MIMAT0015088 hsa-miR-514b-3p 1.58E-01 1.17E+00 4.50E-02 8.64E-01
MIMAT0015087 hsa-miR-514b-5p 8.58E-04 1.00E+00 9.38E-01 9.88E-01
MIMAT0002826 hsa-miR-515-5p -2.28E-02 9.77E-01 7.87E-01 9.88E-01
MIMAT0002859 hsa-miR-516b-5p -5.12E-02 9.50E-01 1.86E-01 9.82E-01
MIMAT0002852 hsa-miR-517a-3p -1.41E-02 9.86E-01 7.25E-01 9.88E-01
MIMAT0002866
hsa-miR-517c3p+hsa-miR-519a-3p -3.11E-02 9.69E-01 5.73E-02 8.98E-01
MIMAT0002844 hsa-miR-518b 4.51E-02 1.05E+00 4.93E-01 9.82E-01
MIMAT0002848 hsa-miR-518c-3p -8.55E-03 9.91E-01 8.02E-01 9.88E-01
MIMAT0002861 hsa-miR-518e-3p 2.83E-03 1.00E+00 9.59E-01 9.88E-01
MIMAT0002842 hsa-miR-518f-3p -1.01E-02 9.90E-01 7.41E-01 9.88E-01
MIMAT0021129
hsa-miR-5196-
3p+hsa-miR-6732-3p -1.73E-01 8.41E-01 8.18E-02 9.55E-01
MIMAT0021128 hsa-miR-5196-5p -4.98E-02 9.51E-01 1.29E-01 9.82E-01
MIMAT0002832 hsa-miR-519c-3p 1.24E-02 1.01E+00 4.03E-01 9.82E-01
MIMAT0002853 hsa-miR-519d-3p 4.36E-02 1.04E+00 3.34E-01 9.82E-01
MIMAT0002833 hsa-miR-520a-5p 1.08E-01 1.11E+00 1.56E-01 9.82E-01
MIMAT0002846 hsa-miR-520c-3p -1.20E-02 9.88E-01 7.96E-01 9.88E-01
MIMAT0002856 hsa-miR-520d-3p -2.65E-02 9.74E-01 7.01E-01 9.82E-01
MIMAT0002830 hsa-miR-520f-3p -1.83E-02 9.82E-01 4.40E-01 9.82E-01

102
MIMAT0002858 hsa-miR-520g-3p -5.00E-02 9.51E-01 5.45E-01 9.82E-01
MIMAT0002867 hsa-miR-520h 5.01E-03 1.01E+00 8.50E-01 9.88E-01
MIMAT0002854 hsa-miR-521 -7.31E-02 9.29E-01 5.37E-02 8.68E-01
MIMAT0002868 hsa-miR-522-3p 1.44E-02 1.01E+00 2.36E-01 9.82E-01
MIMAT0002838 hsa-miR-525-5p -1.56E-02 9.85E-01 4.07E-01 9.82E-01
MIMAT0002845
hsa-miR-526a+hsamiR-518c-5p+hsamiR-518d-5p 2.80E-03 1.00E+00 8.49E-01 9.88E-01
MIMAT0002835 hsa-miR-526b-5p -3.93E-02 9.61E-01 9.74E-02 9.61E-01
MIMAT0004780 hsa-miR-532-3p 2.00E-02 1.02E+00 3.24E-01 9.82E-01
MIMAT0003389 hsa-miR-542-3p 7.53E-03 1.01E+00 6.96E-01 9.82E-01
MIMAT0003340 hsa-miR-542-5p -9.61E-02 9.08E-01 2.01E-01 9.82E-01
MIMAT0004954 hsa-miR-543 4.09E-03 1.00E+00 7.12E-01 9.82E-01
MIMAT0004803 hsa-miR-548a-5p 1.27E-02 1.01E+00 3.99E-01 9.82E-01
MIMAT0018447
hsa-miR-548aa+hsamiR-548t-3p -1.04E-02 9.90E-01 7.26E-01 9.88E-01
MIMAT0018972 hsa-miR-548ah-5p -1.86E-03 9.98E-01 8.90E-01 9.88E-01
MIMAT0019013 hsa-miR-548ak -3.67E-02 9.64E-01 6.13E-01 9.82E-01
MIMAT0022266 hsa-miR-548ar-3p -9.53E-03 9.91E-01 4.45E-01 9.82E-01
MIMAT0022265 hsa-miR-548ar-5p -1.59E-03 9.98E-01 8.80E-01 9.88E-01
MIMAT0004812 hsa-miR-548d-5p -1.07E-02 9.89E-01 8.91E-01 9.88E-01
MIMAT0026736 hsa-miR-548e-5p -2.76E-03 9.97E-01 7.05E-01 9.82E-01
MIMAT0005912 hsa-miR-548g-3p -9.86E-05 1.00E+00 9.94E-01 9.99E-01
MIMAT0005935 hsa-miR-548i -1.96E-03 9.98E-01 9.78E-01 9.93E-01
MIMAT0026737 hsa-miR-548j-3p -5.23E-02 9.49E-01 4.66E-01 9.82E-01
MIMAT0005882 hsa-miR-548k -3.51E-02 9.65E-01 3.43E-01 9.82E-01
MIMAT0005917 hsa-miR-548m 7.94E-03 1.01E+00 7.49E-01 9.88E-01
MIMAT0005916 hsa-miR-548n -7.24E-03 9.93E-01 8.87E-01 9.88E-01
MIMAT0011163 hsa-miR-548q 5.00E-02 1.05E+00 4.30E-01 9.82E-01
MIMAT0015020 hsa-miR-548v 4.91E-02 1.05E+00 5.22E-02 8.68E-01
MIMAT0018354 hsa-miR-548y -5.85E-02 9.43E-01 2.22E-02 8.43E-01
MIMAT0018446
hsa-miR-548z+hsamiR-548h-3p -3.73E-02 9.63E-01 5.48E-01 9.82E-01
MIMAT0003333 hsa-miR-549a -1.35E-02 9.87E-01 7.90E-01 9.88E-01
MIMAT0003233 hsa-miR-551b-3p -5.00E-03 9.95E-01 7.14E-01 9.82E-01
MIMAT0003215 hsa-miR-552-3p 3.86E-02 1.04E+00 3.86E-01 9.82E-01
MIMAT0003219 hsa-miR-555 -9.92E-03 9.90E-01 8.64E-01 9.88E-01
MIMAT0004793 hsa-miR-556-3p 4.75E-02 1.05E+00 2.95E-01 9.82E-01
MIMAT0003220 hsa-miR-556-5p -2.67E-02 9.74E-01 5.39E-01 9.82E-01
MIMAT0022706 hsa-miR-561-5p -1.33E-01 8.75E-01 8.04E-02 9.55E-01
MIMAT0003227 hsa-miR-563 1.23E-02 1.01E+00 3.84E-01 9.82E-01

103
MIMAT0003228 hsa-miR-564 -1.72E-02 9.83E-01 6.55E-01 9.82E-01
MIMAT0003230 hsa-miR-566 -7.77E-02 9.25E-01 2.40E-01 9.82E-01
MIMAT0003235 hsa-miR-570-3p -2.04E-02 9.80E-01 6.03E-01 9.82E-01
MIMAT0003237 hsa-miR-572 1.71E-02 1.02E+00 5.90E-01 9.82E-01
MIMAT0003239 hsa-miR-574-3p -5.33E-02 9.48E-01 3.97E-01 9.82E-01
MIMAT0004795 hsa-miR-574-5p -9.29E-03 9.91E-01 5.93E-01 9.82E-01
MIMAT0003240 hsa-miR-575 -6.45E-02 9.37E-01 2.62E-02 8.43E-01
MIMAT0004796 hsa-miR-576-3p -5.32E-03 9.95E-01 8.43E-01 9.88E-01
MIMAT0003241 hsa-miR-576-5p 5.31E-03 1.01E+00 9.19E-01 9.88E-01
MIMAT0003242 hsa-miR-577 3.77E-02 1.04E+00 5.49E-01 9.82E-01
MIMAT0026616 hsa-miR-579-5p -2.33E-02 9.77E-01 3.04E-01 9.82E-01
MIMAT0004797 hsa-miR-582-3p -3.53E-02 9.65E-01 4.18E-01 9.82E-01
MIMAT0003247 hsa-miR-582-5p -7.69E-03 9.92E-01 4.50E-01 9.82E-01
MIMAT0022708 hsa-miR-584-3p -1.16E-02 9.88E-01 2.12E-01 9.82E-01
MIMAT0003249 hsa-miR-584-5p -1.01E-02 9.90E-01 6.01E-01 9.82E-01
MIMAT0003250 hsa-miR-585-3p 4.43E-03 1.00E+00 6.90E-01 9.82E-01
MIMAT0003253 hsa-miR-587 -8.77E-03 9.91E-01 7.52E-01 9.88E-01
MIMAT0003258 hsa-miR-590-5p -3.47E-02 9.66E-01 4.19E-01 9.82E-01
MIMAT0003259 hsa-miR-591 4.27E-02 1.04E+00 4.08E-01 9.82E-01
MIMAT0003260 hsa-miR-592 2.92E-02 1.03E+00 6.58E-01 9.82E-01
MIMAT0004802 hsa-miR-593-3p 4.03E-02 1.04E+00 3.37E-01 9.82E-01
MIMAT0003263 hsa-miR-595 1.32E-02 1.01E+00 8.47E-01 9.88E-01
MIMAT0003265 hsa-miR-597-5p 3.01E-03 1.00E+00 8.87E-01 9.88E-01
MIMAT0003266 hsa-miR-598-3p -1.71E-02 9.83E-01 9.15E-02 9.61E-01
MIMAT0003271 hsa-miR-603 4.93E-02 1.05E+00 2.29E-01 9.82E-01
MIMAT0003273 hsa-miR-605-5p -3.59E-02 9.65E-01 4.29E-01 9.82E-01
MIMAT0003275 hsa-miR-607 -5.73E-03 9.94E-01 5.40E-01 9.82E-01
MIMAT0003276 hsa-miR-608 -1.91E-02 9.81E-01 3.40E-01 9.82E-01
MIMAT0003280 hsa-miR-612 -1.18E-02 9.88E-01 3.27E-01 9.82E-01
MIMAT0003283 hsa-miR-615-3p -6.40E-03 9.94E-01 5.74E-01 9.82E-01
MIMAT0004805 hsa-miR-616-3p 4.49E-02 1.05E+00 4.65E-01 9.82E-01
MIMAT0003289 hsa-miR-620 -4.84E-02 9.53E-01 4.67E-01 9.82E-01
MIMAT0003295 hsa-miR-626 -1.13E-02 9.89E-01 5.12E-01 9.82E-01
MIMAT0026623 hsa-miR-627-3p -9.60E-03 9.90E-01 5.96E-01 9.82E-01
MIMAT0003296 hsa-miR-627-5p 3.37E-02 1.03E+00 2.45E-02 8.43E-01
MIMAT0003297 hsa-miR-628-3p 2.86E-02 1.03E+00 6.34E-01 9.82E-01
MIMAT0003299 hsa-miR-630 -3.39E-02 9.67E-01 5.90E-01 9.82E-01
MIMAT0003300 hsa-miR-631 9.20E-02 1.10E+00 1.47E-01 9.82E-01
MIMAT0003309 hsa-miR-639 -8.68E-04 9.99E-01 9.60E-01 9.88E-01

104
MIMAT0003310 hsa-miR-640 -9.37E-03 9.91E-01 8.50E-01 9.88E-01
MIMAT0003312 hsa-miR-642a-5p -7.83E-03 9.92E-01 7.57E-01 9.88E-01
MIMAT0003313 hsa-miR-643 -3.00E-02 9.70E-01 6.97E-01 9.82E-01
MIMAT0003314 hsa-miR-644a -2.05E-02 9.80E-01 7.47E-01 9.88E-01
MIMAT0003319 hsa-miR-649 3.92E-02 1.04E+00 5.06E-01 9.82E-01
MIMAT0003320 hsa-miR-650 1.61E-03 1.00E+00 9.42E-01 9.88E-01
MIMAT0025462 hsa-miR-6503-5p 1.63E-02 1.02E+00 5.77E-01 9.82E-01
MIMAT0003321 hsa-miR-651-5p 1.30E-02 1.01E+00 7.42E-01 9.88E-01
MIMAT0022709 hsa-miR-652-5p 1.33E-02 1.01E+00 7.91E-01 9.88E-01
MIMAT0003330 hsa-miR-654-5p 5.20E-02 1.05E+00 3.74E-01 9.82E-01
MIMAT0003331 hsa-miR-655-3p -4.06E-02 9.60E-01 3.61E-01 9.82E-01
MIMAT0003332 hsa-miR-656-3p 2.44E-02 1.02E+00 8.32E-02 9.55E-01
MIMAT0022711 hsa-miR-660-3p 9.95E-03 1.01E+00 7.01E-01 9.82E-01
MIMAT0003326 hsa-miR-663a 5.64E-02 1.06E+00 3.57E-01 9.82E-01
MIMAT0005949 hsa-miR-664a-3p -2.70E-02 9.73E-01 1.43E-01 9.82E-01
MIMAT0022272 hsa-miR-664b-3p -9.08E-02 9.13E-01 2.10E-01 9.82E-01
MIMAT0004952 hsa-miR-665 1.96E-02 1.02E+00 7.06E-01 9.82E-01
MIMAT0003880 hsa-miR-671-5p -3.32E-02 9.67E-01 6.58E-01 9.82E-01
MIMAT0025851 hsa-miR-6720-3p 2.39E-02 1.02E+00 2.83E-01 9.82E-01
MIMAT0025852 hsa-miR-6721-5p -1.41E-02 9.86E-01 7.24E-01 9.88E-01
MIMAT0025856 hsa-miR-6724-5p 4.28E-02 1.04E+00 3.33E-01 9.82E-01
MIMAT0004945 hsa-miR-744-5p -2.04E-01 8.15E-01 2.96E-02 8.43E-01
MIMAT0022929 hsa-miR-758-5p -7.08E-02 9.32E-01 2.40E-01 9.82E-01
MIMAT0010364 hsa-miR-761 -1.31E-02 9.87E-01 7.64E-01 9.88E-01
MIMAT0010367 hsa-miR-764 -1.29E-02 9.87E-01 3.66E-01 9.82E-01
MIMAT0003945 hsa-miR-765 1.34E-03 1.00E+00 9.21E-01 9.88E-01
MIMAT0003882 hsa-miR-767-5p -1.59E-02 9.84E-01 1.03E-01 9.61E-01
MIMAT0003887 hsa-miR-769-3p 2.90E-03 1.00E+00 9.28E-01 9.88E-01
MIMAT0003886 hsa-miR-769-5p 4.46E-03 1.00E+00 8.31E-01 9.88E-01
MIMAT0003948 hsa-miR-770-5p -2.23E-02 9.78E-01 6.77E-01 9.82E-01
MIMAT0004185 hsa-miR-802 -1.41E-02 9.86E-01 2.59E-01 9.82E-01
MIMAT0022717 hsa-miR-873-3p -1.46E-02 9.86E-01 3.96E-01 9.82E-01
MIMAT0004953 hsa-miR-873-5p -7.04E-02 9.32E-01 3.80E-01 9.82E-01
MIMAT0026718 hsa-miR-874-5p 3.43E-03 1.00E+00 9.63E-01 9.88E-01
MIMAT0004925 hsa-miR-876-3p 5.01E-02 1.05E+00 3.83E-01 9.82E-01
MIMAT0004924 hsa-miR-876-5p -1.25E-02 9.88E-01 6.53E-01 9.82E-01
MIMAT0004949 hsa-miR-877-5p 1.52E-02 1.02E+00 7.57E-01 9.88E-01
MIMAT0004948 hsa-miR-885-3p 3.59E-02 1.04E+00 5.87E-01 9.82E-01
MIMAT0026720 hsa-miR-887-5p 6.54E-03 1.01E+00 6.07E-01 9.82E-01

105
MIMAT0004916 hsa-miR-888-5p -1.76E-02 9.83E-01 3.59E-02 8.43E-01
MIMAT0004921 hsa-miR-889-3p -2.21E-02 9.78E-01 4.45E-01 9.82E-01
MIMAT0004912 hsa-miR-890 5.36E-02 1.06E+00 2.96E-01 9.82E-01
MIMAT0004902 hsa-miR-891a-5p -9.59E-04 9.99E-01 9.60E-01 9.88E-01
MIMAT0004913 hsa-miR-891b -5.29E-03 9.95E-01 6.74E-01 9.82E-01
MIMAT0004907 hsa-miR-892a -2.76E-02 9.73E-01 4.42E-01 9.82E-01
MIMAT0004972 hsa-miR-922 5.02E-03 1.01E+00 6.88E-01 9.82E-01
MIMAT0004507 hsa-miR-92a-1-5p -4.35E-02 9.57E-01 5.32E-01 9.82E-01
MIMAT0000092 hsa-miR-92a-3p 2.76E-02 1.03E+00 6.89E-01 9.82E-01
MIMAT0003218 hsa-miR-92b-3p 4.83E-03 1.00E+00 9.24E-01 9.88E-01
MIMAT0000093 hsa-miR-93-5p 8.00E-04 1.00E+00 9.86E-01 9.99E-01
MIMAT0004976 hsa-miR-933 -3.78E-03 9.96E-01 8.08E-01 9.88E-01
MIMAT0004977 hsa-miR-934 -4.83E-02 9.53E-01 3.64E-01 9.82E-01
MIMAT0004978 hsa-miR-935 3.42E-02 1.03E+00 6.30E-01 9.82E-01
MIMAT0004979 hsa-miR-936 3.75E-02 1.04E+00 1.58E-01 9.82E-01
MIMAT0004980 hsa-miR-937-3p -5.58E-02 9.46E-01 1.15E-01 9.82E-01
MIMAT0004982 hsa-miR-939-5p 1.80E-02 1.02E+00 1.22E-01 9.82E-01
MIMAT0004983 hsa-miR-940 -2.12E-02 9.79E-01 7.55E-01 9.88E-01
MIMAT0004984 hsa-miR-941 3.31E-02 1.03E+00 4.49E-01 9.82E-01
MIMAT0004985 hsa-miR-942-5p 2.29E-03 1.00E+00 8.84E-01 9.88E-01
MIMAT0000094 hsa-miR-95-3p -2.37E-02 9.77E-01 3.08E-02 8.43E-01
MIMAT0000095 hsa-miR-96-5p -1.74E-02 9.83E-01 5.22E-01 9.82E-01
MIMAT0000689 hsa-miR-99b-5p -4.29E-02 9.58E-01 5.71E-01 9.82E-01

106
Appendix G. The association of alcohol intake (categorical) and circulating microRNA adjusted for age at biospecimen draw, sex, race/ethnicity, body
mass index (kg/m2), smoking status, batch, time in years between baseline questionnaire and biospecimen draw, and case-control status.
Accessi
on miRNA
Nond
rinker
s
Light drinker IRR
ethanol intake per
drink
Light drinker
nominal pvalue
Light drinker
FDR p-value
Heavy drinker IRR
ethanol intake per
drink
Heavy drinker
nominal pvalue
Heavy drinker
FDR p-value
MIMAT
0000062 hsa-let-7a-5p
1.00(R
ef) 1.11E+00 5.64E-01 9.94E-01 1.08E+00 7.94E-01 9.78E-01
MIMAT
0000063 hsa-let-7b-5p
1.00(R
ef) 9.07E-01 6.18E-02 7.39E-01 8.42E-01 4.01E-02 9.78E-01
MIMAT
0000064 hsa-let-7c-5p
1.00(R
ef) 8.67E-01 2.84E-01 9.68E-01 8.19E-01 3.33E-01 9.78E-01
MIMAT
0000065 hsa-let-7d-5p
1.00(R
ef) 1.17E+00 2.23E-01 8.88E-01 1.08E+00 6.97E-01 9.78E-01
MIMAT
0000067 hsa-let-7f-5p
1.00(R
ef) 1.04E+00 7.96E-01 9.98E-01 9.97E-01 9.89E-01 9.98E-01
MIMAT
0000414 hsa-let-7g-5p
1.00(R
ef) 1.12E+00 2.01E-01 8.60E-01 1.00E+00 9.97E-01 9.98E-01
MIMAT
0000098 hsa-miR-100-5p
1.00(R
ef) 8.82E-01 2.47E-01 9.32E-01 9.39E-01 7.18E-01 9.78E-01
MIMAT
0000102 hsa-miR-105-5p
1.00(R
ef) 9.32E-01 4.62E-01 9.70E-01 1.30E+00 6.95E-02 9.78E-01
MIMAT
0000680 hsa-miR-106b-5p
1.00(R
ef) 9.57E-01 6.62E-01 9.98E-01 1.13E+00 4.20E-01 9.78E-01
MIMAT
0000104 hsa-miR-107
1.00(R
ef) 1.02E+00 4.12E-01 9.70E-01 9.27E-01 6.98E-02 9.78E-01
MIMAT
0000253 hsa-miR-10a-5p
1.00(R
ef) 1.06E+00 1.21E-01 7.39E-01 9.65E-01 5.23E-01 9.78E-01
MIMAT
0000254 hsa-miR-10b-5p
1.00(R
ef) 1.00E+00 9.87E-01 1.00E+00 9.10E-01 3.40E-02 9.78E-01
MIMAT
0005825 hsa-miR-1180-3p
1.00(R
ef) 8.39E-01 2.35E-01 9.07E-01 9.68E-01 8.89E-01 9.84E-01
MIMAT
0005828 hsa-miR-1183
1.00(R
ef) 9.71E-01 7.93E-01 9.98E-01 9.50E-01 7.79E-01 9.78E-01
MIMAT
0022838 hsa-miR-1185-1-3p
1.00(R
ef) 1.00E+00 9.97E-01 1.00E+00 1.32E+00 4.36E-01 9.78E-01
MIMAT
0022713 hsa-miR-1185-2-3p
1.00(R
ef) 1.02E+00 5.80E-01 9.98E-01 9.39E-01 2.08E-01 9.78E-01
MIMAT
0005798 hsa-miR-1185-5p
1.00(R
ef) 1.03E+00 2.08E-01 8.60E-01 9.55E-01 2.59E-01 9.78E-01
MIMAT
0015049 hsa-miR-1193
1.00(R
ef) 9.82E-01 9.16E-01 1.00E+00 9.22E-01 7.55E-01 9.78E-01
MIMAT
0005955 hsa-miR-1197
1.00(R
ef) 1.02E+00 5.55E-01 9.94E-01 9.69E-01 6.03E-01 9.78E-01

107
MIMAT
0005863 hsa
-miR
-1200
1.00(R
ef) 1.07E+00 6.01E
-01 9.98E
-01 7.93E
-01 2.74E
-01 9.78E
-01
MIMAT
0005865 hsa
-miR
-1202
1.00(R
ef) 1.24E+00 1.83E
-01 8.60E
-01 1.11E+00 6.82E
-01 9.78E
-01
MIMAT
0005866 hsa
-miR
-1203
1.00(R
ef) 9.12E
-01 3.39E
-01 9.68E
-01 1.05E+00 7.52E
-01 9.78E
-01
MIMAT
0005869 hsa
-miR
-1205
1.00(R
ef) 1.28E+00 2.27E
-01 8.96E
-01 1.31E+00 4.05E
-01 9.78E
-01
MIMAT
0005870 hsa
-miR
-1206
1.00(R
ef) 9.08E
-01 5.12E
-01 9.80E
-01 9.09E
-01 6.76E
-01 9.78E
-01
MIMAT
0000421 hsa
-miR
-122
-5p
1.00(R
ef) 1.22E+00 2.43E
-02 7.39E
-01 1.31E+00 5.75E
-02 9.78E
-01
MIMAT
0005459 hsa
-miR
-1224
-3p
1.00(R
ef) 1.01E+00 9.25E
-01 1.00E+00 1.09E+00 4.58E
-01 9.78E
-01
MIMAT
0005577 hsa
-miR
-1226
-3p
1.00(R
ef) 9.46E
-01 6.98E
-01 9.98E
-01 8.53E
-01 4.90E
-01 9.78E
-01
MIMAT
0005583 hsa
-miR
-1228
-3p
1.00(R
ef) 1.05E+00 2.05E
-01 8.60E
-01 9.77E
-01 6.71E
-01 9.78E
-01
MIMAT
0005589 hsa
-miR
-1234
-3p
1.00(R
ef) 9.95E
-01 9.16E
-01 1.00E+00 8.99E
-01 1.25E
-01 9.78E
-01
MIMAT
0005591 hsa
-miR
-1236
-3p
1.00(R
ef) 1.04E+00 6.02E
-01 9.98E
-01 1.08E+00 5.13E
-01 9.78E
-01
MIMAT
0005896 hsa
-miR
-1244
1.00(R
ef) 9.01E
-01 3.29E
-01 9.68E
-01 9.93E
-01 9.67E
-01 9.98E
-01
MIMAT
0005897 hsa
-miR
-1245a
1.00(R
ef) 9.97E
-01 9.48E
-01 1.00E+00 1.01E+00 8.96E
-01 9.86E
-01
MIMAT
0019950 hsa
-miR
-1245b
-5p
1.00(R
ef) 1.35E+00 1.67E
-01 8.24E
-01 1.11E+00 7.49E
-01 9.78E
-01
MIMAT
0005898 hsa
-miR
-1246
1.00(R
ef) 7.11E
-01 5.96E
-03 5.35E
-01 7.74E
-01 2.01E
-01 9.78E
-01
MIMAT
0005901 hsa
-miR
-1249
-3p
1.00(R
ef) 9.98E
-01 9.62E
-01 1.00E+00 1.00E+00 9.88E
-01 9.98E
-01
MIMAT
0005904 hsa
-miR
-1253
1.00(R
ef) 9.21E
-01 1.08E
-01 7.39E
-01 1.05E+00 5.25E
-01 9.78E
-01
MIMAT
0005905 hsa
-miR
-1254
1.00(R
ef) 9.50E
-01 8.24E
-01 9.98E
-01 8.66E
-01 6.92E
-01 9.78E
-01
MIMAT
0005906 hsa
-miR
-1255a
1.00(R
ef) 9.83E
-01 5.73E
-01 9.94E
-01 9.50E
-01 2.94E
-01 9.78E
-01
MIMAT
0005908 hsa
-miR
-1257
1.00(R
ef) 8.58E
-01 8.03E
-02 7.39E
-01 1.01E+00 9.52E
-01 9.98E
-01
MIMAT
0005909 hsa
-miR
-1258
1.00(R
ef) 1.01E+00 9.10E
-01 1.00E+00 1.02E+00 8.21E
-01 9.78E
-01
MIMAT
0004602 hsa
-miR
-125a
-3p
1.00(R
ef) 9.62E
-01 8.40E
-01 9.98E
-01 9.57E
-01 8.81E
-01 9.79E
-01

108
MIMAT
0000423 hsa
-miR
-125b
-5p
1.00(R
ef) 1.07E+00 4.66E
-01 9.70E
-01 1.05E+00 7.36E
-01 9.78E
-01
MIMAT
0000445 hsa
-miR
-126
-3p
1.00(R
ef) 1.02E+00 5.02E
-01 9.72E
-01 9.70E
-01 3.91E
-01 9.78E
-01
MIMAT
0005913 hsa
-miR
-1261
1.00(R
ef) 1.13E+00 3.14E
-01 9.68E
-01 1.22E+00 3.11E
-01 9.78E
-01
MIMAT
0005914 hsa
-miR
-1262
1.00(R
ef) 1.00E+00 8.79E
-01 1.00E+00 9.04E
-01 8.43E
-03 8.22E
-01
MIMAT
0005791 hsa
-miR
-1264
1.00(R
ef) 9.88E
-01 9.56E
-01 1.00E+00 9.55E
-01 8.92E
-01 9.85E
-01
MIMAT
0005920 hsa
-miR
-1266
-5p
1.00(R
ef) 1.10E+00 5.18E
-01 9.82E
-01 1.14E+00 5.87E
-01 9.78E
-01
MIMAT
0005922 hsa
-miR
-1268a
1.00(R
ef) 8.03E
-01 3.37E
-01 9.68E
-01 9.84E
-01 9.65E
-01 9.98E
-01
MIMAT
0018925 hsa
-miR
-1268b
1.00(R
ef) 9.96E
-01 8.98E
-01 1.00E+00 9.31E
-01 1.24E
-01 9.78E
-01
MIMAT
0005923 hsa
-miR
-1269a
1.00(R
ef) 9.75E
-01 6.40E
-01 9.98E
-01 1.07E+00 4.61E
-01 9.78E
-01
MIMAT
0000446 hsa
-miR
-127
-3p
1.00(R
ef) 9.17E
-01 8.13E
-02 7.39E
-01 1.07E+00 3.90E
-01 9.78E
-01
MIMAT
0004604 hsa
-miR
-127
-5p
1.00(R
ef) 1.08E+00 6.57E
-01 9.98E
-01 7.41E
-01 3.38E
-01 9.78E
-01
MIMAT
0005924 hsa
-miR
-1270
1.00(R
ef) 1.09E+00 6.27E
-01 9.98E
-01 9.16E
-01 7.60E
-01 9.78E
-01
MIMAT
0005796 hsa
-miR
-1271
-5p
1.00(R
ef) 8.78E
-01 5.84E
-01 9.98E
-01 1.49E+00 2.83E
-01 9.78E
-01
MIMAT
0005925 hsa
-miR
-1272
1.00(R
ef) 9.73E
-01 7.91E
-01 9.98E
-01 9.32E
-01 6.73E
-01 9.78E
-01
MIMAT
0005933 hsa
-miR
-1277
-3p
1.00(R
ef) 6.75E
-01 4.13E
-03 5.33E
-01 1.13E+00 5.92E
-01 9.78E
-01
MIMAT
0005936 hsa
-miR
-1278
1.00(R
ef) 1.09E+00 3.45E
-01 9.68E
-01 1.15E+00 3.54E
-01 9.78E
-01
MIMAT
0005937 hsa
-miR
-1279
1.00(R
ef) 9.59E
-01 7.07E
-01 9.98E
-01 9.51E
-01 7.80E
-01 9.78E
-01
MIMAT
0000424 hsa
-miR
-128
-3p
1.00(R
ef) 1.04E+00 5.68E
-01 9.94E
-01 8.53E
-01 9.62E
-02 9.78E
-01
MIMAT
0005939 hsa
-miR
-1281
1.00(R
ef) 1.01E+00 9.72E
-01 1.00E+00 8.61E
-01 4.92E
-01 9.78E
-01
MIMAT
0005876 hsa
-miR
-1285
-3p
1.00(R
ef) 9.43E
-01 4.52E
-01 9.70E
-01 9.96E
-01 9.72E
-01 9.98E
-01
MIMAT
0022719 hsa
-miR
-1285
-5p
1.00(R
ef) 9.77E
-01 3.72E
-01 9.70E
-01 9.14E
-01 3.30E
-02 9.78E
-01
MIMAT
0005877 hsa
-miR
-1286
1.00(R
ef) 1.04E+00 7.16E
-01 9.98E
-01 9.44E
-01 7.34E
-01 9.78E
-01

109
MIMAT
0005878 hsa
-miR
-1287
-5p
1.00(R
ef) 1.00E+00 9.96E
-01 1.00E+00 1.18E+00 3.21E
-01 9.78E
-01
MIMAT
0004605 hsa
-miR
-129
-
2
-3p
1.00(R
ef) 8.88E
-01 2.98E
-01 9.68E
-01 9.38E
-01 7.25E
-01 9.78E
-01
MIMAT
0005880 hsa
-miR
-1290
1.00(R
ef) 9.65E
-01 1.51E
-01 7.75E
-01 9.74E
-01 4.97E
-01 9.78E
-01
MIMAT
0005883 hsa
-miR
-1293
1.00(R
ef) 1.03E+00 9.02E
-01 1.00E+00 1.52E+00 2.28E
-01 9.78E
-01
MIMAT
0005885 hsa
-miR
-1295a
1.00(R
ef) 1.10E+00 4.80E
-02 7.39E
-01 1.06E+00 4.34E
-01 9.78E
-01
MIMAT
0026637 hsa
-miR
-1296
-3p
1.00(R
ef) 1.04E+00 2.85E
-01 9.68E
-01 9.55E
-01 4.64E
-01 9.78E
-01
MIMAT
0005886 hsa
-miR
-1297
1.00(R
ef) 9.70E
-01 8.18E
-01 9.98E
-01 1.10E+00 6.51E
-01 9.78E
-01
MIMAT
0005800 hsa
-miR
-1298
-5p
1.00(R
ef) 8.62E
-01 1.69E
-01 8.25E
-01 7.13E
-01 4.64E
-02 9.78E
-01
MIMAT
0005887 hsa
-miR
-1299
1.00(R
ef) 1.02E+00 7.99E
-01 9.98E
-01 1.13E+00 3.85E
-01 9.78E
-01
MIMAT
0005890 hsa
-miR
-1302
1.00(R
ef) 1.06E+00 4.30E
-01 9.70E
-01 9.90E
-01 9.24E
-01 9.98E
-01
MIMAT
0022720 hsa
-miR
-1304
-3p
1.00(R
ef) 1.07E+00 6.60E
-01 9.98E
-01 1.04E+00 8.77E
-01 9.79E
-01
MIMAT
0005892 hsa
-miR
-1304
-5p
1.00(R
ef) 1.01E+00 8.84E
-01 1.00E+00 1.09E+00 5.82E
-01 9.78E
-01
MIMAT
0005893 hsa
-miR
-1305
1.00(R
ef) 1.01E+00 7.67E
-01 9.98E
-01 9.69E
-01 4.81E
-01 9.78E
-01
MIMAT
0005950 hsa
-miR
-1306
-3p
1.00(R
ef) 8.28E
-01 1.28E
-01 7.39E
-01 1.14E+00 4.86E
-01 9.78E
-01
MIMAT
0005951 hsa
-miR
-1307
-3p
1.00(R
ef) 9.89E
-01 9.13E
-01 1.00E+00 8.39E
-01 2.91E
-01 9.78E
-01
MIMAT
0022727 hsa
-miR
-1307
-5p
1.00(R
ef) 1.03E+00 5.42E
-01 9.93E
-01 1.05E+00 4.30E
-01 9.78E
-01
MIMAT
0000425 hsa
-miR
-130a
-3p
1.00(R
ef) 8.24E
-01 3.33E
-01 9.68E
-01 5.64E
-01 7.99E
-02 9.78E
-01
MIMAT
0000426 hsa
-miR
-132
-3p
1.00(R
ef) 1.08E+00 5.28E
-02 7.39E
-01 1.03E+00 6.21E
-01 9.78E
-01
MIMAT
0005795 hsa
-miR
-1323
1.00(R
ef) 1.02E+00 5.24E
-01 9.86E
-01 1.00E+00 9.59E
-01 9.98E
-01
MIMAT
0000427 hsa
-miR
-133a
-3p
1.00(R
ef) 1.12E+00 9.38E
-02 7.39E
-01 8.82E
-01 2.47E
-01 9.78E
-01
MIMAT
0026478 hsa
-miR
-133a
-5p
1.00(R
ef) 1.02E+00 7.87E
-01 9.98E
-01 9.71E
-01 7.42E
-01 9.78E
-01
MIMAT
0026481 hsa
-miR
-134
-3p
1.00(R
ef) 1.04E+00 3.40E
-01 9.68E
-01 9.31E
-01 3.15E
-01 9.78E
-01

110
MIMAT
0000448 hsa
-miR
-136
-5p
1.00(R
ef) 1.00E+00 9.87E
-01 1.00E+00 1.08E+00 6.83E
-01 9.78E
-01
MIMAT
0000429 hsa
-miR
-137
1.00(R
ef) 1.09E+00 6.58E
-02 7.39E
-01 1.08E+00 2.81E
-01 9.78E
-01
MIMAT
0000430 hsa
-miR
-138
-5p
1.00(R
ef) 1.03E+00 8.12E
-01 9.98E
-01 9.83E
-01 9.28E
-01 9.98E
-01
MIMAT
0004552 hsa
-miR
-139
-3p
1.00(R
ef) 8.84E
-01 3.13E
-01 9.68E
-01 1.08E+00 6.83E
-01 9.78E
-01
MIMAT
0004597 hsa
-miR
-140
-3p
1.00(R
ef) 1.11E+00 4.04E
-01 9.70E
-01 1.60E+00 1.82E
-02 9.78E
-01
MIMAT
0000431 hsa
-miR
-140
-5p
1.00(R
ef) 1.10E+00 4.48E
-01 9.70E
-01 1.34E+00 1.28E
-01 9.78E
-01
MIMAT
0000432 hsa
-miR
-141
-3p
1.00(R
ef) 9.36E
-01 7.67E
-01 9.98E
-01 1.10E+00 7.81E
-01 9.78E
-01
MIMAT
0000434 hsa
-miR
-142
-3p
1.00(R
ef) 9.48E
-01 4.56E
-01 9.70E
-01 9.55E
-01 6.82E
-01 9.78E
-01
MIMAT
0000435 hsa
-miR
-143
-3p
1.00(R
ef) 1.04E+00 7.41E
-01 9.98E
-01 1.34E+00 1.22E
-01 9.78E
-01
MIMAT
0000449 hsa
-miR
-146a
-5p
1.00(R
ef) 9.09E
-01 3.69E
-01 9.70E
-01 9.60E
-01 8.09E
-01 9.78E
-01
MIMAT
0002809 hsa
-miR
-146b
-5p
1.00(R
ef) 8.45E
-01 9.57E
-02 7.39E
-01 1.03E+00 8.32E
-01 9.78E
-01
MIMAT
0000251 hsa
-miR
-147a
1.00(R
ef) 1.06E+00 5.50E
-01 9.94E
-01 1.02E+00 8.97E
-01 9.86E
-01
MIMAT
0004928 hsa
-miR
-147b
1.00(R
ef) 1.03E+00 7.29E
-01 9.98E
-01 1.09E+00 5.71E
-01 9.78E
-01
MIMAT
0000243 hsa
-miR
-148a
-3p
1.00(R
ef) 1.01E+00 9.53E
-01 1.00E+00 1.21E+00 2.78E
-01 9.78E
-01
MIMAT
0000759 hsa
-miR
-148b
-3p
1.00(R
ef) 1.02E+00 8.90E
-01 1.00E+00 9.24E
-01 7.11E
-01 9.78E
-01
MIMAT
0000450 hsa
-miR
-149
-5p
1.00(R
ef) 9.72E
-01 7.70E
-01 9.98E
-01 1.03E+00 8.36E
-01 9.78E
-01
MIMAT
0000451 hsa
-miR
-150
-5p
1.00(R
ef) 1.19E+00 2.19E
-01 8.78E
-01 1.05E+00 8.21E
-01 9.78E
-01
MIMAT
0000757 hsa
-miR
-151a
-3p
1.00(R
ef) 7.42E
-01 9.98E
-02 7.39E
-01 6.42E
-01 1.48E
-01 9.78E
-01
MIMAT
0007399 hsa
-miR
-1537
-3p
1.00(R
ef) 1.17E+00 3.33E
-01 9.68E
-01 1.92E+00 7.96E
-03 8.22E
-01
MIMAT
0000646 hsa
-miR
-155
-5p
1.00(R
ef) 1.03E+00 5.11E
-01 9.80E
-01 1.03E+00 7.00E
-01 9.78E
-01
MIMAT
0000417 hsa
-miR
-15b
-5p
1.00(R
ef) 8.82E
-01 4.57E
-01 9.70E
-01 8.80E
-01 6.23E
-01 9.78E
-01
MIMAT
0000069 hsa
-miR
-16
-5p
1.00(R
ef) 9.55E
-01 4.35E
-01 9.70E
-01 8.17E
-01 2.98E
-02 9.78E
-01

111
MIMAT
0004558 hsa
-miR
-181a
-
2
-3p
1.00(R
ef) 1.01E+00 7.84E
-01 9.98E
-01 1.06E+00 3.39E
-01 9.78E
-01
MIMAT
0000270 hsa
-miR
-181a
-3p
1.00(R
ef) 1.04E+00 2.62E
-01 9.55E
-01 9.47E
-01 2.96E
-01 9.78E
-01
MIMAT
0000256 hsa
-miR
-181a
-5p
1.00(R
ef) 9.67E
-01 8.54E
-01 1.00E+00 6.62E
-01 1.68E
-01 9.78E
-01
MIMAT
0031893 hsa
-miR
-181b
-
2
-3p
1.00(R
ef) 8.91E
-01 1.17E
-01 7.39E
-01 1.13E+00 3.02E
-01 9.78E
-01
MIMAT
0000257
hsa
-miR
-181b
-5p+hsa
-
miR
-181d
-5p
1.00(R
ef) 9.25E
-01 6.97E
-01 9.98E
-01 8.04E
-01 5.00E
-01 9.78E
-01
MIMAT
0000258 hsa
-miR
-181c
-5p
1.00(R
ef) 1.16E+00 4.73E
-01 9.70E
-01 1.01E+00 9.80E
-01 9.98E
-01
MIMAT
0026608 hsa
-miR
-181d
-3p
1.00(R
ef) 1.04E+00 4.91E
-01 9.71E
-01 1.02E+00 7.87E
-01 9.78E
-01
MIMAT
0000260 hsa
-miR
-182
-3p
1.00(R
ef) 1.04E+00 7.39E
-01 9.98E
-01 8.85E
-01 4.54E
-01 9.78E
-01
MIMAT
0006767 hsa
-miR
-1827
1.00(R
ef) 1.10E+00 6.27E
-01 9.98E
-01 8.67E
-01 6.70E
-01 9.78E
-01
MIMAT
0000261 hsa
-miR
-183
-5p
1.00(R
ef) 1.06E+00 1.63E
-02 7.39E
-01 9.62E
-01 3.17E
-01 9.78E
-01
MIMAT
0000454 hsa
-miR
-184
1.00(R
ef) 1.04E+00 3.02E
-01 9.68E
-01 9.64E
-01 5.03E
-01 9.78E
-01
MIMAT
0000455 hsa
-miR
-185
-5p
1.00(R
ef) 9.88E
-01 7.13E
-01 9.98E
-01 9.58E
-01 3.77E
-01 9.78E
-01
MIMAT
0000456 hsa
-miR
-186
-5p
1.00(R
ef) 1.02E+00 6.08E
-01 9.98E
-01 9.52E
-01 4.50E
-01 9.78E
-01
MIMAT
0000262 hsa
-miR
-187
-3p
1.00(R
ef) 1.04E+00 3.16E
-01 9.68E
-01 9.58E
-01 4.43E
-01 9.78E
-01
MIMAT
0004613 hsa
-miR
-188
-3p
1.00(R
ef) 1.08E+00 4.27E
-01 9.70E
-01 7.23E
-01 3.60E
-02 9.78E
-01
MIMAT
0000457 hsa
-miR
-188
-5p
1.00(R
ef) 1.02E+00 6.31E
-01 9.98E
-01 1.11E+00 5.70E
-02 9.78E
-01
MIMAT
0000072 hsa
-miR
-18a
-5p
1.00(R
ef) 1.08E+00 5.68E
-02 7.39E
-01 9.78E
-01 7.29E
-01 9.78E
-01
MIMAT
0001412 hsa
-miR
-18b
-5p
1.00(R
ef) 1.10E+00 5.80E
-01 9.98E
-01 9.52E
-01 8.50E
-01 9.78E
-01
MIMAT
0026916 hsa
-miR
-1908
-3p
1.00(R
ef) 8.90E
-01 5.47E
-01 9.93E
-01 8.08E
-01 4.94E
-01 9.78E
-01
MIMAT
0026482 hsa
-miR
-190a
-3p
1.00(R
ef) 1.02E+00 8.62E
-01 1.00E+00 1.21E+00 3.56E
-01 9.78E
-01
MIMAT
0000458 hsa
-miR
-190a
-5p
1.00(R
ef) 1.01E+00 9.60E
-01 1.00E+00 1.18E+00 5.46E
-01 9.78E
-01
MIMAT
0000440 hsa
-miR
-191
-5p
1.00(R
ef) 9.21E
-01 3.40E
-01 9.68E
-01 1.01E+00 9.43E
-01 9.98E
-01

112
MIMAT
0007884 hsa
-miR
-1910
-5p
1.00(R
ef) 7.57E
-01 8.41E
-02 7.39E
-01 7.06E
-01 1.64E
-01 9.78E
-01
MIMAT
0000222 hsa
-miR
-192
-5p
1.00(R
ef) 1.00E+00 9.98E
-01 1.00E+00 9.46E
-01 8.06E
-01 9.78E
-01
MIMAT
0000459 hsa
-miR
-193a
-3p
1.00(R
ef) 9.79E
-01 6.49E
-01 9.98E
-01 9.81E
-01 7.94E
-01 9.78E
-01
MIMAT
0002819 hsa
-miR
-193b
-3p
1.00(R
ef) 8.55E
-01 4.44E
-01 9.70E
-01 1.07E+00 8.38E
-01 9.78E
-01
MIMAT
0000226 hsa
-miR
-196a
-5p
1.00(R
ef) 9.65E
-01 4.28E
-01 9.70E
-01 9.11E
-01 1.93E
-01 9.78E
-01
MIMAT
0000227 hsa
-miR
-197
-3p
1.00(R
ef) 1.02E+00 8.36E
-01 9.98E
-01 1.07E+00 6.27E
-01 9.78E
-01
MIMAT
0022691 hsa
-miR
-197
-5p
1.00(R
ef) 1.09E+00 6.97E
-02 7.39E
-01 1.02E+00 8.16E
-01 9.78E
-01
MIMAT
0009447 hsa
-miR
-1972
1.00(R
ef) 1.01E+00 8.06E
-01 9.98E
-01 1.15E+00 6.87E
-02 9.78E
-01
MIMAT
0009448 hsa
-miR
-1973
1.00(R
ef) 1.03E+00 3.47E
-01 9.68E
-01 9.57E
-01 4.19E
-01 9.78E
-01
MIMAT
0009451 hsa
-miR
-1976
1.00(R
ef) 1.03E+00 7.13E
-01 9.98E
-01 1.04E+00 7.02E
-01 9.78E
-01
MIMAT
0000228 hsa
-miR
-198
1.00(R
ef) 9.80E
-01 7.90E
-01 9.98E
-01 9.28E
-01 5.46E
-01 9.78E
-01
MIMAT
0000232
hsa
-miR
-199a
-3p+hsa
-
miR
-199b
-3p
1.00(R
ef) 1.02E+00 5.97E
-01 9.98E
-01 1.02E+00 7.59E
-01 9.78E
-01
MIMAT
0000231 hsa
-miR
-199a
-5p
1.00(R
ef) 1.06E+00 1.33E
-01 7.39E
-01 1.01E+00 8.44E
-01 9.78E
-01
MIMAT
0000263 hsa
-miR
-199b
-5p
1.00(R
ef) 1.05E+00 2.31E
-01 9.03E
-01 1.05E+00 4.29E
-01 9.78E
-01
MIMAT
0000074 hsa
-miR
-19b
-3p
1.00(R
ef) 8.38E
-01 3.04E
-01 9.68E
-01 7.76E
-01 3.57E
-01 9.78E
-01
MIMAT
0000682 hsa
-miR
-200a
-3p
1.00(R
ef) 1.00E+00 9.55E
-01 1.00E+00 9.62E
-01 4.20E
-01 9.78E
-01
MIMAT
0000318 hsa
-miR
-200b
-3p
1.00(R
ef) 1.10E+00 3.06E
-02 7.39E
-01 1.03E+00 6.20E
-01 9.78E
-01
MIMAT
0000617 hsa
-miR
-200c
-3p
1.00(R
ef) 9.56E
-01 6.43E
-01 9.98E
-01 1.17E+00 2.97E
-01 9.78E
-01
MIMAT
0000264 hsa
-miR
-203a
-3p
1.00(R
ef) 9.93E
-01 9.64E
-01 1.00E+00 9.37E
-01 8.05E
-01 9.78E
-01
MIMAT
0031890 hsa
-miR
-203a
-5p
1.00(R
ef) 1.01E+00 7.76E
-01 9.98E
-01 9.44E
-01 2.10E
-01 9.78E
-01
MIMAT
0000266 hsa
-miR
-205
-5p
1.00(R
ef) 6.98E
-01 3.83E
-02 7.39E
-01 1.07E+00 8.10E
-01 9.78E
-01
MIMAT
0009978 hsa
-miR
-2053
1.00(R
ef) 9.71E
-01 3.05E
-01 9.68E
-01 9.79E
-01 6.50E
-01 9.78E
-01

113
MIMAT
0000241 hsa
-miR
-208a
-3p
1.00(R
ef) 1.03E+00 3.23E
-01 9.68E
-01 1.04E+00 3.99E
-01 9.78E
-01
MIMAT
0004960 hsa
-miR
-208b
-3p
1.00(R
ef) 9.69E
-01 2.38E
-01 9.13E
-01 9.51E
-01 2.39E
-01 9.78E
-01
MIMAT
0000076 hsa
-miR
-21
-5p
1.00(R
ef) 9.12E
-01 3.53E
-01 9.68E
-01 1.07E+00 6.69E
-01 9.78E
-01
MIMAT
0000267 hsa
-miR
-210
-3p
1.00(R
ef) 1.07E+00 2.84E
-02 7.39E
-01 1.01E+00 7.62E
-01 9.78E
-01
MIMAT
0026475 hsa
-miR
-210
-5p
1.00(R
ef) 1.11E+00 1.93E
-03 3.33E
-01 9.52E
-01 3.50E
-01 9.78E
-01
MIMAT
0000268 hsa
-miR
-211
-5p
1.00(R
ef) 1.02E+00 4.70E
-01 9.70E
-01 9.39E
-01 1.91E
-01 9.78E
-01
MIMAT
0010133 hsa
-miR
-2110
1.00(R
ef) 1.14E+00 1.29E
-01 7.39E
-01 9.14E
-01 4.98E
-01 9.78E
-01
MIMAT
0009206 hsa
-miR
-2113
1.00(R
ef) 1.06E+00 7.48E
-01 9.98E
-01 9.89E
-01 9.69E
-01 9.98E
-01
MIMAT
0000269 hsa
-miR
-212
-3p
1.00(R
ef) 1.02E+00 6.39E
-01 9.98E
-01 8.92E
-01 5.38E
-02 9.78E
-01
MIMAT
0000272 hsa
-miR
-215
-5p
1.00(R
ef) 9.80E
-01 7.42E
-01 9.98E
-01 1.01E+00 9.44E
-01 9.98E
-01
MIMAT
0000273 hsa
-miR
-216a
-5p
1.00(R
ef) 9.76E
-01 7.97E
-01 9.98E
-01 8.51E
-01 2.92E
-01 9.78E
-01
MIMAT
0004959 hsa
-miR
-216b
-5p
1.00(R
ef) 1.09E+00 1.90E
-01 8.60E
-01 1.04E+00 6.83E
-01 9.78E
-01
MIMAT
0000274 hsa
-miR
-217
1.00(R
ef) 1.19E+00 1.30E
-01 7.39E
-01 1.18E+00 3.50E
-01 9.78E
-01
MIMAT
0000275 hsa
-miR
-218
-5p
1.00(R
ef) 9.77E
-01 8.28E
-01 9.98E
-01 8.36E
-01 2.78E
-01 9.78E
-01
MIMAT
0000276 hsa
-miR
-219a
-5p
1.00(R
ef) 1.74E+00 1.36E
-02 7.02E
-01 1.44E+00 3.02E
-01 9.78E
-01
MIMAT
0019748 hsa
-miR
-219b
-3p
1.00(R
ef) 1.01E+00 9.44E
-01 1.00E+00 1.03E+00 8.44E
-01 9.78E
-01
MIMAT
0000278 hsa
-miR
-221
-3p
1.00(R
ef) 9.53E
-01 6.60E
-01 9.98E
-01 9.59E
-01 8.12E
-01 9.78E
-01
MIMAT
0000279 hsa
-miR
-222
-3p
1.00(R
ef) 8.85E
-01 5.32E
-01 9.88E
-01 7.00E
-01 2.42E
-01 9.78E
-01
MIMAT
0000280 hsa
-miR
-223
-3p
1.00(R
ef) 9.22E
-01 3.30E
-01 9.68E
-01 8.28E
-01 1.60E
-01 9.78E
-01
MIMAT
0000281 hsa
-miR
-224
-5p
1.00(R
ef) 7.14E
-01 8.18E
-02 7.39E
-01 9.26E
-01 8.02E
-01 9.78E
-01
MIMAT
0000078 hsa
-miR
-23a
-3p
1.00(R
ef) 9.43E
-01 1.54E
-01 7.81E
-01 9.20E
-01 2.11E
-01 9.78E
-01
MIMAT
0000418 hsa
-miR
-23b
-3p
1.00(R
ef) 1.07E+00 7.60E
-02 7.39E
-01 9.76E
-01 6.96E
-01 9.78E
-01

114
MIMAT
0018000 hsa
-miR
-23c
1.00(R
ef) 9.88E
-01 8.35E
-01 9.98E
-01 9.14E
-01 3.44E
-01 9.78E
-01
MIMAT
0000081 hsa
-miR
-25
-3p
1.00(R
ef) 8.20E
-01 1.89E
-01 8.60E
-01 6.12E
-01 4.38E
-02 9.78E
-01
MIMAT
0004498 hsa
-miR
-25
-5p
1.00(R
ef) 1.03E+00 6.07E
-01 9.98E
-01 9.43E
-01 4.58E
-01 9.78E
-01
MIMAT
0000082 hsa
-miR
-26a
-5p
1.00(R
ef) 1.06E+00 1.38E
-01 7.54E
-01 1.06E+00 3.11E
-01 9.78E
-01
MIMAT
0000083 hsa
-miR
-26b
-5p
1.00(R
ef) 1.03E+00 2.84E
-01 9.68E
-01 8.82E
-01 9.54E
-03 8.22E
-01
MIMAT
0000084 hsa
-miR
-27a
-3p
1.00(R
ef) 1.14E+00 4.35E
-02 7.39E
-01 1.04E+00 7.05E
-01 9.78E
-01
MIMAT
0004502 hsa
-miR
-28
-3p
1.00(R
ef) 9.61E
-01 4.25E
-01 9.70E
-01 8.73E
-01 8.21E
-02 9.78E
-01
MIMAT
0000085 hsa
-miR
-28
-5p
1.00(R
ef) 1.02E+00 7.90E
-01 9.98E
-01 1.00E+00 9.78E
-01 9.98E
-01
MIMAT
0004679 hsa
-miR
-296
-3p
1.00(R
ef) 1.16E+00 4.86E
-01 9.71E
-01 7.65E
-01 4.46E
-01 9.78E
-01
MIMAT
0004901 hsa
-miR
-298
1.00(R
ef) 9.56E
-01 6.58E
-01 9.98E
-01 8.61E
-01 3.56E
-01 9.78E
-01
MIMAT
0000687 hsa
-miR
-299
-3p
1.00(R
ef) 1.10E+00 2.52E
-01 9.43E
-01 1.07E+00 6.01E
-01 9.78E
-01
MIMAT
0002890 hsa
-miR
-299
-5p
1.00(R
ef) 9.62E
-01 2.62E
-01 9.55E
-01 1.01E+00 8.71E
-01 9.79E
-01
MIMAT
0000086 hsa
-miR
-29a
-3p
1.00(R
ef) 1.14E+00 1.46E
-01 7.75E
-01 9.45E
-01 6.95E
-01 9.78E
-01
MIMAT
0000100 hsa
-miR
-29b
-3p
1.00(R
ef) 1.24E+00 1.49E
-01 7.75E
-01 1.58E+00 3.92E
-02 9.78E
-01
MIMAT
0000681 hsa
-miR
-29c
-3p
1.00(R
ef) 7.88E
-01 2.74E
-01 9.68E
-01 6.57E
-01 2.27E
-01 9.78E
-01
MIMAT
0004903 hsa
-miR
-300
1.00(R
ef) 1.00E+00 9.92E
-01 1.00E+00 8.30E
-01 5.35E
-01 9.78E
-01
MIMAT
0000688 hsa
-miR
-301a
-3p
1.00(R
ef) 9.37E
-01 1.96E
-01 8.60E
-01 8.93E
-01 1.43E
-01 9.78E
-01
MIMAT
0022696 hsa
-miR
-301a
-5p
1.00(R
ef) 1.09E+00 8.43E
-02 7.39E
-01 8.71E
-01 7.04E
-02 9.78E
-01
MIMAT
0004958 hsa
-miR
-301b
-3p
1.00(R
ef) 1.07E+00 4.34E
-01 9.70E
-01 1.12E+00 4.15E
-01 9.78E
-01
MIMAT
0032026 hsa
-miR
-301b
-5p
1.00(R
ef) 1.03E+00 4.04E
-01 9.70E
-01 9.49E
-01 3.01E
-01 9.78E
-01
MIMAT
0000684 hsa
-miR
-302a
-3p
1.00(R
ef) 1.12E+00 1.34E
-01 7.39E
-01 9.73E
-01 8.04E
-01 9.78E
-01
MIMAT
0000683 hsa
-miR
-302a
-5p
1.00(R
ef) 1.06E+00 6.72E
-01 9.98E
-01 8.84E
-01 5.82E
-01 9.78E
-01

115
MIMAT
0000715 hsa
-miR
-302b
-3p
1.00(R
ef) 1.01E+00 7.66E
-01 9.98E
-01 8.94E
-01 1.30E
-01 9.78E
-01
MIMAT
0000717 hsa
-miR
-302c
-3p
1.00(R
ef) 1.13E+00 3.88E
-01 9.70E
-01 1.04E+00 8.74E
-01 9.79E
-01
MIMAT
0000718 hsa
-miR
-302d
-3p
1.00(R
ef) 9.43E
-01 1.15E
-01 7.39E
-01 1.00E+00 9.97E
-01 9.98E
-01
MIMAT
0005931 hsa
-miR
-302e
1.00(R
ef) 1.13E+00 3.42E
-01 9.68E
-01 1.22E+00 3.25E
-01 9.78E
-01
MIMAT
0005932 hsa
-miR
-302f
1.00(R
ef) 1.05E+00 7.77E
-01 9.98E
-01 1.04E+00 8.69E
-01 9.79E
-01
MIMAT
0015378 hsa
-miR
-3065
-3p
1.00(R
ef) 9.85E
-01 7.02E
-01 9.98E
-01 9.09E
-01 1.09E
-01 9.78E
-01
MIMAT
0015027 hsa
-miR
-3074
-3p
1.00(R
ef) 8.08E
-01 3.54E
-01 9.68E
-01 6.60E
-01 2.51E
-01 9.78E
-01
MIMAT
0000088 hsa
-miR
-30a
-3p
1.00(R
ef) 1.01E+00 8.02E
-01 9.98E
-01 1.00E+00 9.43E
-01 9.98E
-01
MIMAT
0000420 hsa
-miR
-30b
-5p
1.00(R
ef) 9.97E
-01 9.77E
-01 1.00E+00 9.45E
-01 7.42E
-01 9.78E
-01
MIMAT
0000244 hsa
-miR
-30c
-5p
1.00(R
ef) 9.45E
-01 7.00E
-01 9.98E
-01 1.54E+00 6.46E
-02 9.78E
-01
MIMAT
0000245 hsa
-miR
-30d
-5p
1.00(R
ef) 7.75E
-01 2.07E
-02 7.39E
-01 7.21E
-01 6.44E
-02 9.78E
-01
MIMAT
0000693 hsa
-miR
-30e
-3p
1.00(R
ef) 1.03E+00 5.61E
-01 9.94E
-01 9.97E
-01 9.63E
-01 9.98E
-01
MIMAT
0000692 hsa
-miR
-30e
-5p
1.00(R
ef) 1.03E+00 3.79E
-01 9.70E
-01 9.83E
-01 7.64E
-01 9.78E
-01
MIMAT
0014996 hsa
-miR
-3131
1.00(R
ef) 9.75E
-01 7.80E
-01 9.98E
-01 9.93E
-01 9.64E
-01 9.98E
-01
MIMAT
0015015 hsa
-miR
-3144
-3p
1.00(R
ef) 9.78E
-01 4.22E
-01 9.70E
-01 9.88E
-01 7.86E
-01 9.78E
-01
MIMAT
0015014 hsa
-miR
-3144
-5p
1.00(R
ef) 1.02E+00 8.48E
-01 1.00E+00 9.78E
-01 9.06E
-01 9.88E
-01
MIMAT
0015019 hsa
-miR
-3147
1.00(R
ef) 1.02E+00 5.17E
-01 9.82E
-01 9.57E
-01 2.73E
-01 9.78E
-01
MIMAT
0015024 hsa
-miR
-3151
-5p
1.00(R
ef) 9.91E
-01 9.67E
-01 1.00E+00 9.24E
-01 8.29E
-01 9.78E
-01
MIMAT
0015035 hsa
-miR
-3161
1.00(R
ef) 1.05E+00 7.26E
-01 9.98E
-01 1.00E+00 9.87E
-01 9.98E
-01
MIMAT
0015043 hsa
-miR
-3168
1.00(R
ef) 1.04E+00 1.97E
-01 8.60E
-01 9.81E
-01 6.76E
-01 9.78E
-01
MIMAT
0018178 hsa
-miR
-3180
1.00(R
ef) 9.88E
-01 8.85E
-01 1.00E+00 1.17E+00 2.45E
-01 9.78E
-01
MIMAT
0015057 hsa
-miR
-3180
-5p
1.00(R
ef) 7.33E
-01 5.12E
-02 7.39E
-01 8.12E
-01 4.11E
-01 9.78E
-01

116
MIMAT
0015089 hsa
-miR
-3202
1.00(R
ef) 8.52E
-01 1.77E
-01 8.46E
-01 9.91E
-01 9.58E
-01 9.98E
-01
MIMAT
0000510 hsa
-miR
-320a
1.00(R
ef) 8.08E
-01 2.85E
-01 9.68E
-01 1.20E+00 5.50E
-01 9.78E
-01
MIMAT
0005793 hsa
-miR
-320c
1.00(R
ef) 8.51E
-01 3.95E
-01 9.70E
-01 1.28E+00 4.00E
-01 9.78E
-01
MIMAT
0015072 hsa
-miR
-320e
1.00(R
ef) 6.38E
-01 6.24E
-06 1.61E
-03 6.59E
-01 8.87E
-03 8.22E
-01
MIMAT
0000755 hsa
-miR
-323a
-3p
1.00(R
ef) 8.88E
-01 5.55E
-01 9.94E
-01 1.02E+00 9.56E
-01 9.98E
-01
MIMAT
0015050 hsa
-miR
-323b
-3p
1.00(R
ef) 9.42E
-01 4.43E
-01 9.70E
-01 1.07E+00 5.88E
-01 9.78E
-01
MIMAT
0000762 hsa
-miR
-324
-3p
1.00(R
ef) 1.00E+00 8.62E
-01 1.00E+00 9.17E
-01 2.85E
-02 9.78E
-01
MIMAT
0000771 hsa
-miR
-325
1.00(R
ef) 9.77E
-01 7.34E
-01 9.98E
-01 1.03E+00 7.58E
-01 9.78E
-01
MIMAT
0026486 hsa
-miR
-328
-5p
1.00(R
ef) 9.72E
-01 7.46E
-01 9.98E
-01 9.12E
-01 4.87E
-01 9.78E
-01
MIMAT
0001629 hsa
-miR
-329
-3p
1.00(R
ef) 1.23E+00 2.56E
-01 9.52E
-01 1.32E+00 3.25E
-01 9.78E
-01
MIMAT
0026555 hsa
-miR
-329
-5p
1.00(R
ef) 9.51E
-01 5.59E
-01 9.94E
-01 1.00E+00 9.98E
-01 9.98E
-01
MIMAT
0004693 hsa
-miR
-330
-5p
1.00(R
ef) 9.63E
-01 8.27E
-01 9.98E
-01 9.08E
-01 7.17E
-01 9.78E
-01
MIMAT
0000765 hsa
-miR
-335
-5p
1.00(R
ef) 1.06E+00 1.66E
-01 8.23E
-01 9.85E
-01 8.26E
-01 9.78E
-01
MIMAT
0000754 hsa
-miR
-337
-3p
1.00(R
ef) 1.05E+00 2.08E
-01 8.60E
-01 9.53E
-01 3.92E
-01 9.78E
-01
MIMAT
0004695 hsa
-miR
-337
-5p
1.00(R
ef) 1.01E+00 6.77E
-01 9.98E
-01 9.47E
-01 2.83E
-01 9.78E
-01
MIMAT
0004701 hsa
-miR
-338
-5p
1.00(R
ef) 9.81E
-01 7.46E
-01 9.98E
-01 9.91E
-01 9.25E
-01 9.98E
-01
MIMAT
0000091 hsa
-miR
-33a
-5p
1.00(R
ef) 7.42E
-01 1.32E
-01 7.39E
-01 8.39E
-01 5.66E
-01 9.78E
-01
MIMAT
0003301 hsa
-miR
-33b
-5p
1.00(R
ef) 1.01E+00 8.31E
-01 9.98E
-01 9.77E
-01 6.25E
-01 9.78E
-01
MIMAT
0004692 hsa
-miR
-340
-5p
1.00(R
ef) 1.02E+00 7.63E
-01 9.98E
-01 8.94E
-01 3.27E
-01 9.78E
-01
MIMAT
0000753 hsa
-miR
-342
-3p
1.00(R
ef) 1.24E+00 2.91E
-01 9.68E
-01 1.41E+00 3.05E
-01 9.78E
-01
MIMAT
0004694 hsa
-miR
-342
-5p
1.00(R
ef) 9.79E
-01 8.55E
-01 1.00E+00 1.18E+00 3.59E
-01 9.78E
-01
MIMAT
0022698 hsa
-miR
-345
-3p
1.00(R
ef) 1.07E+00 3.54E
-01 9.68E
-01 1.01E+00 9.33E
-01 9.98E
-01

117
MIMAT
0000773 hsa
-miR
-346
1.00(R
ef) 9.58E
-01 3.24E
-01 9.68E
-01 9.23E
-01 2.41E
-01 9.78E
-01
MIMAT
0000255 hsa
-miR
-34a
-5p
1.00(R
ef) 1.06E+00 3.21E
-02 7.39E
-01 1.02E+00 6.92E
-01 9.78E
-01
MIMAT
0004676 hsa
-miR
-34b
-3p
1.00(R
ef) 1.08E+00 2.13E
-01 8.67E
-01 1.01E+00 9.43E
-01 9.98E
-01
MIMAT
0004677 hsa
-miR
-34c
-3p
1.00(R
ef) 1.09E+00 5.38E
-01 9.92E
-01 1.14E+00 5.55E
-01 9.78E
-01
MIMAT
0000686 hsa
-miR
-34c
-5p
1.00(R
ef) 9.67E
-01 8.00E
-01 9.98E
-01 9.37E
-01 7.52E
-01 9.78E
-01
MIMAT
0017981 hsa
-miR
-3605
-5p
1.00(R
ef) 9.62E
-01 5.33E
-01 9.88E
-01 1.06E+00 5.80E
-01 9.78E
-01
MIMAT
0000703 hsa
-miR
-361
-5p
1.00(R
ef) 9.81E
-01 9.27E
-01 1.00E+00 1.32E+00 3.85E
-01 9.78E
-01
MIMAT
0017991 hsa
-miR
-3613
-3p
1.00(R
ef) 1.03E+00 4.03E
-01 9.70E
-01 9.89E
-01 8.33E
-01 9.78E
-01
MIMAT
0017992 hsa
-miR
-3614
-5p
1.00(R
ef) 9.98E
-01 9.55E
-01 1.00E+00 1.02E+00 7.77E
-01 9.78E
-01
MIMAT
0017994 hsa
-miR
-3615
1.00(R
ef) 9.21E
-01 6.43E
-01 9.98E
-01 7.74E
-01 3.70E
-01 9.78E
-01
MIMAT
0000705 hsa
-miR
-362
-5p
1.00(R
ef) 1.03E+00 4.90E
-01 9.71E
-01 9.79E
-01 7.52E
-01 9.78E
-01
MIMAT
0000707 hsa
-miR
-363
-3p
1.00(R
ef) 1.05E+00 1.50E
-01 7.75E
-01 9.72E
-01 6.05E
-01 9.78E
-01
MIMAT
0003385 hsa
-miR
-363
-5p
1.00(R
ef) 9.98E
-01 9.92E
-01 1.00E+00 8.80E
-01 5.90E
-01 9.78E
-01
MIMAT
0000710
hsa
-miR
-365a
-3p+hsa
-
miR
-365b
-3p
1.00(R
ef) 9.62E
-01 3.87E
-01 9.70E
-01 9.68E
-01 6.47E
-01 9.78E
-01
MIMAT
0022833 hsa
-miR
-365b
-5p
1.00(R
ef) 7.49E
-01 1.62E
-01 8.11E
-01 6.20E
-01 1.40E
-01 9.78E
-01
MIMAT
0000719 hsa
-miR
-367
-3p
1.00(R
ef) 1.33E+00 2.03E
-01 8.60E
-01 9.57E
-01 9.02E
-01 9.88E
-01
MIMAT
0000721 hsa
-miR
-369
-3p
1.00(R
ef) 1.07E+00 6.19E
-02 7.39E
-01 9.31E
-01 2.26E
-01 9.78E
-01
MIMAT
0001621 hsa
-miR
-369
-5p
1.00(R
ef) 1.01E+00 9.32E
-01 1.00E+00 9.64E
-01 7.77E
-01 9.78E
-01
MIMAT
0018119 hsa
-miR
-3690
1.00(R
ef) 8.99E
-01 4.59E
-01 9.70E
-01 1.31E+00 2.41E
-01 9.78E
-01
MIMAT
0000722 hsa
-miR
-370
-3p
1.00(R
ef) 9.73E
-01 6.13E
-01 9.98E
-01 8.93E
-01 1.86E
-01 9.78E
-01
MIMAT
0004687 hsa
-miR
-371a
-5p
1.00(R
ef) 1.13E+00 9.88E
-02 7.39E
-01 1.18E+00 1.55E
-01 9.78E
-01
MIMAT
0019892 hsa
-miR
-371b
-5p
1.00(R
ef) 9.13E
-01 3.68E
-01 9.70E
-01 7.75E
-01 1.20E
-01 9.78E
-01

118
MIMAT
0004688 hsa
-miR
-374a
-3p
1.00(R
ef) 8.46E
-01 4.41E
-01 9.70E
-01 1.25E+00 5.09E
-01 9.78E
-01
MIMAT
0000727 hsa
-miR
-374a
-5p
1.00(R
ef) 1.09E+00 4.88E
-01 9.71E
-01 1.07E+00 7.40E
-01 9.78E
-01
MIMAT
0022928 hsa
-miR
-376a
-
2
-5p
1.00(R
ef) 1.13E+00 3.64E
-01 9.70E
-01 7.52E
-01 1.97E
-01 9.78E
-01
MIMAT
0000729 hsa
-miR
-376a
-3p
1.00(R
ef) 1.03E+00 3.69E
-01 9.70E
-01 1.03E+00 6.07E
-01 9.78E
-01
MIMAT
0000720 hsa
-miR
-376c
-3p
1.00(R
ef) 1.18E+00 4.32E
-01 9.70E
-01 1.47E+00 2.26E
-01 9.78E
-01
MIMAT
0022861 hsa
-miR
-376c
-5p
1.00(R
ef) 1.27E+00 6.09E
-02 7.39E
-01 1.43E+00 6.87E
-02 9.78E
-01
MIMAT
0000730 hsa
-miR
-377
-3p
1.00(R
ef) 9.79E
-01 8.74E
-01 1.00E+00 1.07E+00 7.43E
-01 9.78E
-01
MIMAT
0018926 hsa
-miR
-378d
1.00(R
ef) 1.05E+00 8.33E
-02 7.39E
-01 9.34E
-01 1.07E
-01 9.78E
-01
MIMAT
0018927 hsa
-miR
-378e
1.00(R
ef) 9.34E
-01 2.19E
-01 8.78E
-01 9.40E
-01 4.73E
-01 9.78E
-01
MIMAT
0018932 hsa
-miR
-378f
1.00(R
ef) 1.07E+00 3.28E
-01 9.68E
-01 9.83E
-01 8.75E
-01 9.79E
-01
MIMAT
0018937 hsa
-miR
-378g
1.00(R
ef) 1.02E+00 6.12E
-01 9.98E
-01 1.03E+00 5.05E
-01 9.78E
-01
MIMAT
0018984 hsa
-miR
-378h
1.00(R
ef) 1.11E+00 4.74E
-02 7.39E
-01 9.82E
-01 8.18E
-01 9.78E
-01
MIMAT
0019074 hsa
-miR
-378i
1.00(R
ef) 1.05E+00 4.81E
-02 7.39E
-01 9.99E
-01 9.80E
-01 9.98E
-01
MIMAT
0000733 hsa
-miR
-379
-5p
1.00(R
ef) 9.98E
-01 9.68E
-01 1.00E+00 1.10E+00 2.32E
-01 9.78E
-01
MIMAT
0000735 hsa
-miR
-380
-3p
1.00(R
ef) 6.93E
-01 1.23E
-01 7.39E
-01 1.23E+00 5.70E
-01 9.78E
-01
MIMAT
0000736 hsa
-miR
-381
-3p
1.00(R
ef) 1.19E+00 7.65E
-02 7.39E
-01 9.41E
-01 7.00E
-01 9.78E
-01
MIMAT
0022862 hsa
-miR
-381
-5p
1.00(R
ef) 8.70E
-01 4.00E
-01 9.70E
-01 9.86E
-01 9.56E
-01 9.98E
-01
MIMAT
0022697 hsa
-miR
-382
-3p
1.00(R
ef) 8.89E
-01 5.48E
-01 9.93E
-01 1.21E+00 5.27E
-01 9.78E
-01
MIMAT
0000737 hsa
-miR
-382
-5p
1.00(R
ef) 1.21E+00 3.14E
-01 9.68E
-01 1.38E+00 2.91E
-01 9.78E
-01
MIMAT
0018205 hsa
-miR
-3928
-3p
1.00(R
ef) 8.94E
-01 6.13E
-01 9.98E
-01 5.47E
-01 1.15E
-01 9.78E
-01
MIMAT
0018349 hsa
-miR
-3934
-5p
1.00(R
ef) 9.95E
-01 9.58E
-01 1.00E+00 8.72E
-01 3.90E
-01 9.78E
-01
MIMAT
0002171 hsa
-miR
-410
-3p
1.00(R
ef) 9.33E
-01 6.21E
-01 9.98E
-01 9.58E
-01 8.44E
-01 9.78E
-01

119
MIMAT
0002170 hsa
-miR
-412
-3p
1.00(R
ef) 1.22E+00 9.80E
-02 7.39E
-01 9.93E
-01 9.72E
-01 9.98E
-01
MIMAT
0003339 hsa
-miR
-421
1.00(R
ef) 9.61E
-01 2.71E
-01 9.68E
-01 9.45E
-01 3.31E
-01 9.78E
-01
MIMAT
0001340 hsa
-miR
-423
-3p
1.00(R
ef) 9.94E
-01 9.74E
-01 1.00E+00 9.12E
-01 7.47E
-01 9.78E
-01
MIMAT
0004748 hsa
-miR
-423
-5p
1.00(R
ef) 7.94E
-01 9.19E
-02 7.39E
-01 6.12E
-01 2.61E
-02 9.78E
-01
MIMAT
0016915 hsa
-miR
-4284
1.00(R
ef) 1.02E+00 9.09E
-01 1.00E+00 1.10E+00 6.68E
-01 9.78E
-01
MIMAT
0016916 hsa
-miR
-4286
1.00(R
ef) 1.04E+00 1.08E
-01 7.39E
-01 9.80E
-01 6.38E
-01 9.78E
-01
MIMAT
0001625 hsa
-miR
-431
-5p
1.00(R
ef) 8.93E
-01 4.77E
-01 9.70E
-01 1.16E+00 5.41E
-01 9.78E
-01
MIMAT
0002814 hsa
-miR
-432
-5p
1.00(R
ef) 1.03E+00 8.26E
-01 9.98E
-01 1.14E+00 4.84E
-01 9.78E
-01
MIMAT
0001627 hsa
-miR
-433
-3p
1.00(R
ef) 1.68E+00 1.94E
-02 7.39E
-01 1.88E+00 6.40E
-02 9.78E
-01
MIMAT
0026554 hsa
-miR
-433
-5p
1.00(R
ef) 1.15E+00 1.98E
-01 8.60E
-01 1.13E+00 4.60E
-01 9.78E
-01
MIMAT
0018934 hsa
-miR
-4421
1.00(R
ef) 1.00E+00 9.92E
-01 1.00E+00 1.01E+00 9.41E
-01 9.98E
-01
MIMAT
0018947 hsa
-miR
-4431
1.00(R
ef) 9.61E
-01 7.91E
-01 9.98E
-01 1.04E+00 8.79E
-01 9.79E
-01
MIMAT
0018961 hsa
-miR
-4443
1.00(R
ef) 1.02E+00 8.54E
-01 1.00E+00 8.97E
-01 4.24E
-01 9.78E
-01
MIMAT
0018973 hsa
-miR
-4451
1.00(R
ef) 1.01E+00 9.53E
-01 1.00E+00 9.97E
-01 9.83E
-01 9.98E
-01
MIMAT
0018976
hsa
-miR
-4454+hsa
-miR
-
7975
1.00(R
ef) 8.74E
-01 3.26E
-02 7.39E
-01 9.85E
-01 8.77E
-01 9.79E
-01
MIMAT
0018977 hsa
-miR
-4455
1.00(R
ef) 9.31E
-01 2.73E
-01 9.68E
-01 1.02E+00 8.33E
-01 9.78E
-01
MIMAT
0018983 hsa
-miR
-4461
1.00(R
ef) 1.05E+00 1.05E
-01 7.39E
-01 9.91E
-01 8.54E
-01 9.79E
-01
MIMAT
0001532 hsa
-miR
-448
1.00(R
ef) 1.04E+00 1.02E
-01 7.39E
-01 9.43E
-01 1.31E
-01 9.78E
-01
MIMAT
0019019 hsa
-miR
-4485
-3p
1.00(R
ef) 1.03E+00 6.74E
-01 9.98E
-01 9.54E
-01 6.51E
-01 9.78E
-01
MIMAT
0019022 hsa
-miR
-4488
1.00(R
ef) 9.94E
-01 9.03E
-01 1.00E+00 9.76E
-01 7.36E
-01 9.78E
-01
MIMAT
0001541 hsa
-miR
-449a
1.00(R
ef) 1.30E+00 7.73E
-02 7.39E
-01 1.41E+00 1.29E
-01 9.78E
-01
MIMAT
0003327 hsa
-miR
-449b
-5p
1.00(R
ef) 1.05E+00 2.02E
-01 8.60E
-01 9.59E
-01 5.13E
-01 9.78E
-01

120
MIMAT
0010251 hsa
-miR
-449c
-5p
1.00(R
ef) 1.01E+00 9.17E
-01 1.00E+00 1.14E+00 4.86E
-01 9.78E
-01
MIMAT
0022700 hsa
-miR
-450a
-
1
-3p
1.00(R
ef) 9.20E
-01 4.75E
-01 9.70E
-01 9.79E
-01 9.05E
-01 9.88E
-01
MIMAT
0031074 hsa
-miR
-450a
-
2
-3p
1.00(R
ef) 1.04E+00 1.47E
-01 7.75E
-01 1.02E+00 6.36E
-01 9.78E
-01
MIMAT
0001545 hsa
-miR
-450a
-5p
1.00(R
ef) 1.16E+00 3.17E
-01 9.68E
-01 1.13E+00 5.71E
-01 9.78E
-01
MIMAT
0004910 hsa
-miR
-450b
-3p
1.00(R
ef) 7.58E
-01 1.05E
-01 7.39E
-01 8.10E
-01 4.25E
-01 9.78E
-01
MIMAT
0019053 hsa
-miR
-4516
1.00(R
ef) 1.06E+00 8.80E
-02 7.39E
-01 1.03E+00 5.66E
-01 9.78E
-01
MIMAT
0001631 hsa
-miR
-451a
1.00(R
ef) 5.94E
-01 1.59E
-06 8.22E
-04 4.43E
-01 2.86E
-06 1.48E
-03
MIMAT
0019070 hsa
-miR
-4531
1.00(R
ef) 1.09E+00 1.98E
-01 8.60E
-01 1.07E+00 5.27E
-01 9.78E
-01
MIMAT
0020959 hsa
-miR
-4536
-3p
1.00(R
ef) 1.03E+00 4.00E
-01 9.70E
-01 9.56E
-01 4.14E
-01 9.78E
-01
MIMAT
0019078 hsa
-miR
-4536
-5p
1.00(R
ef) 1.09E+00 3.74E
-01 9.70E
-01 1.34E+00 4.56E
-02 9.78E
-01
MIMAT
0003885 hsa
-miR
-454
-3p
1.00(R
ef) 1.07E+00 4.14E
-02 7.39E
-01 9.42E
-01 2.31E
-01 9.78E
-01
MIMAT
0004784 hsa
-miR
-455
-3p
1.00(R
ef) 1.06E+00 7.83E
-01 9.98E
-01 8.34E
-01 5.90E
-01 9.78E
-01
MIMAT
0003150 hsa
-miR
-455
-5p
1.00(R
ef) 1.07E+00 1.28E
-01 7.39E
-01 9.48E
-01 4.45E
-01 9.78E
-01
MIMAT
0019709 hsa
-miR
-4647
1.00(R
ef) 1.01E+00 9.05E
-01 1.00E+00 1.14E+00 3.38E
-01 9.78E
-01
MIMAT
0019808 hsa
-miR
-4707
-3p
1.00(R
ef) 9.15E
-01 6.76E
-01 9.98E
-01 8.68E
-01 6.64E
-01 9.78E
-01
MIMAT
0019807 hsa
-miR
-4707
-5p
1.00(R
ef) 1.06E+00 9.26E
-02 7.39E
-01 9.50E
-01 3.39E
-01 9.78E
-01
MIMAT
0019895 hsa
-miR
-4755
-5p
1.00(R
ef) 1.00E+00 9.91E
-01 1.00E+00 1.07E+00 4.43E
-01 9.78E
-01
MIMAT
0019956 hsa
-miR
-4787
-5p
1.00(R
ef) 1.00E+00 9.87E
-01 1.00E+00 1.05E+00 6.70E
-01 9.78E
-01
MIMAT
0019964 hsa
-miR
-4792
1.00(R
ef) 1.03E+00 8.35E
-01 9.98E
-01 7.71E
-01 2.61E
-01 9.78E
-01
MIMAT
0002176 hsa
-miR
-485
-3p
1.00(R
ef) 1.12E+00 5.29E
-01 9.88E
-01 1.17E+00 5.67E
-01 9.78E
-01
MIMAT
0002178 hsa
-miR
-487a
-3p
1.00(R
ef) 9.84E
-01 7.28E
-01 9.98E
-01 9.29E
-01 3.19E
-01 9.78E
-01
MIMAT
0003180 hsa
-miR
-487b
-3p
1.00(R
ef) 1.16E+00 1.72E
-01 8.30E
-01 1.31E+00 9.42E
-02 9.78E
-01

121
MIMAT
0026614 hsa
-miR
-487b
-5p
1.00(R
ef) 1.05E+00 4.91E
-01 9.71E
-01 1.03E+00 7.54E
-01 9.78E
-01
MIMAT
0004763 hsa
-miR
-488
-3p
1.00(R
ef) 1.02E+00 8.95E
-01 1.00E+00 1.05E+00 8.10E
-01 9.78E
-01
MIMAT
0002806 hsa
-miR
-490
-3p
1.00(R
ef) 1.18E+00 4.29E
-01 9.70E
-01 1.11E+00 7.38E
-01 9.78E
-01
MIMAT
0002807 hsa
-miR
-491
-5p
1.00(R
ef) 9.01E
-01 5.66E
-01 9.94E
-01 8.29E
-01 5.19E
-01 9.78E
-01
MIMAT
0003161 hsa
-miR
-493
-3p
1.00(R
ef) 9.63E
-01 8.14E
-01 9.98E
-01 1.13E+00 6.44E
-01 9.78E
-01
MIMAT
0002816 hsa
-miR
-494
-3p
1.00(R
ef) 7.88E
-01 2.84E
-01 9.68E
-01 1.19E+00 6.29E
-01 9.78E
-01
MIMAT
0002817 hsa
-miR
-495
-3p
1.00(R
ef) 1.04E+00 2.78E
-01 9.68E
-01 1.08E+00 2.07E
-01 9.78E
-01
MIMAT
0022924 hsa
-miR
-495
-5p
1.00(R
ef) 1.06E+00 3.90E
-02 7.39E
-01 9.91E
-01 8.34E
-01 9.78E
-01
MIMAT
0002820 hsa
-miR
-497
-5p
1.00(R
ef) 1.01E+00 7.54E
-01 9.98E
-01 8.98E
-01 1.30E
-01 9.78E
-01
MIMAT
0002824 hsa
-miR
-498
1.00(R
ef) 1.05E+00 5.32E
-01 9.88E
-01 9.65E
-01 7.81E
-01 9.78E
-01
MIMAT
0004772 hsa
-miR
-499a
-3p
1.00(R
ef) 1.12E+00 5.72E
-01 9.94E
-01 1.17E+00 6.20E
-01 9.78E
-01
MIMAT
0002870 hsa
-miR
-499a
-5p
1.00(R
ef) 1.11E+00 4.27E
-01 9.70E
-01 1.05E+00 8.28E
-01 9.78E
-01
MIMAT
0019897 hsa
-miR
-499b
-5p
1.00(R
ef) 1.20E+00 3.90E
-01 9.70E
-01 1.78E+00 9.20E
-02 9.78E
-01
MIMAT
0021021 hsa
-miR
-5001
-5p
1.00(R
ef) 1.15E+00 6.64E
-02 7.39E
-01 1.07E+00 5.76E
-01 9.78E
-01
MIMAT
0021044 hsa
-miR
-5010
-3p
1.00(R
ef) 1.03E+00 4.65E
-01 9.70E
-01 9.48E
-01 3.64E
-01 9.78E
-01
MIMAT
0004775 hsa
-miR
-502
-3p
1.00(R
ef) 8.45E
-01 4.72E
-01 9.70E
-01 8.26E
-01 6.12E
-01 9.78E
-01
MIMAT
0002873 hsa
-miR
-502
-5p
1.00(R
ef) 1.02E+00 8.08E
-01 9.98E
-01 1.07E+00 5.37E
-01 9.78E
-01
MIMAT
0022925 hsa
-miR
-503
-3p
1.00(R
ef) 9.15E
-01 3.22E
-01 9.68E
-01 8.36E
-01 2.14E
-01 9.78E
-01
MIMAT
0002874 hsa
-miR
-503
-5p
1.00(R
ef) 9.99E
-01 9.88E
-01 1.00E+00 1.07E+00 6.87E
-01 9.78E
-01
MIMAT
0002878 hsa
-miR
-506
-3p
1.00(R
ef) 8.80E
-01 1.92E
-01 8.60E
-01 9.57E
-01 7.80E
-01 9.78E
-01
MIMAT
0022701 hsa
-miR
-506
-5p
1.00(R
ef) 7.62E
-01 1.44E
-01 7.75E
-01 9.51E
-01 8.66E
-01 9.79E
-01
MIMAT
0002879 hsa
-miR
-507
1.00(R
ef) 1.10E+00 6.89E
-01 9.98E
-01 8.91E
-01 7.60E
-01 9.78E
-01

122
MIMAT
0004778 hsa
-miR
-508
-5p
1.00(R
ef) 1.03E+00 4.76E
-01 9.70E
-01 1.03E+00 6.44E
-01 9.78E
-01
MIMAT
0002881 hsa
-miR
-509
-3p
1.00(R
ef) 1.32E+00 1.03E
-01 7.39E
-01 1.26E+00 3.93E
-01 9.78E
-01
MIMAT
0004779 hsa
-miR
-509
-5p
1.00(R
ef) 9.31E
-01 4.29E
-01 9.70E
-01 1.00E+00 9.97E
-01 9.98E
-01
MIMAT
0026613 hsa
-miR
-510
-3p
1.00(R
ef) 1.05E+00 2.13E
-01 8.67E
-01 1.02E+00 7.90E
-01 9.78E
-01
MIMAT
0002808 hsa
-miR
-511
-5p
1.00(R
ef) 9.46E
-01 8.03E
-01 9.98E
-01 7.42E
-01 3.89E
-01 9.78E
-01
MIMAT
0002822 hsa
-miR
-512
-5p
1.00(R
ef) 1.09E+00 3.61E
-02 7.39E
-01 9.47E
-01 3.82E
-01 9.78E
-01
MIMAT
0004777 hsa
-miR
-513a
-3p
1.00(R
ef) 1.02E+00 5.98E
-01 9.98E
-01 9.19E
-01 1.99E
-01 9.78E
-01
MIMAT
0002877 hsa
-miR
-513a
-5p
1.00(R
ef) 9.80E
-01 9.01E
-01 1.00E+00 1.04E+00 8.88E
-01 9.84E
-01
MIMAT
0005788 hsa
-miR
-513b
-5p
1.00(R
ef) 8.37E
-01 6.69E
-02 7.39E
-01 8.50E
-01 2.85E
-01 9.78E
-01
MIMAT
0005789 hsa
-miR
-513c
-5p
1.00(R
ef) 9.29E
-01 6.98E
-01 9.98E
-01 9.13E
-01 7.69E
-01 9.78E
-01
MIMAT
0002883 hsa
-miR
-514a
-3p
1.00(R
ef) 1.01E+00 8.97E
-01 1.00E+00 9.32E
-01 2.56E
-01 9.78E
-01
MIMAT
0022702 hsa
-miR
-514a
-5p
1.00(R
ef) 1.00E+00 9.83E
-01 1.00E+00 9.07E
-01 6.99E
-01 9.78E
-01
MIMAT
0015088 hsa
-miR
-514b
-3p
1.00(R
ef) 1.51E+00 8.19E
-02 7.39E
-01 2.39E+00 1.88E
-02 9.78E
-01
MIMAT
0015087 hsa
-miR
-514b
-5p
1.00(R
ef) 1.03E+00 3.46E
-01 9.68E
-01 1.02E+00 6.82E
-01 9.78E
-01
MIMAT
0002826 hsa
-miR
-515
-5p
1.00(R
ef) 1.06E+00 7.91E
-01 9.98E
-01 7.96E
-01 5.06E
-01 9.78E
-01
MIMAT
0002859 hsa
-miR
-516b
-5p
1.00(R
ef) 1.11E+00 3.42E
-01 9.68E
-01 8.15E
-01 2.61E
-01 9.78E
-01
MIMAT
0002852 hsa
-miR
-517a
-3p
1.00(R
ef) 9.53E
-01 6.77E
-01 9.98E
-01 1.21E+00 2.95E
-01 9.78E
-01
MIMAT
0002866
hsa
-miR
-517c
-3p+hsa
-
miR
-519a
-3p
1.00(R
ef) 1.02E+00 6.75E
-01 9.98E
-01 9.15E
-01 1.83E
-01 9.78E
-01
MIMAT
0002844 hsa
-miR
-518b
1.00(R
ef) 1.03E+00 8.82E
-01 1.00E+00 1.15E+00 6.43E
-01 9.78E
-01
MIMAT
0002848 hsa
-miR
-518c
-3p
1.00(R
ef) 1.26E+00 1.18E
-02 7.02E
-01 1.09E+00 5.62E
-01 9.78E
-01
MIMAT
0002861 hsa
-miR
-518e
-3p
1.00(R
ef) 1.03E+00 8.31E
-01 9.98E
-01 1.06E+00 8.04E
-01 9.78E
-01
MIMAT
0002842 hsa
-miR
-518f-3p
1.00(R
ef) 8.26E
-01 2.85E
-02 7.39E
-01 9.10E
-01 5.03E
-01 9.78E
-01

123
MIMAT
0021129
hsa
-miR
-5196
-3p+hsa
-
miR
-6732
-3p
1.00(R
ef) 1.19E+00 4.57E
-01 9.70E
-01 6.91E
-01 3.24E
-01 9.78E
-01
MIMAT
0021128 hsa
-miR
-5196
-5p
1.00(R
ef) 9.65E
-01 6.79E
-01 9.98E
-01 8.58E
-01 2.61E
-01 9.78E
-01
MIMAT
0002832 hsa
-miR
-519c
-3p
1.00(R
ef) 1.02E+00 7.03E
-01 9.98E
-01 1.08E+00 2.65E
-01 9.78E
-01
MIMAT
0002853 hsa
-miR
-519d
-3p
1.00(R
ef) 1.11E+00 4.57E
-01 9.70E
-01 1.37E+00 1.57E
-01 9.78E
-01
MIMAT
0002833 hsa
-miR
-520a
-5p
1.00(R
ef) 1.03E+00 8.91E
-01 1.00E+00 1.36E+00 3.37E
-01 9.78E
-01
MIMAT
0002846 hsa
-miR
-520c
-3p
1.00(R
ef) 1.05E+00 7.16E
-01 9.98E
-01 8.96E
-01 6.13E
-01 9.78E
-01
MIMAT
0002856 hsa
-miR
-520d
-3p
1.00(R
ef) 1.07E+00 7.29E
-01 9.98E
-01 1.22E+00 5.11E
-01 9.78E
-01
MIMAT
0002830 hsa
-miR
-520f-3p
1.00(R
ef) 8.73E
-01 4.57E
-02 7.39E
-01 8.97E
-01 3.16E
-01 9.78E
-01
MIMAT
0002858 hsa
-miR
-520g
-3p
1.00(R
ef) 9.16E
-01 6.81E
-01 9.98E
-01 7.62E
-01 4.23E
-01 9.78E
-01
MIMAT
0002867 hsa
-miR
-520h
1.00(R
ef) 1.00E+00 9.99E
-01 1.00E+00 1.13E+00 3.16E
-01 9.78E
-01
MIMAT
0002854 hsa
-miR
-521
1.00(R
ef) 1.09E+00 3.54E
-01 9.68E
-01 7.73E
-01 9.85E
-02 9.78E
-01
MIMAT
0002868 hsa
-miR
-522
-3p
1.00(R
ef) 1.05E+00 1.32E
-01 7.39E
-01 1.03E+00 5.96E
-01 9.78E
-01
MIMAT
0002838 hsa
-miR
-525
-5p
1.00(R
ef) 9.62E
-01 4.52E
-01 9.70E
-01 9.54E
-01 5.50E
-01 9.78E
-01
MIMAT
0002845
hsa
-miR
-526a+hsa
-miR
-
518c
-5p+hsa
-miR
-518d
-
5p
1.00(R
ef) 1.00E+00 9.72E
-01 1.00E+00 1.01E+00 9.32E
-01 9.98E
-01
MIMAT
0002835 hsa
-miR
-526b
-5p
1.00(R
ef) 9.77E
-01 7.10E
-01 9.98E
-01 8.54E
-01 1.14E
-01 9.78E
-01
MIMAT
0004780 hsa
-miR
-532
-3p
1.00(R
ef) 9.88E
-01 8.31E
-01 9.98E
-01 1.03E+00 6.95E
-01 9.78E
-01
MIMAT
0003389 hsa
-miR
-542
-3p
1.00(R
ef) 1.16E+00 6.21E
-03 5.35E
-01 1.08E+00 3.32E
-01 9.78E
-01
MIMAT
0003340 hsa
-miR
-542
-5p
1.00(R
ef) 1.36E+00 1.03E
-01 7.39E
-01 8.85E
-01 6.88E
-01 9.78E
-01
MIMAT
0004954 hsa
-miR
-543
1.00(R
ef) 1.01E+00 6.78E
-01 9.98E
-01 9.99E
-01 9.81E
-01 9.98E
-01
MIMAT
0004803 hsa
-miR
-548a
-5p
1.00(R
ef) 9.80E
-01 6.38E
-01 9.98E
-01 1.01E+00 8.98E
-01 9.86E
-01
MIMAT
0018447
hsa
-miR
-548aa+hsa
-miR
-
548t
-3p
1.00(R
ef) 9.47E
-01 5.02E
-01 9.72E
-01 9.80E
-01 8.72E
-01 9.79E
-01
MIMAT
0018972 hsa
-miR
-548ah
-5p
1.00(R
ef) 1.01E+00 7.38E
-01 9.98E
-01 1.01E+00 8.48E
-01 9.78E
-01

124
MIMAT
0019013 hsa
-miR
-548ak
1.00(R
ef) 9.52E
-01 8.09E
-01 9.98E
-01 7.56E
-01 4.03E
-01 9.78E
-01
MIMAT
0022266 hsa
-miR
-548ar
-3p
1.00(R
ef) 1.00E+00 9.47E
-01 1.00E+00 1.00E+00 9.59E
-01 9.98E
-01
MIMAT
0022265 hsa
-miR
-548ar
-5p
1.00(R
ef) 1.01E+00 8.43E
-01 9.99E
-01 1.02E+00 7.17E
-01 9.78E
-01
MIMAT
0004812 hsa
-miR
-548d
-5p
1.00(R
ef) 9.49E
-01 8.14E
-01 9.98E
-01 1.19E+00 6.34E
-01 9.78E
-01
MIMAT
0026736 hsa
-miR
-548e
-5p
1.00(R
ef) 1.01E+00 4.87E
-01 9.71E
-01 9.89E
-01 7.27E
-01 9.78E
-01
MIMAT
0005912 hsa
-miR
-548g
-3p
1.00(R
ef) 1.02E+00 5.18E
-01 9.82E
-01 1.00E+00 9.66E
-01 9.98E
-01
MIMAT
0005935 hsa
-miR
-548i
1.00(R
ef) 9.39E
-01 7.55E
-01 9.98E
-01 1.22E+00 5.30E
-01 9.78E
-01
MIMAT
0026737 hsa
-miR
-548j
-3p
1.00(R
ef) 9.66E
-01 8.63E
-01 1.00E+00 9.39E
-01 8.49E
-01 9.78E
-01
MIMAT
0005882 hsa
-miR
-548k
1.00(R
ef) 9.93E
-01 9.43E
-01 1.00E+00 8.84E
-01 4.65E
-01 9.78E
-01
MIMAT
0005917 hsa
-miR
-548m
1.00(R
ef) 9.31E
-01 3.05E
-01 9.68E
-01 9.35E
-01 5.40E
-01 9.78E
-01
MIMAT
0005916 hsa
-miR
-548n
1.00(R
ef) 9.89E
-01 9.39E
-01 1.00E+00 9.36E
-01 7.81E
-01 9.78E
-01
MIMAT
0011163 hsa
-miR
-548q
1.00(R
ef) 6.64E
-01 2.75E
-02 7.39E
-01 1.31E+00 3.61E
-01 9.78E
-01
MIMAT
0015020 hsa
-miR
-548v
1.00(R
ef) 1.03E+00 6.83E
-01 9.98E
-01 1.18E+00 1.68E
-01 9.78E
-01
MIMAT
0018354 hsa
-miR
-548y
1.00(R
ef) 8.84E
-01 7.15E
-02 7.39E
-01 8.45E
-01 1.25E
-01 9.78E
-01
MIMAT
0018446
hsa
-miR
-548z+hsa
-miR
-
548h
-3p
1.00(R
ef) 1.34E+00 8.64E
-02 7.39E
-01 8.56E
-01 5.89E
-01 9.78E
-01
MIMAT
0003333 hsa
-miR
-549a
1.00(R
ef) 9.24E
-01 5.68E
-01 9.94E
-01 9.50E
-01 8.15E
-01 9.78E
-01
MIMAT
0003233 hsa
-miR
-551b
-3p
1.00(R
ef) 1.04E+00 3.25E
-01 9.68E
-01 1.02E+00 7.59E
-01 9.78E
-01
MIMAT
0003215 hsa
-miR
-552
-3p
1.00(R
ef) 8.22E
-01 1.31E
-01 7.39E
-01 1.11E+00 6.13E
-01 9.78E
-01
MIMAT
0003219 hsa
-miR
-555
1.00(R
ef) 8.43E
-01 2.72E
-01 9.68E
-01 1.06E+00 7.94E
-01 9.78E
-01
MIMAT
0004793 hsa
-miR
-556
-3p
1.00(R
ef) 9.85E
-01 9.10E
-01 1.00E+00 1.09E+00 6.93E
-01 9.78E
-01
MIMAT
0003220 hsa
-miR
-556
-5p
1.00(R
ef) 1.20E+00 1.29E
-01 7.39E
-01 9.99E
-01 9.97E
-01 9.98E
-01
MIMAT
0022706 hsa
-miR
-561
-5p
1.00(R
ef) 1.24E+00 2.41E
-01 9.17E
-01 7.42E
-01 3.23E
-01 9.78E
-01

125
MIMAT
0003227 hsa
-miR
-563
1.00(R
ef) 1.05E+00 1.98E
-01 8.60E
-01 9.96E
-01 9.53E
-01 9.98E
-01
MIMAT
0003228 hsa
-miR
-564
1.00(R
ef) 1.06E+00 6.06E
-01 9.98E
-01 1.03E+00 8.42E
-01 9.78E
-01
MIMAT
0003230 hsa
-miR
-566
1.00(R
ef) 1.02E+00 9.01E
-01 1.00E+00 5.77E
-01 6.96E
-02 9.78E
-01
MIMAT
0003235 hsa
-miR
-570
-3p
1.00(R
ef) 1.02E+00 8.86E
-01 1.00E+00 8.91E
-01 5.20E
-01 9.78E
-01
MIMAT
0003237 hsa
-miR
-572
1.00(R
ef) 1.08E+00 3.64E
-01 9.70E
-01 1.15E+00 2.83E
-01 9.78E
-01
MIMAT
0003239 hsa
-miR
-574
-3p
1.00(R
ef) 8.93E
-01 4.92E
-01 9.71E
-01 7.92E
-01 3.60E
-01 9.78E
-01
MIMAT
0004795 hsa
-miR
-574
-5p
1.00(R
ef) 9.27E
-01 1.23E
-01 7.39E
-01 9.64E
-01 6.47E
-01 9.78E
-01
MIMAT
0003240 hsa
-miR
-575
1.00(R
ef) 9.58E
-01 5.84E
-01 9.98E
-01 8.40E
-01 1.65E
-01 9.78E
-01
MIMAT
0004796 hsa
-miR
-576
-3p
1.00(R
ef) 9.31E
-01 3.23E
-01 9.68E
-01 8.29E
-01 9.45E
-02 9.78E
-01
MIMAT
0003241 hsa
-miR
-576
-5p
1.00(R
ef) 9.29E
-01 6.37E
-01 9.98E
-01 1.22E+00 4.18E
-01 9.78E
-01
MIMAT
0003242 hsa
-miR
-577
1.00(R
ef) 1.16E+00 4.29E
-01 9.70E
-01 1.19E+00 5.64E
-01 9.78E
-01
MIMAT
0026616 hsa
-miR
-579
-5p
1.00(R
ef) 8.97E
-01 8.70E
-02 7.39E
-01 9.53E
-01 6.34E
-01 9.78E
-01
MIMAT
0004797 hsa
-miR
-582
-3p
1.00(R
ef) 1.19E+00 1.27E
-01 7.39E
-01 9.95E
-01 9.78E
-01 9.98E
-01
MIMAT
0003247 hsa
-miR
-582
-5p
1.00(R
ef) 1.00E+00 1.00E+00 1.00E+00 9.62E
-01 3.57E
-01 9.78E
-01
MIMAT
0022708 hsa
-miR
-584
-3p
1.00(R
ef) 1.03E+00 2.59E
-01 9.55E
-01 9.54E
-01 2.52E
-01 9.78E
-01
MIMAT
0003249 hsa
-miR
-584
-5p
1.00(R
ef) 9.72E
-01 6.13E
-01 9.98E
-01 9.21E
-01 3.59E
-01 9.78E
-01
MIMAT
0003250 hsa
-miR
-585
-3p
1.00(R
ef) 9.89E
-01 7.06E
-01 9.98E
-01 1.00E+00 9.53E
-01 9.98E
-01
MIMAT
0003253 hsa
-miR
-587
1.00(R
ef) 1.00E+00 9.74E
-01 1.00E+00 1.07E+00 5.74E
-01 9.78E
-01
MIMAT
0003258 hsa
-miR
-590
-5p
1.00(R
ef) 1.24E+00 8.19E
-02 7.39E
-01 8.50E
-01 4.58E
-01 9.78E
-01
MIMAT
0003259 hsa
-miR
-591
1.00(R
ef) 1.14E+00 4.00E
-01 9.70E
-01 1.43E+00 1.36E
-01 9.78E
-01
MIMAT
0003260 hsa
-miR
-592
1.00(R
ef) 1.16E+00 4.51E
-01 9.70E
-01 1.21E+00 5.36E
-01 9.78E
-01
MIMAT
0004802 hsa
-miR
-593
-3p
1.00(R
ef) 1.04E+00 7.33E
-01 9.98E
-01 1.33E+00 1.46E
-01 9.78E
-01

126
MIMAT
0003263 hsa
-miR
-595
1.00(R
ef) 9.61E
-01 8.38E
-01 9.98E
-01 1.09E+00 7.86E
-01 9.78E
-01
MIMAT
0003265 hsa
-miR
-597
-5p
1.00(R
ef) 1.11E+00 8.08E
-02 7.39E
-01 1.15E+00 1.48E
-01 9.78E
-01
MIMAT
0003266 hsa
-miR
-598
-3p
1.00(R
ef) 1.01E+00 6.76E
-01 9.98E
-01 9.87E
-01 7.91E
-01 9.78E
-01
MIMAT
0003271 hsa
-miR
-603
1.00(R
ef) 9.40E
-01 6.04E
-01 9.98E
-01 1.26E+00 2.25E
-01 9.78E
-01
MIMAT
0003273 hsa
-miR
-605
-5p
1.00(R
ef) 9.17E
-01 5.04E
-01 9.72E
-01 6.94E
-01 8.69E
-02 9.78E
-01
MIMAT
0003275 hsa
-miR
-607
1.00(R
ef) 1.02E+00 5.24E
-01 9.86E
-01 9.63E
-01 3.73E
-01 9.78E
-01
MIMAT
0003276 hsa
-miR
-608
1.00(R
ef) 9.60E
-01 4.71E
-01 9.70E
-01 9.32E
-01 4.46E
-01 9.78E
-01
MIMAT
0003280 hsa
-miR
-612
1.00(R
ef) 9.49E
-01 1.20E
-01 7.39E
-01 9.76E
-01 6.44E
-01 9.78E
-01
MIMAT
0003283 hsa
-miR
-615
-3p
1.00(R
ef) 1.01E+00 7.44E
-01 9.98E
-01 1.04E+00 3.92E
-01 9.78E
-01
MIMAT
0004805 hsa
-miR
-616
-3p
1.00(R
ef) 1.16E+00 4.02E
-01 9.70E
-01 1.24E+00 4.58E
-01 9.78E
-01
MIMAT
0003289 hsa
-miR
-620
1.00(R
ef) 9.86E
-01 9.40E
-01 1.00E+00 8.22E
-01 5.21E
-01 9.78E
-01
MIMAT
0003295 hsa
-miR
-626
1.00(R
ef) 9.96E
-01 9.38E
-01 1.00E+00 9.21E
-01 3.03E
-01 9.78E
-01
MIMAT
0026623 hsa
-miR
-627
-3p
1.00(R
ef) 9.67E
-01 4.97E
-01 9.72E
-01 9.30E
-01 3.43E
-01 9.78E
-01
MIMAT
0003296 hsa
-miR
-627
-5p
1.00(R
ef) 1.01E+00 8.56E
-01 1.00E+00 1.20E+00 8.91E
-03 8.22E
-01
MIMAT
0003297 hsa
-miR
-628
-3p
1.00(R
ef) 9.17E
-01 5.99E
-01 9.98E
-01 1.15E+00 5.79E
-01 9.78E
-01
MIMAT
0003299 hsa
-miR
-630
1.00(R
ef) 6.20E
-01 7.49E
-03 5.53E
-01 6.00E
-01 7.65E
-02 9.78E
-01
MIMAT
0003300 hsa
-miR
-631
1.00(R
ef) 8.29E
-01 3.47E
-01 9.68E
-01 1.74E+00 7.17E
-02 9.78E
-01
MIMAT
0003309 hsa
-miR
-639
1.00(R
ef) 1.00E+00 9.30E
-01 1.00E+00 1.03E+00 7.01E
-01 9.78E
-01
MIMAT
0003310 hsa
-miR
-640
1.00(R
ef) 1.06E+00 7.00E
-01 9.98E
-01 9.25E
-01 7.33E
-01 9.78E
-01
MIMAT
0003312 hsa
-miR
-642a
-5p
1.00(R
ef) 1.05E+00 4.45E
-01 9.70E
-01 9.48E
-01 6.27E
-01 9.78E
-01
MIMAT
0003313 hsa
-miR
-643
1.00(R
ef) 1.01E+00 9.47E
-01 1.00E+00 9.35E
-01 8.26E
-01 9.78E
-01
MIMAT
0003314 hsa
-miR
-644a
1.00(R
ef) 1.01E+00 9.72E
-01 1.00E+00 1.00E+00 9.91E
-01 9.98E
-01

127
MIMAT
0003319 hsa
-miR
-649
1.00(R
ef) 1.15E+00 4.19E
-01 9.70E
-01 1.15E+00 6.05E
-01 9.78E
-01
MIMAT
0003320 hsa
-miR
-650
1.00(R
ef) 1.01E+00 8.27E
-01 9.98E
-01 1.06E+00 5.32E
-01 9.78E
-01
MIMAT
0025462 hsa
-miR
-6503
-5p
1.00(R
ef) 9.72E
-01 7.20E
-01 9.98E
-01 1.11E+00 3.83E
-01 9.78E
-01
MIMAT
0003321 hsa
-miR
-651
-5p
1.00(R
ef) 9.69E
-01 7.79E
-01 9.98E
-01 1.29E+00 1.56E
-01 9.78E
-01
MIMAT
0022709 hsa
-miR
-652
-5p
1.00(R
ef) 1.02E+00 9.04E
-01 1.00E+00 1.10E+00 6.76E
-01 9.78E
-01
MIMAT
0003330 hsa
-miR
-654
-5p
1.00(R
ef) 6.50E
-01 1.76E
-02 7.39E
-01 8.44E
-01 5.55E
-01 9.78E
-01
MIMAT
0003331 hsa
-miR
-655
-3p
1.00(R
ef) 9.69E
-01 7.90E
-01 9.98E
-01 9.70E
-01 8.68E
-01 9.79E
-01
MIMAT
0003332 hsa
-miR
-656
-3p
1.00(R
ef) 9.61E
-01 3.34E
-01 9.68E
-01 1.10E+00 1.40E
-01 9.78E
-01
MIMAT
0022711 hsa
-miR
-660
-3p
1.00(R
ef) 1.06E+00 4.19E
-01 9.70E
-01 1.02E+00 8.58E
-01 9.79E
-01
MIMAT
0003326 hsa
-miR
-663a
1.00(R
ef) 8.13E
-01 2.32E
-01 9.03E
-01 1.55E+00 9.14E
-02 9.78E
-01
MIMAT
0005949 hsa
-miR
-664a
-3p
1.00(R
ef) 1.04E+00 4.23E
-01 9.70E
-01 8.78E
-01 8.45E
-02 9.78E
-01
MIMAT
0022272 hsa
-miR
-664b
-3p
1.00(R
ef) 9.07E
-01 6.04E
-01 9.98E
-01 7.14E
-01 2.74E
-01 9.78E
-01
MIMAT
0004952 hsa
-miR
-665
1.00(R
ef) 1.11E+00 5.04E
-01 9.72E
-01 1.09E+00 7.34E
-01 9.78E
-01
MIMAT
0003880 hsa
-miR
-671
-5p
1.00(R
ef) 1.12E+00 5.96E
-01 9.98E
-01 8.86E
-01 7.10E
-01 9.78E
-01
MIMAT
0025851 hsa
-miR
-6720
-3p
1.00(R
ef) 1.16E+00 1.25E
-02 7.02E
-01 1.19E+00 5.40E
-02 9.78E
-01
MIMAT
0025852 hsa
-miR
-6721
-5p
1.00(R
ef) 1.09E+00 4.20E
-01 9.70E
-01 1.10E+00 5.81E
-01 9.78E
-01
MIMAT
0025856 hsa
-miR
-6724
-5p
1.00(R
ef) 8.54E
-01 1.94E
-01 8.60E
-01 1.09E+00 6.29E
-01 9.78E
-01
MIMAT
0004945 hsa
-miR
-744
-5p
1.00(R
ef) 8.53E
-01 4.55E
-01 9.70E
-01 6.29E
-01 1.89E
-01 9.78E
-01
MIMAT
0022929 hsa
-miR
-758
-5p
1.00(R
ef) 8.74E
-01 3.94E
-01 9.70E
-01 6.83E
-01 1.32E
-01 9.78E
-01
MIMAT
0010364 hsa
-miR
-761
1.00(R
ef) 8.13E
-01 1.10E
-01 7.39E
-01 8.48E
-01 4.38E
-01 9.78E
-01
MIMAT
0010367 hsa
-miR
-764
1.00(R
ef) 9.90E
-01 8.02E
-01 9.98E
-01 1.02E+00 7.09E
-01 9.78E
-01
MIMAT
0003945 hsa
-miR
-765
1.00(R
ef) 1.01E+00 7.86E
-01 9.98E
-01 1.09E+00 1.84E
-01 9.78E
-01

128
MIMAT
0003882 hsa
-miR
-767
-5p
1.00(R
ef) 1.01E+00 5.65E
-01 9.94E
-01 9.42E
-01 1.39E
-01 9.78E
-01
MIMAT
0003887 hsa
-miR
-769
-3p
1.00(R
ef) 1.04E+00 6.34E
-01 9.98E
-01 1.09E+00 4.94E
-01 9.78E
-01
MIMAT
0003886 hsa
-miR
-769
-5p
1.00(R
ef) 1.02E+00 7.83E
-01 9.98E
-01 1.06E+00 5.74E
-01 9.78E
-01
MIMAT
0003948 hsa
-miR
-770
-5p
1.00(R
ef) 8.84E
-01 3.89E
-01 9.70E
-01 1.05E+00 8.41E
-01 9.78E
-01
MIMAT
0004185 hsa
-miR
-802
1.00(R
ef) 1.00E+00 9.83E
-01 1.00E+00 9.62E
-01 4.73E
-01 9.78E
-01
MIMAT
0022717 hsa
-miR
-873
-3p
1.00(R
ef) 9.94E
-01 9.10E
-01 1.00E+00 1.04E+00 5.91E
-01 9.78E
-01
MIMAT
0004953 hsa
-miR
-873
-5p
1.00(R
ef) 8.79E
-01 5.39E
-01 9.92E
-01 9.51E
-01 8.74E
-01 9.79E
-01
MIMAT
0026718 hsa
-miR
-874
-5p
1.00(R
ef) 6.90E
-01 6.59E
-02 7.39E
-01 7.86E
-01 4.44E
-01 9.78E
-01
MIMAT
0004925 hsa
-miR
-876
-3p
1.00(R
ef) 8.79E
-01 4.60E
-01 9.70E
-01 1.34E+00 2.88E
-01 9.78E
-01
MIMAT
0004924 hsa
-miR
-876
-5p
1.00(R
ef) 1.06E+00 4.57E
-01 9.70E
-01 1.03E+00 7.91E
-01 9.78E
-01
MIMAT
0004949 hsa
-miR
-877
-5p
1.00(R
ef) 9.70E
-01 8.26E
-01 9.98E
-01 1.11E+00 6.38E
-01 9.78E
-01
MIMAT
0004948 hsa
-miR
-885
-3p
1.00(R
ef) 9.96E
-01 9.84E
-01 1.00E+00 1.07E+00 8.31E
-01 9.78E
-01
MIMAT
0026720 hsa
-miR
-887
-5p
1.00(R
ef) 1.03E+00 3.87E
-01 9.70E
-01 1.02E+00 7.43E
-01 9.78E
-01
MIMAT
0004916 hsa
-miR
-888
-5p
1.00(R
ef) 1.02E+00 4.82E
-01 9.71E
-01 9.34E
-01 5.29E
-02 9.78E
-01
MIMAT
0004921 hsa
-miR
-889
-3p
1.00(R
ef) 9.54E
-01 5.45E
-01 9.93E
-01 9.98E
-01 9.88E
-01 9.98E
-01
MIMAT
0004912 hsa
-miR
-890
1.00(R
ef) 9.20E
-01 5.69E
-01 9.94E
-01 1.44E+00 1.05E
-01 9.78E
-01
MIMAT
0004902 hsa
-miR
-891a
-5p
1.00(R
ef) 1.02E+00 7.75E
-01 9.98E
-01 1.03E+00 6.78E
-01 9.78E
-01
MIMAT
0004913 hsa
-miR
-891b
1.00(R
ef) 1.05E+00 1.89E
-01 8.60E
-01 9.63E
-01 5.10E
-01 9.78E
-01
MIMAT
0004907 hsa
-miR
-892a
1.00(R
ef) 9.62E
-01 7.03E
-01 9.98E
-01 8.99E
-01 5.16E
-01 9.78E
-01
MIMAT
0004972 hsa
-miR
-922
1.00(R
ef) 1.01E+00 6.79E
-01 9.98E
-01 9.79E
-01 6.88E
-01 9.78E
-01
MIMAT
0004507 hsa
-miR
-92a
-
1
-5p
1.00(R
ef) 9.63E
-01 8.38E
-01 9.98E
-01 8.02E
-01 4.40E
-01 9.78E
-01
MIMAT
0000092 hsa
-miR
-92a
-3p
1.00(R
ef) 9.36E
-01 7.42E
-01 9.98E
-01 8.62E
-01 6.43E
-01 9.78E
-01

129
MIMAT
0003218 hsa
-miR
-92b
-3p
1.00(R
ef) 1.06E+00 6.65E
-01 9.98E
-01 1.13E+00 5.51E
-01 9.78E
-01
MIMAT
0000093 hsa
-miR
-93
-5p
1.00(R
ef) 7.93E
-01 8.30E
-02 7.39E
-01 7.56E
-01 1.93E
-01 9.78E
-01
MIMAT
0004976 hsa
-miR
-933
1.00(R
ef) 1.07E+00 1.15E
-01 7.39E
-01 1.01E+00 8.60E
-01 9.79E
-01
MIMAT
0004977 hsa
-miR
-934
1.00(R
ef) 9.41E
-01 6.65E
-01 9.98E
-01 7.51E
-01 1.89E
-01 9.78E
-01
MIMAT
0004978 hsa
-miR
-935
1.00(R
ef) 9.76E
-01 9.01E
-01 1.00E+00 9.46E
-01 8.52E
-01 9.78E
-01
MIMAT
0004979 hsa
-miR
-936
1.00(R
ef) 8.56E
-01 4.41E
-02 7.39E
-01 1.12E+00 3.63E
-01 9.78E
-01
MIMAT
0004980 hsa
-miR
-937
-3p
1.00(R
ef) 1.07E+00 4.94E
-01 9.71E
-01 8.90E
-01 4.15E
-01 9.78E
-01
MIMAT
0004982 hsa
-miR
-939
-5p
1.00(R
ef) 1.06E+00 6.26E
-02 7.39E
-01 1.04E+00 4.51E
-01 9.78E
-01
MIMAT
0004983 hsa
-miR
-940
1.00(R
ef) 9.78E
-01 9.05E
-01 1.00E+00 9.91E
-01 9.75E
-01 9.98E
-01
MIMAT
0004984 hsa
-miR
-941
1.00(R
ef) 1.04E+00 7.74E
-01 9.98E
-01 1.25E+00 2.45E
-01 9.78E
-01
MIMAT
0004985 hsa
-miR
-942
-5p
1.00(R
ef) 1.08E+00 7.78E
-02 7.39E
-01 1.08E+00 2.24E
-01 9.78E
-01
MIMAT
0000094 hsa
-miR
-95
-3p
1.00(R
ef) 1.01E+00 6.84E
-01 9.98E
-01 9.53E
-01 2.85E
-01 9.78E
-01
MIMAT
0000095 hsa
-miR
-96
-5p
1.00(R
ef) 1.01E+00 8.63E
-01 1.00E+00 9.13E
-01 4.68E
-01 9.78E
-01
MIMAT
0000689 hsa
-miR
-99b
-5p
1.00(R
ef) 8.30E
-01 3.48E
-01 9.68E
-01 6.94E
-01 2.39E
-01 9.78E
-01

130
Appendix H. Heterogeneity by sex for the association of alcohol intake (continuous per drink) and circulating microRNA adjusted for age at
biospecimen draw, race/ethnicity, body mass index (kg/m2), smoking status, batch, time in years between baseline questionnaire and biospecimen
draw, and case-control status.
Accession miRNA
Males IRR ethanol intake
per drink
Males Nominal
p-value
Females IRR ethanol
intake per drink
Females Nominal
p-value
P for
heterogeneity
MIMAT000
0062 hsa-let-7a-5p 9.50E-01 4.63E-01 1.02E+00 9.05E-01 7.84E-01
MIMAT000
0063 hsa-let-7b-5p 9.72E-01 1.39E-01 9.96E-01 9.29E-01 7.05E-01
MIMAT000
0064 hsa-let-7c-5p 9.26E-01 1.78E-01 1.00E+00 1.00E+00 4.47E-01
MIMAT000
0065 hsa-let-7d-5p 1.01E+00 9.16E-01 9.62E-01 7.35E-01 7.48E-01
MIMAT000
0067 hsa-let-7f-5p 1.01E+00 8.88E-01 8.28E-01 1.47E-01 2.18E-01
MIMAT000
0414 hsa-let-7g-5p 9.56E-01 2.03E-01 1.09E+00 2.97E-01 9.61E-02
MIMAT000
0098 hsa-miR-100-5p 9.76E-01 5.76E-01 9.30E-01 4.56E-01 5.80E-01
MIMAT000
0102 hsa-miR-105-5p 1.01E+00 7.73E-01 1.04E+00 6.19E-01 9.82E-01
MIMAT000
0680 hsa-miR-106b-5p 1.01E+00 7.16E-01 1.11E+00 2.02E-01 3.51E-01
MIMAT000
0104 hsa-miR-107 9.81E-01 6.84E-02 9.75E-01 2.47E-01 6.37E-01
MIMAT000
0253 hsa-miR-10a-5p 1.01E+00 4.29E-01 9.55E-01 1.49E-01 3.89E-01
MIMAT000
0254 hsa-miR-10b-5p 9.80E-01 9.42E-02 9.64E-01 1.37E-01 8.48E-01
MIMAT000
5825 hsa-miR-1180-3p 8.75E-01 4.57E-02 1.14E+00 3.08E-01 1.15E-01
MIMAT000
5828 hsa-miR-1183 9.86E-01 7.21E-01 1.01E+00 9.21E-01 8.59E-01
MIMAT002
2838 hsa-miR-1185-1-3p 1.11E+00 2.21E-01 1.04E+00 8.32E-01 9.01E-01
MIMAT002
2713 hsa-miR-1185-2-3p 9.98E-01 8.99E-01 9.60E-01 1.50E-01 3.48E-01
MIMAT000
5798 hsa-miR-1185-5p 9.96E-01 7.29E-01 9.80E-01 3.47E-01 8.64E-01
MIMAT001
5049 hsa-miR-1193 9.85E-01 8.30E-01 1.07E+00 6.21E-01 6.78E-01
MIMAT000
5955 hsa-miR-1197 1.01E+00 4.30E-01 9.88E-01 7.34E-01 3.90E-01

131
MIMAT000
5863 hsa
-miR
-1200 1.00E+00 9.93E
-01 9.78E
-01 8.43E
-01 6.61E
-01
MIMAT000
5865 hsa
-miR
-1202 9.42E
-01 4.00E
-01 1.01E+00 9.25E
-01 3.64E
-01
MIMAT000
5866 hsa
-miR
-1203 9.82E
-01 6.33E
-01 1.01E+00 9.28E
-01 8.14E
-01
MIMAT000
5869 hsa
-miR
-1205 9.41E
-01 4.85E
-01 1.16E+00 3.92E
-01 1.42E
-01
MIMAT000
5870 hsa
-miR
-1206 9.92E
-01 9.00E
-01 8.68E
-01 2.69E
-01 2.63E
-01
MIMAT000
0421 hsa
-miR
-122
-5p 1.02E+00 5.85E
-01 1.07E+00 4.36E
-01 7.55E
-01
MIMAT000
5459 hsa
-miR
-1224
-3p 9.79E
-01 5.20E
-01 1.09E+00 1.77E
-01 2.11E
-01
MIMAT000
5577 hsa
-miR
-1226
-3p 9.78E
-01 6.70E
-01 9.22E
-01 5.61E
-01 3.91E
-01
MIMAT000
5583 hsa
-miR
-1228
-3p 9.90E
-01 4.51E
-01 9.75E
-01 4.25E
-01 7.88E
-01
MIMAT000
5589 hsa
-miR
-1234
-3p 9.88E
-01 4.84E
-01 9.88E
-01 7.65E
-01 9.13E
-01
MIMAT000
5591 hsa
-miR
-1236
-3p 9.99E
-01 9.78E
-01 1.07E+00 3.56E
-01 4.34E
-01
MIMAT000
5896 hsa
-miR
-1244 1.01E+00 8.34E
-01 1.00E+00 9.72E
-01 9.62E
-01
MIMAT000
5897 hsa
-miR
-1245a 1.01E+00 6.56E
-01 1.01E+00 7.81E
-01 4.62E
-01
MIMAT001
9950 hsa
-miR
-1245b
-5p 1.02E+00 8.68E
-01 9.19E
-01 6.68E
-01 8.57E
-01
MIMAT000
5898 hsa
-miR
-1246 9.07E
-01 4.87E
-02 9.20E
-01 4.39E
-01 9.61E
-01
MIMAT000
5901 hsa
-miR
-1249
-3p 9.79E
-01 3.25E
-01 9.46E
-01 2.11E
-01 7.82E
-01
MIMAT000
5904 hsa
-miR
-1253 9.96E
-01 8.60E
-01 1.05E+00 2.40E
-01 4.52E
-01
MIMAT000
5905 hsa
-miR
-1254 1.06E+00 5.69E
-01 8.86E
-01 5.38E
-01 6.65E
-01
MIMAT000
5906 hsa
-miR
-1255a 9.80E
-01 8.68E
-02 9.87E
-01 6.38E
-01 5.98E
-01
MIMAT000
5908 hsa
-miR
-1257 9.62E
-01 2.58E
-01 1.05E+00 5.50E
-01 3.95E
-01
MIMAT000
5909 hsa
-miR
-1258 1.01E+00 6.73E
-01 1.06E+00 2.11E
-01 2.44E
-01
MIMAT000
4602 hsa
-miR
-125a
-3p 1.01E+00 8.75E
-01 9.22E
-01 6.26E
-01 5.55E
-01

132
MIMAT000
0423 hsa
-miR
-125b
-5p 9.64E
-01 3.20E
-01 1.06E+00 4.44E
-01 2.74E
-01
MIMAT000
0445 hsa
-miR
-126
-3p 9.99E
-01 8.94E
-01 9.93E
-01 7.47E
-01 9.34E
-01
MIMAT000
5913 hsa
-miR
-1261 9.87E
-01 7.88E
-01 1.08E+00 5.22E
-01 5.36E
-01
MIMAT000
5914 hsa
-miR
-1262 9.84E
-01 1.58E
-01 9.62E
-01 5.10E
-02 5.99E
-01
MIMAT000
5791 hsa
-miR
-1264 9.63E
-01 6.69E
-01 7.56E
-01 2.13E
-01 3.37E
-01
MIMAT000
5920 hsa
-miR
-1266
-5p 1.01E+00 8.06E
-01 1.07E+00 6.32E
-01 9.99E
-01
MIMAT000
5922 hsa
-miR
-1268a 9.88E
-01 8.84E
-01 9.32E
-01 7.38E
-01 8.88E
-01
MIMAT001
8925 hsa
-miR
-1268b 9.92E
-01 5.05E
-01 9.85E
-01 5.40E
-01 7.72E
-01
MIMAT000
5923 hsa
-miR
-1269a 1.02E+00 3.43E
-01 9.49E
-01 2.99E
-01 2.89E
-01
MIMAT000
0446 hsa
-miR
-127
-3p 9.96E
-01 8.25E
-01 1.04E+00 4.14E
-01 2.97E
-01
MIMAT000
4604 hsa
-miR
-127
-5p 9.17E
-01 1.08E
-01 8.69E
-01 4.99E
-01 8.33E
-01
MIMAT000
5924 hsa
-miR
-1270 1.00E+00 9.53E
-01 8.34E
-01 3.09E
-01 3.87E
-01
MIMAT000
5796 hsa
-miR
-1271
-5p 1.11E+00 2.26E
-01 9.15E
-01 6.96E
-01 3.26E
-01
MIMAT000
5925 hsa
-miR
-1272 1.03E+00 5.08E
-01 9.92E
-01 9.30E
-01 4.39E
-01
MIMAT000
5933 hsa
-miR
-1277
-3p 1.00E+00 9.67E
-01 8.64E
-01 4.46E
-01 2.66E
-01
MIMAT000
5936 hsa
-miR
-1278 1.04E+00 3.29E
-01 1.09E+00 2.60E
-01 3.69E
-01
MIMAT000
5937 hsa
-miR
-1279 9.92E
-01 8.56E
-01 8.35E
-01 9.98E
-02 3.72E
-01
MIMAT000
0424 hsa
-miR
-128
-3p 9.54E
-01 6.94E
-02 9.57E
-01 4.15E
-01 7.71E
-01
MIMAT000
5939 hsa
-miR
-1281 1.00E+00 9.56E
-01 8.16E
-01 1.11E
-01 3.24E
-01
MIMAT000
5876 hsa
-miR
-1285
-3p 1.01E+00 7.60E
-01 1.10E+00 2.07E
-01 2.97E
-01
MIMAT002
2719 hsa
-miR
-1285
-5p 9.79E
-01 3.61E
-02 9.90E
-01 6.58E
-01 9.99E
-01
MIMAT000
5877 hsa
-miR
-1286 9.86E
-01 7.28E
-01 9.22E
-01 3.98E
-01 6.24E
-01

133
MIMAT000
5878 hsa
-miR
-1287
-5p 1.03E+00 4.43E
-01 1.03E+00 7.41E
-01 8.87E
-01
MIMAT000
4605 hsa
-miR
-129
-
2
-3p 9.12E
-01 5.05E
-02 1.00E+00 9.65E
-01 5.24E
-01
MIMAT000
5880 hsa
-miR
-1290 9.99E
-01 9.05E
-01 9.92E
-01 7.24E
-01 5.12E
-01
MIMAT000
5883 hsa
-miR
-1293 1.01E+00 9.19E
-01 1.23E+00 2.72E
-01 4.82E
-01
MIMAT000
5885 hsa
-miR
-1295a 9.85E
-01 4.61E
-01 1.04E+00 3.33E
-01 1.47E
-01
MIMAT002
6637 hsa
-miR
-1296
-3p 9.82E
-01 2.66E
-01 1.02E+00 5.37E
-01 2.46E
-01
MIMAT000
5886 hsa
-miR
-1297 1.00E+00 9.86E
-01 9.85E
-01 8.95E
-01 7.56E
-01
MIMAT000
5800 hsa
-miR
-1298
-5p 9.33E
-01 1.51E
-01 9.65E
-01 6.98E
-01 7.06E
-01
MIMAT000
5887 hsa
-miR
-1299 1.03E+00 4.67E
-01 1.09E+00 2.60E
-01 4.16E
-01
MIMAT000
5890 hsa
-miR
-1302 1.01E+00 8.00E
-01 9.06E
-01 1.05E
-01 1.80E
-01
MIMAT002
2720 hsa
-miR
-1304
-3p 1.05E+00 3.97E
-01 8.77E
-01 3.25E
-01 4.11E
-01
MIMAT000
5892 hsa
-miR
-1304
-5p 1.04E+00 3.39E
-01 1.05E+00 5.14E
-01 5.97E
-01
MIMAT000
5893 hsa
-miR
-1305 9.91E
-01 4.46E
-01 9.95E
-01 8.41E
-01 9.10E
-01
MIMAT000
5950 hsa
-miR
-1306
-3p 1.01E+00 7.80E
-01 9.43E
-01 5.84E
-01 7.38E
-01
MIMAT000
5951 hsa
-miR
-1307
-3p 9.01E
-01 2.23E
-02 1.03E+00 7.21E
-01 2.29E
-01
MIMAT002
2727 hsa
-miR
-1307
-5p 9.87E
-01 4.15E
-01 1.00E+00 9.66E
-01 3.88E
-01
MIMAT000
0425 hsa
-miR
-130a
-3p 9.09E
-01 2.32E
-01 9.27E
-01 6.92E
-01 8.98E
-01
MIMAT000
0426 hsa
-miR
-132
-3p 1.00E+00 8.85E
-01 1.03E+00 2.80E
-01 1.80E
-01
MIMAT000
5795 hsa
-miR
-1323 1.00E+00 9.28E
-01 9.92E
-01 7.87E
-01 6.67E
-01
MIMAT000
0427 hsa
-miR
-133a
-3p 9.86E
-01 5.78E
-01 9.44E
-01 3.77E
-01 3.12E
-01
MIMAT002
6478 hsa
-miR
-133a
-5p 1.01E+00 7.83E
-01 9.45E
-01 2.98E
-01 4.81E
-01
MIMAT002
6481 hsa
-miR
-134
-3p 9.87E
-01 4.96E
-01 9.67E
-01 3.85E
-01 8.95E
-01

134
MIMAT000
0448 hsa
-miR
-136
-5p 9.60E
-01 3.72E
-01 1.05E+00 6.08E
-01 5.17E
-01
MIMAT000
0429 hsa
-miR
-137 1.01E+00 6.14E
-01 1.01E+00 8.79E
-01 9.53E
-01
MIMAT000
0430 hsa
-miR
-138
-5p 9.79E
-01 6.24E
-01 1.07E+00 5.39E
-01 4.90E
-01
MIMAT000
4552 hsa
-miR
-139
-3p 9.98E
-01 9.58E
-01 1.02E+00 8.29E
-01 8.80E
-01
MIMAT000
4597 hsa
-miR
-140
-3p 1.06E+00 2.49E
-01 1.21E+00 8.22E
-02 3.68E
-01
MIMAT000
0431 hsa
-miR
-140
-5p 1.05E+00 2.97E
-01 1.10E+00 3.24E
-01 3.29E
-01
MIMAT000
0432 hsa
-miR
-141
-3p 1.05E+00 5.85E
-01 1.04E+00 8.22E
-01 5.96E
-01
MIMAT000
0434 hsa
-miR
-142
-3p 9.72E
-01 3.16E
-01 1.04E+00 5.74E
-01 4.76E
-01
MIMAT000
0435 hsa
-miR
-143
-3p 1.04E+00 3.84E
-01 1.11E+00 3.29E
-01 3.00E
-01
MIMAT000
0449 hsa
-miR
-146a
-5p 1.01E+00 8.03E
-01 9.90E
-01 9.19E
-01 9.41E
-01
MIMAT000
2809 hsa
-miR
-146b
-5p 1.05E+00 2.69E
-01 9.48E
-01 5.33E
-01 5.70E
-01
MIMAT000
0251 hsa
-miR
-147a 9.82E
-01 6.10E
-01 9.99E
-01 9.88E
-01 9.64E
-01
MIMAT000
4928 hsa
-miR
-147b 1.04E+00 1.71E
-01 9.37E
-01 4.59E
-01 5.42E
-01
MIMAT000
0243 hsa
-miR
-148a
-3p 1.00E+00 9.58E
-01 1.13E+00 2.01E
-01 3.77E
-01
MIMAT000
0759 hsa
-miR
-148b
-3p 9.44E
-01 3.04E
-01 1.11E+00 3.62E
-01 2.40E
-01
MIMAT000
0450 hsa
-miR
-149
-5p 1.09E+00 1.84E
-02 9.01E
-01 1.93E
-01 3.26E
-02
MIMAT000
0451 hsa
-miR
-150
-5p 1.01E+00 7.89E
-01 9.89E
-01 9.28E
-01 8.39E
-01
MIMAT000
0757 hsa
-miR
-151a
-3p 1.05E+00 5.20E
-01 8.39E
-01 3.24E
-01 2.20E
-01
MIMAT000
7399 hsa
-miR
-1537
-3p 1.09E+00 1.58E
-01 1.22E+00 1.27E
-01 3.92E
-01
MIMAT000
0646 hsa
-miR
-155
-5p 9.92E
-01 6.91E
-01 1.05E+00 2.49E
-01 1.03E
-01
MIMAT000
0417 hsa
-miR
-15b
-5p 9.94E
-01 9.39E
-01 8.40E
-01 2.24E
-01 4.00E
-01
MIMAT000
0069 hsa
-miR
-16
-5p 9.70E
-01 2.08E
-01 9.43E
-01 2.60E
-01 7.67E
-01

135
MIMAT000
4558 hsa
-miR
-181a
-
2
-3p 9.76E
-01 2.00E
-01 1.03E+00 3.76E
-01 1.60E
-01
MIMAT000
0270 hsa
-miR
-181a
-3p 9.92E
-01 5.84E
-01 9.99E
-01 9.84E
-01 4.87E
-01
MIMAT000
0256 hsa
-miR
-181a
-5p 9.40E
-01 3.69E
-01 1.07E+00 6.90E
-01 9.31E
-01
MIMAT003
1893 hsa
-miR
-181b
-
2
-3p 1.02E+00 4.02E
-01 1.01E+00 9.08E
-01 9.65E
-01
MIMAT000
0257 hsa
-miR
-181b
-5p+hsa
-miR
-181d
-5p 9.78E
-01 7.82E
-01 8.28E
-01 3.06E
-01 5.17E
-01
MIMAT000
0258 hsa
-miR
-181c
-5p 8.43E
-01 7.76E
-02 1.10E+00 5.77E
-01 2.79E
-01
MIMAT002
6608 hsa
-miR
-181d
-3p 9.79E
-01 3.34E
-01 1.02E+00 6.50E
-01 4.83E
-01
MIMAT000
0260 hsa
-miR
-182
-3p 1.02E+00 6.92E
-01 9.66E
-01 6.97E
-01 9.01E
-01
MIMAT000
6767 hsa
-miR
-1827 1.04E+00 5.05E
-01 8.68E
-01 5.60E
-01 4.00E
-01
MIMAT000
0261 hsa
-miR
-183
-5p 9.96E
-01 6.57E
-01 9.88E
-01 5.74E
-01 6.94E
-01
MIMAT000
0454 hsa
-miR
-184 1.01E+00 5.22E
-01 9.68E
-01 2.64E
-01 1.69E
-01
MIMAT000
0455 hsa
-miR
-185
-5p 1.00E+00 9.48E
-01 9.72E
-01 2.45E
-01 5.55E
-01
MIMAT000
0456 hsa
-miR
-186
-5p 9.51E
-01 1.60E
-03 1.03E+00 4.03E
-01 2.88E
-02
MIMAT000
0262 hsa
-miR
-187
-3p 9.71E
-01 3.26E
-02 1.03E+00 3.99E
-01 7.31E
-02
MIMAT000
4613 hsa
-miR
-188
-3p 9.61E
-01 3.16E
-01 7.20E
-01 1.23E
-03 4.91E
-03
MIMAT000
0457 hsa
-miR
-188
-5p 1.02E+00 6.34E
-02 1.05E+00 1.84E
-01 6.29E
-01
MIMAT000
0072 hsa
-miR
-18a
-5p 1.01E+00 6.04E
-01 9.96E
-01 8.99E
-01 9.55E
-01
MIMAT000
1412 hsa
-miR
-18b
-5p 9.25E
-01 3.14E
-01 9.78E
-01 8.75E
-01 5.19E
-01
MIMAT002
6916 hsa
-miR
-1908
-3p 9.30E
-01 3.16E
-01 8.12E
-01 2.89E
-01 2.42E
-01
MIMAT002
6482 hsa
-miR
-190a
-3p 9.88E
-01 8.23E
-01 1.02E+00 8.86E
-01 9.37E
-01
MIMAT000
0458 hsa
-miR
-190a
-5p 9.93E
-01 9.17E
-01 1.08E+00 5.91E
-01 4.60E
-01
MIMAT000
0440 hsa
-miR
-191
-5p 9.97E
-01 9.19E
-01 1.02E+00 7.97E
-01 8.80E
-01

136
MIMAT000
7884 hsa
-miR
-1910
-5p 8.54E
-01 3.63E
-02 9.74E
-01 8.46E
-01 1.83E
-01
MIMAT000
0222 hsa
-miR
-192
-5p 9.74E
-01 6.29E
-01 9.88E
-01 9.26E
-01 9.25E
-01
MIMAT000
0459 hsa
-miR
-193a
-3p 1.02E+00 3.85E
-01 9.75E
-01 5.31E
-01 3.76E
-01
MIMAT000
2819 hsa
-miR
-193b
-3p 8.50E
-01 7.40E
-02 1.17E+00 3.53E
-01 1.58E
-01
MIMAT000
0226 hsa
-miR
-196a
-5p 9.98E
-01 9.21E
-01 9.51E
-01 2.49E
-01 2.51E
-01
MIMAT000
0227 hsa
-miR
-197
-3p 1.04E+00 1.90E
-01 1.02E+00 8.24E
-01 9.88E
-01
MIMAT002
2691 hsa
-miR
-197
-5p 9.93E
-01 7.12E
-01 9.71E
-01 4.98E
-01 7.13E
-01
MIMAT000
9447 hsa
-miR
-1972 1.01E+00 4.37E
-01 1.02E+00 6.09E
-01 9.59E
-01
MIMAT000
9448 hsa
-miR
-1973 9.81E
-01 2.39E
-01 9.62E
-01 1.85E
-01 6.06E
-01
MIMAT000
9451 hsa
-miR
-1976 1.03E+00 3.27E
-01 1.02E+00 8.02E
-01 7.05E
-01
MIMAT000
0228 hsa
-miR
-198 9.89E
-01 7.04E
-01 1.03E+00 6.46E
-01 6.07E
-01
MIMAT000
0232 hsa
-miR
-199a
-3p+hsa
-miR
-199b
-3p 1.00E+00 7.61E
-01 1.01E+00 7.88E
-01 7.63E
-01
MIMAT000
0231 hsa
-miR
-199a
-5p 1.01E+00 3.10E
-01 1.01E+00 8.00E
-01 9.92E
-01
MIMAT000
0263 hsa
-miR
-199b
-5p 9.75E
-01 1.44E
-01 1.06E+00 7.87E
-02 1.27E
-02
MIMAT000
0074 hsa
-miR
-19b
-3p 7.91E
-01 7.80E
-03 1.05E+00 7.43E
-01 7.02E
-02
MIMAT000
0682 hsa
-miR
-200a
-3p 1.01E+00 6.14E
-01 1.00E+00 8.68E
-01 7.38E
-01
MIMAT000
0318 hsa
-miR
-200b
-3p 1.00E+00 9.46E
-01 1.01E+00 8.88E
-01 9.06E
-01
MIMAT000
0617 hsa
-miR
-200c
-3p 1.02E+00 5.41E
-01 1.03E+00 7.37E
-01 8.61E
-01
MIMAT000
0264 hsa
-miR
-203a
-3p 9.69E
-01 6.37E
-01 1.01E+00 9.47E
-01 9.14E
-01
MIMAT003
1890 hsa
-miR
-203a
-5p 9.94E
-01 6.26E
-01 9.73E
-01 2.86E
-01 6.72E
-01
MIMAT000
0266 hsa
-miR
-205
-5p 1.00E+00 9.93E
-01 1.01E+00 9.58E
-01 4.93E
-01
MIMAT000
9978 hsa
-miR
-2053 1.00E+00 9.85E
-01 9.65E
-01 1.87E
-01 2.64E
-01

137
MIMAT000
0241 hsa
-miR
-208a
-3p 1.00E+00 9.41E
-01 1.01E+00 6.20E
-01 4.38E
-01
MIMAT000
4960 hsa
-miR
-208b
-3p 9.97E
-01 7.43E
-01 9.77E
-01 3.30E
-01 3.31E
-01
MIMAT000
0076 hsa
-miR
-21
-5p 9.94E
-01 8.80E
-01 1.04E+00 6.44E
-01 6.30E
-01
MIMAT000
0267 hsa
-miR
-210
-3p 9.94E
-01 6.17E
-01 9.86E
-01 5.80E
-01 6.06E
-01
MIMAT002
6475 hsa
-miR
-210
-5p 9.98E
-01 8.36E
-01 9.62E
-01 2.16E
-01 5.59E
-01
MIMAT000
0268 hsa
-miR
-211
-5p 9.82E
-01 1.80E
-01 9.66E
-01 1.93E
-01 6.84E
-01
MIMAT001
0133 hsa
-miR
-2110 9.57E
-01 2.29E
-01 9.60E
-01 5.79E
-01 9.00E
-01
MIMAT000
9206 hsa
-miR
-2113 1.04E+00 5.52E
-01 9.68E
-01 8.37E
-01 9.97E
-01
MIMAT000
0269 hsa
-miR
-212
-3p 9.83E
-01 2.14E
-01 9.85E
-01 6.52E
-01 9.18E
-01
MIMAT000
0272 hsa
-miR
-215
-5p 9.92E
-01 7.31E
-01 9.69E
-01 5.72E
-01 7.17E
-01
MIMAT000
0273 hsa
-miR
-216a
-5p 9.76E
-01 5.11E
-01 9.42E
-01 5.02E
-01 4.38E
-01
MIMAT000
4959 hsa
-miR
-216b
-5p 1.03E+00 1.92E
-01 9.48E
-01 3.60E
-01 1.57E
-01
MIMAT000
0274 hsa
-miR
-217 1.04E+00 3.61E
-01 1.05E+00 6.32E
-01 7.51E
-01
MIMAT000
0275 hsa
-miR
-218
-5p 1.05E+00 2.83E
-01 8.24E
-01 3.55E
-02 4.57E
-02
MIMAT000
0276 hsa
-miR
-219a
-5p 1.03E+00 7.29E
-01 6.69E
-01 8.53E
-02 9.97E
-02
MIMAT001
9748 hsa
-miR
-219b
-3p 1.03E+00 3.92E
-01 9.55E
-01 5.92E
-01 4.69E
-01
MIMAT000
0278 hsa
-miR
-221
-3p 9.64E
-01 3.71E
-01 1.04E+00 7.11E
-01 3.12E
-01
MIMAT000
0279 hsa
-miR
-222
-3p 9.98E
-01 9.84E
-01 8.82E
-01 4.76E
-01 2.28E
-01
MIMAT000
0280 hsa
-miR
-223
-3p 1.00E+00 9.35E
-01 9.68E
-01 6.60E
-01 4.27E
-01
MIMAT000
0281 hsa
-miR
-224
-5p 9.64E
-01 5.98E
-01 8.64E
-01 4.63E
-01 5.72E
-01
MIMAT000
0078 hsa
-miR
-23a
-3p 1.01E+00 5.29E
-01 9.62E
-01 3.08E
-01 1.21E
-01
MIMAT000
0418 hsa
-miR
-23b
-3p 9.83E
-01 3.32E
-01 9.96E
-01 9.04E
-01 5.65E
-01

138
MIMAT001
8000 hsa
-miR
-23c 1.00E+00 8.95E
-01 9.82E
-01 7.36E
-01 5.52E
-01
MIMAT000
0081 hsa
-miR
-25
-3p 9.72E
-01 6.22E
-01 8.96E
-01 4.22E
-01 3.81E
-01
MIMAT000
4498 hsa
-miR
-25
-5p 9.69E
-01 1.27E
-01 1.01E+00 8.31E
-01 2.74E
-01
MIMAT000
0082 hsa
-miR
-26a
-5p 1.00E+00 9.86E
-01 1.03E+00 4.42E
-01 4.68E
-01
MIMAT000
0083 hsa
-miR
-26b
-5p 9.83E
-01 2.11E
-01 9.72E
-01 2.80E
-01 8.65E
-01
MIMAT000
0084 hsa
-miR
-27a
-3p 9.74E
-01 3.48E
-01 9.18E
-01 1.36E
-01 4.81E
-01
MIMAT000
4502 hsa
-miR
-28
-3p 9.57E
-01 2.98E
-02 9.91E
-01 8.32E
-01 2.29E
-01
MIMAT000
0085 hsa
-miR
-28
-5p 9.73E
-01 2.13E
-01 1.04E+00 5.17E
-01 4.60E
-01
MIMAT000
4679 hsa
-miR
-296
-3p 9.61E
-01 6.51E
-01 1.06E+00 7.52E
-01 7.51E
-01
MIMAT000
4901 hsa
-miR
-298 1.02E+00 6.52E
-01 8.79E
-01 1.79E
-01 8.50E
-02
MIMAT000
0687 hsa
-miR
-299
-3p 1.05E+00 1.29E
-01 9.23E
-01 2.74E
-01 2.09E
-01
MIMAT000
2890 hsa
-miR
-299
-5p 1.01E+00 5.81E
-01 9.98E
-01 9.43E
-01 6.22E
-01
MIMAT000
0086 hsa
-miR
-29a
-3p 9.43E
-01 1.33E
-01 9.66E
-01 6.65E
-01 6.88E
-01
MIMAT000
0100 hsa
-miR
-29b
-3p 9.95E
-01 9.29E
-01 1.08E+00 5.67E
-01 4.08E
-01
MIMAT000
0681 hsa
-miR
-29c
-3p 8.61E
-01 1.30E
-01 1.05E+00 8.02E
-01 1.69E
-01
MIMAT000
4903 hsa
-miR
-300 8.90E
-01 2.22E
-01 1.06E+00 7.04E
-01 4.03E
-01
MIMAT000
0688 hsa
-miR
-301a
-3p 9.74E
-01 2.18E
-01 9.81E
-01 6.45E
-01 3.99E
-01
MIMAT002
2696 hsa
-miR
-301a
-5p 9.92E
-01 6.64E
-01 9.10E
-01 3.06E
-02 6.68E
-02
MIMAT000
4958 hsa
-miR
-301b
-3p 9.74E
-01 4.32E
-01 1.07E+00 3.43E
-01 2.64E
-01
MIMAT003
2026 hsa
-miR
-301b
-5p 9.98E
-01 8.68E
-01 9.53E
-01 6.88E
-02 2.28E
-01
MIMAT000
0684 hsa
-miR
-302a
-3p 9.78E
-01 4.96E
-01 9.30E
-01 2.32E
-01 6.74E
-01
MIMAT000
0683 hsa
-miR
-302a
-5p 9.19E
-01 1.72E
-01 9.55E
-01 7.02E
-01 5.77E
-01

139
MIMAT000
0715 hsa
-miR
-302b
-3p 9.62E
-01 2.92E
-02 9.39E
-01 1.44E
-01 6.14E
-01
MIMAT000
0717 hsa
-miR
-302c
-3p 9.12E
-01 1.22E
-01 9.64E
-01 7.56E
-01 7.41E
-01
MIMAT000
0718 hsa
-miR
-302d
-3p 9.94E
-01 6.39E
-01 1.01E+00 8.81E
-01 6.16E
-01
MIMAT000
5931 hsa
-miR
-302e 9.89E
-01 8.39E
-01 1.16E+00 1.50E
-01 7.40E
-02
MIMAT000
5932 hsa
-miR
-302f 1.06E+00 3.71E
-01 9.44E
-01 7.08E
-01 1.76E
-01
MIMAT001
5378 hsa
-miR
-3065
-3p 9.75E
-01 1.53E
-01 9.90E
-01 7.38E
-01 5.93E
-01
MIMAT001
5027 hsa
-miR
-3074
-3p 8.60E
-01 1.82E
-01 9.63E
-01 8.45E
-01 5.92E
-01
MIMAT000
0088 hsa
-miR
-30a
-3p 9.65E
-01 2.14E
-02 1.05E+00 1.68E
-01 9.80E
-03
MIMAT000
0420 hsa
-miR
-30b
-5p 1.01E+00 7.46E
-01 1.08E+00 4.15E
-01 4.18E
-01
MIMAT000
0244 hsa
-miR
-30c
-5p 9.96E
-01 9.47E
-01 1.24E+00 1.12E
-01 2.37E
-01
MIMAT000
0245 hsa
-miR
-30d
-5p 9.46E
-01 2.08E
-01 9.77E
-01 8.11E
-01 9.14E
-01
MIMAT000
0693 hsa
-miR
-30e
-3p 9.75E
-01 2.07E
-01 9.98E
-01 9.65E
-01 4.73E
-01
MIMAT000
0692 hsa
-miR
-30e
-5p 9.91E
-01 5.65E
-01 9.71E
-01 3.36E
-01 6.43E
-01
MIMAT001
4996 hsa
-miR
-3131 1.01E+00 6.81E
-01 1.04E+00 6.45E
-01 7.55E
-01
MIMAT001
5015 hsa
-miR
-3144
-3p 9.76E
-01 1.89E
-02 1.00E+00 9.91E
-01 6.75E
-01
MIMAT001
5014 hsa
-miR
-3144
-5p 1.01E+00 8.92E
-01 9.36E
-01 5.11E
-01 6.51E
-01
MIMAT001
5019 hsa
-miR
-3147 9.89E
-01 2.62E
-01 9.92E
-01 7.24E
-01 9.93E
-01
MIMAT001
5024 hsa
-miR
-3151
-5p 9.32E
-01 4.53E
-01 1.12E+00 5.76E
-01 6.73E
-01
MIMAT001
5035 hsa
-miR
-3161 1.04E+00 5.09E
-01 8.22E
-01 9.21E
-02 7.44E
-02
MIMAT001
5043 hsa
-miR
-3168 1.00E+00 7.70E
-01 9.77E
-01 3.59E
-01 4.51E
-01
MIMAT001
8178 hsa
-miR
-3180 1.01E+00 8.21E
-01 1.04E+00 6.38E
-01 8.96E
-01
MIMAT001
5057 hsa
-miR
-3180
-5p 1.00E+00 9.67E
-01 1.03E+00 8.19E
-01 7.50E
-01

140
MIMAT001
5089 hsa
-miR
-3202 9.76E
-01 6.37E
-01 1.00E+00 9.93E
-01 9.65E
-01
MIMAT000
0510 hsa
-miR
-320a 1.09E+00 1.99E
-01 8.63E
-01 4.24E
-01 1.91E
-01
MIMAT000
5793 hsa
-miR
-320c 9.47E
-01 4.58E
-01 9.85E
-01 9.24E
-01 8.42E
-01
MIMAT001
5072 hsa
-miR
-320e 9.72E
-01 4.27E
-01 9.26E
-01 4.16E
-01 4.23E
-01
MIMAT000
0755 hsa
-miR
-323a
-3p 9.79E
-01 7.98E
-01 1.08E+00 6.64E
-01 3.49E
-01
MIMAT001
5050 hsa
-miR
-323b
-3p 1.01E+00 7.91E
-01 1.03E+00 7.07E
-01 7.86E
-01
MIMAT000
0762 hsa
-miR
-324
-3p 9.79E
-01 6.14E
-02 9.84E
-01 4.41E
-01 7.88E
-01
MIMAT000
0771 hsa
-miR
-325 9.82E
-01 5.10E
-01 1.02E+00 7.82E
-01 5.47E
-01
MIMAT002
6486 hsa
-miR
-328
-5p 9.85E
-01 6.83E
-01 9.61E
-01 5.75E
-01 9.59E
-01
MIMAT000
1629 hsa
-miR
-329
-3p 1.08E+00 2.40E
-01 9.88E
-01 9.37E
-01 7.51E
-01
MIMAT002
6555 hsa
-miR
-329
-5p 1.03E+00 3.86E
-01 9.27E
-01 3.29E
-01 2.99E
-01
MIMAT000
4693 hsa
-miR
-330
-5p 9.96E
-01 9.52E
-01 8.57E
-01 3.26E
-01 3.66E
-01
MIMAT000
0765 hsa
-miR
-335
-5p 9.81E
-01 3.07E
-01 9.73E
-01 4.84E
-01 8.08E
-01
MIMAT000
0754 hsa
-miR
-337
-3p 9.90E
-01 5.15E
-01 1.01E+00 8.00E
-01 4.98E
-01
MIMAT000
4695 hsa
-miR
-337
-5p 1.00E+00 9.53E
-01 9.80E
-01 4.58E
-01 5.90E
-01
MIMAT000
4701 hsa
-miR
-338
-5p 9.90E
-01 7.05E
-01 1.01E+00 9.14E
-01 6.48E
-01
MIMAT000
0091 hsa
-miR
-33a
-5p 9.16E
-01 3.30E
-01 9.88E
-01 9.44E
-01 8.86E
-01
MIMAT000
3301 hsa
-miR
-33b
-5p 9.81E
-01 1.49E
-01 9.99E
-01 9.66E
-01 4.59E
-01
MIMAT000
4692 hsa
-miR
-340
-5p 9.63E
-01 1.56E
-01 9.39E
-01 3.47E
-01 9.91E
-01
MIMAT000
0753 hsa
-miR
-342
-3p 1.02E+00 7.58E
-01 1.21E+00 2.82E
-01 2.47E
-01
MIMAT000
4694 hsa
-miR
-342
-5p 9.99E
-01 9.89E
-01 1.03E+00 7.53E
-01 6.34E
-01
MIMAT002
2698 hsa
-miR
-345
-3p 9.83E
-01 5.24E
-01 1.04E+00 5.62E
-01 2.98E
-01

141
MIMAT000
0773 hsa
-miR
-346 9.77E
-01 1.74E
-01 9.86E
-01 7.11E
-01 5.04E
-01
MIMAT000
0255 hsa
-miR
-34a
-5p 1.01E+00 5.08E
-01 9.98E
-01 9.48E
-01 9.91E
-01
MIMAT000
4676 hsa
-miR
-34b
-3p 9.90E
-01 7.32E
-01 9.55E
-01 3.73E
-01 5.33E
-01
MIMAT000
4677 hsa
-miR
-34c
-3p 1.00E+00 9.98E
-01 8.79E
-01 3.34E
-01 4.13E
-01
MIMAT000
0686 hsa
-miR
-34c
-5p 9.90E
-01 8.49E
-01 1.10E+00 3.94E
-01 5.81E
-01
MIMAT001
7981 hsa
-miR
-3605
-5p 1.01E+00 7.92E
-01 1.02E+00 6.66E
-01 7.60E
-01
MIMAT000
0703 hsa
-miR
-361
-5p 1.12E+00 1.72E
-01 9.25E
-01 6.72E
-01 4.05E
-01
MIMAT001
7991 hsa
-miR
-3613
-3p 9.71E
-01 3.93E
-02 1.01E+00 6.83E
-01 3.50E
-02
MIMAT001
7992 hsa
-miR
-3614
-5p 1.02E+00 1.84E
-01 9.83E
-01 6.39E
-01 3.52E
-01
MIMAT001
7994 hsa
-miR
-3615 8.36E
-01 4.35E
-02 1.07E+00 6.64E
-01 8.63E
-02
MIMAT000
0705 hsa
-miR
-362
-5p 1.00E+00 9.87E
-01 9.97E
-01 9.28E
-01 8.24E
-01
MIMAT000
0707 hsa
-miR
-363
-3p 9.78E
-01 7.53E
-02 9.78E
-01 4.77E
-01 8.06E
-01
MIMAT000
3385 hsa
-miR
-363
-5p 9.47E
-01 4.16E
-01 8.88E
-01 3.64E
-01 6.95E
-01
MIMAT000
0710 hsa
-miR
-365a
-3p+hsa
-miR
-365b
-3p 9.83E
-01 3.82E
-01 1.00E+00 9.34E
-01 6.99E
-01
MIMAT002
2833 hsa
-miR
-365b
-5p 7.32E
-01 8.03E
-03 8.19E
-01 3.06E
-01 7.36E
-01
MIMAT000
0719 hsa
-miR
-367
-3p 1.00E+00 1.00E+00 9.37E
-01 7.35E
-01 5.88E
-01
MIMAT000
0721 hsa
-miR
-369
-3p 9.99E
-01 9.26E
-01 9.44E
-01 9.32E
-02 1.92E
-01
MIMAT000
1621 hsa
-miR
-369
-5p 9.63E
-01 3.13E
-01 9.96E
-01 9.58E
-01 7.52E
-01
MIMAT001
8119 hsa
-miR
-3690 9.99E
-01 9.78E
-01 1.27E+00 5.72E
-02 6.01E
-02
MIMAT000
0722 hsa
-miR
-370
-3p 9.73E
-01 2.01E
-01 9.96E
-01 9.29E
-01 4.57E
-01
MIMAT000
4687 hsa
-miR
-371a
-5p 1.02E+00 5.71E
-01 9.40E
-01 3.23E
-01 8.22E
-01
MIMAT001
9892 hsa
-miR
-371b
-5p 9.79E
-01 5.78E
-01 1.03E+00 7.70E
-01 6.74E
-01

142
MIMAT000
4688 hsa
-miR
-374a
-3p 9.76E
-01 7.80E
-01 9.31E
-01 7.20E
-01 6.62E
-01
MIMAT000
0727 hsa
-miR
-374a
-5p 1.05E+00 3.45E
-01 1.09E+00 4.45E
-01 8.38E
-01
MIMAT002
2928 hsa
-miR
-376a
-
2
-5p 9.26E
-01 1.71E
-01 9.36E
-01 5.90E
-01 4.53E
-01
MIMAT000
0729 hsa
-miR
-376a
-3p 1.00E+00 9.19E
-01 1.01E+00 6.70E
-01 7.27E
-01
MIMAT000
0720 hsa
-miR
-376c
-3p 1.10E+00 2.73E
-01 1.11E+00 5.42E
-01 8.64E
-01
MIMAT002
2861 hsa
-miR
-376c
-5p 1.02E+00 7.08E
-01 1.03E+00 7.84E
-01 7.70E
-01
MIMAT000
0730 hsa
-miR
-377
-3p 1.03E+00 6.08E
-01 9.90E
-01 9.35E
-01 7.76E
-01
MIMAT001
8926 hsa
-miR
-378d 9.87E
-01 2.62E
-01 9.75E
-01 2.80E
-01 7.98E
-01
MIMAT001
8927 hsa
-miR
-378e 9.71E
-01 1.49E
-01 1.03E+00 5.86E
-01 3.01E
-01
MIMAT001
8932 hsa
-miR
-378f 9.85E
-01 6.01E
-01 9.21E
-01 1.71E
-01 7.83E
-01
MIMAT001
8937 hsa
-miR
-378g 9.86E
-01 2.68E
-01 9.99E
-01 9.65E
-01 5.64E
-01
MIMAT001
8984 hsa
-miR
-378h 9.64E
-01 6.15E
-02 1.03E+00 5.81E
-01 1.45E
-01
MIMAT001
9074 hsa
-miR
-378i 9.92E
-01 3.88E
-01 1.01E+00 6.55E
-01 1.81E
-01
MIMAT000
0733 hsa
-miR
-379
-5p 9.77E
-01 2.75E
-01 1.08E+00 8.63E
-02 6.09E
-02
MIMAT000
0735 hsa
-miR
-380
-3p 8.75E
-01 1.83E
-01 1.03E+00 9.01E
-01 2.12E
-01
MIMAT000
0736 hsa
-miR
-381
-3p 9.18E
-01 5.58E
-02 1.01E+00 9.40E
-01 2.71E
-01
MIMAT002
2862 hsa
-miR
-381
-5p 9.87E
-01 8.58E
-01 7.52E
-01 5.94E
-02 5.85E
-02
MIMAT002
2697 hsa
-miR
-382
-3p 1.11E+00 1.56E
-01 1.03E+00 8.58E
-01 3.86E
-01
MIMAT000
0737 hsa
-miR
-382
-5p 1.09E+00 2.33E
-01 1.02E+00 9.06E
-01 7.69E
-01
MIMAT001
8205 hsa
-miR
-3928
-3p 9.44E
-01 4.97E
-01 5.83E
-01 8.38E
-02 9.76E
-02
MIMAT001
8349 hsa
-miR
-3934
-5p 9.66E
-01 3.57E
-01 1.04E+00 6.74E
-01 3.58E
-01
MIMAT000
2171 hsa
-miR
-410
-3p 9.17E
-01 1.76E
-01 1.09E+00 4.60E
-01 1.11E
-01

143
MIMAT000
2170 hsa
-miR
-412
-3p 9.80E
-01 6.67E
-01 9.52E
-01 6.32E
-01 9.19E
-01
MIMAT000
3339 hsa
-miR
-421 9.89E
-01 4.23E
-01 1.01E+00 6.67E
-01 5.92E
-01
MIMAT000
1340 hsa
-miR
-423
-3p 9.94E
-01 9.26E
-01 7.90E
-01 1.75E
-01 2.55E
-01
MIMAT000
4748 hsa
-miR
-423
-5p 9.86E
-01 7.79E
-01 9.30E
-01 5.59E
-01 3.81E
-01
MIMAT001
6915 hsa
-miR
-4284 9.97E
-01 9.62E
-01 9.99E
-01 9.91E
-01 8.53E
-01
MIMAT001
6916 hsa
-miR
-4286 9.82E
-01 1.22E
-01 1.02E+00 3.00E
-01 4.90E
-02
MIMAT000
1625 hsa
-miR
-431
-5p 9.78E
-01 7.34E
-01 1.06E+00 6.70E
-01 3.92E
-01
MIMAT000
2814 hsa
-miR
-432
-5p 1.05E+00 2.51E
-01 1.02E+00 8.67E
-01 8.31E
-01
MIMAT000
1627 hsa
-miR
-433
-3p 9.66E
-01 7.10E
-01 1.26E+00 2.14E
-01 2.52E
-01
MIMAT002
6554 hsa
-miR
-433
-5p 1.03E+00 4.21E
-01 1.01E+00 8.86E
-01 6.49E
-01
MIMAT001
8934 hsa
-miR
-4421 1.04E+00 4.01E
-01 9.48E
-01 6.36E
-01 6.35E
-01
MIMAT001
8947 hsa
-miR
-4431 1.01E+00 9.05E
-01 1.10E+00 4.88E
-01 5.52E
-01
MIMAT001
8961 hsa
-miR
-4443 1.00E+00 9.40E
-01 9.15E
-01 2.64E
-01 3.52E
-01
MIMAT001
8973 hsa
-miR
-4451 9.13E
-01 2.84E
-02 9.95E
-01 9.52E
-01 2.53E
-01
MIMAT001
8976 hsa
-miR
-4454+hsa
-miR
-7975 1.01E+00 6.26E
-01 1.03E+00 6.16E
-01 8.83E
-01
MIMAT001
8977 hsa
-miR
-4455 9.77E
-01 4.23E
-01 1.02E+00 7.49E
-01 3.79E
-01
MIMAT001
8983 hsa
-miR
-4461 9.94E
-01 6.57E
-01 9.99E
-01 9.61E
-01 4.49E
-01
MIMAT000
1532 hsa
-miR
-448 9.76E
-01 2.59E
-02 9.86E
-01 5.05E
-01 4.32E
-01
MIMAT001
9019 hsa
-miR
-4485
-3p 9.81E
-01 4.95E
-01 9.52E
-01 3.93E
-01 8.67E
-01
MIMAT001
9022 hsa
-miR
-4488 9.66E
-01 8.58E
-02 1.04E+00 2.90E
-01 4.89E
-02
MIMAT000
1541 hsa
-miR
-449a 1.02E+00 7.33E
-01 1.13E+00 3.10E
-01 4.09E
-01
MIMAT000
3327 hsa
-miR
-449b
-5p 9.91E
-01 5.80E
-01 9.89E
-01 7.50E
-01 8.85E
-01

144
MIMAT001
0251 hsa
-miR
-449c
-5p 1.01E+00 9.10E
-01 1.16E+00 1.50E
-01 1.38E
-01
MIMAT002
2700 hsa
-miR
-450a
-
1
-3p 9.82E
-01 7.14E
-01 8.64E
-01 1.43E
-01 1.72E
-01
MIMAT003
1074 hsa
-miR
-450a
-
2
-3p 9.93E
-01 5.66E
-01 9.84E
-01 4.96E
-01 9.57E
-01
MIMAT000
1545 hsa
-miR
-450a
-5p 9.46E
-01 4.26E
-01 9.08E
-01 4.07E
-01 5.48E
-01
MIMAT000
4910 hsa
-miR
-450b
-3p 9.07E
-01 2.47E
-01 1.04E+00 7.71E
-01 6.20E
-01
MIMAT001
9053 hsa
-miR
-4516 9.90E
-01 4.08E
-01 1.03E+00 3.10E
-01 2.20E
-01
MIMAT000
1631 hsa
-miR
-451a 9.23E
-01 5.39E
-02 8.25E
-01 4.78E
-02 2.42E
-01
MIMAT001
9070 hsa
-miR
-4531 9.97E
-01 9.23E
-01 1.11E+00 6.77E
-02 2.26E
-01
MIMAT002
0959 hsa
-miR
-4536
-3p 1.00E+00 9.95E
-01 9.86E
-01 6.41E
-01 8.07E
-01
MIMAT001
9078 hsa
-miR
-4536
-5p 1.08E+00 3.09E
-02 1.10E+00 2.47E
-01 9.13E
-01
MIMAT000
3885 hsa
-miR
-454
-3p 1.00E+00 7.98E
-01 9.66E
-01 2.21E
-01 2.84E
-01
MIMAT000
4784 hsa
-miR
-455
-3p 8.84E
-01 2.13E
-01 6.31E
-01 4.66E
-02 2.68E
-01
MIMAT000
3150 hsa
-miR
-455
-5p 9.85E
-01 4.15E
-01 1.00E+00 9.34E
-01 4.72E
-01
MIMAT001
9709 hsa
-miR
-4647 1.01E+00 8.63E
-01 1.07E+00 3.59E
-01 3.12E
-01
MIMAT001
9808 hsa
-miR
-4707
-3p 8.99E
-01 2.56E
-01 1.04E+00 8.36E
-01 5.48E
-01
MIMAT001
9807 hsa
-miR
-4707
-5p 9.94E
-01 6.86E
-01 9.77E
-01 4.24E
-01 7.42E
-01
MIMAT001
9895 hsa
-miR
-4755
-5p 9.96E
-01 8.49E
-01 1.08E+00 1.23E
-01 1.48E
-01
MIMAT001
9956 hsa
-miR
-4787
-5p 9.85E
-01 6.68E
-01 9.08E
-01 1.58E
-01 2.77E
-01
MIMAT001
9964 hsa
-miR
-4792 9.68E
-01 5.77E
-01 8.30E
-01 1.60E
-01 3.15E
-01
MIMAT000
2176 hsa
-miR
-485
-3p 9.19E
-01 2.76E
-01 1.15E+00 3.44E
-01 2.53E
-01
MIMAT000
2178 hsa
-miR
-487a
-3p 9.86E
-01 4.46E
-01 9.88E
-01 7.87E
-01 9.38E
-01
MIMAT000
3180 hsa
-miR
-487b
-3p 1.01E+00 7.46E
-01 1.07E+00 4.64E
-01 2.83E
-01

145
MIMAT002
6614 hsa
-miR
-487b
-5p 1.01E+00 5.84E
-01 1.01E+00 8.56E
-01 8.41E
-01
MIMAT000
4763 hsa
-miR
-488
-3p 9.61E
-01 4.57E
-01 1.07E+00 5.24E
-01 1.56E
-01
MIMAT000
2806 hsa
-miR
-490
-3p 1.03E+00 7.40E
-01 9.14E
-01 6.08E
-01 6.01E
-01
MIMAT000
2807 hsa
-miR
-491
-5p 1.01E+00 9.38E
-01 9.42E
-01 7.27E
-01 5.95E
-01
MIMAT000
3161 hsa
-miR
-493
-3p 9.59E
-01 4.99E
-01 1.14E+00 3.76E
-01 3.81E
-01
MIMAT000
2816 hsa
-miR
-494
-3p 1.03E+00 7.71E
-01 1.03E+00 8.67E
-01 4.36E
-01
MIMAT000
2817 hsa
-miR
-495
-3p 1.01E+00 3.99E
-01 1.01E+00 6.89E
-01 8.81E
-01
MIMAT002
2924 hsa
-miR
-495
-5p 9.87E
-01 2.40E
-01 9.92E
-01 7.46E
-01 8.77E
-01
MIMAT000
2820 hsa
-miR
-497
-5p 9.99E
-01 9.55E
-01 9.96E
-01 9.15E
-01 5.60E
-01
MIMAT000
2824 hsa
-miR
-498 9.91E
-01 7.80E
-01 9.83E
-01 7.97E
-01 9.96E
-01
MIMAT000
4772 hsa
-miR
-499a
-3p 1.04E+00 5.93E
-01 8.37E
-01 3.52E
-01 5.45E
-01
MIMAT000
2870 hsa
-miR
-499a
-5p 1.02E+00 6.43E
-01 9.67E
-01 7.77E
-01 6.09E
-01
MIMAT001
9897 hsa
-miR
-499b
-5p 9.41E
-01 4.42E
-01 1.69E+00 7.59E
-03 2.12E
-02
MIMAT002
1021 hsa
-miR
-5001
-5p 1.00E+00 9.64E
-01 9.47E
-01 4.09E
-01 9.42E
-01
MIMAT002
1044 hsa
-miR
-5010
-3p 9.87E
-01 4.27E
-01 1.01E+00 8.41E
-01 6.38E
-01
MIMAT000
4775 hsa
-miR
-502
-3p 8.92E
-01 2.37E
-01 1.08E+00 7.19E
-01 2.32E
-01
MIMAT000
2873 hsa
-miR
-502
-5p 9.78E
-01 4.77E
-01 1.02E+00 6.76E
-01 6.21E
-01
MIMAT002
2925 hsa
-miR
-503
-3p 9.17E
-01 1.90E
-02 9.85E
-01 8.52E
-01 4.68E
-01
MIMAT000
2874 hsa
-miR
-503
-5p 9.63E
-01 3.13E
-01 1.13E+00 1.80E
-01 1.30E
-01
MIMAT000
2878 hsa
-miR
-506
-3p 1.03E+00 4.94E
-01 1.08E+00 3.73E
-01 7.95E
-01
MIMAT002
2701 hsa
-miR
-506
-5p 1.00E+00 9.94E
-01 1.00E+00 9.99E
-01 8.55E
-01
MIMAT000
2879 hsa
-miR
-507 8.59E
-01 1.77E
-01 1.20E+00 3.62E
-01 1.56E
-01

146
MIMAT000
4778 hsa
-miR
-508
-5p 9.75E
-01 1.43E
-01 9.91E
-01 8.31E
-01 3.60E
-01
MIMAT000
2881 hsa
-miR
-509
-3p 9.91E
-01 8.86E
-01 1.14E+00 3.77E
-01 3.40E
-01
MIMAT000
4779 hsa
-miR
-509
-5p 9.47E
-01 1.18E
-01 1.02E+00 8.51E
-01 3.41E
-01
MIMAT002
6613 hsa
-miR
-510
-3p 1.01E+00 4.52E
-01 9.82E
-01 5.80E
-01 6.18E
-01
MIMAT000
2808 hsa
-miR
-511
-5p 9.87E
-01 8.98E
-01 1.01E+00 9.47E
-01 8.73E
-01
MIMAT000
2822 hsa
-miR
-512
-5p 9.86E
-01 3.66E
-01 9.82E
-01 6.02E
-01 9.66E
-01
MIMAT000
4777 hsa
-miR
-513a
-3p 9.83E
-01 3.56E
-01 9.71E
-01 4.05E
-01 8.31E
-01
MIMAT000
2877 hsa
-miR
-513a
-5p 9.68E
-01 6.04E
-01 1.01E+00 9.21E
-01 9.93E
-01
MIMAT000
5788 hsa
-miR
-513b
-5p 9.37E
-01 1.10E
-01 1.02E+00 8.16E
-01 3.14E
-01
MIMAT000
5789 hsa
-miR
-513c
-5p 9.77E
-01 7.39E
-01 8.88E
-01 5.71E
-01 8.56E
-01
MIMAT000
2883 hsa
-miR
-514a
-3p 1.01E+00 4.79E
-01 9.66E
-01 3.36E
-01 3.84E
-01
MIMAT002
2702 hsa
-miR
-514a
-5p 1.12E+00 6.05E
-02 1.20E+00 1.84E
-01 2.74E
-01
MIMAT001
5088 hsa
-miR
-514b
-3p 1.29E+00 2.86E
-03 1.07E+00 7.49E
-01 7.87E
-01
MIMAT001
5087 hsa
-miR
-514b
-5p 1.00E+00 9.19E
-01 9.98E
-01 9.49E
-01 8.21E
-01
MIMAT000
2826 hsa
-miR
-515
-5p 1.08E+00 4.00E
-01 6.51E
-01 5.74E
-02 7.43E
-02
MIMAT000
2859 hsa
-miR
-516b
-5p 9.41E
-01 1.72E
-01 1.03E+00 7.67E
-01 7.51E
-01
MIMAT000
2852 hsa
-miR
-517a
-3p 9.37E
-01 1.68E
-01 1.17E+00 9.89E
-02 2.05E
-02
MIMAT000
2866 hsa
-miR
-517c
-3p+hsa
-miR
-519a
-3p 9.64E
-01 5.10E
-02 9.88E
-01 7.40E
-01 6.32E
-01
MIMAT000
2844 hsa
-miR
-518b 1.06E+00 4.39E
-01 1.08E+00 6.73E
-01 8.23E
-01
MIMAT000
2848 hsa
-miR
-518c
-3p 9.83E
-01 6.70E
-01 1.01E+00 8.77E
-01 6.67E
-01
MIMAT000
2861 hsa
-miR
-518e
-3p 9.59E
-01 5.06E
-01 1.13E+00 3.36E
-01 2.47E
-01
MIMAT000
2842 hsa
-miR
-518f-3p 9.98E
-01 9.39E
-01 9.11E
-01 2.81E
-01 3.54E
-01

147
MIMAT002
1129 hsa
-miR
-5196
-3p+hsa
-miR
-6732
-3p 9.22E
-01 4.46E
-01 6.31E
-01 7.81E
-02 3.96E
-01
MIMAT002
1128 hsa
-miR
-5196
-5p 9.33E
-01 5.77E
-02 1.01E+00 8.55E
-01 5.37E
-01
MIMAT000
2832 hsa
-miR
-519c
-3p 1.02E+00 3.12E
-01 9.81E
-01 6.10E
-01 4.96E
-01
MIMAT000
2853 hsa
-miR
-519d
-3p 1.04E+00 4.57E
-01 1.01E+00 9.19E
-01 5.86E
-01
MIMAT000
2833 hsa
-miR
-520a
-5p 1.07E+00 4.48E
-01 1.05E+00 7.87E
-01 8.05E
-01
MIMAT000
2846 hsa
-miR
-520c
-3p 9.91E
-01 8.62E
-01 9.21E
-01 5.25E
-01 8.53E
-01
MIMAT000
2856 hsa
-miR
-520d
-3p 1.01E+00 8.44E
-01 7.41E
-01 1.34E
-01 2.26E
-01
MIMAT000
2830 hsa
-miR
-520f-3p 9.73E
-01 2.89E
-01 1.02E+00 7.02E
-01 7.52E
-01
MIMAT000
2858 hsa
-miR
-520g
-3p 9.73E
-01 7.49E
-01 8.55E
-01 4.15E
-01 5.03E
-01
MIMAT000
2867 hsa
-miR
-520h 9.94E
-01 8.31E
-01 1.02E+00 7.09E
-01 7.07E
-01
MIMAT000
2854 hsa
-miR
-521 9.01E
-01 1.96E
-02 1.01E+00 8.81E
-01 9.01E
-02
MIMAT000
2868 hsa
-miR
-522
-3p 1.01E+00 3.56E
-01 1.03E+00 3.15E
-01 4.28E
-01
MIMAT000
2838 hsa
-miR
-525
-5p 9.85E
-01 4.76E
-01 9.86E
-01 7.44E
-01 4.84E
-01
MIMAT000
2845
hsa
-miR
-526a+hsa
-miR
-518c
-
5p+hsa
-miR
-518d
-5p 9.94E
-01 7.08E
-01 1.03E+00 4.04E
-01 5.01E
-01
MIMAT000
2835 hsa
-miR
-526b
-5p 9.47E
-01 4.20E
-02 9.77E
-01 6.74E
-01 7.71E
-01
MIMAT000
4780 hsa
-miR
-532
-3p 1.03E+00 1.52E
-01 9.67E
-01 4.85E
-01 3.18E
-01
MIMAT000
3389 hsa
-miR
-542
-3p 9.91E
-01 6.65E
-01 1.08E+00 9.41E
-02 2.67E
-02
MIMAT000
3340 hsa
-miR
-542
-5p 9.93E
-01 9.24E
-01 7.29E
-01 1.06E
-01 5.41E
-01
MIMAT000
4954 hsa
-miR
-543 1.00E+00 7.81E
-01 1.00E+00 9.91E
-01 7.97E
-01
MIMAT000
4803 hsa
-miR
-548a
-5p 1.02E+00 2.77E
-01 9.93E
-01 8.45E
-01 8.92E
-01
MIMAT001
8447 hsa
-miR
-548aa+hsa
-miR
-548t
-3p 9.73E
-01 3.91E
-01 1.11E+00 1.63E
-01 3.71E
-01
MIMAT001
8972 hsa
-miR
-548ah
-5p 9.97E
-01 8.64E
-01 1.01E+00 8.24E
-01 8.26E
-01

148
MIMAT001
9013 hsa
-miR
-548ak 8.65E
-01 9.69E
-02 1.20E+00 3.32E
-01 1.60E
-01
MIMAT002
2266 hsa
-miR
-548ar
-3p 9.91E
-01 4.88E
-01 9.89E
-01 7.25E
-01 9.70E
-01
MIMAT002
2265 hsa
-miR
-548ar
-5p 9.93E
-01 5.07E
-01 1.02E+00 4.86E
-01 5.69E
-01
MIMAT000
4812 hsa
-miR
-548d
-5p 1.02E+00 8.47E
-01 8.09E
-01 3.55E
-01 5.47E
-01
MIMAT002
6736 hsa
-miR
-548e
-5p 9.97E
-01 7.07E
-01 9.94E
-01 7.23E
-01 9.89E
-01
MIMAT000
5912 hsa
-miR
-548g
-3p 1.01E+00 6.62E
-01 9.73E
-01 3.39E
-01 3.30E
-01
MIMAT000
5935 hsa
-miR
-548i 1.01E+00 8.61E
-01 1.06E+00 7.54E
-01 7.58E
-01
MIMAT002
6737 hsa
-miR
-548j
-3p 9.50E
-01 4.84E
-01 9.93E
-01 9.70E
-01 6.39E
-01
MIMAT000
5882 hsa
-miR
-548k 9.77E
-01 5.59E
-01 9.01E
-01 2.74E
-01 9.41E
-01
MIMAT000
5917 hsa
-miR
-548m 1.02E+00 4.37E
-01 9.34E
-01 2.64E
-01 3.28E
-01
MIMAT000
5916 hsa
-miR
-548n 9.95E
-01 9.37E
-01 1.01E+00 9.07E
-01 8.83E
-01
MIMAT001
1163 hsa
-miR
-548q 1.05E+00 5.48E
-01 1.23E+00 1.82E
-01 5.13E
-01
MIMAT001
5020 hsa
-miR
-548v 1.07E+00 1.09E
-02 1.01E+00 8.48E
-01 6.54E
-01
MIMAT001
8354 hsa
-miR
-548y 9.27E
-01 7.94E
-03 9.85E
-01 8.15E
-01 8.11E
-01
MIMAT001
8446 hsa
-miR
-548z+hsa
-miR
-548h
-3p 9.64E
-01 5.95E
-01 9.29E
-01 6.50E
-01 6.45E
-01
MIMAT000
3333 hsa
-miR
-549a 9.71E
-01 6.17E
-01 1.00E+00 9.94E
-01 9.44E
-01
MIMAT000
3233 hsa
-miR
-551b
-3p 9.85E
-01 3.63E
-01 1.05E+00 6.99E
-02 4.67E
-02
MIMAT000
3215 hsa
-miR
-552
-3p 1.06E+00 2.52E
-01 9.67E
-01 7.64E
-01 5.01E
-01
MIMAT000
3219 hsa
-miR
-555 1.03E+00 6.51E
-01 9.88E
-01 9.21E
-01 7.45E
-01
MIMAT000
4793 hsa
-miR
-556
-3p 1.04E+00 4.53E
-01 1.11E+00 3.81E
-01 9.86E
-01
MIMAT000
3220 hsa
-miR
-556
-5p 9.80E
-01 6.78E
-01 9.25E
-01 4.73E
-01 5.32E
-01
MIMAT002
2706 hsa
-miR
-561
-5p 8.63E
-01 7.60E
-02 7.93E
-01 2.01E
-01 6.81E
-01

149
MIMAT000
3227 hsa
-miR
-563 1.02E+00 1.85E
-01 9.51E
-01 1.79E
-01 1.40E
-01
MIMAT000
3228 hsa
-miR
-564 9.46E
-01 2.15E
-01 1.10E+00 2.56E
-01 1.01E
-01
MIMAT000
3230 hsa
-miR
-566 8.65E
-01 4.63E
-02 9.99E
-01 9.95E
-01 4.03E
-01
MIMAT000
3235 hsa
-miR
-570
-3p 9.43E
-01 1.84E
-01 1.07E+00 5.05E
-01 2.80E
-01
MIMAT000
3237 hsa
-miR
-572 1.02E+00 5.14E
-01 1.01E+00 9.16E
-01 9.36E
-01
MIMAT000
3239 hsa
-miR
-574
-3p 9.92E
-01 9.11E
-01 6.51E
-01 6.95E
-03 3.28E
-02
MIMAT000
4795 hsa
-miR
-574
-5p 9.92E
-01 6.70E
-01 9.51E
-01 2.55E
-01 3.97E
-01
MIMAT000
3240 hsa
-miR
-575 9.45E
-01 5.80E
-02 8.92E
-01 1.24E
-01 5.15E
-01
MIMAT000
4796 hsa
-miR
-576
-3p 1.01E+00 6.99E
-01 9.40E
-01 3.29E
-01 6.58E
-01
MIMAT000
3241 hsa
-miR
-576
-5p 9.52E
-01 4.24E
-01 1.15E+00 2.55E
-01 1.10E
-01
MIMAT000
3242 hsa
-miR
-577 9.65E
-01 5.91E
-01 1.18E+00 2.94E
-01 4.35E
-01
MIMAT002
6616 hsa
-miR
-579
-5p 9.79E
-01 3.47E
-01 9.41E
-01 3.29E
-01 4.05E
-01
MIMAT000
4797 hsa
-miR
-582
-3p 9.56E
-01 3.71E
-01 9.76E
-01 8.11E
-01 8.16E
-01
MIMAT000
3247 hsa
-miR
-582
-5p 9.89E
-01 3.08E
-01 1.00E+00 9.20E
-01 5.61E
-01
MIMAT002
2708 hsa
-miR
-584
-3p 9.87E
-01 1.76E
-01 9.86E
-01 5.53E
-01 8.50E
-01
MIMAT000
3249 hsa
-miR
-584
-5p 9.87E
-01 5.53E
-01 1.00E+00 9.62E
-01 8.48E
-01
MIMAT000
3250 hsa
-miR
-585
-3p 1.01E+00 2.80E
-01 9.84E
-01 5.41E
-01 2.41E
-01
MIMAT000
3253 hsa
-miR
-587 1.00E+00 9.62E
-01 9.69E
-01 6.63E
-01 9.15E
-01
MIMAT000
3258 hsa
-miR
-590
-5p 1.01E+00 7.70E
-01 6.26E
-01 8.73E
-03 1.66E
-02
MIMAT000
3259 hsa
-miR
-591 9.72E
-01 6.31E
-01 1.27E+00 6.79E
-02 1.50E
-02
MIMAT000
3260 hsa
-miR
-592 1.00E+00 9.68E
-01 9.68E
-01 8.48E
-01 9.99E
-01
MIMAT000
4802 hsa
-miR
-593
-3p 1.01E+00 8.97E
-01 1.19E+00 1.31E
-01 2.06E
-01

150
MIMAT000
3263 hsa
-miR
-595 9.88E
-01 8.79E
-01 1.04E+00 8.12E
-01 9.91E
-01
MIMAT000
3265 hsa
-miR
-597
-5p 9.99E
-01 9.63E
-01 1.01E+00 8.54E
-01 6.16E
-01
MIMAT000
3266 hsa
-miR
-598
-3p 9.83E
-01 1.02E
-01 9.90E
-01 7.28E
-01 8.46E
-01
MIMAT000
3271 hsa
-miR
-603 1.05E+00 3.26E
-01 1.05E+00 6.39E
-01 7.38E
-01
MIMAT000
3273 hsa
-miR
-605
-5p 9.83E
-01 7.16E
-01 7.86E
-01 7.92E
-02 1.16E
-01
MIMAT000
3275 hsa
-miR
-607 9.98E
-01 7.95E
-01 9.66E
-01 1.83E
-01 2.42E
-01
MIMAT000
3276 hsa
-miR
-608 9.79E
-01 3.31E
-01 9.41E
-01 2.59E
-01 3.47E
-01
MIMAT000
3280 hsa
-miR
-612 9.87E
-01 2.86E
-01 1.00E+00 9.77E
-01 5.28E
-01
MIMAT000
3283 hsa
-miR
-615
-3p 9.84E
-01 2.02E
-01 1.03E+00 2.77E
-01 1.27E
-01
MIMAT000
4805 hsa
-miR
-616
-3p 1.02E+00 7.74E
-01 9.41E
-01 7.40E
-01 6.74E
-01
MIMAT000
3289 hsa
-miR
-620 9.71E
-01 6.77E
-01 7.32E
-01 1.12E
-01 1.31E
-01
MIMAT000
3295 hsa
-miR
-626 1.00E+00 9.11E
-01 9.30E
-01 1.16E
-01 2.49E
-01
MIMAT002
6623 hsa
-miR
-627
-3p 9.93E
-01 7.35E
-01 9.83E
-01 6.78E
-01 9.27E
-01
MIMAT000
3296 hsa
-miR
-627
-5p 1.03E+00 8.63E
-02 1.06E+00 1.53E
-01 5.07E
-01
MIMAT000
3297 hsa
-miR
-628
-3p 9.98E
-01 9.76E
-01 1.10E+00 4.55E
-01 4.03E
-01
MIMAT000
3299 hsa
-miR
-630 9.92E
-01 8.94E
-01 5.57E
-01 6.54E
-03 1.53E
-02
MIMAT000
3300 hsa
-miR
-631 9.34E
-01 3.48E
-01 1.97E+00 6.92E
-06 1.16E
-04
MIMAT000
3309 hsa
-miR
-639 1.01E+00 7.48E
-01 1.00E+00 9.48E
-01 9.84E
-01
MIMAT000
3310 hsa
-miR
-640 9.11E
-01 8.34E
-02 1.16E+00 2.61E
-01 1.70E
-01
MIMAT000
3312 hsa
-miR
-642a
-5p 9.88E
-01 6.44E
-01 1.01E+00 9.08E
-01 3.89E
-01
MIMAT000
3313 hsa
-miR
-643 1.05E+00 6.12E
-01 7.61E
-01 1.47E
-01 2.84E
-01
MIMAT000
3314 hsa
-miR
-644a 1.02E+00 8.32E
-01 8.67E
-01 3.15E
-01 5.17E
-01

151
MIMAT000
3319 hsa
-miR
-649 1.03E+00 6.61E
-01 1.09E+00 5.76E
-01 7.23E
-01
MIMAT000
3320 hsa
-miR
-650 9.86E
-01 5.49E
-01 1.05E+00 3.17E
-01 2.99E
-01
MIMAT002
5462 hsa
-miR
-6503
-5p 1.02E+00 5.45E
-01 1.02E+00 7.73E
-01 8.17E
-01
MIMAT000
3321 hsa
-miR
-651
-5p 1.01E+00 8.37E
-01 9.99E
-01 9.93E
-01 7.38E
-01
MIMAT002
2709 hsa
-miR
-652
-5p 9.70E
-01 6.08E
-01 1.12E+00 3.52E
-01 4.34E
-01
MIMAT000
3330 hsa
-miR
-654
-5p 1.10E+00 1.26E
-01 9.45E
-01 7.53E
-01 3.78E
-01
MIMAT000
3331 hsa
-miR
-655
-3p 9.88E
-01 8.14E
-01 8.44E
-01 9.74E
-02 2.38E
-01
MIMAT000
3332 hsa
-miR
-656
-3p 1.02E+00 1.40E
-01 1.01E+00 7.89E
-01 9.26E
-01
MIMAT002
2711 hsa
-miR
-660
-3p 1.01E+00 7.57E
-01 1.03E+00 6.61E
-01 3.33E
-01
MIMAT000
3326 hsa
-miR
-663a 1.07E+00 3.42E
-01 1.00E+00 9.88E
-01 7.20E
-01
MIMAT000
5949 hsa
-miR
-664a
-3p 9.73E
-01 1.78E
-01 9.56E
-01 2.93E
-01 8.31E
-01
MIMAT002
2272 hsa
-miR
-664b
-3p 9.06E
-01 2.47E
-01 1.03E+00 8.49E
-01 7.09E
-01
MIMAT000
4952 hsa
-miR
-665 9.96E
-01 9.46E
-01 1.09E+00 5.01E
-01 2.79E
-01
MIMAT000
3880 hsa
-miR
-671
-5p 8.73E
-01 1.63E
-01 1.12E+00 4.88E
-01 6.84E
-02
MIMAT002
5851 hsa
-miR
-6720
-3p 1.04E+00 1.79E
-01 9.98E
-01 9.72E
-01 5.01E
-01
MIMAT002
5852 hsa
-miR
-6721
-5p 9.49E
-01 2.29E
-01 1.07E+00 4.58E
-01 2.67E
-01
MIMAT002
5856 hsa
-miR
-6724
-5p 9.97E
-01 9.53E
-01 1.08E+00 4.40E
-01 6.86E
-01
MIMAT000
4945 hsa
-miR
-744
-5p 8.12E
-01 5.52E
-02 7.15E
-01 1.60E
-01 7.53E
-01
MIMAT002
2929 hsa
-miR
-758
-5p 9.16E
-01 2.25E
-01 9.29E
-01 5.87E
-01 9.92E
-01
MIMAT001
0364 hsa
-miR
-761 9.53E
-01 3.17E
-01 1.09E+00 4.55E
-01 2.01E
-01
MIMAT001
0367 hsa
-miR
-764 9.85E
-01 3.51E
-01 1.01E+00 7.78E
-01 5.17E
-01
MIMAT000
3945 hsa
-miR
-765 9.99E
-01 9.36E
-01 1.01E+00 7.56E
-01 9.69E
-01

152
MIMAT000
3882 hsa
-miR
-767
-5p 9.79E
-01 4.67E
-02 1.00E+00 8.36E
-01 3.04E
-01
MIMAT000
3887 hsa
-miR
-769
-3p 1.01E+00 6.91E
-01 9.92E
-01 9.10E
-01 8.29E
-01
MIMAT000
3886 hsa
-miR
-769
-5p 1.00E+00 8.47E
-01 1.02E+00 7.36E
-01 9.82E
-01
MIMAT000
3948 hsa
-miR
-770
-5p 9.29E
-01 2.15E
-01 1.07E+00 5.96E
-01 4.50E
-01
MIMAT000
4185 hsa
-miR
-802 9.80E
-01 1.56E
-01 1.01E+00 8.02E
-01 4.73E
-01
MIMAT002
2717 hsa
-miR
-873
-3p 9.92E
-01 6.58E
-01 9.26E
-01 1.03E
-01 9.53E
-02
MIMAT000
4953 hsa
-miR
-873
-5p 9.13E
-01 3.37E
-01 1.01E+00 9.48E
-01 5.67E
-01
MIMAT002
6718 hsa
-miR
-874
-5p 9.01E
-01 2.70E
-01 1.16E+00 3.69E
-01 1.40E
-01
MIMAT000
4925 hsa
-miR
-876
-3p 1.06E+00 3.46E
-01 1.02E+00 8.91E
-01 7.25E
-01
MIMAT000
4924 hsa
-miR
-876
-5p 9.89E
-01 7.11E
-01 1.01E+00 8.51E
-01 4.73E
-01
MIMAT000
4949 hsa
-miR
-877
-5p 9.93E
-01 8.95E
-01 1.03E+00 8.06E
-01 9.15E
-01
MIMAT000
4948 hsa
-miR
-885
-3p 1.04E+00 5.49E
-01 9.71E
-01 8.73E
-01 9.18E
-01
MIMAT002
6720 hsa
-miR
-887
-5p 1.00E+00 9.89E
-01 1.03E+00 3.21E
-01 3.95E
-01
MIMAT000
4916 hsa
-miR
-888
-5p 9.83E
-01 6.70E
-02 9.80E
-01 2.98E
-01 9.27E
-01
MIMAT000
4921 hsa
-miR
-889
-3p 9.65E
-01 2.77E
-01 9.96E
-01 9.52E
-01 5.32E
-01
MIMAT000
4912 hsa
-miR
-890 1.01E+00 8.10E
-01 1.04E+00 7.80E
-01 9.33E
-01
MIMAT000
4902 hsa
-miR
-891a
-5p 1.01E+00 5.61E
-01 9.60E
-01 3.56E
-01 5.18E
-01
MIMAT000
4913 hsa
-miR
-891b 1.01E+00 6.19E
-01 9.43E
-01 7.41E
-02 1.21E
-01
MIMAT000
4907 hsa
-miR
-892a 9.70E
-01 4.34E
-01 8.79E
-01 1.87E
-01 4.71E
-01
MIMAT000
4972 hsa
-miR
-922 1.01E+00 4.19E
-01 9.82E
-01 4.99E
-01 5.39E
-01
MIMAT000
4507 hsa
-miR
-92a
-
1
-5p 8.66E
-01 8.17E
-02 1.09E+00 6.04E
-01 2.77E
-01
MIMAT000
0092 hsa
-miR
-92a
-3p 9.98E
-01 9.81E
-01 1.06E+00 7.55E
-01 6.72E
-01

153
MIMAT000
3218 hsa
-miR
-92b
-3p 8.78E
-01 6.06E
-02 1.22E+00 5.82E
-02 1.91E
-02
MIMAT000
0093 hsa
-miR
-93
-5p 1.02E+00 6.88E
-01 9.11E
-01 4.58E
-01 4.34E
-01
MIMAT000
4976 hsa
-miR
-933 9.95E
-01 7.55E
-01 1.02E+00 6.52E
-01 5.93E
-01
MIMAT000
4977 hsa
-miR
-934 9.58E
-01 4.86E
-01 9.24E
-01 5.05E
-01 8.49E
-01
MIMAT000
4978 hsa
-miR
-935 9.40E
-01 4.67E
-01 1.04E+00 7.93E
-01 1.22E
-01
MIMAT000
4979 hsa
-miR
-936 1.03E+00 3.86E
-01 1.11E+00 1.04E
-01 2.97E
-01
MIMAT000
4980 hsa
-miR
-937
-3p 9.48E
-01 1.80E
-01 9.50E
-01 5.22E
-01 9.15E
-01
MIMAT000
4982 hsa
-miR
-939
-5p 1.03E+00 2.66E
-02 9.80E
-01 4.85E
-01 3.06E
-01
MIMAT000
4983 hsa
-miR
-940 9.18E
-01 2.72E
-01 1.05E+00 7.54E
-01 5.39E
-01
MIMAT000
4984 hsa
-miR
-941 1.05E+00 3.02E
-01 1.07E+00 5.16E
-01 6.43E
-01
MIMAT000
4985 hsa
-miR
-942
-5p 1.00E+00 7.98E
-01 1.00E+00 9.86E
-01 9.59E
-01
MIMAT000
0094 hsa
-miR
-95
-3p 9.78E
-01 7.50E
-02 9.69E
-01 2.03E
-01 8.59E
-01
MIMAT000
0095 hsa
-miR
-96
-5p 9.81E
-01 5.24E
-01 8.96E
-01 1.30E
-01 3.21E
-01
MIMAT000
0689 hsa
-miR
-99b
-5p 9.69E
-01 7.17E
-01 9.22E
-01 6.20E
-01 7.89E
-01

154
Appendix I. Heterogeneity by race/ethnicity for the association of alcohol intake (continuous per drink) and circulating microRNA adjusted for age at
biospecimen draw, sex, body mass index (kg/m2), smoking status, batch, time in years between baseline questionnaire and biospecimen draw, and casecontrol status.
Accession miRNA
African
American/
Black IRR
ethanol
intake per
drink
African
American/
Black
nominal pvalue
Japanese
America
n IRR
ethanol
intake
per drink
Japanese
America
n
nominal
p-value
Latino
IRR
ethanol
intake
per
drink
Latino
nomina
l pvalue
Native
Hawaiia
n IRR
ethanol
intake
per drink
Native
Hawaiia
n
nominal
p-value
White
IRR
ethanol
intake
per drink
White
nomina
l pvalue
p for
heterogeneit
y
MIMAT000006
2
hsa-let-7a5p 9.76E-01 8.29E-01 7.71E-01 1.58E-01 8.46E-01
3.14E01 8.10E-01 2.66E-01 1.06E+00
6.40E01 7.13E-01
MIMAT000006
3
hsa-let-7b5p 1.00E+00 9.83E-01 9.31E-01 1.83E-01 9.69E-01
3.12E01 9.75E-01 6.32E-01 9.72E-01
3.89E01 9.73E-01
MIMAT000006
4
hsa-let-7c5p 9.49E-01 6.17E-01 9.83E-01 8.86E-01 8.46E-01
2.13E01 6.25E-01 2.26E-02 1.01E+00
9.09E01 3.30E-01
MIMAT000006
5
hsa-let-7d5p 9.43E-01 5.10E-01 1.01E+00 9.21E-01
1.06E+0
0
4.76E01 7.67E-01 1.13E-01 9.18E-01
3.82E01 8.54E-01
MIMAT000006
7
hsa-let-7f5p 9.43E-01 5.11E-01 1.09E+00 5.13E-01
1.00E+0
0
9.84E01 4.00E-01 2.85E-03 1.13E+00
2.60E01 1.20E-01
MIMAT000041
4
hsa-let-7g5p 1.01E+00 9.36E-01 9.46E-01 5.97E-01
1.02E+0
0
7.97E01 9.83E-01 8.72E-01 1.06E+00
5.25E01 5.96E-01
MIMAT000009
8
hsa-miR100-5p 1.08E+00 5.46E-01 1.12E+00 5.46E-01 NULL NULL 4.52E-01 4.06E-02 9.06E-01
5.40E01 4.94E-01
MIMAT000010
2
hsa-miR105-5p 1.02E+00 7.66E-01 1.01E+00 8.68E-01
1.05E+0
0
4.10E01 8.48E-01 1.12E-01 1.10E+00
9.88E02 1.44E-01
MIMAT000068
0
hsa-miR106b-5p 1.03E+00 6.94E-01 9.83E-01 8.59E-01
1.00E+0
0
9.91E01 7.78E-01 5.60E-02 1.09E+00
2.50E01 7.06E-01
MIMAT000010
4
hsa-miR107 9.77E-01 6.20E-01 9.73E-01 7.11E-01 9.84E-01
8.33E01 1.03E+00 8.09E-01 1.00E+00
9.92E01 6.22E-01
MIMAT000025
3
hsa-miR10a-5p 9.45E-01 8.33E-03 9.69E-01 3.54E-01 9.89E-01
6.34E01 9.34E-01 3.69E-02 1.03E+00
1.82E01 1.47E-01
MIMAT000025
4
hsa-miR10b-5p 1.03E+00 6.09E-01 7.13E-01 7.99E-04
1.02E+0
0
7.52E01 1.09E+00 4.03E-01 9.31E-01
2.70E01 4.88E-02
MIMAT000582
5
hsa-miR1180-3p 9.96E-01 8.70E-01 9.79E-01 6.46E-01
1.01E+0
0
7.89E01 9.16E-01 9.09E-02 9.88E-01
7.57E01 5.74E-01
MIMAT000582
8
hsa-miR1183 9.75E-01 6.31E-01 1.01E+00 8.95E-01
1.01E+0
0
8.84E01 9.36E-01 5.13E-01 9.69E-01
5.68E01 8.79E-01
MIMAT002283
8
hsa-miR1185-1-3p 9.11E-01 4.51E-01 9.74E-01 8.48E-01 9.52E-01
7.17E01 1.05E+00 8.00E-01 1.02E+00
8.74E01 4.66E-01
MIMAT002271
3
hsa-miR1185-2-3p 1.00E+00 9.86E-01 8.09E-01 1.69E-01 9.24E-01
1.78E01 9.62E-01 6.68E-01 1.08E+00
4.01E01 6.34E-01
MIMAT000579
8
hsa-miR1185-5p 1.00E+00 9.84E-01 1.03E+00 3.86E-01 9.94E-01
7.66E01 1.01E+00 7.33E-01 1.01E+00
7.63E01 5.87E-01

155
MIMAT001504
9
hsa-miR1193 9.20E-01 9.80E-02 1.02E+00 7.47E-01 9.64E-01
4.41E01 8.77E-01 1.17E-01 9.04E-01
8.62E02 7.48E-01
MIMAT000595
5
hsa-miR1197 9.82E-01 5.50E-01 9.58E-01 4.37E-01 9.78E-01
6.06E01 1.10E+00 1.89E-01 9.97E-01
9.40E01 7.46E-01
MIMAT000586
3
hsa-miR1200 8.29E-01 2.26E-01 1.07E+00 7.15E-01 8.93E-01
4.49E01 9.86E-01 9.47E-01 1.16E+00
3.99E01 7.78E-01
MIMAT000586
5
hsa-miR1202 7.69E-01 4.94E-02 1.07E+00 6.12E-01
1.06E+0
0
5.01E01 8.89E-01 4.13E-01 1.05E+00
6.41E01 6.28E-01
MIMAT000586
6
hsa-miR1203 7.98E-01 3.95E-01 1.24E+00 3.14E-01 9.00E-01
4.60E01 1.40E+00 1.23E-01 8.78E-01
4.33E01 8.12E-01
MIMAT000586
9
hsa-miR1205 9.76E-01 6.59E-01 1.03E+00 7.42E-01 9.51E-01
5.01E01 9.48E-01 5.70E-01 1.01E+00
7.75E01 3.90E-01
MIMAT000587
0
hsa-miR1206 9.97E-01 9.06E-01 1.02E+00 5.24E-01 9.40E-01
1.00E01 9.53E-01 4.67E-01 9.86E-01
6.01E01 5.65E-01
MIMAT000042
1
hsa-miR122-5p 9.84E-01 5.88E-01 1.00E+00 9.23E-01
1.03E+0
0
4.42E01 9.43E-01 4.09E-01 9.79E-01
5.68E01 7.18E-01
MIMAT000545
9
hsa-miR1224-3p 9.17E-01 1.63E-01 1.04E+00 6.30E-01 9.81E-01
8.22E01 9.67E-01 7.54E-01 9.29E-01
1.77E01 9.48E-01
MIMAT000557
7
hsa-miR1226-3p 9.74E-01 7.66E-01 1.06E+00 6.76E-01 6.80E-01
3.42E02 9.32E-01 7.18E-01 1.07E+00
5.53E01 2.98E-01
MIMAT000558
3
hsa-miR1228-3p 9.47E-01 6.95E-01 7.58E-01 1.28E-01
1.04E+0
0
8.43E01 9.20E-01 7.38E-01 1.05E+00
6.99E01 5.60E-02
MIMAT000558
9
hsa-miR1234-3p 9.67E-01 2.39E-01 1.03E+00 5.79E-01 9.31E-01
1.21E01 1.01E+00 9.11E-01 9.78E-01
5.00E01 5.74E-01
MIMAT000559
1
hsa-miR1236-3p 1.05E+00 4.19E-01 9.73E-01 7.79E-01
1.04E+0
0
7.07E01 1.07E+00 6.28E-01 9.69E-01
7.07E01 8.89E-01
MIMAT000589
6
hsa-miR1244 9.84E-01 4.61E-01 9.64E-01 3.63E-01
1.01E+0
0
7.71E01 9.51E-01 3.41E-01 9.93E-01
8.05E01 1.97E-01
MIMAT000589
7
hsa-miR1245a 9.67E-01 2.28E-01 1.01E+00 8.35E-01 9.44E-01
1.63E01 9.34E-01 3.31E-01 1.02E+00
4.89E01 5.27E-02
MIMAT001995
0
hsa-miR1245b-5p 9.44E-01 2.39E-01 1.03E+00 6.63E-01 9.90E-01
8.50E01 9.37E-01 5.76E-01 1.03E+00
5.97E01 9.15E-02
MIMAT000589
8
hsa-miR1246 1.10E+00 3.72E-01 9.37E-01 6.90E-01 9.49E-01
7.51E01 1.23E+00 1.88E-01 8.60E-01
2.55E01 8.16E-01
MIMAT000590
1
hsa-miR1249-3p 9.27E-01 2.65E-01 8.90E-01 2.38E-01 9.92E-01
9.19E01 8.51E-01 2.15E-01 9.67E-01
6.26E01 9.09E-01
MIMAT000590
4
hsa-miR1253 8.82E-01 5.64E-01 7.15E-01 1.99E-01 9.48E-01
5.71E01 9.03E-01 5.17E-01 7.68E-01
1.31E01 5.37E-01
MIMAT000590
5
hsa-miR1254 9.67E-01 1.73E-01 9.56E-01 2.47E-01
1.03E+0
0
2.22E01 9.63E-01 4.92E-01 9.95E-01
8.60E01 1.00E+00
MIMAT000590
6
hsa-miR1255a 1.13E+00 2.23E-01 8.54E-01 3.37E-01
1.27E+0
0
2.09E02 9.20E-01 6.38E-01 7.02E-01
1.42E02 6.07E-02
MIMAT000590
8
hsa-miR1257 1.01E+00 9.66E-01 1.35E+00 1.31E-01
1.18E+0
0
2.05E01 5.50E-01 2.28E-01 1.23E+00
2.56E01 2.02E-01

156
MIMAT000590
9
hsa-miR1258 9.78E-01 2.18E-01 9.82E-01 5.61E-01
1.01E+0
0
7.07E01 9.29E-01 3.35E-02 1.01E+00
6.68E01 6.94E-01
MIMAT000460
2
hsa-miR125a-3p 1.02E+00 7.60E-01 9.06E-01 3.62E-01
1.01E+0
0
8.51E01 9.56E-01 6.44E-01 9.16E-01
2.85E01 3.28E-01
MIMAT000042
3
hsa-miR125b-5p 9.91E-01 6.88E-01 9.98E-01 9.50E-01 9.46E-01
1.26E01 1.04E+00 5.80E-01 9.86E-01
6.31E01 4.08E-01
MIMAT000044
5
hsa-miR126-3p 9.94E-01 8.04E-01 1.02E+00 5.45E-01 9.29E-01
7.31E02 1.02E+00 7.37E-01 1.06E+00
6.63E02 8.45E-01
MIMAT000591
3
hsa-miR1261 9.46E-01 5.28E-01 8.17E-01 1.03E-01 9.66E-01
6.17E01 9.80E-01 8.19E-01 9.61E-01
6.59E01 5.93E-01
MIMAT000591
4
hsa-miR1262 1.10E+00 3.03E-01 9.04E-01 4.17E-01 9.62E-01
5.24E01 9.65E-01 7.51E-01 8.97E-01
2.89E01 3.69E-01
MIMAT000579
1
hsa-miR1264 8.43E-01 2.91E-01 1.07E+00 7.13E-01 9.81E-01
9.09E01 5.91E-01 8.89E-02 1.24E+00
1.46E01 3.87E-01
MIMAT000592
0
hsa-miR1266-5p 9.99E-01 9.82E-01 9.68E-01 7.31E-01
1.02E+0
0
7.59E01 7.96E-01 6.78E-02 1.05E+00
4.23E01 9.47E-02
MIMAT000592
2
hsa-miR1268a 8.90E-01 3.20E-01 1.19E+00 2.45E-01 8.57E-01
2.67E01 1.18E+00 3.77E-01 8.87E-01
2.37E01 3.37E-01
MIMAT001892
5
hsa-miR1268b 1.02E+00 1.71E-01 9.85E-01 5.85E-01 9.45E-01
3.04E02 1.01E+00 8.73E-01 9.86E-01
4.84E01 6.74E-02
MIMAT000592
3
hsa-miR1269a 9.14E-01 2.12E-01 1.01E+00 9.38E-01
1.06E+0
0
2.98E01 9.29E-01 4.02E-01 9.72E-01
6.63E01 4.51E-02
MIMAT000044
6
hsa-miR127-3p 9.80E-01 2.70E-01 1.03E+00 4.04E-01
1.02E+0
0
3.99E01 9.77E-01 4.89E-01 9.92E-01
6.81E01 7.71E-01
MIMAT000460
4
hsa-miR127-5p 8.55E-01 4.13E-01 1.27E+00 1.68E-01 5.75E-01
5.11E04 7.00E-01 2.32E-01 1.31E+00
6.31E02 2.15E-01
MIMAT000592
4
hsa-miR1270 8.39E-01 3.36E-01 8.06E-01 3.00E-01 4.75E-01
4.86E02 4.25E-01 9.44E-02 1.05E+00
8.15E01 5.09E-01
MIMAT000579
6
hsa-miR1271-5p 7.20E-01 2.43E-01 8.13E-01 3.99E-01
1.01E+0
0
9.20E01 9.94E-01 9.83E-01 1.03E+00
8.75E01 9.51E-01
MIMAT000592
5
hsa-miR1272 9.57E-01 4.87E-01 9.42E-01 4.81E-01 9.31E-01
3.13E01 9.40E-01 5.48E-01 9.47E-01
4.26E01 9.60E-01
MIMAT000593
3
hsa-miR1277-3p 1.07E+00 6.58E-01 9.19E-01 6.67E-01
1.01E+0
0
9.45E01 1.49E+00 2.21E-01 1.08E+00
4.96E01 8.51E-01
MIMAT000593
6
hsa-miR1278 6.52E-01 1.22E-01 9.60E-01 8.22E-01 9.82E-01
8.97E01 1.28E+00 2.54E-01 9.53E-01
7.28E01 9.10E-01
MIMAT000593
7
hsa-miR1279 1.01E+00 9.00E-01 9.28E-01 2.70E-01 9.85E-01
7.24E01 1.04E+00 5.49E-01 9.64E-01
5.13E01 2.42E-01
MIMAT000042
4
hsa-miR128-3p 7.01E-01 2.90E-02 1.17E+00 2.30E-01 8.89E-01
3.26E01 9.92E-01 9.52E-01 1.05E+00
6.25E01 3.78E-01
MIMAT000593
9
hsa-miR1281 9.46E-01 6.96E-01 8.87E-01 5.95E-01 9.34E-01
7.47E01 5.01E-01 1.47E-01 1.14E+00
4.22E01 8.59E-01
MIMAT000587
6
hsa-miR1285-3p 8.77E-01 5.79E-01 1.02E+00 9.34E-01 8.48E-01
5.80E01 6.15E-01 6.90E-02 9.54E-01
7.82E01 6.47E-01

157
MIMAT002271
9
hsa-miR1285-5p 1.04E+00 1.91E-01 1.01E+00 7.68E-01 9.19E-01
4.87E03 1.01E+00 8.41E-01 9.90E-01
7.19E01 7.04E-01
MIMAT000587
7
hsa-miR1286 9.76E-01 5.95E-01 9.65E-01 6.07E-01 9.76E-01
6.46E01 8.81E-01 1.90E-01 9.71E-01
6.04E01 1.37E-01
MIMAT000587
8
hsa-miR1287-5p 8.90E-01 1.36E-01 9.27E-01 4.31E-01 8.69E-01
6.98E02 8.81E-01 1.88E-01 1.00E+00
9.63E01 9.95E-01
MIMAT000460
5
hsa-miR129-2-3p 1.01E+00 8.91E-01 1.13E+00 3.28E-01
1.06E+0
0
4.21E01 9.74E-01 8.69E-01 9.85E-01
8.68E01 6.16E-01
MIMAT000588
0
hsa-miR1290 1.02E+00 7.62E-01 1.02E+00 8.38E-01 8.29E-01
5.28E02 1.13E+00 1.96E-01 1.03E+00
7.28E01 6.84E-01
MIMAT000588
3
hsa-miR1293 8.40E-01 4.38E-01 1.02E+00 9.01E-01
1.10E+0
0
3.23E01 8.18E-01 2.93E-01 9.79E-01
9.04E01 8.52E-01
MIMAT000588
5
hsa-miR1295a 9.68E-01 8.63E-01 1.11E+00 6.20E-01 8.00E-01
4.15E01 7.45E-01 3.64E-01 8.26E-01
4.37E01 2.21E-01
MIMAT002663
7
hsa-miR1296-3p 1.04E+00 7.44E-01 8.63E-01 4.16E-01 4.69E-01
7.70E03 1.05E+00 8.41E-01 8.72E-01
4.25E01 5.19E-01
MIMAT000588
6
hsa-miR1297 9.27E-01 1.47E-02 1.04E+00 3.81E-01 9.33E-01
1.02E01 9.70E-01 5.22E-01 9.82E-01
5.87E01 2.70E-01
MIMAT000580
0
hsa-miR1298-5p 9.95E-01 7.65E-01 9.75E-01 2.98E-01 9.65E-01
1.97E01 9.37E-01 8.54E-02 1.00E+00
8.11E01 7.27E-01
MIMAT000588
7
hsa-miR1299 9.00E-01 4.19E-01 1.11E+00 5.53E-01
1.03E+0
0
7.54E01 1.04E+00 7.99E-01 8.89E-01
3.10E01 3.31E-01
MIMAT000589
0
hsa-miR1302 1.04E+00 5.48E-01 1.07E+00 4.36E-01 8.22E-01
4.85E02 9.79E-01 8.02E-01 8.42E-01
1.23E02 3.68E-01
MIMAT002272
0
hsa-miR1304-3p 9.80E-01 2.55E-01 9.88E-01 6.30E-01 9.78E-01
3.70E01 9.83E-01 6.37E-01 9.91E-01
6.03E01 7.73E-01
MIMAT000589
2
hsa-miR1304-5p 9.67E-01 2.08E-01 1.00E+00 8.99E-01 9.83E-01
6.30E01 1.05E+00 4.16E-01 1.03E+00
1.95E01 5.85E-01
MIMAT000589
3
hsa-miR1305 1.15E+00 3.13E-01 8.77E-01 5.11E-01
1.04E+0
0
8.56E01 1.95E-01 5.75E-02 7.98E-01
2.12E01 8.69E-01
MIMAT000595
0
hsa-miR1306-3p 9.20E-01 2.28E-01 9.21E-01 3.67E-01 8.66E-01
1.72E01 9.81E-01 8.87E-01 9.95E-01
9.49E01 8.50E-01
MIMAT000595
1
hsa-miR1307-3p 1.02E+00 3.45E-01 1.01E+00 6.89E-01
1.05E+0
0
2.57E02 9.40E-01 1.64E-01 9.87E-01
6.36E01 7.65E-01
MIMAT002272
7
hsa-miR1307-5p 1.00E+00 9.91E-01 9.93E-01 9.25E-01 9.18E-01
3.02E01 9.66E-01 7.55E-01 1.00E+00
9.76E01 5.19E-01
MIMAT000042
5
hsa-miR130a-3p 9.43E-01 4.34E-01 8.95E-01 3.22E-01 8.12E-01
7.16E02 1.09E+00 5.29E-01 9.41E-01
4.05E01 2.11E-01
MIMAT000042
6
hsa-miR132-3p 1.01E+00 9.14E-01 9.76E-01 7.90E-01
1.10E+0
0
1.37E01 1.07E+00 4.78E-01 1.03E+00
6.97E01 1.11E-01
MIMAT000579
5
hsa-miR1323 9.89E-01 9.20E-01 7.01E-01 6.74E-02
1.01E+0
0
9.38E01 1.00E+00 9.74E-01 1.17E+00
2.15E01 4.21E-01
MIMAT000042
7
hsa-miR133a-3p 9.40E-01 1.76E-01 1.03E+00 6.38E-01 9.33E-01
3.44E01 1.10E+00 3.77E-01 9.75E-01
6.17E01 2.54E-01

158
MIMAT002647
8
hsa-miR133a-5p 9.35E-01 4.98E-01 9.13E-01 5.00E-01
1.12E+0
0
2.50E01 1.00E+00 9.80E-01 1.24E+00
3.54E02 9.22E-01
MIMAT002648
1
hsa-miR134-3p 9.81E-01 5.24E-01 1.03E+00 6.00E-01
1.01E+0
0
8.40E01 1.17E+00 5.88E-02 9.76E-01
4.91E01 3.25E-03
MIMAT000044
8
hsa-miR136-5p 9.44E-01 1.82E-01 1.07E+00 2.90E-01 8.56E-01
4.06E02 1.05E+00 6.47E-01 9.77E-01
6.01E01 4.13E-01
MIMAT000042
9
hsa-miR137 6.79E-01 9.57E-02 9.02E-01 4.72E-01 9.79E-01
8.30E01 1.01E+00 9.59E-01 1.18E+00
1.05E01 9.52E-01
MIMAT000043
0
hsa-miR138-5p 9.29E-01 2.66E-01 9.18E-01 3.66E-01
1.12E+0
0
7.00E02 8.64E-01 2.30E-01 1.01E+00
9.15E01 2.06E-01
MIMAT000455
2
hsa-miR139-3p 1.12E+00 2.62E-01 9.09E-01 5.22E-01
1.07E+0
0
4.32E01 1.01E+00 9.58E-01 1.02E+00
8.30E01 9.99E-01
MIMAT000459
7
hsa-miR140-3p 9.34E-01 1.36E-01 9.71E-01 7.15E-01 8.86E-01
9.72E03 1.19E+00 4.36E-03 1.07E+00
2.71E01 8.67E-01
MIMAT000043
1
hsa-miR140-5p 1.01E+00 6.54E-01 9.61E-01 1.39E-01 9.45E-01
5.83E02 9.93E-01 8.47E-01 1.01E+00
5.31E01 5.65E-01
MIMAT000043
2
hsa-miR141-3p 9.80E-01 8.28E-01 1.06E+00 6.36E-01 9.98E-01
9.88E01 9.15E-01 5.61E-01 9.52E-01
5.49E01 8.25E-01
MIMAT000043
4
hsa-miR142-3p 8.81E-01 8.74E-02 9.91E-01 9.31E-01 8.00E-01
6.26E02 1.09E+00 4.84E-01 8.49E-01
3.26E02 9.48E-01
MIMAT000043
5
hsa-miR143-3p 9.82E-01 6.07E-01 1.05E+00 2.47E-01
1.01E+0
0
7.67E01 9.78E-01 5.82E-01 9.38E-01
5.10E02 9.89E-01
MIMAT000044
9
hsa-miR146a-5p 9.71E-01 4.25E-01 9.99E-01 9.82E-01 9.91E-01
8.49E01 8.42E-01 7.11E-02 1.03E+00
5.99E01 7.55E-01
MIMAT000280
9
hsa-miR146b-5p 9.89E-01 5.44E-01 9.78E-01 4.80E-01
1.04E+0
0
5.00E02 9.82E-01 4.94E-01 9.68E-01
1.08E01 1.49E-01
MIMAT000025
1
hsa-miR147a 5.67E-01 7.42E-02 1.06E+00 8.12E-01 6.98E-01
1.27E01 1.10E+00 6.89E-01 1.07E+00
6.98E01 4.95E-01
MIMAT000492
8
hsa-miR147b 9.93E-01 8.18E-01 9.92E-01 8.51E-01 9.37E-01
1.49E01 9.57E-01 4.98E-01 9.70E-01
3.67E01 2.96E-01
MIMAT000024
3
hsa-miR148a-3p NULL NULL 8.12E-01 9.41E-02 9.56E-01
5.07E01 1.21E+00 6.20E-02 8.54E-01
1.19E01 2.17E-01
MIMAT000075
9
hsa-miR148b-3p 1.07E+00 3.02E-01 8.88E-01 1.46E-01 9.45E-01
3.69E01 9.11E-01 3.14E-01 1.04E+00
5.67E01 3.38E-02
MIMAT000045
0
hsa-miR149-5p 9.75E-01 4.18E-01 9.63E-01 3.90E-01 9.33E-01
1.34E01 9.50E-01 4.28E-01 1.01E+00
8.17E01 9.98E-01
MIMAT000045
1
hsa-miR150-5p 9.56E-01 6.12E-01 9.54E-01 6.82E-01 9.27E-01
4.01E01 8.27E-01 1.48E-01 1.15E+00
9.97E02 9.68E-01
MIMAT000075
7
hsa-miR151a-3p 1.15E+00 2.28E-01 1.13E+00 4.55E-01 7.61E-01
1.54E01 6.76E-01 1.62E-01 9.36E-01
5.76E01 7.43E-01
MIMAT000739
9
hsa-miR1537-3p 9.72E-01 4.94E-01 9.48E-01 4.27E-01 8.75E-01
2.35E02 1.00E+00 9.67E-01 9.58E-01
3.43E01 2.14E-01
MIMAT000064
6
hsa-miR155-5p 1.08E+00 3.38E-01 9.45E-01 5.99E-01 9.45E-01
4.43E01 9.93E-01 9.36E-01 9.88E-01
8.96E01 9.51E-01

159
MIMAT000041 7
hsa
-miR
-
15b
-5p 8.56E
-01 1.27E
-01 9.28E
-01 5.43E
-01
1.00E+00
9.73E
-
01 7.55E
-01 2.47E
-02 8.90E
-01
1.57E
-
01 8.22E
-01
MIMAT000006 9
hsa
-miR
-
16
-5p 9.77E
-01 7.07E
-01 1.00E+00 9.99E
-01 9.29E
-01
2.70E
-
01 1.01E+00 8.97E
-01 9.88E
-01
8.67E
-
01 1.93E
-01
MIMAT000455 8
hsa
-miR
-
181a
-
2
-3p 9.87E
-01 7.11E
-01 8.86E
-01 3.54E
-02 8.98E
-01
4.56E
-
02 1.00E+00 9.64E
-01 1.01E+00
8.58E
-
01 6.85E
-01
MIMAT000027 0
hsa
-miR
-
181a
-3p 9.16E
-01 5.48E
-01 1.02E+00 9.18E
-01 9.41E
-01
6.16E
-
01 8.93E
-01 4.17E
-01 1.03E+00
8.11E
-
01 4.04E
-01
MIMAT000025 6
hsa
-miR
-
181a
-5p 8.72E
-01 3.98E
-01 8.49E
-01 3.69E
-01
1.22E+00
2.57E
-
01 8.37E
-01 5.17E
-01 1.09E+00
5.43E
-
01 5.23E
-01
MIMAT003189 3
hsa
-miR
-
181b
-
2
-3p 9.23E
-01 2.19E
-01 1.05E+00 5.57E
-01 9.85E
-01
7.54E
-
01 9.34E
-01 2.89E
-01 9.37E
-01
2.99E
-
01 8.21E
-01
MIMAT000025 7
hsa
-miR
-
181b
-
5p+hsa
-
miR
-181d
-
5p 9.93E
-01 9.19E
-01 8.21E
-01 4.64E
-02
1.02E+00
7.20E
-
01 1.06E+00 4.93E
-01 9.59E
-01
5.66E
-
01 4.85E
-01
MIMAT000025 8
hsa
-miR
-
181c
-5p 1.00E+00 8.89E
-01 9.64E
-01 6.59E
-02 9.53E
-01
1.29E
-
01 1.04E+00 1.35E
-01 1.00E+00
8.74E
-
01 5.24E
-01
MIMAT002660 8
hsa
-miR
-
181d
-3p 1.22E+00 1.36E
-01 6.99E
-01 8.43E
-02
1.07E+00
6.28E
-
01 1.36E+00 7.67E
-02 9.28E
-01
5.98E
-
01 5.46E
-01
MIMAT000026 0
hsa
-miR
-
182
-3p 9.66E
-01 6.70E
-01 1.01E+00 9.65E
-01
1.04E+00
6.11E
-
01 9.70E
-01 7.85E
-01 9.43E
-01
5.57E
-
01 3.93E
-01
MIMAT000676 7
hsa
-miR
-
1827 1.02E+00 5.71E
-01 9.94E
-01 8.96E
-01
1.02E+00
5.39E
-
01 9.75E
-01 5.68E
-01 9.53E
-01
1.25E
-
01 5.80E
-01
MIMAT000026 1
hsa
-miR
-
183
-5p 9.92E
-01 5.99E
-01 9.88E
-01 6.02E
-01 9.48E
-01
3.66E
-
02 9.97E
-01 9.23E
-01 9.60E
-01
3.11E
-
02 1.61E
-01
MIMAT000045 4
hsa
-miR
-
184 9.86E
-01 6.29E
-01 1.06E+00 1.39E
-01
1.01E+00
8.64E
-
01 9.55E
-01 4.34E
-01 1.00E+00
9.37E
-
01 7.45E
-01
MIMAT000045 5
hsa
-miR
-
185
-5p 1.01E+00 9.52E
-01 1.00E+00 9.71E
-01
1.01E+00
8.59E
-
01 1.17E+00 1.87E
-01 8.47E
-01
9.81E
-
02 2.18E
-01
MIMAT000045 6
hsa
-miR
-
186
-5p 1.03E+00 7.57E
-01 1.16E+00 1.94E
-01
1.00E+00
9.96E
-
01 9.00E
-01 4.13E
-01 1.01E+00
9.52E
-
01 6.86E
-01
MIMAT000026 2
hsa
-miR
-
187
-3p 5.35E
-01 1.14E
-01 8.52E
-01 4.67E
-01 7.82E
-01
2.84E
-
01 8.67E
-01 5.87E
-01 1.02E+00
8.88E
-
01 7.24E
-01
MIMAT000461 3
hsa
-miR
-
188
-3p 8.47E
-01 1.61E
-01 9.69E
-01 8.25E
-01 9.63E
-01
6.94E
-
01 7.62E
-01 1.06E
-01 8.74E
-01
1.80E
-
01 NULL
MIMAT000045 7
hsa
-miR
-
188
-5p 1.02E+00 7.86E
-01 1.16E+00 2.22E
-01
1.08E+00
3.30E
-
01 1.30E+00 5.32E
-02 9.87E
-01
8.88E
-
01 5.84E
-01
MIMAT000007 2
hsa
-miR
-
18a
-5p 9.83E
-01 8.23E
-01 9.76E
-01 8.25E
-01 9.70E
-01
6.80E
-
01 1.09E+00 4.28E
-01 8.33E
-01
7.05E
-
02 6.83E
-01
MIMAT000141 2
hsa
-miR
-
18b
-5p 9.46E
-01 3.70E
-01 1.12E+00 2.20E
-01
1.05E+00
2.69E
-
01 9.20E
-01 4.14E
-01 1.03E+00
5.77E
-
01 7.14E
-01
MIMAT002691 6
hsa
-miR
-
1908
-3p 1.06E+00 4.36E
-01 1.06E+00 5.82E
-01 9.98E
-01
9.86E
-
01 9.58E
-01 8.19E
-01 9.82E
-01
8.37E
-
01 7.90E
-01

160
MIMAT002648
2
hsa-miR190a-3p 9.85E-01 5.59E-01 9.79E-01 5.63E-01 9.93E-01
7.70E01 9.79E-01 5.78E-01 1.02E+00
5.41E01 5.02E-01
MIMAT000045
8
hsa-miR190a-5p 1.11E+00 1.48E-01 1.00E+00 9.95E-01 9.85E-01
8.85E01 1.30E+00 1.39E-01 9.87E-01
8.80E01 5.99E-01
MIMAT000044
0
hsa-miR191-5p 1.04E+00 7.50E-01 8.19E-01 3.46E-01 7.06E-01
1.49E01 7.79E-01 3.30E-01 8.49E-01
3.12E01 9.61E-01
MIMAT000788
4
hsa-miR1910-5p 1.02E+00 6.66E-01 1.03E+00 5.08E-01
1.02E+0
0
6.49E01 1.05E+00 5.90E-01 9.89E-01
7.58E01 6.42E-01
MIMAT000022
2
hsa-miR192-5p 1.05E+00 6.43E-01 8.62E-01 3.29E-01 9.93E-01
9.36E01 8.44E-01 2.56E-01 9.64E-01
7.45E01 8.32E-01
MIMAT000045
9
hsa-miR193a-3p 1.09E+00 6.79E-01 1.15E+00 4.76E-01
1.01E+0
0
9.15E01 1.68E+00 2.48E-02 8.45E-01
4.59E01 5.88E-01
MIMAT000281
9
hsa-miR193b-3p 9.79E-01 2.84E-01 1.01E+00 6.88E-01 9.49E-01
4.35E02 1.06E+00 1.20E-01 1.01E+00
7.39E01 1.56E-01
MIMAT000022
6
hsa-miR196a-5p 9.75E-01 2.31E-01 1.02E+00 6.28E-01 9.71E-01
3.12E01 9.31E-01 1.92E-01 1.02E+00
3.74E01 5.23E-01
MIMAT000022
7
hsa-miR197-3p 9.72E-01 3.11E-01 9.56E-01 3.28E-01 9.86E-01
6.58E01 1.01E+00 7.45E-01 9.87E-01
6.86E01 4.19E-01
MIMAT002269
1
hsa-miR197-5p 1.02E+00 6.97E-01 9.27E-01 3.28E-01
1.00E+0
0
9.98E01 1.08E+00 3.38E-01 9.71E-01
5.35E01 7.16E-01
MIMAT000944
7
hsa-miR1972 4.61E-01 4.12E-02 9.44E-01 7.42E-01 NULL NULL 8.95E-01 6.58E-01 9.97E-01
9.78E01 8.83E-01
MIMAT000944
8
hsa-miR1973 1.02E+00 4.03E-01 9.87E-01 6.88E-01
1.00E+0
0
8.51E01 1.03E+00 4.50E-01 9.75E-01
2.22E01 5.09E-01
MIMAT000945
1
hsa-miR1976 1.00E+00 8.85E-01 1.06E+00 1.88E-01 9.54E-01
2.40E01 9.78E-01 6.49E-01 1.04E+00
1.03E01 5.04E-01
MIMAT000022
8
hsa-miR198 9.96E-01 9.44E-01 9.79E-01 7.60E-01 9.97E-01
9.48E01 9.67E-01 6.94E-01 1.03E+00
5.78E01 9.75E-01
MIMAT000023
2
hsa-miR199a3p+hsamiR-199b3p 9.70E-01 2.72E-01 1.07E+00 1.47E-01
1.01E+0
0
8.44E01 1.04E+00 4.85E-01 9.97E-01
9.11E01 5.62E-01
MIMAT000023
1
hsa-miR199a-5p 8.69E-01 1.86E-01 8.85E-01 2.72E-01
1.07E+0
0
2.95E01 1.09E+00 3.80E-01 9.00E-01
2.21E01 1.45E-02
MIMAT000026
3
hsa-miR199b-5p 1.08E+00 4.53E-01 1.01E+00 9.53E-01
1.07E+0
0
5.04E01 1.03E+00 8.30E-01 8.71E-01
3.07E01 1.72E-01
MIMAT000007
4
hsa-miR19b-3p 9.82E-01 7.81E-01 1.02E+00 8.43E-01
1.05E+0
0
6.11E01 9.32E-01 5.95E-01 9.97E-01
9.65E01 8.50E-01
MIMAT000068
2
hsa-miR200a-3p 9.73E-01 6.93E-01 1.03E+00 7.34E-01
1.02E+0
0
7.53E01 9.67E-01 7.73E-01 1.12E+00
7.50E02 9.34E-01
MIMAT000031
8
hsa-miR200b-3p 9.04E-01 2.97E-01 1.03E+00 7.46E-01 9.52E-01
3.88E01 8.68E-01 1.51E-01 1.06E+00
5.66E01 7.67E-01
MIMAT000061
7
hsa-miR200c-3p 9.33E-01 4.37E-01 1.07E+00 5.60E-01
1.07E+0
0
3.15E01 1.31E+00 2.74E-02 9.28E-01
4.48E01 7.38E-01

161
MIMAT000026 4
hsa
-miR
-
203a
-3p 6.70E
-01 2.15E
-01 1.09E+00 7.23E
-01
1.02E+00
8.98E
-
01 NULL NULL 7.85E
-01
1.83E
-
01 5.72E
-01
MIMAT003189 0
hsa
-miR
-
203a
-5p 9.80E
-01 3.21E
-01 9.51E
-01 6.91E
-02
1.02E+00
5.43E
-
01 9.35E
-01 8.79E
-02 9.76E
-01
2.50E
-
01 3.90E
-01
MIMAT000026 6
hsa
-miR
-
205
-5p 9.94E
-01 7.28E
-01 9.72E
-01 3.59E
-01
1.00E+00
9.55E
-
01 9.56E
-01 2.18E
-01 1.01E+00
8.02E
-
01 7.58E
-01
MIMAT000997 8
hsa
-miR
-
2053 9.29E
-01 2.06E
-01 9.69E
-01 6.47E
-01 9.45E
-01
4.53E
-
01 1.04E+00 7.57E
-01 1.11E+00
6.38E
-
02 2.45E
-01
MIMAT000024 1
hsa
-miR
-
208a
-3p 8.92E
-01 6.86E
-01 1.14E+00 4.79E
-01
1.10E+00
6.76E
-
01 6.04E
-01 1.68E
-01 9.23E
-01
5.61E
-
01 7.47E
-01
MIMAT000496 0
hsa
-miR
-
208b
-3p 8.85E
-01 1.32E
-01 NULL NULL 9.29E
-01
2.79E
-
01 8.17E
-01 4.62E
-02 1.06E+00
4.70E
-
01 7.60E
-01
MIMAT000007 6
hsa
-miR
-
21
-5p 9.75E
-01 7.03E
-01 9.32E
-01 4.38E
-01 8.79E
-01
2.04E
-
01 1.14E+00 2.73E
-01 1.08E+00
3.49E
-
01 8.10E
-01
MIMAT000026 7
hsa
-miR
-
210
-3p 9.42E
-01 2.04E
-01 1.01E+00 8.22E
-01
1.05E+00
1.64E
-
01 1.03E+00 4.12E
-01 1.03E+00
4.26E
-
01 9.64E
-02
MIMAT002647 5
hsa
-miR
-
210
-5p 9.19E
-01 1.74E
-01 9.40E
-01 4.44E
-01 9.06E
-01
1.84E
-
01 9.90E
-01 9.17E
-01 1.07E+00
1.82E
-
01 4.02E
-01
MIMAT000026 8
hsa
-miR
-
211
-5p 1.03E+00 4.21E
-01 9.73E
-01 6.08E
-01 9.85E
-01
6.18E
-
01 9.12E
-01 1.01E
-01 1.03E+00
3.37E
-
01 9.57E
-01
MIMAT001013 3
hsa
-miR
-
2110 9.76E
-01 4.27E
-01 1.00E+00 9.90E
-01
1.00E+00
8.53E
-
01 9.77E
-01 5.81E
-01 9.86E
-01
6.45E
-
01 8.72E
-01
MIMAT000920 6
hsa
-miR
-
2113 1.02E+00 5.14E
-01 1.03E+00 5.96E
-01 9.43E
-01
1.83E
-
01 1.05E+00 4.62E
-01 1.00E+00
9.66E
-
01 5.14E
-01
MIMAT000026 9
hsa
-miR
-
212
-3p 7.99E
-01 3.40E
-01 6.66E
-01 1.53E
-01
1.04E+00
5.58E
-
01 1.14E+00 1.22E
-01 8.52E
-01
4.73E
-
01 9.77E
-01
MIMAT000027 2
hsa
-miR
-
215
-5p 7.56E
-01 2.76E
-01 1.50E+00 7.75E
-02 9.17E
-01
5.75E
-
01 1.05E+00 8.52E
-01 1.22E+00
2.50E
-
01 7.34E
-01
MIMAT000027 3
hsa
-miR
-
216a
-5p 8.57E
-01 6.33E
-02 1.06E+00 5.46E
-01
1.03E+00
6.72E
-
01 8.99E
-01 5.32E
-01 9.38E
-01
4.01E
-
01 7.05E
-01
MIMAT000495 9
hsa
-miR
-
216b
-5p 1.01E+00 7.04E
-01 9.91E
-01 7.35E
-01 9.90E
-01
7.22E
-
01 9.49E
-01 2.37E
-01 1.00E+00
9.36E
-
01 8.61E
-01
MIMAT000027 4
hsa
-miR
-
217 7.50E
-01 2.90E
-01 7.48E
-01 2.45E
-01 9.94E
-01
8.90E
-
01 9.48E
-01 3.67E
-01 1.34E+00
1.25E
-
02 4.62E
-01
MIMAT000027 5
hsa
-miR
-
218
-5p 9.85E
-01 8.26E
-01 1.01E+00 9.52E
-01
1.09E+00
1.28E
-
01 1.03E+00 8.13E
-01 1.04E+00
6.19E
-
01 3.61E
-01
MIMAT000027 6
hsa
-miR
-
219a
-5p 7.75E
-01 4.56E
-02 9.39E
-01 5.81E
-01 9.93E
-01
9.18E
-
01 8.47E
-01 1.76E
-01 1.05E+00
5.28E
-
01 8.76E
-01
MIMAT001974 8
hsa
-miR
-
219b
-3p 1.05E+00 1.43E
-01 1.05E+00 2.39E
-01 9.84E
-01
5.75E
-
01 1.16E+00 1.64E
-02 1.00E+00
9.87E
-
01 2.95E
-01
MIMAT000027 8
hsa
-miR
-
221
-3p 9.68E
-01 4.25E
-01 9.82E
-01 7.44E
-01 8.74E
-01
4.72E
-
02 7.94E
-01 3.04E
-02 9.92E
-01
8.43E
-
01 5.45E
-01
MIMAT000027 9
hsa
-miR
-
222
-3p 8.56E
-01 1.69E
-01 9.69E
-01 8.09E
-01 9.27E
-01
6.03E
-
01 6.51E
-01 8.55E
-02 1.03E+00
7.66E
-
01 5.12E
-01

162
MIMAT000028 0
hsa
-miR
-
223
-3p 1.00E+00 9.88E
-01 9.77E
-01 7.62E
-01
1.09E+00
7.90E
-
02 9.64E
-01 6.09E
-01 9.92E
-01
9.02E
-
01 6.86E
-01
MIMAT000028 1
hsa
-miR
-
224
-5p 9.74E
-01 2.38E
-01 1.00E+00 9.45E
-01 9.79E
-01
1.81E
-
01 9.89E
-01 6.88E
-01 9.91E
-01
6.21E
-
01 3.53E
-01
MIMAT000007 8
hsa
-miR
-
23a
-3p 9.89E
-01 5.46E
-01 9.76E
-01 3.64E
-01 9.72E
-01
1.27E
-
01 9.85E
-01 5.35E
-01 9.76E
-01
2.59E
-
01 9.30E
-01
MIMAT000041 8
hsa
-miR
-
23b
-3p 9.99E
-01 9.70E
-01 9.74E
-01 3.02E
-01
1.01E+00
4.38E
-
01 9.79E
-01 4.72E
-01 1.00E+00
9.51E
-
01 4.80E
-01
MIMAT001800 0
hsa
-miR
-
23c 9.04E
-01 3.35E
-01 1.07E+00 6.83E
-01 9.45E
-01
7.30E
-
01 1.02E+00 9.09E
-01 9.92E
-01
9.47E
-
01 2.57E
-01
MIMAT000008 1
hsa
-miR
-
25
-3p 9.39E
-01 1.83E
-02 1.05E+00 1.27E
-01 9.97E
-01
9.34E
-
01 9.18E
-01 1.01E
-01 1.03E+00
1.64E
-
01 7.49E
-01
MIMAT000449 8
hsa
-miR
-
25
-5p 9.03E
-01 5.19E
-01 9.98E
-01 9.92E
-01
1.05E+00
8.17E
-
01 3.31E
-01 1.64E
-02 1.23E+00
1.58E
-
01 1.74E
-01
MIMAT000008 2
hsa
-miR
-
26a
-5p 9.74E
-01 2.27E
-01 9.37E
-01 2.03E
-02 9.28E
-01
6.75E
-
03 9.50E
-01 2.04E
-01 1.02E+00
2.97E
-
01 9.93E
-01
MIMAT000008 3
hsa
-miR
-
26b
-5p 8.40E
-01 1.61E
-01 8.61E
-01 2.75E
-01
1.01E+00
9.11E
-
01 9.11E
-01 6.55E
-01 9.38E
-01
5.77E
-
01 2.60E
-01
MIMAT000008 4
hsa
-miR
-
27a
-3p 9.86E
-01 8.83E
-01 1.09E+00 4.11E
-01 9.49E
-01
3.98E
-
01 9.52E
-01 5.86E
-01 1.04E+00
6.62E
-
01 5.89E
-02
MIMAT000450 2
hsa
-miR
-
28
-3p 9.74E
-01 3.37E
-01 1.00E+00 9.37E
-01
1.01E+00
6.00E
-
01 9.33E
-01 9.86E
-02 9.88E
-01
6.39E
-
01 3.22E
-01
MIMAT000008 5
hsa
-miR
-
28
-5p 1.09E+00 5.72E
-01 1.11E+00 6.30E
-01 6.56E
-01
1.70E
-
01 3.51E
-01 1.27E
-01 1.15E+00
2.99E
-
01 6.61E
-01
MIMAT000467 9
hsa
-miR
-
296
-3p 9.98E
-01 9.86E
-01 1.07E+00 5.70E
-01
1.06E+00
5.53E
-
01 1.14E+00 4.29E
-01 8.39E
-01
4.22E
-
02 1.86E
-01
MIMAT000490 1
hsa
-miR
-
298 1.51E+00 4.85E
-03 8.47E
-01 4.70E
-01
1.04E+00
8.20E
-
01 7.16E
-01 2.79E
-01 8.00E
-01
1.44E
-
01 1.85E
-01
MIMAT000068 7
hsa
-miR
-
299
-3p 8.68E
-01 1.82E
-01 1.01E+00 9.11E
-01
1.11E+00
2.46E
-
01 9.14E
-01 5.54E
-01 1.15E+00
2.31E
-
01 1.48E
-01
MIMAT000289 0
hsa
-miR
-
299
-5p 1.08E+00 5.80E
-01 7.90E
-01 3.14E
-01 7.20E
-01
2.98E
-
01 5.04E
-01 4.79E
-02 9.66E
-01
8.01E
-
01 5.97E
-01
MIMAT000008 6
hsa
-miR
-
29a
-3p 1.00E+00 8.34E
-01 9.79E
-01 4.99E
-01 9.66E
-01
3.07E
-
01 9.27E
-01 1.20E
-01 1.00E+00
9.97E
-
01 6.94E
-01
MIMAT000010 0
hsa
-miR
-
29b
-3p 7.09E
-01 8.87E
-02 9.51E
-01 7.09E
-01
1.04E+00
7.64E
-
01 7.97E
-01 2.70E
-01 1.09E+00
3.75E
-
01 3.49E
-01
MIMAT000068 1
hsa
-miR
-
29c
-3p 1.00E+00 9.86E
-01 1.05E+00 5.92E
-01 9.76E
-01
6.66E
-
01 9.23E
-01 3.68E
-01 9.44E
-01
4.77E
-
01 3.49E
-01
MIMAT000490 3
hsa
-miR
-
300 9.24E
-01 3.83E
-01 9.17E
-01 4.97E
-01
1.06E+00
4.39E
-
01 1.00E+00 9.75E
-01 1.18E+00
7.96E
-
02 7.43E
-01
MIMAT000068 8
hsa
-miR
-
301a
-3p 1.17E+00 2.02E
-01 1.01E+00 9.56E
-01 9.93E
-01
9.45E
-
01 6.12E
-01 1.60E
-03 1.10E+00
5.35E
-
01 4.80E
-01
MIMAT002269 6
hsa
-miR
-
301a
-5p 8.14E
-01 2.88E
-01 1.19E+00 3.03E
-01
1.30E+00
7.29E
-
02 9.44E
-01 7.77E
-01 1.10E+00
4.51E
-
01 8.13E
-01

163
MIMAT000495 8
hsa
-miR
-
301b
-3p 1.01E+00 9.29E
-01 9.20E
-01 6.13E
-01 7.14E
-01
1.22E
-
01 4.40E
-01 2.65E
-02 1.03E+00
7.79E
-
01 5.62E
-02
MIMAT003202 6
hsa
-miR
-
301b
-5p 9.15E
-01 5.38E
-01 4.64E
-01 8.17E
-03 9.23E
-01
7.16E
-
01 6.08E
-01 1.28E
-01 1.11E+00
4.02E
-
01 2.00E
-01
MIMAT000068 4
hsa
-miR
-
302a
-3p 1.05E+00 6.22E
-01 1.03E+00 8.49E
-01 9.21E
-01
3.77E
-
01 9.08E
-01 5.44E
-01 9.01E
-01
3.48E
-
01 9.61E
-01
MIMAT000068 3
hsa
-miR
-
302a
-5p 1.08E+00 3.25E
-01 1.06E+00 5.53E
-01
1.02E+00
8.84E
-
01 8.87E
-01 4.79E
-01 1.05E+00
5.92E
-
01 3.78E
-01
MIMAT000071 5
hsa
-miR
-
302b
-3p 1.03E+00 6.43E
-01 9.94E
-01 9.36E
-01
1.05E+00
2.49E
-
01 1.03E+00 6.72E
-01 1.06E+00
3.37E
-
01 3.17E
-01
MIMAT000071 7
hsa
-miR
-
302c
-3p 8.58E
-01 3.96E
-01 7.42E
-01 1.93E
-01 9.16E
-01
6.28E
-
01 8.10E
-01 4.80E
-01 1.04E+00
7.64E
-
01 1.60E
-01
MIMAT000071 8
hsa
-miR
-
302d
-3p 6.56E
-01 1.24E
-01 1.01E+00 9.55E
-01 9.21E
-01
6.73E
-
01 1.10E+00 7.15E
-01 7.51E
-01
6.35E
-
02 2.51E
-01
MIMAT000593 1
hsa
-miR
-
302e 1.01E+00 8.18E
-01 1.04E+00 3.86E
-01
1.02E+00
3.95E
-
01 9.68E
-01 4.10E
-01 9.97E
-01
9.30E
-
01 6.11E
-01
MIMAT000593 2
hsa
-miR
-
302f 9.14E
-01 5.62E
-01 1.11E+00 4.57E
-01 9.16E
-01
2.64E
-
01 9.80E
-01 8.25E
-01 1.11E+00
3.18E
-
01 8.39E
-01
MIMAT001537 8
hsa
-miR
-
3065
-3p 9.37E
-01 4.61E
-01 1.07E+00 5.99E
-01 8.14E
-01
1.01E
-
01 1.03E+00 8.51E
-01 9.19E
-01
3.60E
-
01 7.42E
-01
MIMAT001502 7
hsa
-miR
-
3074
-3p 1.03E+00 8.30E
-01 1.13E+00 3.96E
-01
1.03E+00
7.59E
-
01 1.03E+00 8.01E
-01 9.50E
-01
6.37E
-
01 9.06E
-01
MIMAT000008 8
hsa
-miR
-
30a
-3p 1.00E+00 9.92E
-01 9.91E
-01 7.16E
-01 9.47E
-01
3.94E
-
02 9.99E
-01 9.74E
-01 9.87E
-01
5.23E
-
01 6.72E
-01
MIMAT000042 0
hsa
-miR
-
30b
-5p 9.22E
-01 5.84E
-01 1.26E+00 2.83E
-01 7.36E
-01
1.85E
-
01 7.76E
-01 7.75E
-02 1.47E+00
8.15E
-
02 4.13E
-01
MIMAT000024 4
hsa
-miR
-
30c
-5p 9.14E
-01 1.50E
-02 1.00E+00 9.65E
-01
1.01E+00
7.46E
-
01 9.72E
-01 7.48E
-01 9.50E
-01
1.94E
-
01 8.22E
-01
MIMAT000024 5
hsa
-miR
-
30d
-5p 1.04E+00 3.67E
-01 1.01E+00 8.98E
-01 9.67E
-01
2.90E
-
01 1.07E+00 2.68E
-01 1.00E+00
9.28E
-
01 3.29E
-01
MIMAT000069 3
hsa
-miR
-
30e
-3p 9.10E
-01 4.30E
-01 7.93E
-01 1.77E
-01
1.12E+00
2.67E
-
01 8.06E
-01 3.63E
-01 9.81E
-01
8.64E
-
01 4.71E
-01
MIMAT000069 2
hsa
-miR
-
30e
-5p 9.92E
-01 8.11E
-01 9.63E
-01 4.84E
-01
1.03E+00
3.58E
-
01 9.77E
-01 6.63E
-01 9.91E
-01
8.22E
-
01 8.93E
-01
MIMAT001499 6
hsa
-miR
-
3131 9.98E
-01 8.96E
-01 9.92E
-01 7.08E
-01
1.01E+00
6.41E
-
01 9.75E
-01 2.85E
-01 9.96E
-01
7.96E
-
01 2.56E
-01
MIMAT001501 5
hsa
-miR
-
3144
-3p 1.01E+00 9.22E
-01 1.03E+00 8.96E
-01
1.11E+00
4.42E
-
01 8.06E
-01 2.02E
-01 9.73E
-01
8.56E
-
01 6.01E
-01
MIMAT001501 4
hsa
-miR
-
3144
-5p 9.89E
-01 6.28E
-01 9.92E
-01 8.08E
-01 9.80E
-01
5.40E
-
01 9.39E
-01 1.40E
-01 1.04E+00
1.33E
-
01 9.70E
-01
MIMAT001501 9
hsa
-miR
-
3147 1.34E
-01 1.94E
-02 1.01E+00 9.45E
-01
1.18E+00
1.51E
-
01 9.68E
-01 8.62E
-01 6.69E
-01
5.54E
-
02 7.30E
-01
MIMAT001502 4
hsa
-miR
-
3151
-5p 8.48E
-01 6.57E
-03 9.60E
-01 5.34E
-01
1.06E+00
2.25E
-
01 9.25E
-01 3.51E
-01 1.00E+00
9.87E
-
01 4.82E
-01

164
MIMAT001503
5
hsa-miR3161 8.88E-01 4.51E-01 1.35E+00 1.07E-01 9.66E-01
7.36E01 1.54E+00 6.33E-03 9.38E-01
6.92E01 1.26E-02
MIMAT001504
3
hsa-miR3168 1.00E+00 9.52E-01 1.05E+00 4.41E-01
1.04E+0
0
4.79E01 1.06E+00 5.15E-01 1.05E+00
3.13E01 9.24E-01
MIMAT001817
8
hsa-miR3180 8.84E-01 4.90E-02 9.88E-01 8.75E-01 8.86E-01
8.01E02 9.98E-01 9.81E-01 9.65E-01
5.55E01 6.10E-01
MIMAT001505
7
hsa-miR3180-5p 8.85E-01 3.22E-01 9.03E-01 3.98E-01 9.44E-01
6.17E01 8.68E-01 4.37E-01 1.09E+00
3.96E01 3.11E-01
MIMAT001508
9
hsa-miR3202 9.96E-01 9.66E-01 8.94E-01 3.95E-01 8.94E-01
3.62E01 1.26E+00 1.26E-01 1.06E+00
5.73E01 6.09E-01
MIMAT000051
0
hsa-miR320a 9.73E-01 5.22E-01 9.44E-01 3.90E-01 8.91E-01
1.44E01 1.06E+00 4.17E-01 9.69E-01
5.30E01 3.90E-01
MIMAT000579
3
hsa-miR320c 9.93E-01 9.64E-01 8.13E-01 2.80E-01
1.20E+0
0
1.19E01 9.07E-01 5.80E-01 8.85E-01
3.57E01 2.69E-01
MIMAT001507
2
hsa-miR320e 1.02E+00 4.02E-01 1.00E+00 9.68E-01 9.46E-01
1.88E01 9.62E-01 4.06E-01 9.92E-01
7.40E01 1.34E-01
MIMAT000075
5
hsa-miR323a-3p 9.85E-01 8.66E-01 1.02E+00 8.83E-01 9.85E-01
8.99E01 8.94E-01 5.43E-01 9.78E-01
7.95E01 2.43E-01
MIMAT001505
0
hsa-miR323b-3p 5.95E-01 7.35E-02 8.08E-01 3.32E-01
1.03E+0
0
7.36E01 1.01E+00 9.59E-01 7.62E-01
8.14E02 8.46E-01
MIMAT000076
2
hsa-miR324-3p 9.91E-01 9.37E-01 8.56E-01 3.16E-01 6.71E-01
5.42E02 1.14E+00 4.98E-01 8.54E-01
1.90E01 1.45E-01
MIMAT000077
1
hsa-miR325 9.90E-01 7.54E-01 1.02E+00 6.83E-01
1.05E+0
0
1.96E01 9.84E-01 7.85E-01 1.02E+00
5.30E01 9.80E-01
MIMAT002648
6
hsa-miR328-5p 8.50E-01 9.50E-02 8.60E-01 1.44E-01
1.02E+0
0
7.39E01 1.14E+00 2.16E-01 8.68E-01
1.33E01 1.62E-01
MIMAT000162
9
hsa-miR329-3p 9.80E-01 5.09E-01 1.02E+00 6.78E-01 9.86E-01
5.30E01 9.84E-01 6.86E-01 1.07E+00
1.21E02 4.75E-01
MIMAT002655
5
hsa-miR329-5p 1.02E+00 8.84E-01 9.94E-01 9.72E-01 7.49E-01
1.05E01 8.14E-01 3.89E-01 9.00E-01
4.18E01 7.33E-01
MIMAT000469
3
hsa-miR330-5p 9.19E-01 1.03E-01 9.80E-01 7.48E-01 8.96E-01
1.31E01 1.03E+00 8.01E-01 1.05E+00
3.39E01 2.82E-01
MIMAT000076
5
hsa-miR335-5p 8.40E-01 1.43E-01 9.99E-01 9.96E-01 8.42E-01
1.83E01 1.13E+00 4.37E-01 9.80E-01
8.46E01 2.82E-01
MIMAT000075
4
hsa-miR337-3p 5.95E-01 1.21E-01 8.02E-01 3.20E-01
1.01E+0
0
9.09E01 1.06E+00 7.70E-01 9.62E-01
8.02E01 8.40E-01
MIMAT000469
5
hsa-miR337-5p 9.99E-01 9.73E-01 9.81E-01 6.92E-01 9.43E-01
1.67E01 1.01E+00 9.49E-01 9.57E-01
3.36E01 1.72E-01
MIMAT000470
1
hsa-miR338-5p 1.01E+00 6.62E-01 9.92E-01 7.18E-01 9.63E-01
8.22E02 9.89E-01 7.70E-01 9.95E-01
7.52E01 6.30E-01
MIMAT000009
1
hsa-miR33a-5p 1.11E+00 2.99E-01 1.10E+00 5.42E-01 8.80E-01
4.89E01 6.27E-01 5.65E-02 8.88E-01
3.47E01 9.70E-01
MIMAT000330
1
hsa-miR33b-5p 8.95E-01 7.93E-02 9.94E-01 9.45E-01
1.05E+0
0
4.28E01 9.24E-01 4.90E-01 1.09E+00
1.54E01 7.51E-01

165
MIMAT000469 2
hsa
-miR
-
340
-5p 1.02E+00 6.99E
-01 9.51E
-01 4.07E
-01 9.46E
-01
2.17E
-
01 1.06E+00 4.07E
-01 9.86E
-01
5.96E
-
01 9.95E
-01
MIMAT000075 3
hsa
-miR
-
342
-3p 9.35E
-01 5.89E
-01 1.12E+00 4.32E
-01
1.01E+00
9.59E
-
01 1.13E+00 6.11E
-01 7.01E
-01
1.71E
-
02 5.53E
-01
MIMAT000469 4
hsa
-miR
-
342
-5p 9.76E
-01 2.46E
-01 9.97E
-01 9.12E
-01 9.87E
-01
6.54E
-
01 1.07E+00 2.49E
-01 9.84E
-01
4.27E
-
01 4.30E
-01
MIMAT002269 8
hsa
-miR
-
345
-3p 7.03E
-01 1.42E
-01 1.02E+00 9.08E
-01 6.77E
-01
8.96E
-
02 7.83E
-01 2.71E
-01 9.68E
-01
8.12E
-
01 2.47E
-01
MIMAT000077 3
hsa
-miR
-
346 1.18E+00 2.23E
-01 5.78E
-01 2.96E
-02 9.31E
-01
7.23E
-
01 9.62E
-01 9.05E
-01 9.28E
-01
6.16E
-
01 1.83E
-01
MIMAT000025 5
hsa
-miR
-
34a
-5p 1.06E+00 1.82E
-01 1.02E+00 7.05E
-01
1.01E+00
7.27E
-
01 9.80E
-01 7.14E
-01 9.66E
-01
3.47E
-
01 1.18E
-01
MIMAT000467 6
hsa
-miR
-
34b
-3p 9.73E
-01 2.16E
-01 9.83E
-01 5.88E
-01
1.03E+00
6.68E
-
02 1.00E+00 9.04E
-01 1.01E+00
7.71E
-
01 2.09E
-01
MIMAT000467 7
hsa
-miR
-
34c
-3p 1.06E+00 6.66E
-01 1.18E+00 3.30E
-01
1.49E+00
8.89E
-
02 1.10E+00 7.72E
-01 9.38E
-01
6.61E
-
01 6.73E
-01
MIMAT000068 6
hsa
-miR
-
34c
-5p 9.54E
-01 4.12E
-01 1.07E+00 4.60E
-01
1.18E+00
8.47E
-
03 1.04E+00 7.74E
-01 9.84E
-01
8.25E
-
01 3.87E
-01
MIMAT001798 1
hsa
-miR
-
3605
-5p 1.04E+00 5.57E
-01 8.53E
-01 1.40E
-01 8.84E
-01
2.32E
-
01 1.11E+00 4.06E
-01 9.09E
-01
1.93E
-
01 2.50E
-01
MIMAT000070 3
hsa
-miR
-
361
-5p 9.48E
-01 1.41E
-01 9.60E
-01 4.84E
-01 9.68E
-01
5.08E
-
01 9.16E
-01 3.10E
-01 1.04E+00
3.71E
-
01 3.48E
-01
MIMAT001799 1
hsa
-miR
-
3613
-3p 9.47E
-01 7.20E
-01 8.77E
-01 4.97E
-01 6.02E
-01
7.54E
-
02 6.32E
-01 5.24E
-03 8.95E
-01
4.35E
-
01 8.72E
-01
MIMAT001799 2
hsa
-miR
-
3614
-5p 9.89E
-01 8.94E
-01 9.92E
-01 9.45E
-01 9.31E
-01
4.08E
-
01 1.01E+00 9.39E
-01 9.62E
-01
6.45E
-
01 1.00E+00
MIMAT001799 4
hsa
-miR
-
3615 1.00E+00 9.82E
-01 1.10E+00 2.35E
-01
1.07E+00
3.60E
-
01 9.25E
-01 5.33E
-01 9.40E
-01
3.73E
-
01 5.49E
-01
MIMAT000070 5
hsa
-miR
-
362
-5p 9.62E
-01 2.00E
-01 9.84E
-01 6.87E
-01 9.59E
-01
2.61E
-
01 1.06E+00 2.94E
-01 1.01E+00
6.59E
-
01 3.91E
-01
MIMAT000070 7
hsa
-miR
-
363
-3p 9.89E
-01 5.99E
-01 1.03E+00 3.42E
-01 9.91E
-01
8.03E
-
01 1.03E+00 6.73E
-01 9.77E
-01
3.26E
-
01 9.13E
-01
MIMAT000338 5
hsa
-miR
-
363
-5p 9.57E
-01 2.88E
-01 1.02E+00 7.39E
-01
1.01E+00
7.03E
-
01 1.05E+00 4.68E
-01 1.02E+00
6.88E
-
01 4.29E
-02
MIMAT000071 0
hsa
-miR
-
365a
-
3p+hsa
-
miR
-365b
-
3p 1.01E+00 9.19E
-01 7.88E
-01 2.25E
-01 7.38E
-01
1.27E
-
01 6.95E
-01 8.98E
-02 1.05E+00
7.50E
-
01 9.41E
-01
MIMAT002283 3
hsa
-miR
-
365b
-5p 9.83E
-01 7.07E
-01 1.01E+00 8.11E
-01 9.79E
-01
5.67E
-
01 9.68E
-01 6.10E
-01 1.07E+00
1.51E
-
01 1.14E
-02
MIMAT000071 9
hsa
-miR
-
367
-3p 9.59E
-01 2.13E
-01 1.01E+00 8.10E
-01
1.02E+00
7.18E
-
01 9.85E
-01 8.39E
-01 9.79E
-01
5.36E
-
01 9.51E
-01
MIMAT000072 1
hsa
-miR
-
369
-3p 1.07E+00 6.95E
-01 6.30E
-01 1.12E
-01 9.90E
-01
9.03E
-
01 1.22E+00 1.63E
-01 9.35E
-01
6.34E
-
01 6.07E
-01

166
MIMAT000162
1
hsa-miR369-5p 9.82E-01 7.47E-01 1.00E+00 9.92E-01
1.07E+0
0
1.40E01 9.52E-01 4.99E-01 1.09E+00
1.37E01 8.60E-01
MIMAT001811
9
hsa-miR3690 9.69E-01 3.45E-01 9.44E-01 2.76E-01
1.02E+0
0
5.64E01 9.69E-01 5.66E-01 9.90E-01
7.89E01 9.23E-01
MIMAT000072
2
hsa-miR370-3p 9.98E-01 9.09E-01 1.02E+00 3.22E-01 9.97E-01
8.67E01 9.34E-01 4.10E-02 9.76E-01
1.68E01 5.23E-01
MIMAT000468
7
hsa-miR371a-5p 8.44E-01 1.84E-01 1.08E+00 5.58E-01
1.10E+0
0
2.80E01 1.14E+00 3.32E-01 9.26E-01
4.30E01 2.80E-01
MIMAT001989
2
hsa-miR371b-5p 1.02E+00 9.18E-01 7.85E-01 3.09E-01
1.45E+0
0
2.31E04 1.15E+00 3.84E-01 9.63E-01
8.04E01 4.45E-01
MIMAT000468
8
hsa-miR374a-3p 1.00E+00 9.90E-01 9.88E-01 6.58E-01 9.56E-01
1.29E01 9.88E-01 7.19E-01 9.78E-01
2.74E01 2.98E-01
MIMAT000072
7
hsa-miR374a-5p 1.00E+00 8.93E-01 1.01E+00 6.56E-01 9.59E-01
2.37E01 1.02E+00 7.17E-01 9.92E-01
7.48E01 7.69E-01
MIMAT002292
8
hsa-miR376a-2-5p 8.50E-01 6.75E-01 9.81E-01 9.13E-01
1.15E+0
0
1.24E01 1.00E+00 9.70E-01 1.11E+00
4.68E01 2.56E-01
MIMAT000072
9
hsa-miR376a-3p 1.02E+00 2.39E-01 9.89E-01 7.46E-01 9.81E-01
4.78E01 9.25E-01 7.78E-02 9.95E-01
8.31E01 6.46E-01
MIMAT000072
0
hsa-miR376c-3p 8.74E-01 9.14E-02 1.03E+00 7.68E-01 9.31E-01
5.06E01 1.05E+00 7.23E-01 9.94E-01
9.41E01 3.78E-01
MIMAT002286
1
hsa-miR376c-5p 9.85E-01 4.47E-01 1.00E+00 9.39E-01 8.97E-01
6.06E04 9.44E-01 2.20E-01 1.04E+00
1.13E01 1.59E-01
MIMAT000073
0
hsa-miR377-3p 9.66E-01 2.37E-01 9.72E-01 4.93E-01 9.77E-01
3.78E01 9.80E-01 6.61E-01 9.73E-01
3.70E01 3.46E-02
MIMAT001892
6
hsa-miR378d 9.94E-01 7.23E-01 9.98E-01 9.27E-01 9.84E-01
3.88E01 9.45E-01 2.93E-02 9.90E-01
5.87E01 1.90E-02
MIMAT001892
7
hsa-miR378e 1.01E+00 7.70E-01 9.10E-01 9.87E-02 9.99E-01
9.80E01 1.02E+00 7.71E-01 9.61E-01
4.12E01 3.44E-01
MIMAT001893
2
hsa-miR378f 9.87E-01 5.51E-01 1.01E+00 6.08E-01
1.02E+0
0
5.50E01 9.95E-01 8.85E-01 1.01E+00
5.32E01 6.04E-01
MIMAT001893
7
hsa-miR378g 7.65E-01 2.41E-01 1.03E+00 8.36E-01 9.57E-01
1.58E01 1.00E+00 9.95E-01 8.85E-01
3.28E01 7.45E-01
MIMAT001898
4
hsa-miR378h 9.12E-01 5.05E-01 7.29E-01 3.23E-02 9.87E-01
8.68E01 9.21E-01 5.71E-01 9.78E-01
8.17E01 1.65E-01
MIMAT001907
4
hsa-miR378i 4.59E-01 3.57E-02 1.13E+00 5.05E-01
1.02E+0
0
8.53E01 9.11E-01 5.77E-01 1.06E+00
6.89E01 3.40E-01
MIMAT000073
3
hsa-miR379-5p 9.51E-01 3.63E-02 9.61E-01 2.53E-01 9.84E-01
5.56E01 9.98E-01 9.57E-01 1.00E+00
9.87E01 3.99E-01
MIMAT000073
5
hsa-miR380-3p 8.51E-01 3.52E-02 9.78E-01 7.98E-01 8.16E-01
7.15E02 9.07E-01 4.55E-01 8.88E-01
1.19E01 8.85E-01
MIMAT000073
6
hsa-miR381-3p 1.01E+00 6.78E-01 1.02E+00 5.47E-01
1.05E+0
0
2.57E02 1.02E+00 6.82E-01 1.02E+00
5.66E01 4.76E-01
MIMAT002286
2
hsa-miR381-5p 9.70E-01 3.80E-01 9.77E-01 6.60E-01 9.81E-01
5.26E01 9.78E-01 6.41E-01 1.01E+00
7.81E01 9.32E-01

167
MIMAT002269
7
hsa-miR382-3p 9.53E-01 1.20E-01 9.39E-01 1.93E-01 8.84E-01
1.67E02 1.10E+00 1.51E-01 9.96E-01
8.96E01 4.58E-01
MIMAT000073
7
hsa-miR382-5p 1.00E+00 9.47E-01 9.73E-01 4.96E-01
1.04E+0
0
2.15E01 1.05E+00 3.85E-01 9.82E-01
5.36E01 1.51E-01
MIMAT001820
5
hsa-miR3928-3p 1.05E+00 3.41E-01 9.69E-01 6.10E-01 8.99E-01
1.65E01 9.56E-01 6.92E-01 1.02E+00
6.89E01 8.58E-02
MIMAT001834
9
hsa-miR3934-5p 9.40E-01 7.23E-01 8.07E-01 2.63E-01
1.03E+0
0
7.45E01 9.33E-01 6.42E-01 1.15E+00
2.14E01 9.70E-01
MIMAT000217
1
hsa-miR410-3p 1.00E+00 8.79E-01 9.84E-01 5.68E-01
1.02E+0
0
4.36E01 1.05E+00 1.25E-01 9.94E-01
8.19E01 4.35E-01
MIMAT000217
0
hsa-miR412-3p 7.67E-01 1.23E-01 4.61E-01 2.07E-03 9.00E-01
5.35E01 1.15E+00 3.86E-01 9.00E-01
3.99E01 1.82E-01
MIMAT000333
9
hsa-miR421 8.09E-01 1.11E-01 1.02E+00 9.04E-01 9.62E-01
7.18E01 9.68E-01 8.49E-01 1.04E+00
7.14E01 5.43E-01
MIMAT000134
0
hsa-miR423-3p 1.00E+00 9.92E-01 9.58E-01 3.27E-01
1.04E+0
0
1.58E01 9.85E-01 7.22E-01 9.41E-01
5.26E02 4.93E-01
MIMAT000474
8
hsa-miR423-5p 1.00E+00 9.41E-01 1.03E+00 5.32E-01 9.47E-01
1.91E01 1.03E+00 6.24E-01 9.89E-01
7.79E01 6.94E-01
MIMAT001691
5
hsa-miR4284 7.67E-01 1.62E-01 5.55E-01 2.01E-02 7.91E-01
2.78E01 1.10E+00 6.59E-01 1.03E+00
8.45E01 7.04E-01
MIMAT001691
6
hsa-miR4286 9.67E-01 2.63E-01 1.01E+00 7.26E-01
1.04E+0
0
1.49E01 9.94E-01 8.79E-01 1.01E+00
8.42E01 3.59E-01
MIMAT000162
5
hsa-miR431-5p 1.02E+00 7.06E-01 1.00E+00 9.52E-01
1.03E+0
0
5.19E01 9.71E-01 6.57E-01 9.38E-01
3.29E01 3.55E-01
MIMAT000281
4
hsa-miR432-5p 9.60E-01 7.03E-02 1.04E+00 1.35E-01
1.01E+0
0
8.66E01 9.32E-01 1.02E-01 1.05E+00
7.69E02 6.99E-01
MIMAT000162
7
hsa-miR433-3p 1.02E+00 3.06E-01 1.01E+00 8.53E-01 9.52E-01
5.76E02 9.52E-01 2.27E-01 1.01E+00
6.11E01 2.42E-01
MIMAT002655
4
hsa-miR433-5p 1.02E+00 3.59E-01 9.83E-01 5.64E-01 9.62E-01
2.51E01 9.42E-01 2.05E-01 1.03E+00
1.75E01 9.94E-02
MIMAT001893
4
hsa-miR4421 8.90E-01 7.64E-02 9.47E-01 5.04E-01
1.02E+0
0
6.85E01 9.24E-01 3.30E-01 1.04E+00
5.34E01 2.49E-01
MIMAT001894
7
hsa-miR4431 1.08E+00 4.51E-01 9.86E-01 9.22E-01
1.00E+0
0
9.73E01 1.11E+00 4.43E-01 1.02E+00
8.43E01 9.57E-02
MIMAT001896
1
hsa-miR4443 9.47E-01 7.41E-01 9.06E-01 6.38E-01
1.14E+0
0
2.38E01 6.68E-01 5.89E-02 8.49E-01
2.81E01 1.01E-01
MIMAT001897
3
hsa-miR4451 9.23E-01 5.47E-01 1.11E+00 5.90E-01
1.05E+0
0
7.11E01 1.38E+00 8.66E-02 7.25E-01
8.58E02 3.58E-01
MIMAT001897
6
hsa-miR4454+hsamiR-7975 8.86E-01 4.23E-03 1.03E+00 6.15E-01
1.02E+0
0
5.96E01 1.11E+00 1.49E-01 9.43E-01
2.18E01 8.17E-01
MIMAT001897
7
hsa-miR4455 9.84E-01 4.72E-01 9.78E-01 4.72E-01 9.93E-01
6.61E01 9.99E-01 9.84E-01 9.62E-01
1.04E01 4.30E-01
MIMAT001898
3
hsa-miR4461 9.04E-01 2.94E-01 1.06E+00 6.53E-01
1.06E+0
0
4.31E01 1.11E+00 3.53E-01 1.04E+00
7.18E01 3.16E-01

168
MIMAT000153
2
hsa-miR448 9.94E-01 8.40E-01 9.79E-01 6.43E-01 9.36E-01
1.92E01 9.57E-01 5.31E-01 1.00E+00
9.40E01 6.93E-01
MIMAT001901
9
hsa-miR4485-3p 9.15E-01 7.82E-02 9.83E-01 7.74E-01 9.99E-01
9.70E01 1.01E+00 8.50E-01 9.68E-01
4.51E01 4.58E-01
MIMAT001902
2
hsa-miR4488 9.61E-01 8.12E-02 9.95E-01 8.89E-01
1.01E+0
0
8.12E01 1.04E+00 3.19E-01 9.95E-01
8.50E01 7.61E-01
MIMAT000154
1
hsa-miR449a 1.01E+00 7.88E-01 1.09E+00 8.42E-02
1.01E+0
0
7.65E01 9.99E-01 9.79E-01 1.00E+00
9.98E01 2.13E-01
MIMAT000332
7
hsa-miR449b-5p 9.66E-01 6.79E-01 1.12E+00 2.61E-01
1.09E+0
0
4.53E01 9.06E-01 5.83E-01 9.87E-01
8.79E01 6.41E-01
MIMAT001025
1
hsa-miR449c-5p 1.14E+00 4.46E-01 7.78E-01 2.25E-01 7.65E-01
2.50E01 6.96E-01 1.11E-01 1.06E+00
7.14E01 3.96E-01
MIMAT002270
0
hsa-miR450a-1-3p 1.05E+00 6.38E-01 1.05E+00 7.44E-01
1.01E+0
0
9.41E01 9.59E-01 7.68E-01 9.21E-01
5.22E01 9.70E-01
MIMAT003107
4
hsa-miR450a-2-3p 1.00E+00 9.06E-01 1.01E+00 7.36E-01 9.53E-01
2.54E01 9.72E-01 6.51E-01 1.01E+00
8.56E01 6.94E-01
MIMAT000154
5
hsa-miR450a-5p 9.92E-01 7.27E-01 1.01E+00 8.09E-01 9.35E-01
6.90E02 9.49E-01 2.79E-01 9.62E-01
1.40E01 5.59E-01
MIMAT000491
0
hsa-miR450b-3p 9.08E-01 1.23E-01 9.53E-01 5.85E-01 9.76E-01
6.37E01 1.03E+00 7.54E-01 1.02E+00
7.96E01 2.16E-01
MIMAT001905
3
hsa-miR4516 9.61E-01 6.21E-02 9.96E-01 8.93E-01 9.50E-01
5.97E02 1.02E+00 5.93E-01 1.02E+00
3.99E01 8.42E-01
MIMAT000163
1
hsa-miR451a 9.69E-01 2.66E-01 1.03E+00 3.88E-01 9.49E-01
1.74E01 1.03E+00 5.25E-01 9.95E-01
8.52E01 1.72E-02
MIMAT001907
0
hsa-miR4531 1.22E+00 1.40E-01 8.25E-01 3.22E-01
1.05E+0
0
5.94E01 5.45E-01 2.19E-02 1.04E+00
7.76E01 5.86E-01
MIMAT002095
9
hsa-miR4536-3p 1.01E+00 9.46E-01 1.01E+00 9.59E-01
1.03E+0
0
7.32E01 1.02E+00 8.89E-01 9.54E-01
7.58E01 6.92E-01
MIMAT001907
8
hsa-miR4536-5p 9.62E-01 2.93E-01 9.69E-01 5.12E-01 9.93E-01
8.26E01 9.44E-01 3.05E-01 1.03E+00
4.94E01 3.18E-02
MIMAT000388
5
hsa-miR454-3p 9.73E-01 8.25E-01 6.67E-01 5.95E-02 9.76E-01
8.53E01 6.71E-01 1.02E-01 7.47E-01
7.53E02 9.53E-02
MIMAT000478
4
hsa-miR455-3p 8.98E-01 3.26E-01 8.56E-01 2.64E-01 9.18E-01
5.39E01 8.85E-01 3.70E-01 1.02E+00
8.04E01 3.21E-01
MIMAT000315
0
hsa-miR455-5p 6.20E-01 7.73E-02 1.18E+00 3.35E-01 8.56E-01
4.28E01 5.41E-01 8.44E-02 9.80E-01
8.87E01 4.00E-01
MIMAT001970
9
hsa-miR4647 9.44E-01 6.19E-02 9.94E-01 9.01E-01
1.04E+0
0
2.89E01 9.68E-01 6.52E-01 9.75E-01
4.77E01 8.02E-02
MIMAT001980
8
hsa-miR4707-3p 9.00E-01 5.24E-01 4.45E-01 1.27E-03
1.05E+0
0
6.49E01 1.16E+00 4.08E-01 9.13E-01
4.40E01 9.08E-01
MIMAT001980
7
hsa-miR4707-5p 1.06E+00 6.26E-01 1.03E+00 8.18E-01 9.28E-01
6.36E01 1.05E+00 8.06E-01 1.06E+00
6.28E01 8.87E-01
MIMAT001989
5
hsa-miR4755-5p 1.02E+00 5.73E-01 1.06E+00 2.22E-01 9.70E-01
4.13E01 8.80E-01 8.58E-02 9.84E-01
6.28E01 7.69E-01

169
MIMAT001995 6
hsa
-miR
-
4787
-5p 5.37E
-01 9.13E
-02 1.18E+00 2.79E
-01 8.52E
-01
4.92E
-
01 8.45E
-01 5.68E
-01 1.01E+00
9.69E
-
01 9.69E
-01
MIMAT001996 4
hsa
-miR
-
4792 1.10E+00 3.91E
-01 1.01E+00 9.25E
-01
1.06E+00
7.30E
-
01 9.78E
-01 9.23E
-01 8.08E
-01
1.20E
-
01 8.53E
-01
MIMAT000217 6
hsa
-miR
-
485
-3p 1.01E+00 8.37E
-01 1.00E+00 9.45E
-01 9.03E
-01
1.37E
-
02 1.01E+00 9.12E
-01 9.90E
-01
7.34E
-
01 6.06E
-01
MIMAT000217 8
hsa
-miR
-
487a
-3p 1.03E+00 7.18E
-01 1.05E+00 5.90E
-01
1.06E+00
3.20E
-
01 1.00E+00 9.67E
-01 9.70E
-01
6.56E
-
01 5.66E
-01
MIMAT000318 0
hsa
-miR
-
487b
-3p 8.72E
-01 3.84E
-04 1.02E+00 6.67E
-01
1.03E+00
3.36E
-
01 8.69E
-01 2.03E
-02 9.71E
-01
3.90E
-
01 9.69E
-01
MIMAT002661 4
hsa
-miR
-
487b
-5p 1.06E+00 4.89E
-01 8.12E
-01 1.32E
-01 9.88E
-01
8.76E
-
01 1.11E+00 3.51E
-01 9.94E
-01
9.58E
-
01 4.60E
-01
MIMAT000476 3
hsa
-miR
-
488
-3p 1.01E+00 9.47E
-01 1.03E+00 9.04E
-01 NULL NULL 6.73E
-01 1.26E
-01 7.78E
-01
1.94E
-
01 5.49E
-01
MIMAT000280 6
hsa
-miR
-
490
-3p 7.93E
-01 2.83E
-01 8.77E
-01 4.02E
-01
1.09E+00
4.03E
-
01 7.78E
-01 1.86E
-01 9.83E
-01
9.04E
-
01 6.21E
-01
MIMAT000280 7
hsa
-miR
-
491
-5p 9.79E
-01 3.13E
-01 9.90E
-01 7.10E
-01 9.65E
-01
2.80E
-
01 9.88E
-01 7.54E
-01 1.02E+00
4.67E
-
01 4.47E
-01
MIMAT000316 1
hsa
-miR
-
493
-3p 9.71E
-01 3.37E
-01 1.00E+00 9.43E
-01 9.24E
-01
1.50E
-
01 9.05E
-01 2.05E
-01 9.96E
-01
8.91E
-
01 7.12E
-01
MIMAT000281 6
hsa
-miR
-
494
-3p 9.88E
-01 4.93E
-01 9.78E
-01 3.83E
-01
1.04E+00
3.31E
-
02 1.02E+00 4.68E
-01 9.70E
-01
1.40E
-
01 6.12E
-01
MIMAT000281 7
hsa
-miR
-
495
-3p 1.04E+00 5.35E
-01 1.02E+00 8.69E
-01 9.52E
-01
4.42E
-
01 1.16E+00 1.70E
-01 8.93E
-01
2.11E
-
01 4.11E
-01
MIMAT002292 4
hsa
-miR
-
495
-5p 7.58E
-01 2.67E
-01 1.05E+00 7.79E
-01 8.40E
-01
4.53E
-
01 9.57E
-01 8.67E
-01 1.03E+00
8.31E
-
01 7.89E
-01
MIMAT000282 0
hsa
-miR
-
497
-5p 9.62E
-01 1.03E
-01 1.01E+00 8.49E
-01
1.00E+00
9.18E
-
01 9.85E
-01 6.71E
-01 1.00E+00
8.75E
-
01 8.95E
-01
MIMAT000282 4
hsa
-miR
-
498 9.62E
-01 5.16E
-01 1.00E+00 9.89E
-01 9.12E
-01
2.13E
-
01 7.48E
-01 3.26E
-02 9.57E
-01
4.65E
-
01 9.47E
-01
MIMAT000477 2
hsa
-miR
-
499a
-3p 9.51E
-01 4.36E
-01 9.72E
-01 7.72E
-01
1.01E+00
8.71E
-
01 8.77E
-01 2.30E
-01 8.09E
-01
1.24E
-
02 1.28E
-01
MIMAT000287 0
hsa
-miR
-
499a
-5p 9.84E
-01 6.39E
-01 9.36E
-01 1.81E
-01 8.89E
-01
9.17E
-
03 9.43E
-01 3.23E
-01 1.03E+00
4.25E
-
01 7.85E
-01
MIMAT001989 7
hsa
-miR
-
499b
-5p 1.03E+00 7.81E
-01 7.47E
-01 8.04E
-02 9.20E
-01
3.53E
-
01 1.28E+00 5.02E
-02 8.30E
-01
1.60E
-
01 7.07E
-01
MIMAT002102 1
hsa
-miR
-
5001
-5p 1.02E+00 6.05E
-01 9.44E
-01 2.94E
-01 9.93E
-01
9.08E
-
01 1.01E+00 9.43E
-01 1.01E+00
7.65E
-
01 3.17E
-01
MIMAT002104 4
hsa
-miR
-
5010
-3p 1.02E+00 6.79E
-01 9.72E
-01 6.95E
-01 9.06E
-01
1.64E
-
01 9.59E
-01 7.28E
-01 1.13E+00
7.96E
-
02 1.00E
-01
MIMAT000477 5
hsa
-miR
-
502
-3p 7.06E
-01 1.21E
-01 1.02E+00 8.97E
-01
1.11E+00
4.97E
-
01 8.22E
-01 3.82E
-01 8.85E
-01
2.97E
-
01 8.65E
-01
MIMAT000287 3
hsa
-miR
-
502
-5p 9.75E
-01 6.32E
-01 9.13E
-01 1.58E
-01 9.53E
-01
1.91E
-
01 9.99E
-01 9.82E
-01 1.01E+00
9.01E
-
01 6.71E
-01

170
MIMAT002292 5
hsa
-miR
-
503
-3p 9.70E
-01 8.19E
-01 6.87E
-01 7.81E
-02 9.86E
-01
9.52E
-
01 1.66E+00 9.04E
-02 8.78E
-01
3.97E
-
01 7.03E
-01
MIMAT000287 4
hsa
-miR
-
503
-5p 9.39E
-01 7.03E
-01 6.54E
-01 1.29E
-01
1.10E+00
4.10E
-
01 6.43E
-01 2.41E
-01 7.09E
-01
6.87E
-
02 5.00E
-01
MIMAT000287 8
hsa
-miR
-
506
-3p 9.85E
-01 8.05E
-01 1.09E+00 2.47E
-01
1.03E+00
7.34E
-
01 9.30E
-01 5.61E
-01 1.01E+00
9.10E
-
01 7.61E
-01
MIMAT002270 1
hsa
-miR
-
506
-5p 1.08E+00 5.95E
-01 8.69E
-01 4.99E
-01
1.00E+00
9.93E
-
01 1.29E+00 3.46E
-01 9.62E
-01
7.72E
-
01 4.51E
-01
MIMAT000287 9
hsa
-miR
-
507 9.69E
-01 1.82E
-01 9.93E
-01 8.49E
-01
1.03E+00
1.50E
-
01 9.79E
-01 6.55E
-01 1.01E+00
5.67E
-
01 9.48E
-01
MIMAT000477 8
hsa
-miR
-
508
-5p 1.05E+00 7.19E
-01 1.03E+00 8.98E
-01 8.84E
-01
3.71E
-
01 1.29E+00 9.95E
-02 1.10E+00
5.23E
-
01 3.96E
-02
MIMAT000288 1
hsa
-miR
-
509
-3p 8.68E
-01 3.51E
-02 1.07E+00 4.70E
-01 9.78E
-01
7.39E
-
01 9.72E
-01 7.93E
-01 9.14E
-01
1.62E
-
01 6.63E
-01
MIMAT000477 9
hsa
-miR
-
509
-5p 9.90E
-01 9.51E
-01 7.80E
-01 3.88E
-01 8.65E
-01
1.91E
-
01 9.04E
-01 6.84E
-01 1.02E+00
9.32E
-
01 2.57E
-01
MIMAT002661 3
hsa
-miR
-
510
-3p 1.19E+00 4.76E
-02 7.96E
-01 1.06E
-01
1.04E+00
6.96E
-
01 8.22E
-01 2.80E
-01 8.57E
-01
1.61E
-
01 8.94E
-02
MIMAT000280 8
hsa
-miR
-
511
-5p 7.26E
-01 1.64E
-01 9.96E
-01 9.83E
-01 8.33E
-01
3.08E
-
01 1.03E+00 8.70E
-01 1.21E+00
1.65E
-
01 1.83E
-01
MIMAT000282 2
hsa
-miR
-
512
-5p 9.56E
-01 6.19E
-02 1.01E+00 8.29E
-01 9.54E
-01
1.21E
-
01 9.77E
-01 5.65E
-01 9.94E
-01
7.41E
-
01 3.63E
-01
MIMAT000477 7
hsa
-miR
-
513a
-3p 7.55E
-01 2.64E
-01 9.48E
-01 7.75E
-01
1.26E+00
3.81E
-
02 1.00E+00 9.88E
-01 1.07E+00
6.06E
-
01 3.80E
-01
MIMAT000287 7
hsa
-miR
-
513a
-5p 9.46E
-01 4.58E
-01 8.65E
-01 1.60E
-01
1.07E+00
3.23E
-
01 9.59E
-01 6.80E
-01 9.79E
-01
7.77E
-
01
MIMAT000578 8
hsa
-miR
-
513b
-5p 9.99E
-01 9.89E
-01 1.03E+00 6.14E
-01 9.19E
-01
2.20E
-
01 9.71E
-01 7.45E
-01 1.06E+00
1.58E
-
01 8.17E
-01
MIMAT000578 9
hsa
-miR
-
513c
-5p 9.54E
-01 5.72E
-01 8.96E
-01 3.81E
-01 9.67E
-01
7.35E
-
01 1.11E+00 5.54E
-01 9.84E
-01
8.53E
-
01 5.10E
-01
MIMAT000288 3
hsa
-miR
-
514a
-3p 9.16E
-01 4.20E
-01 1.17E+00 2.08E
-01
1.15E+00
3.30E
-
01 9.06E
-01 5.86E
-01 9.73E
-01
7.78E
-
01 3.14E
-01
MIMAT002270 2
hsa
-miR
-
514a
-5p 1.01E+00 7.92E
-01 1.05E+00 3.80E
-01
1.05E+00
3.67E
-
01 9.02E
-01 2.05E
-01 1.04E+00
3.81E
-
01 5.37E
-02
MIMAT001508 8
hsa
-miR
-
514b
-3p 9.24E
-01 4.97E
-01 1.09E+00 5.53E
-01 9.63E
-01
7.82E
-
01 1.22E+00 2.72E
-01 9.25E
-01
5.01E
-
01 1.22E
-02
MIMAT001508 7
hsa
-miR
-
514b
-5p 9.40E
-01 5.38E
-01 1.04E+00 7.26E
-01
1.04E+00
7.03E
-
01 6.94E
-01 4.97E
-02 1.22E+00
2.87E
-
02 1.88E
-01
MIMAT000282 6
hsa
-miR
-
515
-5p 1.02E+00 8.87E
-01 1.04E+00 8.00E
-01
1.08E+00
6.74E
-
01 1.02E+00 9.35E
-01 1.22E+00
6.56E
-
02 2.76E
-01
MIMAT000285 9
hsa
-miR
-
516b
-5p 1.02E+00 8.79E
-01 8.23E
-01 1.51E
-01 9.91E
-01
9.39E
-
01 8.13E
-01 1.36E
-01 1.16E+00
1.58E
-
01 9.95E
-01
MIMAT000285 2
hsa
-miR
-
517a
-3p 1.05E+00 4.47E
-01 9.01E
-01 1.84E
-01
1.00E+00
9.92E
-
01 9.06E
-01 2.12E
-01 1.00E+00
9.99E
-
01 2.75E
-01

171
MIMAT000286
6
hsa-miR517c3p+hsamiR-519a3p 1.02E+00 4.91E-01 1.02E+00 5.89E-01 9.64E-01
3.18E01 1.07E+00 2.03E-01 9.69E-01
2.40E01 6.61E-01
MIMAT000284
4
hsa-miR518b 4.38E-01 5.26E-02 9.61E-01 8.54E-01 9.68E-01
8.96E01 8.13E-01 3.45E-01 1.10E+00
5.27E01 2.21E-02
MIMAT000284
8
hsa-miR518c-3p 1.03E+00 8.36E-01 8.24E-01 2.84E-01 9.76E-01
9.04E01 1.21E+00 4.98E-01 9.94E-01
9.65E01 8.15E-01
MIMAT000286
1
hsa-miR518e-3p 9.78E-01 5.16E-01 9.60E-01 3.83E-01 9.45E-01
1.60E01 9.73E-01 6.34E-01 1.01E+00
8.86E01 1.76E-01
MIMAT000284
2
hsa-miR518f-3p 1.07E+00 3.58E-01 9.44E-01 5.54E-01 9.01E-01
3.46E01 8.83E-01 3.89E-01 1.04E+00
6.51E01 6.48E-01
MIMAT002112
9
hsa-miR5196-
3p+hsamiR-6732-
3p 9.95E-01 9.52E-01 1.12E+00 3.92E-01 5.71E-01
5.70E03 7.13E-01 5.67E-02 1.06E+00
6.00E01 9.19E-01
MIMAT002112
8
hsa-miR5196-5p 9.70E-01 7.15E-01 1.06E+00 5.93E-01
1.01E+0
0
8.50E01 1.01E+00 9.24E-01 9.96E-01
9.61E01 6.57E-01
MIMAT000283
2
hsa-miR519c-3p 9.40E-01 2.22E-01 1.05E+00 4.23E-01
1.01E+0
0
7.48E01 9.39E-01 2.82E-01 9.70E-01
5.26E01 4.43E-01
MIMAT000285
3
hsa-miR519d-3p 1.05E+00 7.20E-01 1.25E+00 2.81E-01 7.98E-01
2.10E01 1.18E+00 3.30E-01 9.30E-01
6.35E01 8.40E-01
MIMAT000283
3
hsa-miR520a-5p 9.61E-01 6.23E-01 1.03E+00 7.57E-01 9.63E-01
4.90E01 9.09E-01 2.77E-01 8.71E-01
1.10E01 8.25E-04
MIMAT000284
6
hsa-miR520c-3p 9.38E-01 4.52E-01 8.19E-01 6.49E-02
1.08E+0
0
2.46E01 9.45E-01 6.26E-01 9.90E-01
9.11E01 9.88E-01
MIMAT000285
6
hsa-miR520d-3p 9.72E-01 2.79E-01 9.86E-01 7.27E-01 9.56E-01
2.36E01 9.69E-01 5.99E-01 1.00E+00
8.75E01 6.36E-01
MIMAT000283
0
hsa-miR520f-3p 9.97E-01 9.08E-01 9.72E-01 4.38E-01 9.94E-01
7.54E01 9.86E-01 6.64E-01 9.28E-01
1.88E02 3.63E-01
MIMAT000285
8
hsa-miR520g-3p 9.81E-01 6.85E-01 1.03E+00 6.23E-01 9.77E-01
4.56E01 9.97E-01 9.64E-01 9.69E-01
4.94E01 4.93E-01
MIMAT000286
7
hsa-miR520h 1.00E+00 8.87E-01 9.57E-01 1.33E-01 9.58E-01
1.78E01 9.51E-01 3.40E-01 9.87E-01
5.33E01 2.21E-02
MIMAT000285
4
hsa-miR521 1.04E+00 2.73E-01 9.55E-01 2.27E-01 9.95E-01
8.37E01 9.74E-01 4.91E-01 9.99E-01
9.76E01 9.88E-01
MIMAT000286
8
hsa-miR522-3p 9.36E-01 1.36E-01 9.93E-01 9.03E-01 9.34E-01
3.05E01 9.14E-01 2.71E-01 9.85E-01
7.80E01 3.72E-01
MIMAT000283
8
hsa-miR525-5p 1.03E+00 6.75E-01 1.13E+00 2.96E-01
1.08E+0
0
2.67E01 1.05E+00 6.46E-01 1.01E+00
9.44E01 2.44E-01
MIMAT000284
5
hsa-miR526a+hsamiR-518c- 9.87E-01 8.55E-01 1.07E+00 4.37E-01 9.94E-01
9.20E01 9.48E-01 6.52E-01 1.03E+00
6.98E01 3.76E-01

172
5p+hsamiR-518d5p
MIMAT000283
5
hsa-miR526b-5p 1.03E+00 5.81E-01 1.03E+00 6.79E-01
1.02E+0
0
7.09E01 1.09E+00 1.25E-01 1.01E+00
8.72E01 7.73E-01
MIMAT000478
0
hsa-miR532-3p 1.03E+00 6.71E-01 1.05E+00 6.09E-01
1.03E+0
0
6.59E01 8.90E-01 2.25E-01 8.77E-01
1.17E01 5.23E-01
MIMAT000338
9
hsa-miR542-3p 7.73E-01 2.27E-01 7.63E-01 2.42E-01
1.01E+0
0
9.57E01 1.56E+00 9.66E-02 1.27E+00
1.13E01 9.66E-01
MIMAT000334
0
hsa-miR542-5p 9.99E-01 9.89E-01 1.02E+00 9.00E-01 9.95E-01
9.70E01 1.06E+00 7.84E-01 9.86E-01
8.79E01 9.65E-01
MIMAT000495
4
hsa-miR543 7.40E-01 9.16E-02 9.51E-01 7.15E-01 9.23E-01
5.74E01 1.01E+00 9.58E-01 9.02E-01
2.99E01 6.50E-01
MIMAT000480
3
hsa-miR548a-5p 1.02E+00 3.60E-01 9.70E-01 2.58E-01 9.41E-01
1.77E02 9.94E-01 8.64E-01 9.97E-01
8.88E01 5.23E-01
MIMAT001844
7
hsa-miR548aa+hsa
-miR-548t3p 9.04E-01 2.85E-01 1.06E+00 5.72E-01 8.91E-01
3.55E01 1.09E+00 5.68E-01 9.38E-01
3.95E01 4.24E-02
MIMAT001897
2
hsa-miR548ah-5p 1.05E+00 5.66E-01 9.38E-01 6.40E-01
1.04E+0
0
6.11E01 1.07E+00 5.31E-01 9.92E-01
9.30E01 8.18E-01
MIMAT001901
3
hsa-miR548ak 9.79E-01 2.37E-01 9.83E-01 5.45E-01
1.01E+0
0
6.98E01 1.01E+00 8.45E-01 9.94E-01
7.65E01 4.66E-02
MIMAT002226
6
hsa-miR548ar-3p 7.90E-01 6.09E-02 1.09E+00 4.03E-01 9.74E-01
8.25E01 8.50E-01 3.67E-01 9.21E-01
3.17E01 5.65E-01
MIMAT002226
5
hsa-miR548ar-5p 1.20E+00 1.57E-01 1.04E+00 8.40E-01
1.06E+0
0
5.66E01 7.92E-01 1.30E-01 1.44E+00
4.49E03 5.69E-01
MIMAT000481
2
hsa-miR548d-5p 9.53E-01 5.98E-01 1.05E+00 6.72E-01
1.13E+0
0
7.91E02 9.89E-01 9.22E-01 9.52E-01
5.87E01 3.73E-01
MIMAT002673
6
hsa-miR548e-5p 9.70E-01 1.82E-01 9.69E-01 3.24E-01
1.04E+0
0
4.33E02 9.81E-01 6.65E-01 1.05E+00
4.56E02 8.38E-01
MIMAT000591
2
hsa-miR548g-3p 7.33E-01 2.95E-01 1.10E+00 6.27E-01 9.89E-01
9.56E01 6.73E-01 2.47E-01 9.39E-01
7.01E01 6.00E-01
MIMAT000593
5
hsa-miR548i 9.12E-01 3.58E-01 8.41E-01 1.91E-01
1.06E+0
0
4.84E01 9.21E-01 5.40E-01 9.13E-01
4.39E01 1.38E-01
MIMAT002673
7
hsa-miR548j-3p 1.06E+00 6.62E-01 9.22E-01 6.48E-01
1.04E+0
0
7.86E01 9.38E-01 7.23E-01 9.91E-01
9.56E01 3.95E-01
MIMAT000588
2
hsa-miR548k 1.08E+00 2.19E-01 8.74E-01 1.63E-01
1.14E+0
0
4.89E02 8.67E-01 2.26E-01 9.37E-01
3.90E01 9.26E-01
MIMAT000591
7
hsa-miR548m 9.89E-01 9.36E-01 8.49E-01 4.22E-01 9.56E-01
7.04E01 1.14E+00 4.93E-01 1.33E+00
8.19E02 7.51E-02
MIMAT000591
6
hsa-miR548n 9.62E-01 2.46E-01 9.91E-01 8.04E-01 9.89E-01
7.93E01 9.18E-01 1.18E-01 9.70E-01
3.64E01 7.58E-01
MIMAT001116
3
hsa-miR548q 8.36E-01 4.22E-01 1.08E+00 7.31E-01 8.51E-01
4.91E01 1.37E+00 9.91E-02 9.36E-01
7.22E01 3.37E-01

173
MIMAT001502
0
hsa-miR548v 9.17E-01 2.63E-01 1.05E+00 6.52E-01 9.41E-01
4.03E01 9.35E-01 5.76E-01 9.57E-01
5.71E01 6.53E-01
MIMAT001835
4
hsa-miR548y 1.05E+00 7.00E-01 9.12E-01 6.47E-01
1.02E+0
0
8.68E01 1.35E+00 7.11E-02 7.65E-01
1.01E01 3.90E-01
MIMAT001844
6
hsa-miR548z+hsamiR-548h3p 8.78E-01 2.50E-02 9.79E-01 7.23E-01 9.47E-01
2.63E01 1.05E+00 4.08E-01 1.02E+00
6.32E01 7.69E-01
MIMAT000333
3
hsa-miR549a 9.69E-01 4.54E-01 1.03E+00 6.41E-01 9.44E-01
3.63E01 1.02E+00 8.23E-01 9.78E-01
6.63E01 8.09E-01
MIMAT000323
3
hsa-miR551b-3p 1.09E+00 2.83E-01 9.73E-01 8.23E-01 8.53E-01
2.51E01 1.03E+00 8.58E-01 1.13E+00
1.81E01 5.48E-01
MIMAT000321
5
hsa-miR552-3p 9.80E-01 7.18E-01 1.05E+00 4.84E-01 8.22E-01
2.55E02 9.69E-01 7.46E-01 1.03E+00
6.49E01 1.67E-01
MIMAT000321
9
hsa-miR555 8.66E-01 1.54E-02 1.08E+00 2.17E-01 8.59E-01
4.29E02 7.58E-01 1.02E-02 1.05E+00
3.99E01 9.04E-01
MIMAT000479
3
hsa-miR556-3p 9.18E-01 2.74E-01 9.42E-01 6.00E-01 9.86E-01
9.03E01 1.15E+00 4.51E-01 1.06E+00
4.90E01 6.29E-01
MIMAT000322
0
hsa-miR556-5p 9.49E-01 6.29E-01 8.87E-01 3.72E-01 9.48E-01
6.12E01 5.09E-01 1.60E-02 1.08E+00
4.54E01 1.91E-01
MIMAT002270
6
hsa-miR561-5p 9.61E-01 5.70E-01 1.07E+00 5.49E-01 8.87E-01
2.30E01 1.14E+00 3.71E-01 9.26E-01
3.49E01 7.81E-01
MIMAT000322
7
hsa-miR563 9.25E-01 1.63E-02 9.85E-01 7.66E-01 9.89E-01
6.93E01 9.37E-01 1.26E-01 9.63E-01
3.41E01 2.23E-01
MIMAT000322
8
hsa-miR564 8.83E-01 2.80E-01 1.03E+00 8.20E-01 8.89E-01
3.78E01 1.20E+00 1.67E-01 8.05E-01
6.11E02 8.98E-01
MIMAT000323
0
hsa-miR566 9.72E-01 1.72E-01 9.96E-01 9.13E-01 9.99E-01
9.71E01 1.04E+00 3.61E-01 1.01E+00
5.79E01 3.17E-01
MIMAT000323
5
hsa-miR570-3p 9.53E-01 7.36E-01 1.18E+00 2.84E-01 9.92E-01
9.60E01 1.10E+00 6.59E-01 9.92E-01
9.51E01 9.64E-01
MIMAT000323
7
hsa-miR572 1.00E+00 8.64E-01 9.79E-01 5.45E-01 9.07E-01
1.93E02 9.41E-01 3.35E-01 9.89E-01
6.79E01 6.53E-01
MIMAT000323
9
hsa-miR574-3p 8.77E-01 4.90E-01 9.75E-01 9.08E-01 7.38E-01
2.82E01 4.69E-01 1.22E-01 8.31E-01
2.64E01 8.54E-01
MIMAT000479
5
hsa-miR574-5p 9.92E-01 7.46E-01 1.01E+00 7.01E-01 9.61E-01
9.18E02 1.00E+00 9.94E-01 9.91E-01
7.58E01 7.02E-01
MIMAT000324
0
hsa-miR575 9.65E-01 1.72E-01 9.41E-01 1.25E-01
1.02E+0
0
6.24E01 9.73E-01 5.86E-01 9.90E-01
6.91E01 2.66E-01
MIMAT000479
6
hsa-miR576-3p 7.98E-01 1.05E-01 9.65E-01 8.48E-01 6.90E-01
7.53E02 1.19E+00 4.40E-01 1.03E+00
7.89E01 7.21E-01
MIMAT000324
1
hsa-miR576-5p 9.97E-01 9.70E-01 1.04E+00 6.87E-01
1.03E+0
0
6.85E01 9.54E-01 6.83E-01 1.01E+00
8.97E01 2.96E-01
MIMAT000324
2
hsa-miR577 1.02E+00 8.73E-01 1.14E+00 4.10E-01 9.91E-01
9.21E01 9.83E-01 9.09E-01 1.01E+00
9.40E01 8.39E-01

174
MIMAT002661
6
hsa-miR579-5p 9.94E-01 8.31E-01 9.81E-01 6.31E-01 9.77E-01
5.41E01 9.11E-01 1.29E-01 1.02E+00
4.38E01 2.36E-01
MIMAT000479
7
hsa-miR582-3p 1.04E+00 7.01E-01 7.45E-01 3.19E-02 9.54E-01
5.63E01 8.91E-01 4.10E-01 9.58E-01
6.89E01 1.47E-01
MIMAT000324
7
hsa-miR582-5p 9.86E-01 8.59E-01 8.17E-01 8.81E-02 9.55E-01
4.89E01 8.45E-01 1.27E-01 9.48E-01
5.05E01 7.93E-01
MIMAT002270
8
hsa-miR584-3p 1.07E+00 4.68E-01 9.67E-01 7.65E-01
1.02E+0
0
8.38E01 1.02E+00 8.80E-01 1.06E+00
4.53E01 5.60E-01
MIMAT000324
9
hsa-miR584-5p 9.55E-01 1.45E-01 1.00E+00 9.62E-01 9.99E-01
9.84E01 9.15E-01 8.12E-02 9.94E-01
8.62E01 6.24E-01
MIMAT000325
0
hsa-miR585-3p 9.91E-01 6.68E-01 9.66E-01 3.27E-01 9.76E-01
5.03E01 9.79E-01 7.30E-01 1.00E+00
9.95E01 4.83E-01
MIMAT000325
3
hsa-miR587 9.67E-01 5.95E-01 1.06E+00 5.49E-01
1.08E+0
0
1.94E01 1.01E+00 8.81E-01 9.55E-01
4.81E01 5.78E-01
MIMAT000325
8
hsa-miR590-5p 9.94E-01 7.09E-01 1.01E+00 7.57E-01 9.27E-01
1.39E03 1.01E+00 7.55E-01 9.85E-01
4.18E01 2.47E-01
MIMAT000325
9
hsa-miR591 9.47E-01 5.21E-01 1.10E+00 4.31E-01
1.06E+0
0
5.07E01 8.65E-01 3.09E-01 8.94E-01
2.58E01 2.31E-01
MIMAT000326
0
hsa-miR592 9.93E-01 6.68E-01 9.54E-01 8.74E-02 9.88E-01
5.06E01 1.03E+00 2.61E-01 9.87E-01
4.35E01 7.55E-01
MIMAT000480
2
hsa-miR593-3p 9.89E-01 9.09E-01 1.02E+00 8.56E-01 9.18E-01
4.22E01 9.06E-01 5.73E-01 1.12E+00
3.02E01 5.78E-01
MIMAT000326
3
hsa-miR595 1.16E+00 3.87E-01 5.59E-01 8.94E-02
1.02E+0
0
8.74E01 8.02E-01 5.41E-01 1.00E+00
9.99E01 6.71E-01
MIMAT000326
5
hsa-miR597-5p 7.97E-01 8.25E-02 1.03E+00 8.47E-01
1.05E+0
0
6.20E01 1.14E+00 3.63E-01 9.21E-01
4.51E01 1.43E-01
MIMAT000326
6
hsa-miR598-3p 1.00E+00 9.75E-01 1.01E+00 6.15E-01 9.67E-01
2.99E01 9.13E-01 2.40E-02 1.01E+00
5.63E01 5.24E-01
MIMAT000327
1
hsa-miR603 1.01E+00 8.93E-01 9.17E-01 2.99E-01
1.12E+0
0
1.70E01 1.09E+00 4.76E-01 1.01E+00
8.31E01 5.38E-01
MIMAT000327
3
hsa-miR605-5p 9.56E-01 6.86E-01 8.77E-01 4.49E-01
1.11E+0
0
2.69E01 9.43E-01 7.48E-01 1.04E+00
7.19E01 8.16E-01
MIMAT000327
5
hsa-miR607 8.85E-01 2.34E-01 9.82E-01 8.62E-01
1.08E+0
0
5.36E01 1.00E+00 9.80E-01 9.27E-01
3.76E01 3.64E-01
MIMAT000327
6
hsa-miR608 1.06E+00 6.58E-01 1.23E+00 2.33E-01
1.02E+0
0
9.28E01 8.90E-01 7.03E-01 1.02E+00
8.56E01 7.88E-01
MIMAT000328
0
hsa-miR612 8.85E-01 4.87E-01 8.39E-01 3.70E-01
1.10E+0
0
4.10E01 8.89E-01 5.08E-01 1.03E+00
8.35E01 8.63E-01
MIMAT000328
3
hsa-miR615-3p 1.01E+00 8.63E-01 8.39E-01 5.79E-02 9.62E-01
5.46E01 1.00E+00 1.00E+00
#VALUE
! NULL 9.16E-01
MIMAT000480
5
hsa-miR616-3p 1.06E+00 5.85E-01 1.08E+00 5.93E-01 8.93E-01
4.54E01 7.48E-01 2.59E-01 1.17E+00
2.17E01 4.86E-01
MIMAT000328
9
hsa-miR620 9.78E-01 8.97E-01 1.15E+00 4.08E-01
1.24E+0
0
2.19E01 9.78E-01 9.43E-01 6.18E-01
1.45E02 6.08E-01

175
MIMAT000329
5
hsa-miR626 1.02E+00 6.53E-01 1.03E+00 7.42E-01
1.05E+0
0
3.24E01 1.00E+00 9.55E-01 1.00E+00
9.60E01 2.30E-01
MIMAT002662
3
hsa-miR627-3p 8.95E-01 3.15E-01 1.00E+00 9.89E-01
1.09E+0
0
4.47E01 4.54E-01 3.34E-03 9.96E-01
9.69E01 4.34E-01
MIMAT000329
6
hsa-miR627-5p 9.81E-01 2.46E-01 9.61E-01 1.03E-01 9.97E-01
9.14E01 9.31E-01 8.24E-02 9.81E-01
2.41E01 8.56E-01
MIMAT000329
7
hsa-miR628-3p 9.38E-01 2.19E-01 1.03E+00 6.69E-01 9.60E-01
4.77E01 9.11E-01 2.61E-01 1.06E+00
2.03E01 6.60E-01
MIMAT000329
9
hsa-miR630 9.42E-01 3.00E-01 1.03E+00 7.56E-01 8.97E-01
2.03E01 8.25E-01 1.60E-01 1.04E+00
5.40E01 7.33E-01
MIMAT000330
0
hsa-miR631 1.01E+00 9.65E-01 1.14E+00 4.43E-01
1.16E+0
0
1.17E01 1.08E-01 6.48E-02 1.01E+00
9.25E01 5.58E-01
MIMAT000330
9
hsa-miR639 8.51E-01 2.75E-01 1.11E+00 5.13E-01 6.90E-01
4.98E02 8.93E-01 5.82E-01 9.91E-01
9.36E01 2.63E-01
MIMAT000331
0
hsa-miR640 9.85E-01 5.96E-01 1.00E+00 9.31E-01 9.13E-01
4.10E02 9.50E-01 5.34E-01 9.75E-01
4.07E01 4.00E-01
MIMAT000331
2
hsa-miR642a-5p 9.79E-01 3.79E-01 1.01E+00 8.53E-01 9.62E-01
2.89E01 9.27E-01 1.03E-01 1.01E+00
6.38E01 8.52E-01
MIMAT000331
3
hsa-miR643 1.01E+00 4.79E-01 1.00E+00 9.49E-01 9.69E-01
3.14E01 9.87E-01 7.66E-01 9.66E-01
1.76E01 9.03E-01
MIMAT000331
4
hsa-miR644a 9.57E-01 2.57E-01 1.02E+00 6.88E-01 8.86E-01
7.73E02 1.04E+00 5.55E-01 1.04E+00
3.88E01 1.88E-01
MIMAT000331
9
hsa-miR649 1.11E+00 4.95E-01 7.36E-01 1.06E-01
1.13E+0
0
5.04E01 1.11E+00 6.89E-01 9.49E-01
7.33E01 9.24E-02
MIMAT000332
0
hsa-miR650 9.86E-01 5.22E-01 9.96E-01 8.92E-01 9.52E-01
1.18E01 9.19E-01 6.42E-02 9.93E-01
7.16E01 9.40E-01
MIMAT002546
2
hsa-miR6503-5p 9.74E-01 8.06E-01 1.06E+00 6.48E-01 9.05E-01
4.86E01 1.15E+00 3.76E-01 8.77E-01
2.07E01 6.01E-01
MIMAT000332
1
hsa-miR651-5p 9.48E-01 2.93E-01 8.92E-01 9.92E-02 8.98E-01
8.66E02 9.97E-01 9.75E-01 1.01E+00
8.36E01 8.12E-01
MIMAT002270
9
hsa-miR652-5p 5.47E-01 1.24E-01 8.02E-01 3.45E-01 8.99E-01
4.91E01 1.06E+00 8.00E-01 3.62E-01
1.75E03 8.66E-01
MIMAT000333
0
hsa-miR654-5p 1.00E+00 9.84E-01 9.80E-01 7.57E-01 8.65E-01
2.79E02 1.07E+00 4.49E-01 1.03E+00
5.20E01 6.52E-01
MIMAT000333
1
hsa-miR655-3p 9.30E-01 1.27E-02 9.89E-01 7.92E-01
1.03E+0
0
4.16E01 9.42E-01 2.83E-01 9.74E-01
4.36E01 1.18E-01
MIMAT000333
2
hsa-miR656-3p 9.77E-01 2.19E-01 9.94E-01 8.33E-01
1.03E+0
0
2.25E01 9.97E-01 9.37E-01 1.01E+00
5.53E01 6.01E-01
MIMAT002271
1
hsa-miR660-3p 8.18E-01 1.82E-01 7.70E-01 1.17E-01
1.05E+0
0
6.34E01 1.07E+00 6.96E-01 7.80E-01
5.03E02 8.01E-01
MIMAT000332
6
hsa-miR663a 1.00E+00 9.83E-01 7.52E-01 2.81E-01
1.01E+0
0
8.79E01 1.12E+00 5.28E-01 1.24E+00
1.83E01 9.18E-03
MIMAT000594
9
hsa-miR664a-3p 9.33E-01 2.13E-01 1.04E+00 6.01E-01 8.69E-01
4.10E02 1.07E+00 3.37E-01 1.03E+00
5.89E01 3.76E-01

176
MIMAT002227 2
hsa
-miR
-
664b
-3p 9.87E
-01 6.48E
-01 9.86E
-01 7.15E
-01
1.05E+00
1.10E
-
01 1.03E+00 3.77E
-01 1.01E+00
6.72E
-
01 4.02E
-01
MIMAT000495 2
hsa
-miR
-
665 7.34E
-01 2.01E
-02 9.98E
-01 9.82E
-01 9.21E
-01
4.50E
-
01 1.12E+00 3.73E
-01 1.01E+00
9.45E
-
01 6.35E
-02
MIMAT000388 0
hsa
-miR
-
671
-5p 9.65E
-01 1.01E
-01 9.88E
-01 6.88E
-01 9.90E
-01
7.54E
-
01 8.93E
-01 2.22E
-02 1.01E+00
8.32E
-
01 3.37E
-01
MIMAT002585 1
hsa
-miR
-
6720
-3p 9.33E
-01 5.96E
-01 7.18E
-01 1.68E
-01
1.22E+00
1.01E
-
01 1.05E+00 8.27E
-01 1.05E+00
6.94E
-
01 5.74E
-03
MIMAT002585 2
hsa
-miR
-
6721
-5p 1.00E+00 9.68E
-01 1.00E+00 9.63E
-01
1.01E+00
8.16E
-
01 9.03E
-01 6.16E
-02 1.01E+00
6.52E
-
01 1.75E
-01
MIMAT002585 6
hsa
-miR
-
6724
-5p 9.91E
-01 5.07E
-01 9.62E
-01 9.75E
-02 9.56E
-01
2.24E
-
02 1.00E+00 9.95E
-01 9.87E
-01
4.61E
-
01 8.26E
-01
MIMAT000494 5
hsa
-miR
-
744
-5p 1.11E+00 2.11E
-01 1.03E+00 8.34E
-01 9.62E
-01
7.96E
-
01 1.09E+00 7.31E
-01 1.06E+00
5.72E
-
01 1.57E
-02
MIMAT002292 9
hsa
-miR
-
758
-5p 9.21E
-01 1.46E
-01 9.63E
-01 5.98E
-01
1.00E+00
9.60E
-
01 1.12E+00 2.63E
-01 1.01E+00
8.16E
-
01 4.27E
-01
MIMAT001036 4
hsa
-miR
-
761 9.44E
-01 1.58E
-02 1.02E+00 5.48E
-01 9.71E
-01
3.04E
-
01 1.00E+00 9.85E
-01 1.01E+00
4.86E
-
01 6.94E
-01
MIMAT001036 7
hsa
-miR
-
764 9.97E
-01 9.09E
-01 9.97E
-01 9.22E
-01 9.81E
-01
3.08E
-
01 1.00E+00 9.92E
-01 1.03E+00
2.78E
-
01 7.19E
-01
MIMAT000394 5
hsa
-miR
-
765 6.95E
-01 3.45E
-02 9.92E
-01 9.57E
-01
1.14E+00
3.65E
-
01 7.51E
-01 2.02E
-01 9.54E
-01
6.88E
-
01 4.75E
-01
MIMAT000388 2
hsa
-miR
-
767
-5p 1.03E+00 2.87E
-01 1.02E+00 6.54E
-01
1.00E+00
8.77E
-
01 1.09E+00 1.99E
-01 9.96E
-01
8.82E
-
01 2.61E
-01
MIMAT000388 7
hsa
-miR
-
769
-3p 9.59E
-01 1.03E
-01 9.41E
-01 9.83E
-02 9.70E
-01
1.21E
-
01 1.00E+00 9.45E
-01 1.01E+00
5.74E
-
01 6.57E
-01
MIMAT000388 6
hsa
-miR
-
769
-5p 1.01E+00 6.60E
-01 1.02E+00 5.95E
-01 9.71E
-01
4.36E
-
01 9.36E
-01 2.79E
-01 9.86E
-01
6.53E
-
01 3.95E
-01
MIMAT000394 8
hsa
-miR
-
770
-5p 9.59E
-01 1.68E
-01 1.02E+00 6.67E
-01 9.56E
-01
2.58E
-
01 9.78E
-01 7.44E
-01 1.03E+00
3.69E
-
01 2.23E
-01
MIMAT000418 5
hsa
-miR
-
802 4.37E
-01 5.85E
-02 7.18E
-01 1.26E
-01 6.51E
-01
6.92E
-
02 6.98E
-01 3.72E
-01 9.26E
-01
6.56E
-
01 2.63E
-01
MIMAT002271 7
hsa
-miR
-
873
-3p 9.91E
-01 7.07E
-01 9.95E
-01 8.78E
-01 9.23E
-01
7.23E
-
02 9.85E
-01 7.70E
-01 1.00E+00
9.27E
-
01 1.70E
-01
MIMAT000495 3
hsa
-miR
-
873
-5p 9.55E
-01 1.08E
-02 9.89E
-01 6.93E
-01
1.02E+00
3.82E
-
01 9.05E
-01 3.51E
-02 1.01E+00
4.68E
-
01 4.31E
-01
MIMAT002671 8
hsa
-miR
-
874
-5p 1.02E+00 7.62E
-01 9.21E
-01 3.17E
-01
1.09E+00
5.01E
-
02 9.61E
-01 6.57E
-01 1.02E+00
6.95E
-
01 6.57E
-01
MIMAT000492 5
hsa
-miR
-
876
-3p 9.35E
-01 1.65E
-01 1.00E+00 9.59E
-01 9.86E
-01
7.98E
-
01 9.58E
-01 6.43E
-01 9.95E
-01
9.10E
-
01 8.27E
-01
MIMAT000492 4
hsa
-miR
-
876
-5p 9.88E
-01 4.93E
-01 9.89E
-01 6.15E
-01 9.63E
-01
1.21E
-
01 9.63E
-01 2.66E
-01 9.68E
-01
9.35E
-
02 6.96E
-01
MIMAT000494 9
hsa
-miR
-
877
-5p 1.06E+00 4.84E
-01 8.92E
-01 3.48E
-01 6.47E
-01
1.13E
-
02 1.35E+00 2.16E
-02 1.12E+00
1.60E
-
01 5.62E
-01

177
MIMAT000494
8
hsa-miR885-3p 1.01E+00 7.50E-01 1.00E+00 9.13E-01 9.56E-01
2.85E01 1.02E+00 7.53E-01 9.68E-01
2.24E01 6.95E-01
MIMAT002672
0
hsa-miR887-5p 9.34E-01 2.72E-01 8.85E-01 1.65E-01 8.96E-01
2.20E01 1.06E+00 6.70E-01 9.33E-01
3.33E01 8.36E-01
MIMAT000491
6
hsa-miR888-5p 9.68E-01 4.95E-01 9.86E-01 8.17E-01
1.07E+0
0
2.94E01 1.01E+00 8.96E-01 9.52E-01
3.22E01 9.48E-01
MIMAT000492
1
hsa-miR889-3p 9.99E-01 9.46E-01 1.00E+00 9.11E-01 9.34E-01
5.12E02 1.02E+00 6.46E-01 9.89E-01
6.13E01 7.02E-01
MIMAT000491
2
hsa-miR890 9.41E-01 3.42E-01 1.01E+00 8.77E-01 8.50E-01
1.17E01 9.71E-01 8.33E-01 9.15E-01
1.74E01 4.48E-01
MIMAT000490
2
hsa-miR891a-5p 1.00E+00 9.95E-01 1.13E+00 2.29E-01
1.08E+0
0
3.11E01 7.89E-01 7.95E-02 9.79E-01
7.70E01 6.88E-01
MIMAT000491
3
hsa-miR891b 1.11E+00 3.46E-02 9.84E-01 7.96E-01 9.76E-01
5.23E01 1.05E+00 4.45E-01 9.42E-01
1.95E01 9.58E-01
MIMAT000490
7
hsa-miR892a 9.42E-01 5.99E-01 9.94E-01 9.70E-01
1.06E+0
0
4.71E01 1.20E+00 2.09E-01 7.76E-01
4.36E02 2.66E-01
MIMAT000497
2
hsa-miR922 9.76E-01 5.75E-01 1.04E+00 5.41E-01
1.05E+0
0
3.18E01 1.08E+00 3.77E-01 9.19E-01
8.13E02 8.53E-01
MIMAT000450
7
hsa-miR92a-1-5p 9.77E-01 6.73E-01 1.02E+00 7.95E-01 8.68E-01
8.87E02 9.80E-01 8.86E-01 9.49E-01
4.24E01 2.27E-01
MIMAT000009
2
hsa-miR92a-3p 9.82E-01 4.63E-01 9.65E-01 3.66E-01
1.02E+0
0
3.33E01 1.04E+00 3.85E-01 9.79E-01
5.15E01 9.53E-01
MIMAT000321
8
hsa-miR92b-3p 9.97E-01 8.88E-01 1.00E+00 9.75E-01 9.22E-01
8.36E03 9.92E-01 8.29E-01 1.02E+00
5.39E01 5.93E-01
MIMAT000009
3
hsa-miR93-5p 1.04E+00 6.47E-01 1.13E+00 3.35E-01 7.64E-01
1.02E01 7.75E-01 2.22E-01 9.46E-01
5.08E01 7.97E-01
MIMAT000497
6
hsa-miR933 9.82E-01 4.35E-01 9.90E-01 7.54E-01 9.40E-01
3.25E02 1.09E+00 1.11E-01 9.99E-01
9.83E01 3.58E-01
MIMAT000497
7
hsa-miR934 9.44E-01 3.31E-01 1.00E+00 9.97E-01
1.10E+0
0
1.09E01 1.06E+00 5.64E-01 1.04E+00
6.30E01 5.05E-01
MIMAT000497
8
hsa-miR935 9.85E-01 4.80E-01 1.02E+00 5.65E-01 9.51E-01
1.10E01 9.64E-01 4.07E-01 9.98E-01
9.51E01 4.57E-01
MIMAT000497
9
hsa-miR936 5.81E-01 8.71E-02 1.18E+00 4.06E-01 6.35E-01
1.40E01 5.55E-01 2.16E-01 8.65E-01
3.07E01 5.24E-01
MIMAT000498
0
hsa-miR937-3p 9.58E-01 1.49E-01 1.03E+00 4.42E-01
1.01E+0
0
7.86E01 9.85E-01 8.14E-01 9.71E-01
3.38E01 7.91E-01
MIMAT000498
2
hsa-miR939-5p 9.72E-01 5.89E-01 1.12E+00 1.80E-01 9.25E-01
4.40E01 9.09E-01 3.65E-01 1.06E+00
3.22E01 8.59E-01
MIMAT000498
3
hsa-miR940 9.88E-01 9.41E-01 8.27E-01 4.22E-01
1.17E+0
0
3.80E01 7.92E-01 5.23E-01 9.10E-01
4.99E01 4.71E-03
MIMAT000498
4
hsa-miR941 1.00E+00 9.49E-01 9.98E-01 9.59E-01 9.35E-01
7.46E02 9.53E-01 2.72E-01 1.00E+00
9.29E01 2.56E-01
MIMAT000498
5
hsa-miR942-5p 9.75E-01 5.05E-01 9.94E-01 9.19E-01
1.06E+0
0
1.50E01 9.44E-01 3.97E-01 9.41E-01
1.49E01 3.67E-01

178
MIMAT000009
4
hsa-miR95-3p 9.30E-01 5.34E-01 8.80E-01 3.91E-01
1.01E+0
0
9.57E01 8.39E-01 4.01E-01 8.83E-01
2.68E01 7.05E-01
MIMAT000009
5
hsa-miR96-5p 9.97E-01 9.64E-01 9.07E-01 2.77E-01 9.20E-01
3.56E01 9.47E-01 6.69E-01 1.03E+00
7.08E01 9.92E-01
MIMAT000068
9
hsa-miR99b-5p 1.24E+00 7.78E-02 1.26E+00 1.58E-01
1.10E+0
0
3.92E01 9.12E-01 6.75E-01 1.04E+00
6.96E01 1.22E-01

179
Appendix J. Heterogeneity by body mass index (kg/m2) for the association of alcohol intake (continuous per drink) and circulating microRNA
adjusted for age at biospecimen draw, sex, race/ethnicity, smoking status, batch, time in years between baseline questionnaire and biospecimen draw,
and case-control status.
Accessi
on miRNA
BMI <25 IRR
ethanol intake per
drink
BMI <25
nominal pvalue
BMI 25-29.9 IRR
ethanol intake per
drink
BMI 25-29.9
nominal pvalue
BMI ≥30 IRR
ethanol intake per
drink
BMI ≥30
nominal pvalue
P for
heteroge
neity
MIMAT
0000062 hsa-let-7a-5p 1.09E+00 5.15E-01 9.50E-01 5.70E-01 8.47E-01 3.98E-01 7.91E-01
MIMAT
0000063 hsa-let-7b-5p 9.55E-01 2.10E-01 9.84E-01 5.38E-01 1.00E+00 9.90E-01 5.60E-01
MIMAT
0000064 hsa-let-7c-5p 1.02E+00 8.61E-01 8.87E-01 7.68E-02 8.18E-01 3.18E-01 2.10E-01
MIMAT
0000065 hsa-let-7d-5p 9.53E-01 5.85E-01 1.02E+00 8.13E-01 1.05E+00 5.75E-01 5.30E-01
MIMAT
0000067 hsa-let-7f-5p 1.01E+00 9.08E-01 9.78E-01 7.43E-01 1.04E+00 8.19E-01 7.90E-01
MIMAT
0000414 hsa-let-7g-5p 1.01E+00 9.33E-01 1.01E+00 7.99E-01 1.10E+00 1.56E-01 3.84E-01
MIMAT
0000098 hsa-miR-100-5p 1.12E+00 4.33E-01 9.77E-01 8.23E-01 1.01E+00 9.44E-01 6.99E-01
MIMAT
0000102 hsa-miR-105-5p 1.07E+00 2.68E-01 1.06E+00 2.04E-01 1.04E+00 5.97E-01 3.28E-01
MIMAT
0000680 hsa-miR-106b-5p 9.68E-01 6.52E-01 1.06E+00 2.04E-01 8.86E-01 3.19E-01 2.73E-01
MIMAT
0000104 hsa-miR-107 1.02E+00 7.21E-01 9.71E-01 4.33E-01 1.12E+00 2.55E-01 2.44E-01
MIMAT
0000253 hsa-miR-10a-5p 9.88E-01 5.89E-01 9.72E-01 6.35E-02 9.87E-01 6.05E-01 5.93E-01
MIMAT
0000254 hsa-miR-10b-5p 9.59E-01 4.78E-01 9.58E-01 3.69E-01 1.07E+00 2.39E-01 6.75E-01
MIMAT
0005825 hsa-miR-1180-3p 9.87E-01 6.79E-01 9.67E-01 1.40E-01 1.01E+00 6.41E-01 7.82E-01
MIMAT
0005828 hsa-miR-1183 1.00E+00 9.81E-01 1.00E+00 9.15E-01 8.92E-01 1.64E-01 1.50E-01
MIMAT
0022838 hsa-miR-1185-1-3p 1.07E+00 5.20E-01 8.64E-01 5.32E-02 1.02E+00 9.16E-01 8.10E-01
MIMAT
0022713 hsa-miR-1185-2-3p 9.56E-01 6.38E-01 1.05E+00 4.82E-01 9.68E-01 6.68E-01 6.46E-01
MIMAT
0005798 hsa-miR-1185-5p 1.05E+00 9.55E-02 9.86E-01 4.86E-01 1.02E+00 5.32E-01 8.01E-01
MIMAT
0015049 hsa-miR-1193 9.80E-01 6.70E-01 9.43E-01 1.04E-01 8.74E-01 2.80E-02 2.03E-01

180
MIMAT
0005955 hsa
-miR
-1197 9.96E
-01 9.01E
-01 9.54E
-01 7.74E
-02 1.06E+00 1.66E
-01 1.62E
-02
MIMAT
0005863 hsa
-miR
-1200 1.06E+00 7.14E
-01 1.02E+00 8.38E
-01 8.41E
-01 4.27E
-01 2.21E
-01
MIMAT
0005865 hsa
-miR
-1202 1.01E+00 9.36E
-01 9.58E
-01 5.05E
-01 1.07E+00 4.20E
-01 8.66E
-01
MIMAT
0005866 hsa
-miR
-1203 1.29E+00 9.18E
-02 9.42E
-01 6.20E
-01 8.54E
-01 3.68E
-01 4.87E
-01
MIMAT
0005869 hsa
-miR
-1205 1.03E+00 6.45E
-01 9.42E
-01 1.25E
-01 1.20E+00 4.33E
-02 4.80E
-01
MIMAT
0005870 hsa
-miR
-1206 1.02E+00 3.50E
-01 9.76E
-01 2.11E
-01 9.81E
-01 6.81E
-01 9.15E
-01
MIMAT
0000421 hsa
-miR
-122
-5p 1.02E+00 6.06E
-01 9.72E
-01 2.29E
-01 1.07E+00 2.46E
-01 7.45E
-01
MIMAT
0005459 hsa
-miR
-1224
-3p 9.48E
-01 3.22E
-01 9.51E
-01 2.21E
-01 1.02E+00 8.35E
-01 3.11E
-01
MIMAT
0005577 hsa
-miR
-1226
-3p 9.58E
-01 6.94E
-01 9.31E
-01 3.41E
-01 9.51E
-01 6.65E
-01 5.33E
-01
MIMAT
0005583 hsa
-miR
-1228
-3p 9.24E
-01 5.27E
-01 9.10E
-01 2.73E
-01 1.38E+00 1.65E
-01 5.38E
-01
MIMAT
0005589 hsa
-miR
-1234
-3p 1.00E+00 8.79E
-01 9.82E
-01 4.18E
-01 9.73E
-01 5.79E
-01 1.54E
-01
MIMAT
0005591 hsa
-miR
-1236
-3p 1.03E+00 7.05E
-01 9.84E
-01 7.42E
-01 1.14E+00 3.08E
-01 9.24E
-01
MIMAT
0005896 hsa
-miR
-1244 9.63E
-01 1.80E
-01 9.90E
-01 6.24E
-01 1.00E+00 8.68E
-01 8.14E
-01
MIMAT
0005897 hsa
-miR
-1245a 9.90E
-01 7.32E
-01 9.84E
-01 4.16E
-01 9.51E
-01 3.66E
-01 7.84E
-01
MIMAT
0019950 hsa
-miR
-1245b
-5p 1.07E+00 1.39E
-01 9.01E
-01 3.88E
-03 1.01E+00 8.65E
-01 6.35E
-01
MIMAT
0005898 hsa
-miR
-1246 1.06E+00 6.40E
-01 9.87E
-01 8.73E
-01 1.21E+00 4.50E
-02 8.68E
-01
MIMAT
0005901 hsa
-miR
-1249
-3p 9.32E
-01 3.33E
-01 9.79E
-01 6.42E
-01 9.67E
-01 7.25E
-01 1.19E
-01
MIMAT
0005904 hsa
-miR
-1253 8.80E
-01 3.82E
-01 8.36E
-01 1.79E
-01 1.07E+00 4.68E
-01 4.65E
-01
MIMAT
0005905 hsa
-miR
-1254 9.69E
-01 2.32E
-01 9.81E
-01 3.47E
-01 1.04E+00 1.68E
-01 3.95E
-01
MIMAT
0005906 hsa
-miR
-1255a 9.40E
-01 5.84E
-01 9.84E
-01 8.37E
-01 1.20E+00 6.06E
-02 4.85E
-01
MIMAT
0005908 hsa
-miR
-1257 1.22E+00 2.25E
-01 1.14E+00 2.55E
-01 1.42E+00 2.58E
-02 2.41E
-01
MIMAT
0005909 hsa
-miR
-1258 1.02E+00 5.13E
-01 9.78E
-01 1.66E
-01 1.01E+00 4.08E
-01 9.29E
-01

181
MIMAT
0004602 hsa
-miR
-125a
-3p 9.66E
-01 6.51E
-01 9.73E
-01 5.83E
-01 1.05E+00 4.31E
-01 8.49E
-01
MIMAT
0000423 hsa
-miR
-125b
-5p 9.98E
-01 9.28E
-01 9.78E
-01 2.52E
-01 9.97E
-01 9.32E
-01 6.50E
-01
MIMAT
0000445 hsa
-miR
-126
-3p 1.06E+00 2.66E
-02 9.87E
-01 5.09E
-01 9.83E
-01 7.38E
-01 4.16E
-01
MIMAT
0005913 hsa
-miR
-1261 8.86E
-01 1.42E
-01 9.45E
-01 3.55E
-01 1.03E+00 6.40E
-01 6.62E
-01
MIMAT
0005914 hsa
-miR
-1262 1.01E+00 9.32E
-01 9.18E
-01 2.11E
-01 1.07E+00 3.97E
-01 6.64E
-01
MIMAT
0005791 hsa
-miR
-1264 1.07E+00 6.31E
-01 9.96E
-01 9.69E
-01 8.93E
-01 6.88E
-01 4.11E
-01
MIMAT
0005920 hsa
-miR
-1266
-5p 9.90E
-01 8.89E
-01 9.73E
-01 5.23E
-01 1.01E+00 8.79E
-01 2.63E
-01
MIMAT
0005922 hsa
-miR
-1268a 1.01E+00 9.24E
-01 9.44E
-01 4.30E
-01 9.68E
-01 8.63E
-01 2.84E
-01
MIMAT
0018925 hsa
-miR
-1268b 1.00E+00 8.52E
-01 9.88E
-01 3.51E
-01 9.76E
-01 4.71E
-01 7.39E
-01
MIMAT
0005923 hsa
-miR
-1269a 8.93E
-01 7.10E
-02 9.76E
-01 6.14E
-01 1.04E+00 5.11E
-01 9.06E
-01
MIMAT
0000446 hsa
-miR
-127
-3p 9.98E
-01 9.21E
-01 9.81E
-01 2.15E
-01 1.03E+00 2.40E
-01 5.73E
-01
MIMAT
0004604 hsa
-miR
-127
-5p 9.19E
-01 6.01E
-01 1.02E+00 8.52E
-01 1.06E+00 7.21E
-01 2.41E
-01
MIMAT
0005924 hsa
-miR
-1270 7.18E
-01 5.10E
-02 7.23E
-01 9.24E
-02 1.04E+00 8.56E
-01 4.93E
-01
MIMAT
0005796 hsa
-miR
-1271
-5p 9.21E
-01 6.19E
-01 8.73E
-01 3.18E
-01 1.09E+00 5.54E
-01 9.67E
-01
MIMAT
0005925 hsa
-miR
-1272 1.04E+00 4.94E
-01 8.83E
-01 8.75E
-03 9.70E
-01 7.93E
-01 1.88E
-01
MIMAT
0005933 hsa
-miR
-1277
-3p 1.06E+00 6.61E
-01 1.09E+00 3.53E
-01 1.39E+00 2.62E
-01 3.27E
-03
MIMAT
0005936 hsa
-miR
-1278 8.65E
-01 3.21E
-01 9.22E
-01 4.48E
-01 1.03E+00 8.00E
-01 1.38E
-01
MIMAT
0005937 hsa
-miR
-1279 9.18E
-01 7.90E
-02 1.03E+00 3.67E
-01 9.29E
-01 1.15E
-01 2.68E
-01
MIMAT
0000424 hsa
-miR
-128
-3p 1.05E+00 5.52E
-01 9.71E
-01 6.79E
-01 9.93E
-01 9.35E
-01 5.03E
-01
MIMAT
0005939 hsa
-miR
-1281 9.05E
-01 4.94E
-01 1.00E+00 9.73E
-01 9.97E
-01 9.91E
-01 9.95E
-01
MIMAT
0005876 hsa
-miR
-1285
-3p 7.96E
-01 2.43E
-01 1.08E+00 5.32E
-01 8.79E
-01 6.31E
-01 8.98E
-01
MIMAT
0022719 hsa
-miR
-1285
-5p 1.00E+00 9.80E
-01 1.02E+00 2.28E
-01 9.39E
-01 3.25E
-02 8.10E
-01

182
MIMAT
0005877 hsa
-miR
-1286 1.04E+00 4.47E
-01 9.48E
-01 1.39E
-01 9.23E
-01 3.22E
-01 3.09E
-01
MIMAT
0005878 hsa
-miR
-1287
-5p 9.57E
-01 4.92E
-01 9.25E
-01 1.07E
-01 8.96E
-01 1.60E
-01 6.77E
-01
MIMAT
0004605 hsa
-miR
-129
-
2
-3p 1.06E+00 5.11E
-01 8.92E
-01 1.13E
-01 1.30E+00 9.28E
-03 1.19E
-01
MIMAT
0005880 hsa
-miR
-1290 1.03E+00 6.72E
-01 9.98E
-01 9.62E
-01 1.05E+00 4.59E
-01 4.65E
-01
MIMAT
0005883 hsa
-miR
-1293 1.00E+00 9.90E
-01 7.95E
-01 8.25E
-02 1.08E+00 4.90E
-01 7.84E
-01
MIMAT
0005885 hsa
-miR
-1295a 9.95E
-01 9.78E
-01 8.91E
-01 4.10E
-01 1.04E+00 7.67E
-01 1.02E
-01
MIMAT
0026637 hsa
-miR
-1296
-3p 1.02E+00 8.67E
-01 1.10E+00 3.18E
-01 8.58E
-01 5.44E
-01 6.45E
-01
MIMAT
0005886 hsa
-miR
-1297 1.01E+00 6.83E
-01 9.61E
-01 9.07E
-02 9.27E
-01 8.43E
-02 7.39E
-01
MIMAT
0005800 hsa
-miR
-1298
-5p 9.92E
-01 6.80E
-01 9.77E
-01 6.82E
-02 1.02E+00 6.40E
-01 9.08E
-01
MIMAT
0005887 hsa
-miR
-1299 9.73E
-01 8.32E
-01 9.73E
-01 7.44E
-01 1.15E+00 1.27E
-01 2.20E
-02
MIMAT
0005890 hsa
-miR
-1302 9.69E
-01 6.09E
-01 9.98E
-01 9.72E
-01 8.85E
-01 1.12E
-01 3.37E
-01
MIMAT
0022720 hsa
-miR
-1304
-3p 9.96E
-01 8.34E
-01 9.78E
-01 7.31E
-02 9.80E
-01 5.48E
-01 4.36E
-01
MIMAT
0005892 hsa
-miR
-1304
-5p 1.01E+00 7.64E
-01 9.97E
-01 8.84E
-01 1.01E+00 8.87E
-01 2.72E
-02
MIMAT
0005893 hsa
-miR
-1305 9.12E
-01 5.70E
-01 1.05E+00 6.26E
-01 8.46E
-01 5.93E
-01 1.03E
-01
MIMAT
0005950 hsa
-miR
-1306
-3p 9.41E
-01 4.08E
-01 9.06E
-01 5.19E
-02 9.77E
-01 7.84E
-01 5.31E
-01
MIMAT
0005951 hsa
-miR
-1307
-3p 1.02E+00 5.02E
-01 9.82E
-01 3.32E
-01 1.03E+00 1.36E
-01 4.35E
-02
MIMAT
0022727 hsa
-miR
-1307
-5p 1.02E+00 7.23E
-01 1.01E+00 8.60E
-01 9.16E
-01 4.78E
-01 6.73E
-01
MIMAT
0000425 hsa
-miR
-130a
-3p 9.30E
-01 3.68E
-01 9.37E
-01 2.23E
-01 8.97E
-01 3.99E
-01 5.25E
-01
MIMAT
0000426 hsa
-miR
-132
-3p 9.61E
-01 5.24E
-01 9.88E
-01 7.96E
-01 1.20E+00 1.33E
-03 1.72E
-01
MIMAT
0005795 hsa
-miR
-1323 9.09E
-01 4.08E
-01 9.80E
-01 8.16E
-01 9.40E
-01 5.27E
-01 1.64E
-01
MIMAT
0000427 hsa
-miR
-133a
-3p 9.83E
-01 7.30E
-01 9.62E
-01 2.24E
-01 1.07E+00 3.88E
-01 8.16E
-01
MIMAT
0026478 hsa
-miR
-133a
-5p 1.00E+00 9.88E
-01 1.02E+00 8.03E
-01 1.24E+00 2.45E
-01 2.25E
-01

183
MIMAT
0026481 hsa
-miR
-134
-3p 9.74E
-01 4.77E
-01 9.79E
-01 4.01E
-01 1.09E+00 3.41E
-02 6.42E
-01
MIMAT
0000448 hsa
-miR
-136
-5p 1.01E+00 8.79E
-01 9.63E
-01 2.50E
-01 9.54E
-01 4.70E
-01 8.43E
-01
MIMAT
0000429 hsa
-miR
-137 8.57E
-01 1.45E
-01 1.11E+00 1.29E
-01 9.88E
-01 8.99E
-01 3.01E
-01
MIMAT
0000430 hsa
-miR
-138
-5p 8.95E
-01 1.15E
-01 1.01E+00 8.59E
-01 1.17E+00 1.00E
-02 4.80E
-01
MIMAT
0004552 hsa
-miR
-139
-3p 1.12E+00 2.99E
-01 9.28E
-01 3.13E
-01 1.09E+00 3.54E
-01 2.91E
-01
MIMAT
0004597 hsa
-miR
-140
-3p 9.65E
-01 5.00E
-01 1.04E+00 3.79E
-01 1.12E+00 1.60E
-03 1.48E
-01
MIMAT
0000431 hsa
-miR
-140
-5p 1.01E+00 5.60E
-01 9.84E
-01 2.65E
-01 9.64E
-01 2.23E
-01 9.66E
-01
MIMAT
0000432 hsa
-miR
-141
-3p 1.03E+00 7.47E
-01 9.55E
-01 4.40E
-01 1.08E+00 4.65E
-01 6.13E
-02
MIMAT
0000434 hsa
-miR
-142
-3p 8.32E
-01 1.41E
-02 9.49E
-01 3.28E
-01 1.08E+00 2.54E
-01 9.39E
-01
MIMAT
0000435 hsa
-miR
-143
-3p 9.85E
-01 5.95E
-01 9.81E
-01 3.85E
-01 1.02E+00 5.57E
-01 2.60E
-01
MIMAT
0000449 hsa
-miR
-146a
-5p 1.02E+00 6.51E
-01 9.59E
-01 1.21E
-01 9.69E
-01 6.61E
-01 1.73E
-01
MIMAT
0002809 hsa
-miR
-146b
-5p 9.62E
-01 5.14E
-02 9.88E
-01 4.07E
-01 1.05E+00 3.27E
-02 3.06E
-01
MIMAT
0000251 hsa
-miR
-147a 9.38E
-01 7.34E
-01 9.63E
-01 7.27E
-01 1.12E+00 4.34E
-01 4.40E
-02
MIMAT
0004928 hsa
-miR
-147b 1.04E+00 2.67E
-01 9.51E
-01 3.30E
-02 9.53E
-01 3.95E
-01 7.91E
-01
MIMAT
0000243 hsa
-miR
-148a
-3p 9.11E
-01 2.84E
-01 9.24E
-01 2.25E
-01 9.96E
-01 9.58E
-01 8.54E
-01
MIMAT
0000759 hsa
-miR
-148b
-3p 1.05E+00 4.34E
-01 1.02E+00 6.06E
-01 8.61E
-01 8.21E
-02 4.89E
-01
MIMAT
0000450 hsa
-miR
-149
-5p 9.57E
-01 1.54E
-01 1.00E+00 9.40E
-01 9.52E
-01 3.91E
-01 1.30E
-03
MIMAT
0000451 hsa
-miR
-150
-5p 1.01E+00 8.66E
-01 9.40E
-01 2.93E
-01 9.77E
-01 7.71E
-01 2.61E
-01
MIMAT
0000757 hsa
-miR
-151a
-3p 1.17E+00 1.91E
-01 8.52E
-01 1.35E
-01 1.30E+00 1.79E
-01 4.42E
-01
MIMAT
0007399 hsa
-miR
-1537
-3p 1.00E+00 9.16E
-01 9.26E
-01 2.25E
-02 9.95E
-01 9.34E
-01 9.04E
-01
MIMAT
0000646 hsa
-miR
-155
-5p 9.38E
-01 4.08E
-01 1.05E+00 3.25E
-01 1.01E+00 8.94E
-01 3.24E
-01
MIMAT
0000417 hsa
-miR
-15b
-5p 1.08E+00 3.68E
-01 8.37E
-01 9.90E
-03 9.34E
-01 4.61E
-01 1.01E
-01

184
MIMAT
0000069 hsa
-miR
-16
-5p 9.94E
-01 9.20E
-01 9.76E
-01 5.81E
-01 9.22E
-01 2.59E
-01 8.11E
-01
MIMAT
0004558 hsa
-miR
-181a
-
2
-3p 9.58E
-01 2.67E
-01 9.86E
-01 6.09E
-01 9.74E
-01 6.00E
-01 1.68E
-01
MIMAT
0000270 hsa
-miR
-181a
-3p 1.07E+00 5.61E
-01 9.29E
-01 4.74E
-01 1.01E+00 8.91E
-01 2.49E
-01
MIMAT
0000256 hsa
-miR
-181a
-5p 1.04E+00 7.67E
-01 9.82E
-01 8.34E
-01 1.05E+00 8.34E
-01 1.92E
-02
MIMAT
0031893 hsa
-miR
-181b
-
2
-3p 1.00E+00 9.94E
-01 9.21E
-01 4.27E
-02 1.03E+00 5.38E
-01 9.93E
-01
MIMAT
0000257
hsa
-miR
-181b
-5p+hsa
-
miR
-181d
-5p 9.78E
-01 7.60E
-01 9.70E
-01 5.10E
-01 1.09E+00 1.37E
-01 4.30E
-01
MIMAT
0000258 hsa
-miR
-181c
-5p 9.98E
-01 9.16E
-01 1.00E+00 8.56E
-01 9.75E
-01 3.02E
-01 9.36E
-01
MIMAT
0026608 hsa
-miR
-181d
-3p 1.09E+00 5.36E
-01 1.04E+00 6.70E
-01 9.49E
-01 6.70E
-01 2.51E
-01
MIMAT
0000260 hsa
-miR
-182
-3p 1.00E+00 9.98E
-01 9.69E
-01 6.32E
-01 1.09E+00 2.50E
-01 1.79E
-02
MIMAT
0006767 hsa
-miR
-1827 1.02E+00 5.74E
-01 1.00E+00 8.36E
-01 9.93E
-01 7.76E
-01 3.05E
-01
MIMAT
0000261 hsa
-miR
-183
-5p 9.76E
-01 1.27E
-01 9.78E
-01 7.72E
-02 9.85E
-01 6.21E
-01 2.41E
-01
MIMAT
0000454 hsa
-miR
-184 1.03E+00 3.48E
-01 9.88E
-01 6.17E
-01 1.03E+00 5.93E
-01 3.14E
-01
MIMAT
0000455 hsa
-miR
-185
-5p 9.51E
-01 5.23E
-01 9.55E
-01 4.42E
-01 1.03E+00 6.83E
-01 6.21E
-01
MIMAT
0000456 hsa
-miR
-186
-5p 1.13E+00 1.55E
-01 9.96E
-01 9.48E
-01 9.71E
-01 7.24E
-01 1.26E
-01
MIMAT
0000262 hsa
-miR
-187
-3p 7.99E
-01 1.85E
-01 8.23E
-01 1.28E
-01 NULL NULL 8.95E
-01
MIMAT
0004613 hsa
-miR
-188
-3p 9.51E
-01 6.11E
-01 8.87E
-01 1.06E
-01 8.25E
-01 2.20E
-01 8.93E
-01
MIMAT
0000457 hsa
-miR
-188
-5p 1.20E+00 4.34E
-02 9.53E
-01 4.48E
-01 1.24E+00 6.45E
-03 7.24E
-01
MIMAT
0000072 hsa
-miR
-18a
-5p 9.49E
-01 5.38E
-01 9.78E
-01 6.73E
-01 1.01E+00 8.92E
-01 5.09E
-02
MIMAT
0001412 hsa
-miR
-18b
-5p 9.56E
-01 4.61E
-01 1.01E+00 8.57E
-01 1.11E+00 6.88E
-02 9.00E
-01
MIMAT
0026916 hsa
-miR
-1908
-3p 1.02E+00 7.67E
-01 1.02E+00 7.74E
-01 1.26E+00 3.99E
-02 2.68E
-01
MIMAT
0026482 hsa
-miR
-190a
-3p 9.85E
-01 5.76E
-01 9.83E
-01 3.34E
-01 1.02E+00 3.72E
-01 3.14E
-01
MIMAT
0000458 hsa
-miR
-190a
-5p 1.01E+00 9.18E
-01 1.07E+00 2.38E
-01 1.04E+00 7.92E
-01 4.71E
-02

185
MIMAT
0000440 hsa
-miR
-191
-5p 9.18E
-01 5.75E
-01 8.75E
-01 1.70E
-01 8.89E
-01 5.98E
-01 1.29E
-01
MIMAT
0007884 hsa
-miR
-1910
-5p 1.01E+00 7.71E
-01 1.01E+00 7.72E
-01 1.09E+00 2.31E
-01 4.99E
-01
MIMAT
0000222 hsa
-miR
-192
-5p 9.51E
-01 6.58E
-01 9.36E
-01 3.65E
-01 1.02E+00 8.24E
-01 6.85E
-01
MIMAT
0000459 hsa
-miR
-193a
-3p 7.74E
-01 1.88E
-01 1.19E+00 8.60E
-02 1.10E+00 4.08E
-01 1.57E
-01
MIMAT
0002819 hsa
-miR
-193b
-3p 1.01E+00 7.09E
-01 9.83E
-01 2.45E
-01 9.84E
-01 6.09E
-01 9.74E
-01
MIMAT
0000226 hsa
-miR
-196a
-5p 9.64E
-01 1.27E
-01 9.86E
-01 4.31E
-01 1.02E+00 4.28E
-01 1.79E
-02
MIMAT
0000227 hsa
-miR
-197
-3p 9.23E
-01 1.22E
-02 1.01E+00 6.55E
-01 1.01E+00 6.34E
-01 3.27E
-01
MIMAT
0022691 hsa
-miR
-197
-5p 9.56E
-01 4.12E
-01 9.97E
-01 9.33E
-01 1.06E+00 2.24E
-01 4.24E
-01
MIMAT
0009447 hsa
-miR
-1972 9.00E
-01 4.30E
-01 8.97E
-01 2.90E
-01 1.20E+00 1.34E
-01 7.79E
-01
MIMAT
0009448 hsa
-miR
-1973 9.90E
-01 6.37E
-01 9.90E
-01 5.37E
-01 1.03E+00 1.25E
-01 2.81E
-01
MIMAT
0009451 hsa
-miR
-1976 1.03E+00 3.83E
-01 1.02E+00 3.57E
-01 9.65E
-01 4.14E
-01 2.83E
-02
MIMAT
0000228 hsa
-miR
-198 1.04E+00 4.94E
-01 9.79E
-01 5.72E
-01 1.06E+00 1.85E
-01 5.18E
-01
MIMAT
0000232
hsa
-miR
-199a
-3p+hsa
-
miR
-199b
-3p 1.02E+00 5.12E
-01 9.95E
-01 8.18E
-01 1.03E+00 5.82E
-01 6.93E
-02
MIMAT
0000231 hsa
-miR
-199a
-5p 1.02E+00 8.04E
-01 9.52E
-01 3.87E
-01 1.02E+00 7.90E
-01 8.40E
-01
MIMAT
0000263 hsa
-miR
-199b
-5p 1.11E+00 3.10E
-01 9.09E
-01 2.57E
-01 1.06E+00 5.00E
-01 7.21E
-01
MIMAT
0000074 hsa
-miR
-19b
-3p 1.06E+00 4.00E
-01 9.58E
-01 3.60E
-01 1.09E+00 4.61E
-01 3.10E
-01
MIMAT
0000682 hsa
-miR
-200a
-3p 9.86E
-01 8.30E
-01 1.03E+00 4.70E
-01 1.03E+00 6.66E
-01 6.43E
-03
MIMAT
0000318 hsa
-miR
-200b
-3p 1.03E+00 6.78E
-01 9.16E
-01 9.51E
-02 9.54E
-01 5.18E
-01 2.29E
-01
MIMAT
0000617 hsa
-miR
-200c
-3p 1.02E+00 8.37E
-01 9.85E
-01 8.03E
-01 1.17E+00 3.41E
-02 2.67E
-01
MIMAT
0000264 hsa
-miR
-203a
-3p 8.48E
-01 3.71E
-01 9.17E
-01 5.13E
-01 1.19E+00 1.35E
-01 4.00E
-01
MIMAT
0031890 hsa
-miR
-203a
-5p 9.76E
-01 1.95E
-01 9.63E
-01 9.67E
-03 1.05E+00 1.55E
-01 2.12E
-01
MIMAT
0000266 hsa
-miR
-205
-5p 9.82E
-01 3.47E
-01 9.85E
-01 3.26E
-01 1.02E+00 3.71E
-01 4.48E
-01

186
MIMAT
0009978 hsa
-miR
-2053 1.01E+00 8.12E
-01 9.81E
-01 6.45E
-01 1.01E+00 9.25E
-01 9.99E
-03
MIMAT
0000241 hsa
-miR
-208a
-3p 1.16E+00 3.12E
-01 9.02E
-01 3.93E
-01 1.12E+00 6.50E
-01 3.07E
-01
MIMAT
0004960 hsa
-miR
-208b
-3p 9.59E
-01 5.43E
-01 9.02E
-01 6.72E
-02 8.63E
-01 5.60E
-02 2.63E
-03
MIMAT
0000076 hsa
-miR
-21
-5p 9.82E
-01 7.99E
-01 1.00E+00 9.36E
-01 1.13E+00 3.66E
-02 4.09E
-01
MIMAT
0000267 hsa
-miR
-210
-3p 1.04E+00 3.69E
-01 1.00E+00 9.81E
-01 1.01E+00 6.92E
-01 5.55E
-01
MIMAT
0026475 hsa
-miR
-210
-5p 1.01E+00 9.21E
-01 9.68E
-01 4.03E
-01 9.85E
-01 8.31E
-01 1.35E
-01
MIMAT
0000268 hsa
-miR
-211
-5p 9.90E
-01 7.65E
-01 1.02E+00 4.78E
-01 9.86E
-01 6.72E
-01 2.53E
-01
MIMAT
0010133 hsa
-miR
-2110 1.00E+00 9.63E
-01 9.69E
-01 1.21E
-01 1.04E+00 1.69E
-01 1.05E
-01
MIMAT
0009206 hsa
-miR
-2113 1.01E+00 8.33E
-01 1.01E+00 6.45E
-01 9.69E
-01 5.15E
-01 9.17E
-01
MIMAT
0000269 hsa
-miR
-212
-3p 8.25E
-01 2.20E
-01 8.07E
-01 1.08E
-01 1.05E+00 3.54E
-01 2.03E
-01
MIMAT
0000272 hsa
-miR
-215
-5p 1.08E+00 6.98E
-01 1.02E+00 8.38E
-01 9.83E
-01 9.31E
-01 5.33E
-01
MIMAT
0000273 hsa
-miR
-216a
-5p 9.95E
-01 9.47E
-01 9.14E
-01 1.28E
-01 1.09E+00 1.91E
-01 6.55E
-01
MIMAT
0004959 hsa
-miR
-216b
-5p 1.01E+00 4.56E
-01 9.87E
-01 3.96E
-01 1.03E+00 5.77E
-01 4.28E
-01
MIMAT
0000274 hsa
-miR
-217 1.13E+00 2.64E
-01 7.59E
-01 5.02E
-02 1.01E+00 7.17E
-01 1.57E
-01
MIMAT
0000275 hsa
-miR
-218
-5p 9.93E
-01 9.26E
-01 9.93E
-01 8.83E
-01 1.14E+00 2.63E
-02 6.51E
-01
MIMAT
0000276 hsa
-miR
-219a
-5p 9.54E
-01 5.79E
-01 9.04E
-01 1.04E
-01 1.07E+00 2.90E
-01 3.54E
-01
MIMAT
0019748 hsa
-miR
-219b
-3p 1.05E+00 1.19E
-01 1.02E+00 3.42E
-01 1.03E+00 3.83E
-01 6.13E
-01
MIMAT
0000278 hsa
-miR
-221
-3p 9.88E
-01 7.94E
-01 9.35E
-01 2.15E
-02 9.45E
-01 4.71E
-01 6.04E
-01
MIMAT
0000279 hsa
-miR
-222
-3p 8.94E
-01 2.70E
-01 9.34E
-01 3.16E
-01 1.06E+00 7.34E
-01 8.65E
-01
MIMAT
0000280 hsa
-miR
-223
-3p 1.00E+00 9.49E
-01 1.04E+00 3.46E
-01 1.04E+00 4.52E
-01 1.65E
-02
MIMAT
0000281 hsa
-miR
-224
-5p 9.81E
-01 2.96E
-01 9.75E
-01 6.06E
-02 1.00E+00 9.06E
-01 4.40E
-01
MIMAT
0000078 hsa
-miR
-23a
-3p 9.90E
-01 5.78E
-01 9.59E
-01 3.38E
-03 9.85E
-01 3.69E
-01 7.36E
-02

187
MIMAT
0000418 hsa
-miR
-23b
-3p 1.00E+00 9.94E
-01 9.87E
-01 2.86E
-01 1.03E+00 8.86E
-02 6.06E
-01
MIMAT
0018000 hsa
-miR
-23c 8.96E
-01 3.47E
-01 9.48E
-01 4.91E
-01 1.04E+00 8.53E
-01 8.27E
-01
MIMAT
0000081 hsa
-miR
-25
-3p 9.84E
-01 4.83E
-01 9.90E
-01 5.66E
-01 1.03E+00 3.55E
-01 1.01E
-01
MIMAT
0004498 hsa
-miR
-25
-5p 1.10E+00 5.20E
-01 9.06E
-01 3.96E
-01 1.27E+00 3.87E
-01 8.81E
-01
MIMAT
0000082 hsa
-miR
-26a
-5p 9.73E
-01 1.66E
-01 9.83E
-01 2.31E
-01 9.59E
-01 2.33E
-01 7.51E
-01
MIMAT
0000083 hsa
-miR
-26b
-5p 9.17E
-01 4.00E
-01 9.42E
-01 4.36E
-01 9.51E
-01 6.92E
-01 5.26E
-01
MIMAT
0000084 hsa
-miR
-27a
-3p 1.08E+00 3.25E
-01 8.76E
-01 4.77E
-02 1.04E+00 5.55E
-01 3.58E
-01
MIMAT
0004502 hsa
-miR
-28
-3p 9.81E
-01 4.28E
-01 9.78E
-01 2.40E
-01 1.02E+00 5.31E
-01 8.50E
-01
MIMAT
0000085 hsa
-miR
-28
-5p 1.06E+00 7.08E
-01 1.06E+00 5.40E
-01 1.13E+00 6.92E
-01 9.56E
-01
MIMAT
0004679 hsa
-miR
-296
-3p 1.04E+00 6.03E
-01 9.69E
-01 6.00E
-01 1.09E+00 4.68E
-01 1.81E
-01
MIMAT
0004901 hsa
-miR
-298 1.16E+00 3.03E
-01 9.38E
-01 5.78E
-01 1.22E+00 3.12E
-01 7.15E
-03
MIMAT
0000687 hsa
-miR
-299
-3p 1.02E+00 7.98E
-01 1.08E+00 2.72E
-01 7.63E
-01 1.20E
-01 2.38E
-01
MIMAT
0002890 hsa
-miR
-299
-5p 9.74E
-01 8.66E
-01 8.85E
-01 2.87E
-01 1.03E+00 8.71E
-01 4.66E
-01
MIMAT
0000086 hsa
-miR
-29a
-3p 9.58E
-01 2.90E
-02 9.96E
-01 7.78E
-01 1.01E+00 8.09E
-01 6.46E
-01
MIMAT
0000100 hsa
-miR
-29b
-3p 9.94E
-01 9.53E
-01 9.44E
-01 4.09E
-01 1.05E+00 7.98E
-01 4.23E
-01
MIMAT
0000681 hsa
-miR
-29c
-3p 1.08E+00 2.18E
-01 8.68E
-01 1.14E
-02 1.02E+00 7.07E
-01 7.75E
-01
MIMAT
0004903 hsa
-miR
-300 1.02E+00 8.34E
-01 9.64E
-01 5.76E
-01 1.12E+00 1.31E
-01 3.68E
-01
MIMAT
0000688 hsa
-miR
-301a
-3p 1.12E+00 3.36E
-01 1.14E+00 1.92E
-01 9.49E
-01 6.28E
-01 4.77E
-01
MIMAT
0022696 hsa
-miR
-301a
-5p 1.11E+00 4.14E
-01 9.84E
-01 8.44E
-01 1.10E+00 6.41E
-01 1.97E
-01
MIMAT
0004958 hsa
-miR
-301b
-3p 1.04E+00 7.15E
-01 8.42E
-01 1.01E
-01 6.72E
-01 8.44E
-02 2.36E
-01
MIMAT
0032026 hsa
-miR
-301b
-5p 8.57E
-01 2.58E
-01 9.55E
-01 6.60E
-01 7.03E
-01 1.80E
-01 4.99E
-01
MIMAT
0000684 hsa
-miR
-302a
-3p 9.64E
-01 7.18E
-01 1.01E+00 8.83E
-01 8.63E
-01 2.07E
-01 6.90E
-02

188
MIMAT
0000683 hsa
-miR
-302a
-5p 1.05E+00 4.96E
-01 1.03E+00 5.44E
-01 9.66E
-01 8.18E
-01 9.63E
-01
MIMAT
0000715 hsa
-miR
-302b
-3p 1.04E+00 4.28E
-01 1.03E+00 4.48E
-01 1.04E+00 4.49E
-01 8.58E
-01
MIMAT
0000717 hsa
-miR
-302c
-3p 9.80E
-01 8.95E
-01 1.05E+00 5.80E
-01 6.65E
-01 1.62E
-01 3.67E
-02
MIMAT
0000718 hsa
-miR
-302d
-3p 9.37E
-01 6.47E
-01 8.62E
-01 2.26E
-01 7.67E
-01 2.99E
-01 8.40E
-01
MIMAT
0005931 hsa
-miR
-302e 9.89E
-01 6.87E
-01 1.01E+00 7.47E
-01 1.02E+00 4.35E
-01 5.44E
-01
MIMAT
0005932 hsa
-miR
-302f 1.01E+00 9.03E
-01 1.11E+00 1.31E
-01 1.00E+00 9.82E
-01 5.55E
-02
MIMAT
0015378 hsa
-miR
-3065
-3p 1.06E+00 5.26E
-01 8.84E
-01 5.29E
-02 9.72E
-01 7.29E
-01 5.73E
-01
MIMAT
0015027 hsa
-miR
-3074
-3p 1.04E+00 7.04E
-01 9.39E
-01 4.36E
-01 1.03E+00 7.51E
-01 3.65E
-02
MIMAT
0000088 hsa
-miR
-30a
-3p 9.93E
-01 6.67E
-01 9.90E
-01 4.52E
-01 9.73E
-01 4.02E
-01 4.35E
-01
MIMAT
0000420 hsa
-miR
-30b
-5p 1.22E+00 2.21E
-01 1.01E+00 9.61E
-01 9.72E
-01 8.33E
-01 8.69E
-01
MIMAT
0000244 hsa
-miR
-30c
-5p 1.01E+00 6.72E
-01 9.36E
-01 1.12E
-02 1.02E+00 7.65E
-01 1.91E
-01
MIMAT
0000245 hsa
-miR
-30d
-5p 1.00E+00 9.41E
-01 1.04E+00 1.51E
-01 9.66E
-01 3.01E
-01 7.80E
-01
MIMAT
0000693 hsa
-miR
-30e
-3p 7.90E
-01 6.72E
-02 9.78E
-01 7.64E
-01 1.09E+00 6.78E
-01 5.64E
-01
MIMAT
0000692 hsa
-miR
-30e
-5p 1.01E+00 8.02E
-01 9.81E
-01 4.83E
-01 1.04E+00 1.84E
-01 8.44E
-01
MIMAT
0014996 hsa
-miR
-3131 1.01E+00 6.06E
-01 9.83E
-01 1.00E
-01 1.01E+00 5.34E
-01 4.82E
-01
MIMAT
0015015 hsa
-miR
-3144
-3p 1.08E+00 6.37E
-01 9.59E
-01 6.73E
-01 9.89E
-01 9.34E
-01 4.19E
-01
MIMAT
0015014 hsa
-miR
-3144
-5p 1.01E+00 6.01E
-01 9.89E
-01 4.70E
-01 1.01E+00 7.29E
-01 7.16E
-01
MIMAT
0015019 hsa
-miR
-3147 9.74E
-01 8.60E
-01 9.05E
-01 3.97E
-01 9.71E
-01 8.24E
-01 3.34E
-01
MIMAT
0015024 hsa
-miR
-3151
-5p 9.40E
-01 1.82E
-01 9.44E
-01 1.14E
-01 1.11E+00 3.90E
-02 7.58E
-01
MIMAT
0015035 hsa
-miR
-3161 1.13E+00 3.53E
-01 1.09E+00 3.64E
-01 9.15E
-01 4.38E
-01 2.82E
-01
MIMAT
0015043 hsa
-miR
-3168 1.01E+00 7.95E
-01 9.82E
-01 6.30E
-01 1.13E+00 1.02E
-02 1.82E
-02
MIMAT
0018178 hsa
-miR
-3180 9.47E
-01 3.43E
-01 9.51E
-01 2.02E
-01 9.34E
-01 3.54E
-01 7.18E
-01

189
MIMAT
0015057 hsa
-miR
-3180
-5p 9.66E
-01 7.02E
-01 1.10E+00 1.90E
-01 9.32E
-01 6.59E
-01 9.65E
-01
MIMAT
0015089 hsa
-miR
-3202 9.61E
-01 6.82E
-01 1.00E+00 9.95E
-01 1.17E+00 4.14E
-02 8.74E
-01
MIMAT
0000510 hsa
-miR
-320a 9.71E
-01 5.72E
-01 9.82E
-01 6.22E
-01 1.02E+00 7.37E
-01 4.06E
-01
MIMAT
0005793 hsa
-miR
-320c 8.45E
-01 1.93E
-01 1.05E+00 5.87E
-01 1.10E+00 3.98E
-01 5.33E
-02
MIMAT
0015072 hsa
-miR
-320e 1.02E+00 5.44E
-01 9.81E
-01 2.80E
-01 1.02E+00 5.99E
-01 2.60E
-01
MIMAT
0000755 hsa
-miR
-323a
-3p 1.06E+00 5.25E
-01 9.09E
-01 1.63E
-01 1.13E+00 4.44E
-01 9.06E
-01
MIMAT
0015050 hsa
-miR
-323b
-3p 9.18E
-01 5.27E
-01 7.37E
-01 3.68E
-02 1.07E+00 4.94E
-01 6.14E
-01
MIMAT
0000762 hsa
-miR
-324
-3p 8.98E
-01 3.49E
-01 8.46E
-01 5.97E
-02 1.07E+00 6.25E
-01 5.47E
-01
MIMAT
0000771 hsa
-miR
-325 9.90E
-01 7.31E
-01 9.91E
-01 7.19E
-01 1.06E+00 8.66E
-02 3.43E
-01
MIMAT
0026486 hsa
-miR
-328
-5p 8.49E
-01 3.60E
-02 9.50E
-01 3.34E
-01 1.04E+00 5.10E
-01 3.55E
-01
MIMAT
0001629 hsa
-miR
-329
-3p 1.03E+00 3.39E
-01 1.01E+00 6.84E
-01 9.92E
-01 7.34E
-01 1.06E
-01
MIMAT
0026555 hsa
-miR
-329
-5p 1.06E+00 6.68E
-01 8.80E
-01 1.61E
-01 8.57E
-01 5.54E
-01 2.91E
-01
MIMAT
0004693 hsa
-miR
-330
-5p 9.52E
-01 2.67E
-01 9.59E
-01 2.58E
-01 1.10E+00 2.53E
-01 5.53E
-01
MIMAT
0000765 hsa
-miR
-335
-5p 9.37E
-01 5.18E
-01 1.00E+00 9.75E
-01 1.00E+00 9.71E
-01 7.95E
-02
MIMAT
0000754 hsa
-miR
-337
-3p 7.93E
-01 1.25E
-01 8.25E
-01 1.24E
-01 1.17E+00 1.84E
-01 2.88E
-01
MIMAT
0004695 hsa
-miR
-337
-5p 9.67E
-01 3.55E
-01 9.84E
-01 5.08E
-01 9.59E
-01 4.59E
-01 4.04E
-01
MIMAT
0004701 hsa
-miR
-338
-5p 9.94E
-01 6.70E
-01 1.00E+00 9.17E
-01 9.77E
-01 3.57E
-01 1.71E
-01
MIMAT
0000091 hsa
-miR
-33a
-5p 1.09E+00 4.73E
-01 9.67E
-01 6.28E
-01 7.31E
-01 1.81E
-01 6.24E
-01
MIMAT
0003301 hsa
-miR
-33b
-5p 9.48E
-01 3.40E
-01 9.80E
-01 6.52E
-01 1.28E+00 1.45E
-03 4.31E
-02
MIMAT
0004692 hsa
-miR
-340
-5p 9.79E
-01 5.93E
-01 9.85E
-01 5.63E
-01 9.77E
-01 6.17E
-01 6.66E
-01
MIMAT
0000753 hsa
-miR
-342
-3p 8.81E
-01 2.98E
-01 9.84E
-01 8.34E
-01 9.83E
-01 9.40E
-01 8.31E
-01
MIMAT
0004694 hsa
-miR
-342
-5p 9.96E
-01 8.54E
-01 9.68E
-01 4.63E
-02 1.08E+00 2.66E
-02 3.33E
-01

190
MIMAT
0022698 hsa
-miR
-345
-3p 9.19E
-01 5.52E
-01 8.82E
-01 2.45E
-01 1.01E+00 9.34E
-01 3.99E
-01
MIMAT
0000773 hsa
-miR
-346 1.04E+00 7.78E
-01 9.76E
-01 8.07E
-01 1.11E+00 7.25E
-01 4.39E
-01
MIMAT
0000255 hsa
-miR
-34a
-5p 9.97E
-01 9.44E
-01 1.02E+00 4.37E
-01 1.04E+00 1.83E
-01 5.04E
-01
MIMAT
0004676 hsa
-miR
-34b
-3p 9.85E
-01 4.96E
-01 9.98E
-01 9.10E
-01 1.02E+00 2.38E
-01 5.76E
-01
MIMAT
0004677 hsa
-miR
-34c
-3p 1.10E+00 4.77E
-01 1.01E+00 9.34E
-01 1.35E+00 2.41E
-01 8.95E
-01
MIMAT
0000686 hsa
-miR
-34c
-5p 9.14E
-01 2.08E
-01 9.87E
-01 7.66E
-01 1.26E+00 5.16E
-04 2.94E
-01
MIMAT
0017981 hsa
-miR
-3605
-5p 1.00E+00 9.57E
-01 9.64E
-01 4.98E
-01 1.01E+00 9.27E
-01 4.25E
-01
MIMAT
0000703 hsa
-miR
-361
-5p 9.93E
-01 8.80E
-01 9.53E
-01 5.95E
-02 1.02E+00 6.28E
-01 9.71E
-01
MIMAT
0017991 hsa
-miR
-3613
-3p 9.07E
-01 4.66E
-01 9.92E
-01 9.29E
-01 8.78E
-01 3.67E
-01 4.69E
-01
MIMAT
0017992 hsa
-miR
-3614
-5p 9.08E
-01 2.28E
-01 1.03E+00 5.61E
-01 9.26E
-01 3.85E
-01 2.40E
-02
MIMAT
0017994 hsa
-miR
-3615 1.09E+00 1.10E
-01 9.61E
-01 3.56E
-01 1.13E+00 2.45E
-01 9.46E
-01
MIMAT
0000705 hsa
-miR
-362
-5p 1.03E+00 2.50E
-01 9.57E
-01 4.24E
-02 1.02E+00 7.37E
-01 3.27E
-02
MIMAT
0000707 hsa
-miR
-363
-3p 1.04E+00 1.10E
-01 9.78E
-01 1.66E
-01 9.59E
-01 3.71E
-01 1.48E
-01
MIMAT
0003385 hsa
-miR
-363
-5p 9.65E
-01 4.56E
-01 9.99E
-01 9.65E
-01 1.07E+00 9.76E
-02 6.53E
-01
MIMAT
0000710
hsa
-miR
-365a
-3p+hsa
-
miR
-365b
-3p 8.11E
-01 1.42E
-01 1.03E+00 7.04E
-01 7.43E
-01 1.27E
-01 4.14E
-01
MIMAT
0022833 hsa
-miR
-365b
-5p 1.02E+00 6.58E
-01 1.01E+00 7.15E
-01 9.75E
-01 5.65E
-01 8.28E
-03
MIMAT
0000719 hsa
-miR
-367
-3p 1.02E+00 5.20E
-01 9.61E
-01 1.16E
-01 9.84E
-01 8.02E
-01 2.71E
-01
MIMAT
0000721 hsa
-miR
-369
-3p 6.78E
-01 2.68E
-02 1.11E+00 2.23E
-01 1.13E+00 2.30E
-01 2.82E
-01
MIMAT
0001621 hsa
-miR
-369
-5p 1.02E+00 6.53E
-01 1.07E+00 5.11E
-02 9.23E
-01 1.35E
-01 2.11E
-01
MIMAT
0018119 hsa
-miR
-3690 9.51E
-01 1.96E
-01 9.91E
-01 6.98E
-01 1.01E+00 6.57E
-01 3.59E
-01
MIMAT
0000722 hsa
-miR
-370
-3p 1.01E+00 6.94E
-01 9.88E
-01 3.55E
-01 9.80E
-01 3.61E
-01 8.81E
-01
MIMAT
0004687 hsa
-miR
-371a
-5p 9.59E
-01 6.81E
-01 9.59E
-01 5.48E
-01 1.14E+00 1.30E
-01 1.19E
-01

191
MIMAT
0019892 hsa
-miR
-371b
-5p 1.31E+00 4.43E
-02 6.90E
-01 4.03E
-02 1.10E+00 3.14E
-01 6.48E
-01
MIMAT
0004688 hsa
-miR
-374a
-3p 9.66E
-01 4.99E
-02 9.90E
-01 4.46E
-01 9.84E
-01 6.79E
-01 9.03E
-01
MIMAT
0000727 hsa
-miR
-374a
-5p 9.79E
-01 3.63E
-01 1.00E+00 9.97E
-01 1.07E+00 1.37E
-01 1.02E
-01
MIMAT
0022928 hsa
-miR
-376a
-
2
-5p 1.03E+00 7.81E
-01 8.42E
-01 1.71E
-01 1.34E+00 2.46E
-03 9.12E
-01
MIMAT
0000729 hsa
-miR
-376a
-3p 1.01E+00 6.37E
-01 9.98E
-01 8.65E
-01 9.73E
-01 4.91E
-01 2.11E
-01
MIMAT
0000720 hsa
-miR
-376c
-3p 1.03E+00 6.08E
-01 9.14E
-01 1.21E
-01 1.11E+00 1.91E
-01 9.46E
-01
MIMAT
0022861 hsa
-miR
-376c
-5p 9.87E
-01 5.88E
-01 9.94E
-01 7.36E
-01 9.41E
-01 3.47E
-02 5.73E
-01
MIMAT
0000730 hsa
-miR
-377
-3p 9.95E
-01 8.50E
-01 9.32E
-01 1.42E
-03 9.88E
-01 6.42E
-01 3.58E
-01
MIMAT
0018926 hsa
-miR
-378d 1.00E+00 8.98E
-01 9.87E
-01 3.45E
-01 9.82E
-01 3.91E
-01 5.02E
-01
MIMAT
0018927 hsa
-miR
-378e 9.41E
-01 1.19E
-01 1.00E+00 9.95E
-01 1.03E+00 3.26E
-01 6.70E
-01
MIMAT
0018932 hsa
-miR
-378f 1.02E+00 3.65E
-01 9.91E
-01 5.44E
-01 1.04E+00 1.85E
-01 1.11E
-01
MIMAT
0018937 hsa
-miR
-378g 8.96E
-01 2.62E
-01 9.12E
-01 2.57E
-01 9.70E
-01 6.22E
-01 1.17E
-02
MIMAT
0018984 hsa
-miR
-378h 8.46E
-01 8.93E
-02 9.34E
-01 3.43E
-01 1.05E+00 5.23E
-01 6.63E
-01
MIMAT
0019074 hsa
-miR
-378i 9.94E
-01 9.69E
-01 8.32E
-01 8.36E
-02 1.03E+00 8.15E
-01 9.01E
-01
MIMAT
0000733 hsa
-miR
-379
-5p 9.98E
-01 9.15E
-01 9.72E
-01 1.26E
-01 9.86E
-01 6.25E
-01 6.99E
-01
MIMAT
0000735 hsa
-miR
-380
-3p 9.51E
-01 4.42E
-01 9.08E
-01 6.00E
-02 9.22E
-01 4.38E
-01 2.61E
-01
MIMAT
0000736 hsa
-miR
-381
-3p 1.04E+00 1.50E
-01 1.01E+00 4.16E
-01 1.05E+00 1.87E
-02 2.03E
-01
MIMAT
0022862 hsa
-miR
-381
-5p 1.05E+00 2.27E
-01 9.44E
-01 2.72E
-02 9.93E
-01 7.90E
-01 9.55E
-01
MIMAT
0022697 hsa
-miR
-382
-3p 9.78E
-01 5.22E
-01 9.20E
-01 3.44E
-04 1.11E+00 1.41E
-02 5.11E
-01
MIMAT
0000737 hsa
-miR
-382
-5p 9.98E
-01 9.53E
-01 9.73E
-01 1.51E
-01 1.07E+00 4.72E
-02 5.58E
-01
MIMAT
0018205 hsa
-miR
-3928
-3p 9.86E
-01 7.79E
-01 1.01E+00 8.18E
-01 9.23E
-01 3.85E
-01 8.52E
-01
MIMAT
0018349 hsa
-miR
-3934
-5p 9.90E
-01 9.28E
-01 9.49E
-01 5.62E
-01 8.47E
-01 6.16E
-02 3.91E
-01

192
MIMAT
0002171 hsa
-miR
-410
-3p 1.01E+00 7.09E
-01 9.81E
-01 1.99E
-01 1.09E+00 4.50E
-03 7.10E
-01
MIMAT
0002170 hsa
-miR
-412
-3p 8.31E
-01 1.88E
-01 7.24E
-01 5.13E
-03 1.28E+00 1.02E
-02 8.71E
-01
MIMAT
0003339 hsa
-miR
-421 1.01E+00 9.40E
-01 9.66E
-01 6.31E
-01 9.75E
-01 7.88E
-01 3.59E
-01
MIMAT
0001340 hsa
-miR
-423
-3p 9.90E
-01 7.59E
-01 9.63E
-01 1.06E
-01 1.06E+00 2.28E
-02 3.40E
-02
MIMAT
0004748 hsa
-miR
-423
-5p 1.00E+00 9.05E
-01 1.00E+00 9.40E
-01 9.58E
-01 2.91E
-01 8.56E
-02
MIMAT
0016915 hsa
-miR
-4284 6.66E
-01 6.72E
-03 8.89E
-01 2.84E
-01 1.08E+00 4.85E
-01 6.09E
-01
MIMAT
0016916 hsa
-miR
-4286 9.90E
-01 7.22E
-01 9.79E
-01 3.31E
-01 1.06E+00 2.31E
-02 2.78E
-01
MIMAT
0001625 hsa
-miR
-431
-5p 9.28E
-01 1.91E
-01 1.02E+00 6.47E
-01 1.04E+00 3.70E
-01 4.64E
-01
MIMAT
0002814 hsa
-miR
-432
-5p 1.02E+00 2.88E
-01 9.88E
-01 4.20E
-01 1.03E+00 4.58E
-01 7.55E
-01
MIMAT
0001627 hsa
-miR
-433
-3p 1.06E+00 1.72E
-02 9.89E
-01 4.56E
-01 9.80E
-01 4.20E
-01 5.43E
-01
MIMAT
0026554 hsa
-miR
-433
-5p 9.96E
-01 8.50E
-01 1.01E+00 3.39E
-01 9.81E
-01 6.56E
-01 6.87E
-01
MIMAT
0018934 hsa
-miR
-4421 1.03E+00 5.75E
-01 9.49E
-01 2.23E
-01 1.01E+00 8.34E
-01 5.11E
-01
MIMAT
0018947 hsa
-miR
-4431 1.15E+00 1.63E
-01 9.09E
-01 2.55E
-01 1.05E+00 6.41E
-01 1.96E
-01
MIMAT
0018961 hsa
-miR
-4443 8.62E
-01 3.24E
-01 9.81E
-01 8.51E
-01 1.07E+00 5.40E
-01 9.87E
-01
MIMAT
0018973 hsa
-miR
-4451 9.72E
-01 8.47E
-01 9.43E
-01 5.32E
-01 1.37E+00 1.21E
-02 1.99E
-01
MIMAT
0018976
hsa
-miR
-4454+hsa
-miR
-
7975 1.01E+00 7.55E
-01 9.35E
-01 2.53E
-02 1.06E+00 1.59E
-01 2.11E
-03
MIMAT
0018977 hsa
-miR
-4455 1.00E+00 8.39E
-01 9.62E
-01 2.21E
-02 9.83E
-01 3.60E
-01 6.99E
-01
MIMAT
0018983 hsa
-miR
-4461 1.06E+00 5.08E
-01 1.01E+00 8.17E
-01 1.12E+00 9.54E
-02 3.06E
-02
MIMAT
0001532 hsa
-miR
-448 1.02E+00 6.34E
-01 9.80E
-01 3.94E
-01 9.47E
-01 3.23E
-01 1.92E
-02
MIMAT
0019019 hsa
-miR
-4485
-3p 9.27E
-01 5.74E
-02 9.81E
-01 5.33E
-01 1.02E+00 5.75E
-01 1.04E
-01
MIMAT
0019022 hsa
-miR
-4488 9.46E
-01 1.78E
-02 9.95E
-01 7.65E
-01 1.01E+00 7.59E
-01 7.11E
-02
MIMAT
0001541 hsa
-miR
-449a 1.03E+00 3.66E
-01 9.99E
-01 9.66E
-01 1.04E+00 1.87E
-01 4.37E
-01

193
MIMAT
0003327 hsa
-miR
-449b
-5p 1.04E+00 5.82E
-01 9.37E
-01 2.95E
-01 1.22E+00 1.90E
-01 8.49E
-01
MIMAT
0010251 hsa
-miR
-449c
-5p 1.07E+00 6.34E
-01 9.02E
-01 3.95E
-01 8.88E
-01 4.93E
-01 3.97E
-01
MIMAT
0022700 hsa
-miR
-450a
-
1
-3p 1.00E+00 9.78E
-01 1.03E+00 6.84E
-01 1.00E+00 9.88E
-01 3.99E
-01
MIMAT
0031074 hsa
-miR
-450a
-
2
-3p 1.01E+00 8.35E
-01 9.96E
-01 8.54E
-01 1.01E+00 9.00E
-01 7.19E
-02
MIMAT
0001545 hsa
-miR
-450a
-5p 9.99E
-01 9.54E
-01 9.72E
-01 1.11E
-01 9.15E
-01 5.99E
-02 8.29E
-01
MIMAT
0004910 hsa
-miR
-450b
-3p 9.54E
-01 4.53E
-01 9.78E
-01 5.89E
-01 1.03E+00 6.31E
-01 1.25E
-01
MIMAT
0019053 hsa
-miR
-4516 1.01E+00 7.21E
-01 9.86E
-01 3.73E
-01 9.96E
-01 9.09E
-01 5.27E
-01
MIMAT
0001631 hsa
-miR
-451a 9.87E
-01 6.30E
-01 9.88E
-01 5.52E
-01 1.02E+00 6.53E
-01 6.63E
-01
MIMAT
0019070 hsa
-miR
-4531 1.14E+00 3.21E
-01 9.98E
-01 9.84E
-01 1.11E+00 3.19E
-01 9.61E
-02
MIMAT
0020959 hsa
-miR
-4536
-3p 1.01E+00 9.69E
-01 1.04E+00 6.59E
-01 1.09E+00 3.68E
-01 4.89E
-01
MIMAT
0019078 hsa
-miR
-4536
-5p 9.88E
-01 7.37E
-01 9.54E
-01 6.55E
-02 1.00E+00 8.91E
-01 4.72E
-02
MIMAT
0003885 hsa
-miR
-454
-3p 9.12E
-01 4.68E
-01 8.30E
-01 9.99E
-02 9.24E
-01 5.98E
-01 9.17E
-01
MIMAT
0004784 hsa
-miR
-455
-3p 8.65E
-01 1.54E
-01 1.00E+00 9.52E
-01 1.02E+00 8.64E
-01 2.26E
-01
MIMAT
0003150 hsa
-miR
-455
-5p 1.07E+00 6.07E
-01 7.82E
-01 5.45E
-02 9.36E
-01 8.04E
-01 7.07E
-01
MIMAT
0019709 hsa
-miR
-4647 1.01E+00 8.53E
-01 9.58E
-01 6.40E
-02 1.02E+00 5.92E
-01 2.86E
-02
MIMAT
0019808 hsa
-miR
-4707
-3p 6.09E
-01 1.00E
-03 1.03E+00 7.12E
-01 9.86E
-01 9.07E
-01 7.29E
-01
MIMAT
0019807 hsa
-miR
-4707
-5p 1.17E+00 1.38E
-01 9.09E
-01 2.66E
-01 1.09E+00 6.81E
-01 3.88E
-01
MIMAT
0019895 hsa
-miR
-4755
-5p 1.00E+00 8.81E
-01 1.00E+00 9.69E
-01 9.82E
-01 7.17E
-01 1.44E
-02
MIMAT
0019956 hsa
-miR
-4787
-5p 9.49E
-01 6.84E
-01 9.01E
-01 3.65E
-01 1.24E+00 4.03E
-01 8.02E
-01
MIMAT
0019964 hsa
-miR
-4792 1.00E+00 9.87E
-01 9.47E
-01 5.02E
-01 1.26E+00 2.66E
-01 7.27E
-01
MIMAT
0002176 hsa
-miR
-485
-3p 1.03E+00 3.16E
-01 9.83E
-01 4.00E
-01 9.73E
-01 4.66E
-01 6.11E
-01
MIMAT
0002178 hsa
-miR
-487a
-3p 1.05E+00 4.85E
-01 9.71E
-01 5.62E
-01 1.10E+00 1.30E
-01 3.80E
-01

194
MIMAT
0003180 hsa
-miR
-487b
-3p 9.74E
-01 4.49E
-01 9.41E
-01 1.47E
-02 1.01E+00 7.40E
-01 5.17E
-01
MIMAT
0026614 hsa
-miR
-487b
-5p 9.18E
-01 3.77E
-01 9.92E
-01 9.06E
-01 1.08E+00 3.81E
-01 9.40E
-01
MIMAT
0004763 hsa
-miR
-488
-3p 8.86E
-01 4.45E
-01 7.00E
-01 6.31E
-02 1.02E+00 8.81E
-01 4.84E
-02
MIMAT
0002806 hsa
-miR
-490
-3p 9.01E
-01 3.92E
-01 9.49E
-01 5.46E
-01 1.05E+00 6.36E
-01 9.69E
-01
MIMAT
0002807 hsa
-miR
-491
-5p 1.01E+00 7.69E
-01 9.70E
-01 4.06E
-02 1.06E+00 1.71E
-01 2.04E
-01
MIMAT
0003161 hsa
-miR
-493
-3p 9.91E
-01 8.03E
-01 9.64E
-01 1.32E
-01 1.03E+00 5.51E
-01 8.09E
-01
MIMAT
0002816 hsa
-miR
-494
-3p 9.51E
-01 6.76E
-03 9.95E
-01 6.83E
-01 1.04E+00 2.97E
-02 5.24E
-01
MIMAT
0002817 hsa
-miR
-495
-3p 9.14E
-01 2.19E
-01 1.05E+00 3.42E
-01 1.01E+00 8.23E
-01 3.60E
-01
MIMAT
0022924 hsa
-miR
-495
-5p 8.95E
-01 4.55E
-01 9.15E
-01 3.85E
-01 1.02E+00 9.47E
-01 4.64E
-01
MIMAT
0002820 hsa
-miR
-497
-5p 9.99E
-01 9.81E
-01 9.65E
-01 3.47E
-02 1.02E+00 4.21E
-01 2.42E
-01
MIMAT
0002824 hsa
-miR
-498 1.01E+00 9.15E
-01 9.22E
-01 7.32E
-02 8.77E
-01 1.77E
-01 1.38E
-01
MIMAT
0004772 hsa
-miR
-499a
-3p 9.81E
-01 7.98E
-01 8.73E
-01 1.05E
-02 1.01E+00 9.14E
-01 3.58E
-01
MIMAT
0002870 hsa
-miR
-499a
-5p 9.55E
-01 1.79E
-01 9.72E
-01 2.71E
-01 9.31E
-01 1.22E
-01 3.84E
-01
MIMAT
0019897 hsa
-miR
-499b
-5p 9.77E
-01 8.23E
-01 9.49E
-01 4.72E
-01 1.06E+00 5.39E
-01 3.36E
-01
MIMAT
0021021 hsa
-miR
-5001
-5p 1.02E+00 6.45E
-01 9.89E
-01 7.07E
-01 1.01E+00 9.08E
-01 5.53E
-02
MIMAT
0021044 hsa
-miR
-5010
-3p 1.08E+00 1.46E
-01 9.63E
-01 3.15E
-01 1.13E+00 1.92E
-01 5.18E
-01
MIMAT
0004775 hsa
-miR
-502
-3p 9.37E
-01 5.70E
-01 8.81E
-01 1.27E
-01 1.06E+00 7.65E
-01 4.15E
-01
MIMAT
0002873 hsa
-miR
-502
-5p 9.50E
-01 2.78E
-01 9.94E
-01 8.38E
-01 9.95E
-01 9.01E
-01 1.06E
-01
MIMAT
0022925 hsa
-miR
-503
-3p 9.54E
-01 7.27E
-01 1.08E+00 4.36E
-01 1.16E+00 5.93E
-01 8.69E
-01
MIMAT
0002874 hsa
-miR
-503
-5p 6.97E
-01 5.46E
-02 9.05E
-01 3.70E
-01 1.31E+00 4.30E
-02 8.57E
-01
MIMAT
0002878 hsa
-miR
-506
-3p 1.08E+00 1.49E
-01 9.86E
-01 7.17E
-01 9.58E
-01 7.09E
-01 5.63E
-01
MIMAT
0022701 hsa
-miR
-506
-5p 1.45E+00 9.30E
-03 9.17E
-01 4.10E
-01 1.02E+00 9.56E
-01 9.45E
-02

195
MIMAT
0002879 hsa
-miR
-507 1.00E+00 8.79E
-01 9.93E
-01 6.75E
-01 1.02E+00 4.45E
-01 9.25E
-01
MIMAT
0004778 hsa
-miR
-508
-5p 9.85E
-01 9.15E
-01 1.08E+00 3.94E
-01 1.28E+00 3.35E
-02 1.46E
-01
MIMAT
0002881 hsa
-miR
-509
-3p 9.58E
-01 5.14E
-01 9.94E
-01 8.97E
-01 9.00E
-01 2.44E
-01 8.22E
-01
MIMAT
0004779 hsa
-miR
-509
-5p 9.21E
-01 6.26E
-01 1.03E+00 8.12E
-01 9.84E
-01 9.01E
-01 4.16E
-01
MIMAT
0026613 hsa
-miR
-510
-3p 1.05E+00 5.98E
-01 9.98E
-01 9.81E
-01 1.01E+00 9.43E
-01 8.00E
-01
MIMAT
0002808 hsa
-miR
-511
-5p 1.02E+00 9.08E
-01 1.01E+00 9.01E
-01 9.20E
-01 5.56E
-01 6.96E
-01
MIMAT
0002822 hsa
-miR
-512
-5p 9.95E
-01 8.24E
-01 9.65E
-01 2.60E
-02 1.02E+00 5.99E
-01 5.31E
-01
MIMAT
0004777 hsa
-miR
-513a
-3p 9.62E
-01 7.70E
-01 9.12E
-01 4.10E
-01 1.21E+00 6.25E
-02 9.84E
-01
MIMAT
0002877 hsa
-miR
-513a
-5p 8.21E
-01 8.65E
-03 9.54E
-01 3.48E
-01 1.13E+00 6.21E
-02 3.67E
-01
MIMAT
0005788 hsa
-miR
-513b
-5p 1.03E+00 5.47E
-01 1.02E+00 6.05E
-01 9.45E
-01 5.19E
-01 6.07E
-01
MIMAT
0005789 hsa
-miR
-513c
-5p 1.15E+00 1.04E
-01 9.03E
-01 1.23E
-01 1.03E+00 8.68E
-01 1.87E
-01
MIMAT
0002883 hsa
-miR
-514a
-3p 1.12E+00 2.84E
-01 9.37E
-01 3.50E
-01 1.18E+00 3.65E
-01 1.86E
-02
MIMAT
0022702 hsa
-miR
-514a
-5p 1.05E+00 1.96E
-01 1.00E+00 9.52E
-01 1.07E+00 2.99E
-01 5.93E
-02
MIMAT
0015088 hsa
-miR
-514b
-3p 9.92E
-01 9.43E
-01 1.04E+00 6.16E
-01 1.00E+00 9.89E
-01 9.84E
-01
MIMAT
0015087 hsa
-miR
-514b
-5p 1.10E+00 2.93E
-01 1.01E+00 8.22E
-01 1.04E+00 7.38E
-01 1.92E
-01
MIMAT
0002826 hsa
-miR
-515
-5p 1.03E+00 8.22E
-01 1.04E+00 6.51E
-01 1.13E+00 6.07E
-01 8.03E
-01
MIMAT
0002859 hsa
-miR
-516b
-5p 1.02E+00 8.35E
-01 1.04E+00 6.41E
-01 7.51E
-01 6.67E
-02 6.42E
-01
MIMAT
0002852 hsa
-miR
-517a
-3p 9.87E
-01 8.17E
-01 1.04E+00 3.90E
-01 9.16E
-01 1.60E
-01 3.39E
-01
MIMAT
0002866
hsa
-miR
-517c
-3p+hsa
-
miR
-519a
-3p 1.00E+00 9.86E
-01 1.00E+00 8.21E
-01 1.02E+00 6.77E
-01 1.66E
-02
MIMAT
0002844 hsa
-miR
-518b 9.58E
-01 7.68E
-01 8.21E
-01 1.94E
-01 1.31E+00 3.12E
-02 8.87E
-01
MIMAT
0002848 hsa
-miR
-518c
-3p 9.95E
-01 9.69E
-01 9.95E
-01 9.58E
-01 1.13E+00 6.47E
-01 7.27E
-01
MIMAT
0002861 hsa
-miR
-518e
-3p 9.65E
-01 2.90E
-01 9.97E
-01 9.04E
-01 9.48E
-01 2.41E
-01 6.17E
-01

196
MIMAT
0002842 hsa
-miR
-518f-3p 9.58E
-01 5.56E
-01 1.02E+00 6.37E
-01 9.12E
-01 4.91E
-01 1.93E
-01
MIMAT
0021129
hsa
-miR
-5196
-3p+hsa
-
miR
-6732
-3p 1.18E+00 9.82E
-02 9.03E
-01 1.61E
-01 1.10E+00 4.11E
-01 7.81E
-02
MIMAT
0021128 hsa
-miR
-5196
-5p 1.05E+00 5.64E
-01 9.51E
-01 3.73E
-01 1.08E+00 2.98E
-01 1.53E
-01
MIMAT
0002832 hsa
-miR
-519c
-3p 1.01E+00 7.72E
-01 9.52E
-01 1.20E
-01 1.02E+00 7.09E
-01 4.52E
-01
MIMAT
0002853 hsa
-miR
-519d
-3p 8.25E
-01 2.05E
-01 1.04E+00 7.12E
-01 1.01E+00 9.05E
-01 4.67E
-01
MIMAT
0002833 hsa
-miR
-520a
-5p 9.91E
-01 8.87E
-01 9.12E
-01 7.61E
-02 9.85E
-01 8.17E
-01 8.53E
-01
MIMAT
0002846 hsa
-miR
-520c
-3p 9.85E
-01 8.32E
-01 9.56E
-01 4.42E
-01 1.06E+00 4.34E
-01 1.72E
-01
MIMAT
0002856 hsa
-miR
-520d
-3p 1.00E+00 9.90E
-01 9.79E
-01 3.01E
-01 9.91E
-01 8.39E
-01 4.51E
-01
MIMAT
0002830 hsa
-miR
-520f-3p 9.80E
-01 4.24E
-01 9.49E
-01 8.21E
-03 1.02E+00 5.20E
-01 4.25E
-02
MIMAT
0002858 hsa
-miR
-520g
-3p 9.74E
-01 5.22E
-01 1.00E+00 9.04E
-01 9.80E
-01 5.82E
-01 9.15E
-01
MIMAT
0002867 hsa
-miR
-520h 9.92E
-01 7.05E
-01 9.79E
-01 1.54E
-01 9.38E
-01 1.20E
-01 1.23E
-01
MIMAT
0002854 hsa
-miR
-521 9.84E
-01 5.69E
-01 1.02E+00 2.80E
-01 1.01E+00 7.69E
-01 7.32E
-01
MIMAT
0002868 hsa
-miR
-522
-3p 1.03E+00 4.66E
-01 9.25E
-01 1.67E
-02 1.00E+00 9.99E
-01 4.49E
-02
MIMAT
0002838 hsa
-miR
-525
-5p 1.07E+00 4.17E
-01 9.70E
-01 6.17E
-01 1.10E+00 1.43E
-01 6.12E
-02
MIMAT
0002845
hsa
-miR
-526a+hsa
-miR
-
518c
-5p+hsa
-miR
-518d
-
5p 9.77E
-01 7.30E
-01 1.03E+00 5.49E
-01 9.39E
-01 4.23E
-01 8.90E
-01
MIMAT
0002835 hsa
-miR
-526b
-5p 9.68E
-01 5.22E
-01 1.02E+00 4.90E
-01 1.09E+00 3.14E
-02 1.95E
-01
MIMAT
0004780 hsa
-miR
-532
-3p 9.54E
-01 5.01E
-01 9.48E
-01 3.22E
-01 1.04E+00 4.74E
-01 9.10E
-01
MIMAT
0003389 hsa
-miR
-542
-3p 1.02E+00 8.93E
-01 1.07E+00 4.29E
-01 1.19E+00 4.90E
-01 5.16E
-01
MIMAT
0003340 hsa
-miR
-542
-5p 9.39E
-01 4.81E
-01 1.02E+00 8.06E
-01 1.18E+00 3.61E
-01 9.57E
-01
MIMAT
0004954 hsa
-miR
-543 9.89E
-01 9.14E
-01 8.69E
-01 8.36E
-02 9.03E
-01 5.73E
-01 2.09E
-01
MIMAT
0004803 hsa
-miR
-548a
-5p 9.98E
-01 9.12E
-01 1.00E+00 9.46E
-01 9.54E
-01 9.53E
-02 9.65E
-01
MIMAT
0018447
hsa
-miR
-548aa+hsa
-miR
-
548t
-3p 9.41E
-01 4.43E
-01 9.02E
-01 9.14E
-02 1.10E+00 3.08E
-01 1.94E
-01

197
MIMAT
0018972 hsa
-miR
-548ah
-5p 9.65E
-01 6.71E
-01 9.88E
-01 8.56E
-01 1.13E+00 1.07E
-01 2.24E
-01
MIMAT
0019013 hsa
-miR
-548ak 9.81E
-01 2.90E
-01 9.79E
-01 1.52E
-01 1.02E+00 1.59E
-01 6.81E
-01
MIMAT
0022266 hsa
-miR
-548ar
-3p 9.95E
-01 9.51E
-01 9.37E
-01 2.58E
-01 8.88E
-01 4.43E
-01 1.97E
-01
MIMAT
0022265 hsa
-miR
-548ar
-5p 1.20E+00 1.37E
-01 9.62E
-01 7.25E
-01 1.09E+00 3.64E
-01 4.74E
-01
MIMAT
0004812 hsa
-miR
-548d
-5p 9.64E
-01 6.60E
-01 1.05E+00 3.80E
-01 1.08E+00 2.50E
-01 8.89E
-01
MIMAT
0026736 hsa
-miR
-548e
-5p 9.91E
-01 6.84E
-01 1.01E+00 7.15E
-01 1.05E+00 3.74E
-02 1.75E
-01
MIMAT
0005912 hsa
-miR
-548g
-3p 8.99E
-01 4.95E
-01 9.87E
-01 8.97E
-01 9.86E
-01 9.62E
-01 3.90E
-01
MIMAT
0005935 hsa
-miR
-548i 8.22E
-01 5.90E
-02 9.83E
-01 8.05E
-01 1.05E+00 5.33E
-01 8.97E
-01
MIMAT
0026737 hsa
-miR
-548j
-3p 1.15E+00 2.92E
-01 9.18E
-01 3.55E
-01 1.03E+00 8.54E
-01 6.36E
-01
MIMAT
0005882 hsa
-miR
-548k 9.79E
-01 7.53E
-01 1.06E+00 2.33E
-01 1.08E+00 2.66E
-01 7.36E
-01
MIMAT
0005917 hsa
-miR
-548m 1.02E+00 8.97E
-01 1.06E+00 5.71E
-01 1.06E+00 6.24E
-01 7.49E
-03
MIMAT
0005916 hsa
-miR
-548n 1.03E+00 3.14E
-01 9.20E
-01 4.21E
-04 9.85E
-01 7.79E
-01 2.05E
-01
MIMAT
0011163 hsa
-miR
-548q 9.78E
-01 8.91E
-01 1.02E+00 8.29E
-01 8.80E
-01 4.48E
-01 3.25E
-01
MIMAT
0015020 hsa
-miR
-548v 9.25E
-01 3.07E
-01 9.70E
-01 5.80E
-01 9.92E
-01 9.08E
-01 7.34E
-02
MIMAT
0018354 hsa
-miR
-548y 9.81E
-01 8.86E
-01 1.11E+00 2.57E
-01 1.05E+00 6.70E
-01 2.86E
-01
MIMAT
0018446
hsa
-miR
-548z+hsa
-miR
-
548h
-3p 9.82E
-01 6.92E
-01 9.81E
-01 5.61E
-01 9.67E
-01 5.14E
-01 1.10E
-01
MIMAT
0003333 hsa
-miR
-549a 9.96E
-01 9.23E
-01 9.56E
-01 1.79E
-01 1.11E+00 1.70E
-01 7.55E
-01
MIMAT
0003233 hsa
-miR
-551b
-3p 1.03E+00 7.07E
-01 9.82E
-01 7.75E
-01 1.18E+00 1.10E
-01 9.84E
-02
MIMAT
0003215 hsa
-miR
-552
-3p 1.04E+00 4.97E
-01 9.99E
-01 9.76E
-01 9.05E
-01 1.50E
-01 3.79E
-01
MIMAT
0003219 hsa
-miR
-555 1.06E+00 2.69E
-01 8.99E
-01 3.32E
-03 9.20E
-01 4.27E
-01 7.03E
-01
MIMAT
0004793 hsa
-miR
-556
-3p 9.96E
-01 9.56E
-01 9.96E
-01 9.52E
-01 9.14E
-01 5.78E
-01 5.44E
-01
MIMAT
0003220 hsa
-miR
-556
-5p 8.93E
-01 2.43E
-01 9.49E
-01 4.97E
-01 9.32E
-01 5.55E
-01 4.86E
-01

198
MIMAT
0022706 hsa
-miR
-561
-5p 9.47E
-01 4.79E
-01 9.83E
-01 7.43E
-01 1.11E+00 4.31E
-01 1.14E
-01
MIMAT
0003227 hsa
-miR
-563 9.61E
-01 2.47E
-01 9.57E
-01 6.73E
-02 9.70E
-01 3.43E
-01 5.51E
-02
MIMAT
0003228 hsa
-miR
-564 9.34E
-01 4.94E
-01 8.57E
-01 5.76E
-02 1.02E+00 7.85E
-01 5.84E
-01
MIMAT
0003230 hsa
-miR
-566 9.79E
-01 4.30E
-01 1.00E+00 9.92E
-01 1.00E+00 9.64E
-01 7.25E
-01
MIMAT
0003235 hsa
-miR
-570
-3p 1.10E+00 4.76E
-01 1.09E+00 2.65E
-01 5.20E
-01 1.85E
-02 5.77E
-01
MIMAT
0003237 hsa
-miR
-572 9.90E
-01 6.98E
-01 9.77E
-01 2.29E
-01 9.47E
-01 2.95E
-01 2.08E
-01
MIMAT
0003239 hsa
-miR
-574
-3p 8.66E
-01 3.86E
-01 1.02E+00 8.46E
-01 1.73E
-01 3.61E
-02 7.13E
-01
MIMAT
0004795 hsa
-miR
-574
-5p 1.00E+00 8.61E
-01 9.87E
-01 4.70E
-01 9.78E
-01 3.63E
-01 4.04E
-01
MIMAT
0003240 hsa
-miR
-575 1.02E+00 5.26E
-01 9.63E
-01 4.33E
-02 9.86E
-01 7.64E
-01 7.44E
-01
MIMAT
0004796 hsa
-miR
-576
-3p 1.05E+00 7.12E
-01 1.01E+00 8.77E
-01 4.61E
-01 2.50E
-02 6.90E
-01
MIMAT
0003241 hsa
-miR
-576
-5p 1.03E+00 7.36E
-01 9.86E
-01 7.84E
-01 1.01E+00 9.35E
-01 7.00E
-01
MIMAT
0003242 hsa
-miR
-577 1.18E+00 1.15E
-01 9.68E
-01 6.72E
-01 9.30E
-01 5.41E
-01 9.25E
-01
MIMAT
0026616 hsa
-miR
-579
-5p 1.02E+00 4.17E
-01 9.86E
-01 5.06E
-01 9.83E
-01 6.81E
-01 8.93E
-01
MIMAT
0004797 hsa
-miR
-582
-3p 9.31E
-01 4.54E
-01 1.01E+00 8.99E
-01 9.47E
-01 5.99E
-01 4.28E
-01
MIMAT
0003247 hsa
-miR
-582
-5p 9.55E
-01 5.73E
-01 9.66E
-01 5.36E
-01 9.31E
-01 3.40E
-01 7.22E
-01
MIMAT
0022708 hsa
-miR
-584
-3p 1.06E+00 4.81E
-01 1.07E+00 1.98E
-01 9.45E
-01 7.22E
-01 3.75E
-01
MIMAT
0003249 hsa
-miR
-584
-5p 1.00E+00 9.84E
-01 9.62E
-01 9.72E
-02 1.01E+00 8.38E
-01 4.16E
-01
MIMAT
0003250 hsa
-miR
-585
-3p 9.87E
-01 5.81E
-01 9.82E
-01 3.33E
-01 1.02E+00 5.48E
-01 1.33E
-01
MIMAT
0003253 hsa
-miR
-587 9.48E
-01 4.16E
-01 1.01E+00 8.71E
-01 1.08E+00 1.87E
-01 4.46E
-01
MIMAT
0003258 hsa
-miR
-590
-5p 9.79E
-01 2.26E
-01 9.90E
-01 4.96E
-01 9.53E
-01 1.78E
-02 5.59E
-01
MIMAT
0003259 hsa
-miR
-591 1.02E+00 8.23E
-01 9.46E
-01 3.55E
-01 1.15E+00 3.65E
-01 4.20E
-01
MIMAT
0003260 hsa
-miR
-592 9.70E
-01 8.37E
-02 9.82E
-01 1.55E
-01 1.02E+00 2.92E
-01 7.13E
-01

199
MIMAT
0004802 hsa
-miR
-593
-3p 8.81E
-01 2.07E
-01 1.06E+00 3.73E
-01 1.05E+00 5.98E
-01 2.68E
-01
MIMAT
0003263 hsa
-miR
-595 8.81E
-01 4.54E
-01 1.11E+00 3.54E
-01 1.06E+00 7.15E
-01 3.89E
-01
MIMAT
0003265 hsa
-miR
-597
-5p 1.07E+00 4.89E
-01 9.09E
-01 1.60E
-01 9.86E
-01 9.27E
-01 6.56E
-02
MIMAT
0003266 hsa
-miR
-598
-3p 1.03E+00 1.17E
-01 9.73E
-01 5.77E
-02 9.85E
-01 6.73E
-01 3.11E
-01
MIMAT
0003271 hsa
-miR
-603 1.03E+00 6.51E
-01 9.92E
-01 8.45E
-01 1.02E+00 8.02E
-01 5.42E
-01
MIMAT
0003273 hsa
-miR
-605
-5p 9.84E
-01 8.90E
-01 1.02E+00 7.89E
-01 9.51E
-01 6.42E
-01 1.77E
-01
MIMAT
0003275 hsa
-miR
-607 9.45E
-01 4.75E
-01 9.90E
-01 8.50E
-01 1.00E+00 9.98E
-01 1.10E
-01
MIMAT
0003276 hsa
-miR
-608 1.13E+00 3.48E
-01 9.38E
-01 5.20E
-01 1.31E+00 3.03E
-01 3.13E
-01
MIMAT
0003280 hsa
-miR
-612 8.39E
-01 2.24E
-01 9.66E
-01 7.15E
-01 1.36E+00 8.02E
-03 1.02E
-01
MIMAT
0003283 hsa
-miR
-615
-3p 9.01E
-01 1.24E
-01 1.00E+00 9.99E
-01 NULL NULL 3.89E
-01
MIMAT
0004805 hsa
-miR
-616
-3p 9.79E
-01 8.53E
-01 9.46E
-01 4.89E
-01 1.24E+00 2.51E
-01 8.67E
-01
MIMAT
0003289 hsa
-miR
-620 9.40E
-01 6.54E
-01 1.05E+00 6.15E
-01 1.10E+00 7.01E
-01 4.81E
-01
MIMAT
0003295 hsa
-miR
-626 9.87E
-01 8.24E
-01 1.01E+00 7.10E
-01 1.06E+00 2.73E
-01 2.98E
-01
MIMAT
0026623 hsa
-miR
-627
-3p 9.68E
-01 7.56E
-01 9.23E
-01 2.36E
-01 8.90E
-01 4.66E
-01 3.17E
-01
MIMAT
0003296 hsa
-miR
-627
-5p 9.89E
-01 5.28E
-01 9.70E
-01 1.75E
-02 1.01E+00 8.09E
-01 7.26E
-01
MIMAT
0003297 hsa
-miR
-628
-3p 1.01E+00 9.13E
-01 9.95E
-01 8.79E
-01 9.14E
-01 2.01E
-01 2.03E
-01
MIMAT
0003299 hsa
-miR
-630 1.04E+00 5.32E
-01 9.52E
-01 2.42E
-01 8.82E
-01 2.72E
-01 8.44E
-03
MIMAT
0003300 hsa
-miR
-631 9.52E
-01 7.15E
-01 9.83E
-01 8.37E
-01 1.29E+00 1.71E
-02 9.02E
-03
MIMAT
0003309 hsa
-miR
-639 9.57E
-01 7.02E
-01 9.12E
-01 2.82E
-01 1.02E+00 9.03E
-01 6.78E
-01
MIMAT
0003310 hsa
-miR
-640 1.01E+00 8.22E
-01 9.46E
-01 1.09E
-02 1.06E+00 3.19E
-01 9.96E
-01
MIMAT
0003312 hsa
-miR
-642a
-5p 1.02E+00 3.85E
-01 9.85E
-01 3.83E
-01 9.37E
-01 1.51E
-01 1.49E
-02
MIMAT
0003313 hsa
-miR
-643 1.02E+00 4.05E
-01 9.87E
-01 3.96E
-01 9.71E
-01 4.79E
-01 7.60E
-01

200
MIMAT
0003314 hsa
-miR
-644a 1.02E+00 6.52E
-01 9.49E
-01 7.27E
-02 1.03E+00 6.36E
-01 6.43E
-01
MIMAT
0003319 hsa
-miR
-649 1.02E+00 9.00E
-01 9.37E
-01 5.29E
-01 8.32E
-01 4.63E
-01 9.58E
-01
MIMAT
0003320 hsa
-miR
-650 1.02E+00 3.17E
-01 9.69E
-01 4.99E
-02 9.69E
-01 4.68E
-01 5.49E
-01
MIMAT
0025462 hsa
-miR
-6503
-5p 1.00E+00 9.98E
-01 9.37E
-01 3.85E
-01 1.21E+00 4.77E
-02 1.52E
-01
MIMAT
0003321 hsa
-miR
-651
-5p 9.26E
-01 1.20E
-01 9.89E
-01 7.74E
-01 9.62E
-01 4.41E
-01 3.23E
-01
MIMAT
0022709 hsa
-miR
-652
-5p 6.81E
-01 3.49E
-02 7.82E
-01 1.11E
-01 9.61E
-01 7.51E
-01 9.73E
-02
MIMAT
0003330 hsa
-miR
-654
-5p 1.06E+00 2.47E
-01 9.63E
-01 2.52E
-01 9.74E
-01 5.85E
-01 6.79E
-02
MIMAT
0003331 hsa
-miR
-655
-3p 9.82E
-01 5.88E
-01 9.53E
-01 1.62E
-02 9.97E
-01 9.20E
-01 7.58E
-01
MIMAT
0003332 hsa
-miR
-656
-3p 9.98E
-01 9.22E
-01 1.00E+00 9.45E
-01 1.03E+00 1.72E
-01 1.24E
-01
MIMAT
0022711 hsa
-miR
-660
-3p 8.98E
-01 3.14E
-01 9.47E
-01 5.27E
-01 1.01E+00 9.60E
-01 2.25E
-01
MIMAT
0003326 hsa
-miR
-663a 9.30E
-01 6.74E
-01 1.15E+00 1.48E
-01 1.02E+00 8.53E
-01 7.12E
-01
MIMAT
0005949 hsa
-miR
-664a
-3p 1.00E+00 9.40E
-01 1.03E+00 4.58E
-01 9.38E
-01 2.51E
-01 4.68E
-03
MIMAT
0022272 hsa
-miR
-664b
-3p 9.90E
-01 7.45E
-01 1.02E+00 3.65E
-01 1.05E+00 3.95E
-02 9.73E
-01
MIMAT
0004952 hsa
-miR
-665 8.54E
-01 6.19E
-02 9.42E
-01 3.10E
-01 1.14E+00 1.11E
-01 9.55E
-01
MIMAT
0003880 hsa
-miR
-671
-5p 9.95E
-01 8.37E
-01 9.75E
-01 9.97E
-02 9.45E
-01 2.14E
-01 5.26E
-01
MIMAT
0025851 hsa
-miR
-6720
-3p 8.11E
-01 2.17E
-01 1.02E+00 8.06E
-01 1.45E+00 2.17E
-04 3.18E
-01
MIMAT
0025852 hsa
-miR
-6721
-5p 1.00E+00 9.54E
-01 9.93E
-01 6.69E
-01 1.06E+00 8.62E
-02 5.87E
-01
MIMAT
0025856 hsa
-miR
-6724
-5p 9.83E
-01 2.36E
-01 9.86E
-01 2.14E
-01 9.57E
-01 5.85E
-02 3.85E
-01
MIMAT
0004945 hsa
-miR
-744
-5p 1.11E+00 3.05E
-01 9.99E
-01 9.85E
-01 1.05E+00 7.80E
-01 4.95E
-01
MIMAT
0022929 hsa
-miR
-758
-5p 9.90E
-01 8.32E
-01 9.83E
-01 6.29E
-01 9.73E
-01 7.75E
-01 9.18E
-01
MIMAT
0010364 hsa
-miR
-761 1.01E+00 6.71E
-01 9.96E
-01 8.32E
-01 9.22E
-01 2.65E
-02 5.28E
-01
MIMAT
0010367 hsa
-miR
-764 1.01E+00 7.17E
-01 1.00E+00 7.77E
-01 9.90E
-01 6.41E
-01 1.35E
-01

201
MIMAT
0003945 hsa
-miR
-765 8.79E
-01 2.34E
-01 9.53E
-01 5.21E
-01 1.07E+00 7.26E
-01 1.57E
-01
MIMAT
0003882 hsa
-miR
-767
-5p 1.02E+00 5.58E
-01 9.79E
-01 3.44E
-01 1.09E+00 1.14E
-03 4.12E
-01
MIMAT
0003887 hsa
-miR
-769
-3p 9.90E
-01 6.78E
-01 9.46E
-01 2.52E
-03 9.99E
-01 9.66E
-01 6.50E
-01
MIMAT
0003886 hsa
-miR
-769
-5p 1.04E+00 2.14E
-01 9.72E
-01 1.82E
-01 9.85E
-01 7.84E
-01 7.32E
-01
MIMAT
0003948 hsa
-miR
-770
-5p 1.03E+00 3.72E
-01 9.60E
-01 6.86E
-02 9.93E
-01 8.73E
-01 3.92E
-01
MIMAT
0004185 hsa
-miR
-802 8.45E
-01 2.61E
-01 4.86E
-01 4.00E
-04 1.06E+00 8.40E
-01 5.05E
-01
MIMAT
0022717 hsa
-miR
-873
-3p 1.02E+00 3.60E
-01 9.75E
-01 1.89E
-01 9.36E
-01 1.67E
-01 1.15E
-01
MIMAT
0004953 hsa
-miR
-873
-5p 1.01E+00 6.79E
-01 9.72E
-01 3.98E
-02 1.01E+00 7.47E
-01 8.74E
-01
MIMAT
0026718 hsa
-miR
-874
-5p 1.05E+00 3.58E
-01 9.91E
-01 8.17E
-01 1.10E+00 6.43E
-02 5.83E
-01
MIMAT
0004925 hsa
-miR
-876
-3p 1.03E+00 5.57E
-01 9.30E
-01 2.46E
-02 1.08E+00 2.29E
-01 6.34E
-02
MIMAT
0004924 hsa
-miR
-876
-5p 1.01E+00 3.79E
-01 9.50E
-01 3.24E
-05 9.79E
-01 5.42E
-01 9.33E
-01
MIMAT
0004949 hsa
-miR
-877
-5p 1.04E+00 6.74E
-01 1.07E+00 2.86E
-01 1.03E+00 8.05E
-01 1.76E
-01
MIMAT
0004948 hsa
-miR
-885
-3p 9.79E
-01 4.52E
-01 9.92E
-01 6.95E
-01 1.05E+00 3.74E
-01 1.13E
-01
MIMAT
0026720 hsa
-miR
-887
-5p 9.64E
-01 5.58E
-01 8.97E
-01 2.64E
-02 1.03E+00 8.22E
-01 1.10E
-01
MIMAT
0004916 hsa
-miR
-888
-5p 1.02E+00 7.09E
-01 9.74E
-01 4.28E
-01 9.76E
-01 7.63E
-01 6.80E
-01
MIMAT
0004921 hsa
-miR
-889
-3p 1.03E+00 1.90E
-01 9.88E
-01 4.57E
-01 9.41E
-01 1.08E
-01 6.08E
-01
MIMAT
0004912 hsa
-miR
-890 1.01E+00 8.72E
-01 8.90E
-01 2.59E
-02 8.74E
-01 2.81E
-01 5.65E
-01
MIMAT
0004902 hsa
-miR
-891a
-5p 1.01E+00 8.73E
-01 9.92E
-01 8.74E
-01 1.08E+00 4.27E
-01 2.98E
-02
MIMAT
0004913 hsa
-miR
-891b 9.18E
-01 5.70E
-02 1.08E+00 1.77E
-02 9.51E
-01 2.32E
-01 4.83E
-01
MIMAT
0004907 hsa
-miR
-892a 9.88E
-01 9.15E
-01 9.01E
-01 2.04E
-01 1.15E+00 7.82E
-02 1.10E
-01
MIMAT
0004972 hsa
-miR
-922 9.50E
-01 3.07E
-01 9.96E
-01 9.10E
-01 1.09E+00 5.95E
-02 8.12E
-01
MIMAT
0004507 hsa
-miR
-92a
-
1
-5p 1.03E+00 6.24E
-01 9.18E
-01 4.39E
-02 9.37E
-01 5.88E
-01 6.22E
-01

202
MIMAT
0000092 hsa
-miR
-92a
-3p 9.88E
-01 6.19E
-01 9.74E
-01 2.34E
-01 1.07E+00 2.61E
-03 8.25E
-01
MIMAT
0003218 hsa
-miR
-92b
-3p 9.94E
-01 7.86E
-01 9.99E
-01 9.51E
-01 9.60E
-01 2.36E
-01 6.19E
-01
MIMAT
0000093 hsa
-miR
-93
-5p 1.10E+00 3.00E
-01 9.49E
-01 4.25E
-01 8.26E
-01 3.40E
-01 4.70E
-01
MIMAT
0004976 hsa
-miR
-933 1.00E+00 8.91E
-01 9.80E
-01 2.56E
-01 1.02E+00 5.05E
-01 4.73E
-01
MIMAT
0004977 hsa
-miR
-934 1.08E+00 2.61E
-01 9.93E
-01 8.75E
-01 1.20E+00 2.37E
-03 6.57E
-01
MIMAT
0004978 hsa
-miR
-935 9.87E
-01 5.15E
-01 9.92E
-01 6.00E
-01 1.02E+00 6.58E
-01 8.27E
-01
MIMAT
0004979 hsa
-miR
-936 6.82E
-01 3.22E
-02 8.37E
-01 1.28E
-01 1.27E+00 3.56E
-01 5.01E
-01
MIMAT
0004980 hsa
-miR
-937
-3p 9.85E
-01 6.16E
-01 9.85E
-01 4.80E
-01 9.96E
-01 9.54E
-01 5.71E
-01
MIMAT
0004982 hsa
-miR
-939
-5p 1.11E+00 8.30E
-02 9.32E
-01 1.29E
-01 1.08E+00 2.17E
-01 6.43E
-02
MIMAT
0004983 hsa
-miR
-940 8.80E
-01 4.14E
-01 8.86E
-01 3.13E
-01 8.91E
-01 6.42E
-01 8.50E
-01
MIMAT
0004984 hsa
-miR
-941 9.84E
-01 4.80E
-01 1.00E+00 8.21E
-01 9.26E
-01 1.08E
-01 8.11E
-01
MIMAT
0004985 hsa
-miR
-942
-5p 9.73E
-01 4.94E
-01 9.69E
-01 2.66E
-01 1.11E+00 4.39E
-03 8.89E
-01
MIMAT
0000094 hsa
-miR
-95
-3p 9.67E
-01 7.65E
-01 8.99E
-01 2.10E
-01 1.06E+00 7.18E
-01 2.55E
-02
MIMAT
0000095 hsa
-miR
-96
-5p 1.03E+00 6.64E
-01 9.93E
-01 8.93E
-01 9.09E
-01 4.00E
-01 1.76E
-01
MIMAT
0000689 hsa
-miR
-99b
-5p 1.17E+00 1.53E
-01 1.04E+00 6.66E
-01 1.26E+00 3.76E
-02 6.44E
-01

203
Appendix K. Heterogeneity by smoking status for the association of alcohol intake (continuous per drink) and circulating microRNA adjusted for age
at biospecimen draw, sex, race/ethnicity, body mass index (kg/m2), batch, time in years between baseline questionnaire and biospecimen draw, and
case-control status.
Access
ion miRNA
Never smokers IRR
ethanol intake per
drink
Never
smokers
nominal pvalue
Former smokers
IRR ethanol intake
per drink
Former
smokers
nominal pvalue
Current smokers
IRR ethanol intake
per drink
Current
smokers
nominal pvalue
P for
heterog
eneity
MIMA
T00000
62 hsa-let-7a-5p 9.85E-01 9.16E-01 9.80E-01 8.11E-01 9.24E-01 5.13E-01 9.72E-01
MIMA
T00000
63 hsa-let-7b-5p 9.60E-01 3.37E-01 9.75E-01 2.84E-01 9.82E-01 5.76E-01 9.08E-01
MIMA
T00000
64 hsa-let-7c-5p 1.00E+00 9.64E-01 9.38E-01 4.04E-01 8.41E-01 8.77E-02 7.25E-01
MIMA
T00000
65 hsa-let-7d-5p 1.11E+00 2.54E-01 9.80E-01 7.28E-01 9.37E-01 5.00E-01 2.98E-01
MIMA
T00000
67 hsa-let-7f-5p 8.94E-01 3.42E-01 9.97E-01 9.67E-01 9.61E-01 6.69E-01 7.37E-01
MIMA
T00004
14 hsa-let-7g-5p 1.05E+00 5.24E-01 1.02E+00 5.94E-01 9.67E-01 7.05E-01 8.62E-01
MIMA
T00000
98 hsa-miR-100-5p 1.10E+00 5.47E-01 9.73E-01 7.94E-01 9.28E-01 6.91E-01 2.83E-01
MIMA
T00001
02 hsa-miR-105-5p 1.01E+00 8.72E-01 1.08E+00 5.82E-02 1.02E+00 8.04E-01 4.36E-01
MIMA
T00006
80 hsa-miR-106b-5p 1.05E+00 5.68E-01 9.60E-01 4.58E-01 1.11E+00 1.44E-01 9.29E-01
MIMA
T00001
04 hsa-miR-107 9.90E-01 8.63E-01 1.00E+00 9.94E-01 1.02E+00 7.91E-01 6.60E-01
MIMA
T00002
53 hsa-miR-10a-5p 1.02E+00 3.39E-01 9.66E-01 3.27E-02 9.94E-01 7.43E-01 4.79E-01
MIMA
T00002
54 hsa-miR-10b-5p 1.02E+00 8.16E-01 9.91E-01 8.22E-01 9.43E-01 3.31E-01 5.76E-01

204
MIMA
T00058
25 hsa
-miR
-1180
-3p 9.44E
-01 1.04E
-01 1.01E+00 5.67E
-01 9.99E
-01 9.67E
-01 2.91E
-01
MIMA
T00058
28 hsa
-miR
-1183 1.05E+00 4.34E
-01 9.53E
-01 2.77E
-01 1.01E+00 8.24E
-01 6.75E
-01
MIMA
T00228
38 hsa
-miR
-1185
-
1
-3p 1.11E+00 3.21E
-01 9.33E
-01 3.75E
-01 8.65E
-01 2.43E
-01 2.75E
-01
MIMA
T00227
13 hsa
-miR
-1185
-
2
-3p 1.11E+00 2.74E
-01 9.84E
-01 7.62E
-01 4.46E
-01 1.46E
-02 2.83E
-01
MIMA
T00057
98 hsa
-miR
-1185
-5p 1.02E+00 4.72E
-01 1.01E+00 6.05E
-01 1.00E+00 9.63E
-01 8.93E
-01
MIMA
T00150
49 hsa
-miR
-1193 9.46E
-01 3.18E
-01 9.11E
-01 1.02E
-02 9.79E
-01 6.65E
-01 6.43E
-01
MIMA
T00059
55 hsa
-miR
-1197 9.88E
-01 7.78E
-01 1.00E+00 8.80E
-01 9.76E
-01 5.10E
-01 3.27E
-01
MIMA
T00058
63 hsa
-miR
-1200 9.30E
-01 6.73E
-01 1.00E+00 9.58E
-01 1.21E+00 7.81E
-02 1.29E
-01
MIMA
T00058
65 hsa
-miR
-1202 9.16E
-01 4.11E
-01 1.04E+00 4.93E
-01 9.73E
-01 7.55E
-01 4.43E
-01
MIMA
T00058
66 hsa
-miR
-1203 1.45E+00 2.32E
-02 8.17E
-01 8.54E
-02 1.45E+00 6.43E
-02 2.51E
-01
MIMA
T00058
69 hsa
-miR
-1205 9.43E
-01 3.45E
-01 1.02E+00 7.19E
-01 1.01E+00 7.85E
-01 4.74E
-01
MIMA
T00058
70 hsa
-miR
-1206 1.01E+00 7.61E
-01 9.81E
-01 3.93E
-01 9.85E
-01 5.57E
-01 2.23E
-01
MIMA
T00004
21 hsa
-miR
-122
-5p 1.06E+00 1.15E
-01 9.56E
-01 9.61E
-02 1.02E+00 5.71E
-01 1.61E
-01
MIMA
T00054
59 hsa
-miR
-1224
-3p 9.29E
-01 2.46E
-01 1.01E+00 8.66E
-01 9.64E
-01 5.20E
-01 6.69E
-01
MIMA
T00055
77 hsa
-miR
-1226
-3p 9.73E
-01 8.19E
-01 8.86E
-01 1.15E
-01 1.20E+00 1.03E
-01 8.16E
-01

205
MIMA
T00055
83 hsa
-miR
-1228
-3p 9.96E
-01 9.80E
-01 9.51E
-01 6.16E
-01 9.45E
-01 6.27E
-01 6.51E
-01
MIMA
T00055
89 hsa
-miR
-1234
-3p 9.69E
-01 4.35E
-01 9.65E
-01 1.42E
-01 1.03E+00 3.80E
-01 9.81E
-01
MIMA
T00055
91 hsa
-miR
-1236
-3p 1.01E+00 8.65E
-01 1.01E+00 8.17E
-01 1.08E+00 2.46E
-01 4.82E
-01
MIMA
T00058
96 hsa
-miR
-1244 9.83E
-01 6.01E
-01 9.88E
-01 5.24E
-01 1.00E+00 9.69E
-01 3.15E
-01
MIMA
T00058
97 hsa
-miR
-1245a 9.58E
-01 2.08E
-01 9.81E
-01 4.11E
-01 1.01E+00 6.62E
-01 7.09E
-01
MIMA
T00199
50 hsa
-miR
-1245b
-5p 1.05E+00 4.13E
-01 9.78E
-01 5.38E
-01 9.70E
-01 5.75E
-01 5.03E
-02
MIMA
T00058
98 hsa
-miR
-1246 1.00E+00 9.72E
-01 9.98E
-01 9.79E
-01 9.37E
-01 5.57E
-01 7.28E
-01
MIMA
T00059
01 hsa
-miR
-1249
-3p 1.05E+00 5.28E
-01 9.40E
-01 2.63E
-01 7.79E
-01 1.60E
-02 7.40E
-01
MIMA
T00059
04 hsa
-miR
-1253 7.57E
-01 1.18E
-01 9.90E
-01 9.02E
-01 8.09E
-01 2.12E
-01 7.85E
-01
MIMA
T00059
05 hsa
-miR
-1254 9.61E
-01 2.11E
-01 1.03E+00 1.30E
-01 1.00E+00 8.85E
-01 2.50E
-01
MIMA
T00059
06 hsa
-miR
-1255a 1.04E+00 7.52E
-01 1.22E+00 6.57E
-03 9.71E
-01 7.98E
-01 2.41E
-01
MIMA
T00059
08 hsa
-miR
-1257 9.26E
-01 6.95E
-01 1.37E+00 1.38E
-03 1.06E+00 7.19E
-01 6.30E
-01
MIMA
T00059
09 hsa
-miR
-1258 9.93E
-01 7.70E
-01 1.01E+00 5.27E
-01 1.01E+00 5.75E
-01 9.53E
-01
MIMA
T00046
02 hsa
-miR
-125a
-3p 1.01E+00 9.07E
-01 1.01E+00 8.07E
-01 9.27E
-01 2.63E
-01 7.50E
-01
MIMA
T00004
23 hsa
-miR
-125b
-5p 1.03E+00 4.26E
-01 9.96E
-01 8.44E
-01 9.69E
-01 2.65E
-01 9.86E
-01

206
MIMA
T00004
45 hsa
-miR
-126
-3p 9.80E
-01 4.97E
-01 1.02E+00 4.75E
-01 1.02E+00 5.35E
-01 9.55E
-01
MIMA
T00059
13 hsa
-miR
-1261 9.97E
-01 9.69E
-01 9.58E
-01 3.95E
-01 8.40E
-01 1.08E
-01 3.74E
-01
MIMA
T00059
14 hsa
-miR
-1262 1.11E+00 2.23E
-01 9.46E
-01 3.03E
-01 9.21E
-01 5.37E
-01 4.40E
-01
MIMA
T00057
91 hsa
-miR
-1264 1.07E+00 6.86E
-01 1.05E+00 6.60E
-01 7.44E
-01 8.12E
-02 9.50E
-01
MIMA
T00059
20 hsa
-miR
-1266
-5p 9.96E
-01 9.56E
-01 1.01E+00 8.27E
-01 9.51E
-01 4.38E
-01 9.28E
-01
MIMA
T00059
22 hsa
-miR
-1268a 9.47E
-01 6.51E
-01 1.03E+00 7.42E
-01 9.54E
-01 6.52E
-01 4.21E
-01
MIMA
T00189
25 hsa
-miR
-1268b 1.02E+00 4.22E
-01 9.74E
-01 8.33E
-02 1.01E+00 5.88E
-01 6.11E
-01
MIMA
T00059
23 hsa
-miR
-1269a 1.00E+00 9.71E
-01 1.01E+00 8.75E
-01 9.48E
-01 4.55E
-01 6.61E
-01
MIMA
T00004
46 hsa
-miR
-127
-3p 9.88E
-01 6.47E
-01 9.97E
-01 8.28E
-01 1.01E+00 5.87E
-01 9.50E
-01
MIMA
T00046
04 hsa
-miR
-127
-5p 9.85E
-01 9.33E
-01 8.95E
-01 3.45E
-01 9.45E
-01 7.20E
-01 7.36E
-02
MIMA
T00059
24 hsa
-miR
-1270 6.59E
-01 8.13E
-02 8.74E
-01 3.12E
-01 8.70E
-01 5.18E
-01 9.80E
-01
MIMA
T00057
96 hsa
-miR
-1271
-5p 9.57E
-01 7.98E
-01 1.05E+00 6.28E
-01 9.15E
-01 6.11E
-01 4.47E
-01
MIMA
T00059
25 hsa
-miR
-1272 1.04E+00 5.76E
-01 8.64E
-01 3.15E
-03 9.42E
-01 2.87E
-01 2.57E
-01
MIMA
T00059
33 hsa
-miR
-1277
-3p 1.08E+00 6.35E
-01 1.06E+00 6.23E
-01 1.20E+00 1.69E
-01 9.84E
-02
MIMA
T00059
36 hsa
-miR
-1278 9.24E
-01 6.15E
-01 1.11E+00 2.22E
-01 8.32E
-01 3.11E
-01 3.66E
-01

207
MIMA
T00059
37 hsa
-miR
-1279 9.73E
-01 6.18E
-01 9.97E
-01 9.13E
-01 9.47E
-01 2.98E
-01 9.48E
-01
MIMA
T00004
24 hsa
-miR
-128
-3p 1.08E+00 4.49E
-01 9.77E
-01 7.00E
-01 8.96E
-01 2.82E
-01 7.45E
-01
MIMA
T00059
39 hsa
-miR
-1281 8.54E
-01 3.64E
-01 9.82E
-01 8.82E
-01 9.75E
-01 8.72E
-01 9.87E
-01
MIMA
T00058
76 hsa
-miR
-1285
-3p 1.14E+00 4.56E
-01 7.69E
-01 6.64E
-02 7.29E
-01 2.49E
-01 7.39E
-02
MIMA
T00227
19 hsa
-miR
-1285
-5p 1.00E+00 9.98E
-01 9.81E
-01 3.15E
-01 1.06E+00 2.17E
-02 9.13E
-01
MIMA
T00058
77 hsa
-miR
-1286 9.45E
-01 2.72E
-01 9.78E
-01 5.87E
-01 1.05E+00 3.30E
-01 6.08E
-01
MIMA
T00058
78 hsa
-miR
-1287
-5p 8.80E
-01 8.63E
-02 9.65E
-01 4.03E
-01 8.92E
-01 1.34E
-01 8.96E
-01
MIMA
T00046
05 hsa
-miR
-129
-
2
-3p 1.07E+00 5.20E
-01 1.14E+00 4.03E
-02 1.04E+00 6.58E
-01 4.70E
-01
MIMA
T00058
80 hsa
-miR
-1290 1.10E+00 2.00E
-01 9.81E
-01 6.80E
-01 9.24E
-01 2.69E
-01 5.26E
-01
MIMA
T00058
83 hsa
-miR
-1293 9.21E
-01 5.79E
-01 1.02E+00 7.71E
-01 9.66E
-01 8.49E
-01 2.30E
-01
MIMA
T00058
85 hsa
-miR
-1295a 9.82E
-01 9.24E
-01 9.57E
-01 6.97E
-01 1.00E+00 9.86E
-01 1.87E
-01
MIMA
T00266
37 hsa
-miR
-1296
-3p 1.16E+00 3.04E
-01 8.31E
-01 1.21E
-01 1.01E+00 9.43E
-01 2.66E
-01
MIMA
T00058
86 hsa
-miR
-1297 9.83E
-01 6.42E
-01 9.79E
-01 3.61E
-01 9.87E
-01 6.78E
-01 8.76E
-01
MIMA
T00058
00 hsa
-miR
-1298
-5p 9.93E
-01 7.49E
-01 9.78E
-01 1.42E
-01 1.00E+00 8.11E
-01 3.52E
-01
MIMA
T00058
87 hsa
-miR
-1299 1.00E+00 9.93E
-01 1.07E+00 4.05E
-01 9.26E
-01 5.20E
-01 3.79E
-02

208
MIMA
T00058
90 hsa
-miR
-1302 1.05E+00 4.98E
-01 9.27E
-01 9.10E
-02 9.82E
-01 7.83E
-01 7.90E
-02
MIMA
T00227
20 hsa
-miR
-1304
-3p 9.99E
-01 9.45E
-01 9.85E
-01 3.05E
-01 9.77E
-01 1.79E
-01 9.21E
-01
MIMA
T00058
92 hsa
-miR
-1304
-5p 9.59E
-01 1.50E
-01 1.02E+00 3.37E
-01 1.02E+00 5.22E
-01 2.28E
-02
MIMA
T00058
93 hsa
-miR
-1305 1.02E+00 8.95E
-01 8.44E
-01 2.11E
-01 1.06E+00 6.59E
-01 1.96E
-02
MIMA
T00059
50 hsa
-miR
-1306
-3p 9.33E
-01 3.91E
-01 9.71E
-01 5.62E
-01 8.59E
-01 5.70E
-02 6.13E
-01
MIMA
T00059
51 hsa
-miR
-1307
-3p 1.01E+00 7.03E
-01 1.02E+00 2.54E
-01 1.00E+00 8.39E
-01 5.01E
-01
MIMA
T00227
27 hsa
-miR
-1307
-5p 1.05E+00 4.15E
-01 1.01E+00 8.87E
-01 9.78E
-01 6.94E
-01 2.88E
-01
MIMA
T00004
25 hsa
-miR
-130a
-3p 9.94E
-01 9.46E
-01 9.02E
-01 9.38E
-02 9.01E
-01 2.08E
-01 9.52E
-01
MIMA
T00004
26 hsa
-miR
-132
-3p 9.92E
-01 9.09E
-01 1.08E+00 6.53E
-02 8.33E
-01 1.12E
-02 9.75E
-01
MIMA
T00057
95 hsa
-miR
-1323 9.63E
-01 7.73E
-01 9.61E
-01 5.77E
-01 9.22E
-01 5.39E
-01 5.80E
-01
MIMA
T00004
27 hsa
-miR
-133a
-3p 8.65E
-01 1.57E
-02 9.97E
-01 9.30E
-01 1.03E+00 4.96E
-01 2.48E
-01
MIMA
T00264
78 hsa
-miR
-133a
-5p 1.11E+00 3.43E
-01 1.07E+00 4.16E
-01 9.27E
-01 4.03E
-01 5.90E
-01
MIMA
T00264
81 hsa
-miR
-134
-3p 9.14E
-01 3.02E
-02 1.04E+00 1.43E
-01 9.58E
-01 2.21E
-01 4.72E
-01
MIMA
T00004
48 hsa
-miR
-136
-5p 1.02E+00 7.44E
-01 9.34E
-01 7.14E
-02 9.99E
-01 9.81E
-01 4.29E
-01
MIMA
T00004
29 hsa
-miR
-137 9.80E
-01 8.63E
-01 1.00E+00 9.93E
-01 1.12E+00 1.98E
-01 9.80E
-01

209
MIMA
T00004
30 hsa
-miR
-138
-5p 9.36E
-01 3.96E
-01 1.10E+00 2.14E
-02 9.87E
-01 8.56E
-01 2.43E
-01
MIMA
T00045
52 hsa
-miR
-139
-3p 1.17E+00 1.27E
-01 1.01E+00 9.08E
-01 1.06E+00 6.26E
-01 4.43E
-01
MIMA
T00045
97 hsa
-miR
-140
-3p 1.02E+00 7.82E
-01 1.04E+00 1.43E
-01 9.26E
-01 1.12E
-01 3.80E
-01
MIMA
T00004
31 hsa
-miR
-140
-5p 1.03E+00 2.35E
-01 9.62E
-01 1.43E
-02 1.02E+00 2.04E
-01 8.22E
-01
MIMA
T00004
32 hsa
-miR
-141
-3p 9.45E
-01 5.77E
-01 1.02E+00 7.26E
-01 9.98E
-01 9.86E
-01 2.78E
-01
MIMA
T00004
34 hsa
-miR
-142
-3p 1.03E+00 7.45E
-01 9.22E
-01 1.37E
-01 8.76E
-01 1.05E
-01 5.19E
-01
MIMA
T00004
35 hsa
-miR
-143
-3p 1.02E+00 5.26E
-01 9.90E
-01 6.09E
-01 9.58E
-01 2.02E
-01 1.34E
-01
MIMA
T00004
49 hsa
-miR
-146a
-5p 1.03E+00 5.65E
-01 9.59E
-01 2.17E
-01 9.80E
-01 5.86E
-01 8.90E
-01
MIMA
T00028
09 hsa
-miR
-146b
-5p 9.75E
-01 2.85E
-01 1.01E+00 3.32E
-01 9.87E
-01 4.32E
-01 8.04E
-01
MIMA
T00002
51 hsa
-miR
-147a 7.88E
-01 2.29E
-01 1.15E+00 1.60E
-01 1.06E+00 7.80E
-01 3.45E
-01
MIMA
T00049
28 hsa
-miR
-147b 1.01E+00 8.68E
-01 9.71E
-01 2.46E
-01 9.69E
-01 4.22E
-01 4.17E
-01
MIMA
T00002
43 hsa
-miR
-148a
-3p 9.09E
-01 3.02E
-01 9.35E
-01 2.55E
-01 9.57E
-01 6.58E
-01 4.02E
-01
MIMA
T00007
59 hsa
-miR
-148b
-3p 9.97E
-01 9.66E
-01 9.78E
-01 5.69E
-01 1.03E+00 6.00E
-01 2.67E
-01
MIMA
T00004
50 hsa
-miR
-149
-5p 9.90E
-01 7.70E
-01 9.92E
-01 7.40E
-01 9.69E
-01 3.41E
-01 6.25E
-02
MIMA
T00004
51 hsa
-miR
-150
-5p 1.02E+00 7.87E
-01 9.34E
-01 2.47E
-01 1.01E+00 9.36E
-01 4.84E
-01

210
MIMA
T00007
57 hsa
-miR
-151a
-3p 1.06E+00 6.91E
-01 1.03E+00 7.67E
-01 1.05E+00 6.48E
-01 5.57E
-01
MIMA
T00073
99 hsa
-miR
-1537
-3p 9.82E
-01 7.29E
-01 9.50E
-01 1.23E
-01 9.57E
-01 3.70E
-01 5.59E
-01
MIMA
T00006
46 hsa
-miR
-155
-5p 9.68E
-01 7.08E
-01 1.00E+00 9.18E
-01 9.65E
-01 6.07E
-01 7.58E
-01
MIMA
T00004
17 hsa
-miR
-15b
-5p 9.71E
-01 7.31E
-01 9.47E
-01 3.70E
-01 7.56E
-01 2.57E
-02 6.00E
-01
MIMA
T00000
69 hsa
-miR
-16
-5p 1.02E+00 8.03E
-01 9.62E
-01 3.83E
-01 1.02E+00 6.80E
-01 5.38E
-01
MIMA
T00045
58 hsa
-miR
-181a
-
2
-3p 9.79E
-01 6.28E
-01 9.79E
-01 4.69E
-01 9.49E
-01 1.20E
-01 6.99E
-01
MIMA
T00002
70 hsa
-miR
-181a
-3p 1.01E+00 9.23E
-01 1.00E+00 9.98E
-01 9.81E
-01 8.65E
-01 7.58E
-01
MIMA
T00002
56 hsa
-miR
-181a
-5p 8.12E
-01 1.99E
-01 1.11E+00 2.96E
-01 9.30E
-01 5.56E
-01 7.36E
-01
MIMA
T00318
93 hsa
-miR
-181b
-
2
-3p 1.03E+00 6.13E
-01 9.92E
-01 8.36E
-01 8.58E
-01 2.32E
-02 7.92E
-01
MIMA
T00002
57
hsa
-miR
-181b
-5p+hsa
-
miR
-181d
-5p 9.87E
-01 8.53E
-01 9.83E
-01 6.95E
-01 9.74E
-01 7.34E
-01 2.55E
-01
MIMA
T00002
58 hsa
-miR
-181c
-5p 9.94E
-01 7.06E
-01 9.94E
-01 6.71E
-01 9.89E
-01 4.92E
-01 3.96E
-02
MIMA
T00266
08 hsa
-miR
-181d
-3p 1.11E+00 4.88E
-01 1.01E+00 9.35E
-01 8.91E
-01 3.63E
-01 7.33E
-01
MIMA
T00002
60 hsa
-miR
-182
-3p 1.10E+00 3.21E
-01 9.93E
-01 9.08E
-01 9.02E
-01 2.73E
-01 1.87E
-01
MIMA
T00067
67 hsa
-miR
-1827 1.04E+00 2.37E
-01 9.86E
-01 4.62E
-01 9.91E
-01 7.67E
-01 2.18E
-01
MIMA
T00002
61 hsa
-miR
-183
-5p 9.78E
-01 2.53E
-01 9.67E
-01 2.03E
-02 9.94E
-01 6.91E
-01 9.97E
-01

211
MIMA
T00004
54 hsa
-miR
-184 1.03E+00 4.37E
-01 9.93E
-01 7.95E
-01 1.03E+00 4.16E
-01 8.23E
-01
MIMA
T00004
55 hsa
-miR
-185
-5p 1.10E+00 2.49E
-01 9.73E
-01 6.21E
-01 8.35E
-01 6.10E
-02 4.67E
-01
MIMA
T00004
56 hsa
-miR
-186
-5p 1.11E+00 2.35E
-01 9.77E
-01 6.75E
-01 9.33E
-01 4.99E
-01 3.95E
-01
MIMA
T00002
62 hsa
-miR
-187
-3p 8.38E
-01 3.66E
-01 9.40E
-01 5.77E
-01 8.29E
-01 1.74E
-01 4.52E
-01
MIMA
T00046
13 hsa
-miR
-188
-3p 8.81E
-01 2.89E
-01 8.83E
-01 8.57E
-02 9.85E
-01 8.67E
-01 1.11E
-02
MIMA
T00004
57 hsa
-miR
-188
-5p 1.14E+00 1.82E
-01 1.09E+00 1.34E
-01 9.33E
-01 4.66E
-01 7.73E
-02
MIMA
T00000
72 hsa
-miR
-18a
-5p 8.60E
-01 8.80E
-02 9.75E
-01 6.26E
-01 1.10E+00 2.75E
-01 3.74E
-01
MIMA
T00014
12 hsa
-miR
-18b
-5p 9.28E
-01 2.58E
-01 1.08E+00 5.18E
-02 9.93E
-01 9.15E
-01 2.37E
-01
MIMA
T00269
16 hsa
-miR
-1908
-3p 1.06E+00 5.32E
-01 1.13E+00 5.90E
-02 1.05E+00 5.71E
-01 8.35E
-01
MIMA
T00264
82 hsa
-miR
-190a
-3p 1.00E+00 9.67E
-01 1.00E+00 9.64E
-01 9.55E
-01 1.09E
-01 9.79E
-01
MIMA
T00004
58 hsa
-miR
-190a
-5p 1.04E+00 6.73E
-01 1.01E+00 8.24E
-01 1.11E+00 1.29E
-01 8.23E
-01
MIMA
T00004
40 hsa
-miR
-191
-5p 9.38E
-01 6.95E
-01 8.59E
-01 1.47E
-01 9.25E
-01 5.33E
-01 5.25E
-01
MIMA
T00078
84 hsa
-miR
-1910
-5p 9.59E
-01 3.34E
-01 1.04E+00 1.35E
-01 1.04E+00 3.02E
-01 8.43E
-02
MIMA
T00002
22 hsa
-miR
-192
-5p 1.03E+00 7.83E
-01 9.84E
-01 8.07E
-01 9.14E
-01 3.80E
-01 4.08E
-02
MIMA
T00004
59 hsa
-miR
-193a
-3p 1.18E+00 3.24E
-01 1.07E+00 4.82E
-01 9.23E
-01 8.30E
-01 2.21E
-01

212
MIMA
T00028
19 hsa
-miR
-193b
-3p 9.84E
-01 5.03E
-01 9.96E
-01 8.00E
-01 1.01E+00 6.35E
-01 1.01E
-02
MIMA
T00002
26 hsa
-miR
-196a
-5p 9.77E
-01 4.36E
-01 9.88E
-01 5.01E
-01 1.01E+00 8.06E
-01 2.27E
-02
MIMA
T00002
27 hsa
-miR
-197
-3p 1.00E+00 9.56E
-01 9.83E
-01 4.45E
-01 9.89E
-01 6.83E
-01 1.12E
-01
MIMA
T00226
91 hsa
-miR
-197
-5p 1.01E+00 9.22E
-01 1.02E+00 6.00E
-01 9.78E
-01 5.59E
-01 9.49E
-01
MIMA
T00094
47 hsa
-miR
-1972 9.72E
-01 8.55E
-01 9.02E
-01 3.27E
-01 9.46E
-01 6.32E
-01 7.01E
-01
MIMA
T00094
48 hsa
-miR
-1973 1.01E+00 6.99E
-01 1.01E+00 5.28E
-01 1.01E+00 7.85E
-01 1.03E
-02
MIMA
T00094
51 hsa
-miR
-1976 1.03E+00 3.82E
-01 9.93E
-01 7.34E
-01 1.05E+00 8.31E
-02 5.31E
-01
MIMA
T00002
28 hsa
-miR
-198 1.05E+00 4.27E
-01 1.02E+00 6.12E
-01 9.85E
-01 7.81E
-01 6.82E
-02
MIMA
T00002
32
hsa
-miR
-199a
-3p+hsa
-
miR
-199b
-3p 1.01E+00 8.73E
-01 1.02E+00 4.11E
-01 9.74E
-01 4.45E
-01 3.73E
-01
MIMA
T00002
31 hsa
-miR
-199a
-5p 1.08E+00 3.30E
-01 9.92E
-01 8.60E
-01 9.62E
-01 6.64E
-01 4.63E
-01
MIMA
T00002
63 hsa
-miR
-199b
-5p 1.02E+00 8.84E
-01 1.05E+00 4.47E
-01 9.99E
-01 9.92E
-01 9.37E
-02
MIMA
T00000
74 hsa
-miR
-19b
-3p 9.87E
-01 8.54E
-01 9.78E
-01 6.85E
-01 1.06E+00 3.71E
-01 8.32E
-01
MIMA
T00006
82 hsa
-miR
-200a
-3p 9.17E
-01 2.40E
-01 1.07E+00 1.35E
-01 1.03E+00 5.35E
-01 3.20E
-01
MIMA
T00003
18 hsa
-miR
-200b
-3p 9.51E
-01 5.53E
-01 9.58E
-01 3.77E
-01 1.02E+00 8.42E
-01 5.05E
-02
MIMA
T00006
17 hsa
-miR
-200c
-3p 1.07E+00 4.27E
-01 1.09E+00 1.18E
-01 9.48E
-01 5.64E
-01 2.74E
-01

213
MIMA
T00002
64 hsa
-miR
-203a
-3p 7.57E
-01 2.01E
-01 1.07E+00 4.66E
-01 1.02E+00 9.29E
-01 8.33E
-01
MIMA
T00318
90 hsa
-miR
-203a
-5p 9.59E
-01 7.62E
-02 9.88E
-01 4.53E
-01 9.72E
-01 1.31E
-01 6.51E
-01
MIMA
T00002
66 hsa
-miR
-205
-5p 1.00E+00 8.91E
-01 9.81E
-01 2.17E
-01 1.00E+00 9.85E
-01 6.35E
-01
MIMA
T00099
78 hsa
-miR
-2053 1.08E+00 2.46E
-01 9.48E
-01 2.16E
-01 1.02E+00 6.85E
-01 2.15E
-01
MIMA
T00002
41 hsa
-miR
-208a
-3p 9.80E
-01 9.07E
-01 1.17E+00 1.57E
-01 3.35E
-01 3.40E
-02 1.94E
-01
MIMA
T00049
60 hsa
-miR
-208b
-3p 9.12E
-01 2.69E
-01 9.16E
-01 9.05E
-02 8.63E
-01 3.91E
-02 4.06E
-01
MIMA
T00000
76 hsa
-miR
-21
-5p 1.01E+00 8.81E
-01 1.05E+00 2.52E
-01 1.04E+00 6.07E
-01 7.36E
-01
MIMA
T00002
67 hsa
-miR
-210
-3p 9.94E
-01 8.94E
-01 1.03E+00 1.99E
-01 9.67E
-01 4.36E
-01
1.00E+00
MIMA
T00264
75 hsa
-miR
-210
-5p 1.01E+00 8.07E
-01 9.77E
-01 5.65E
-01 1.01E+00 8.59E
-01 3.88E
-01
MIMA
T00002
68 hsa
-miR
-211
-5p 9.98E
-01 9.67E
-01 1.00E+00 9.16E
-01 1.02E+00 4.73E
-01 9.21E
-01
MIMA
T00101
33 hsa
-miR
-2110 9.87E
-01 6.57E
-01 1.02E+00 3.47E
-01 9.77E
-01 4.44E
-01 6.29E
-01
MIMA
T00092
06 hsa
-miR
-2113 1.03E+00 4.40E
-01 1.02E+00 5.26E
-01 1.00E+00 9.40E
-01 3.59E
-01
MIMA
T00002
69 hsa
-miR
-212
-3p 9.25E
-01 5.79E
-01 9.59E
-01 4.68E
-01 7.84E
-01 3.84E
-01 2.24E
-01
MIMA
T00002
72 hsa
-miR
-215
-5p 1.17E+00 3.55E
-01 9.06E
-01 4.27E
-01 8.14E
-01 2.97E
-01 4.00E
-01
MIMA
T00002
73 hsa
-miR
-216a
-5p 9.38E
-01 4.71E
-01 1.02E+00 6.66E
-01 1.02E+00 8.22E
-01 5.85E
-01

214
MIMA
T00049
59 hsa
-miR
-216b
-5p 9.96E
-01 8.89E
-01 9.98E
-01 9.15E
-01 1.00E+00 9.20E
-01 9.86E
-01
MIMA
T00002
74 hsa
-miR
-217 1.25E+00 1.72E
-02 9.49E
-01 3.01E
-01 1.18E+00 5.32E
-01 4.44E
-01
MIMA
T00002
75 hsa
-miR
-218
-5p 1.01E+00 8.83E
-01 1.08E+00 6.50E
-02 1.02E+00 7.94E
-01 4.49E
-01
MIMA
T00002
76 hsa
-miR
-219a
-5p 9.33E
-01 4.56E
-01 1.01E+00 8.69E
-01 1.02E+00 7.94E
-01 4.62E
-01
MIMA
T00197
48 hsa
-miR
-219b
-3p 1.05E+00 1.33E
-01 1.02E+00 2.50E
-01 1.06E+00 1.22E
-01 3.19E
-01
MIMA
T00002
78 hsa
-miR
-221
-3p 9.76E
-01 6.01E
-01 9.25E
-01 2.94E
-02 9.68E
-01 5.30E
-01 2.37E
-01
MIMA
T00002
79 hsa
-miR
-222
-3p 9.21E
-01 4.48E
-01 9.59E
-01 5.97E
-01 1.06E+00 6.15E
-01 4.24E
-01
MIMA
T00002
80 hsa
-miR
-223
-3p 1.11E+00 8.10E
-02 1.02E+00 5.32E
-01 9.03E
-01 5.59E
-02 7.62E
-01
MIMA
T00002
81 hsa
-miR
-224
-5p 9.96E
-01 8.38E
-01 9.81E
-01 1.43E
-01 9.73E
-01 1.07E
-01 5.38E
-01
MIMA
T00000
78 hsa
-miR
-23a
-3p 9.72E
-01 1.67E
-01 9.76E
-01 6.28E
-02 9.86E
-01 4.69E
-01 4.66E
-01
MIMA
T00004
18 hsa
-miR
-23b
-3p 9.90E
-01 6.16E
-01 9.99E
-01 9.50E
-01 1.00E+00 8.32E
-01 5.95E
-01
MIMA
T00180
00 hsa
-miR
-23c 1.01E+00 9.48E
-01 8.48E
-01 8.81E
-02 1.23E+00 8.42E
-02 8.78E
-01
MIMA
T00000
81 hsa
-miR
-25
-3p 1.01E+00 7.06E
-01 1.01E+00 6.08E
-01 9.86E
-01 5.79E
-01 8.64E
-01
MIMA
T00044
98 hsa
-miR
-25
-5p 9.71E
-01 8.58E
-01 1.07E+00 5.81E
-01 7.31E
-01 3.07E
-01 8.76E
-01
MIMA
T00000
82 hsa
-miR
-26a
-5p 9.57E
-01 5.89E
-02 9.80E
-01 1.85E
-01 9.76E
-01 2.40E
-01 8.86E
-02

215
MIMA
T00000
83 hsa
-miR
-26b
-5p 1.06E+00 5.79E
-01 9.01E
-01 2.23E
-01 8.44E
-01 1.84E
-01 2.17E
-01
MIMA
T00000
84 hsa
-miR
-27a
-3p 9.27E
-01 4.22E
-01 1.01E+00 8.79E
-01 1.08E+00 3.74E
-01 9.38E
-01
MIMA
T00045
02 hsa
-miR
-28
-3p 9.44E
-01 5.44E
-02 1.01E+00 5.76E
-01 1.01E+00 6.27E
-01 9.48E
-01
MIMA
T00000
85 hsa
-miR
-28
-5p 8.64E
-01 4.54E
-01 9.88E
-01 9.27E
-01 1.24E+00 5.10E
-02 8.53E
-01
MIMA
T00046
79 hsa
-miR
-296
-3p 1.10E+00 3.22E
-01 9.83E
-01 8.05E
-01 1.02E+00 7.81E
-01 6.49E
-01
MIMA
T00049
01 hsa
-miR
-298 1.13E+00 5.02E
-01 1.13E+00 2.83E
-01 6.72E
-01 7.74E
-02 5.73E
-01
MIMA
T00006
87 hsa
-miR
-299
-3p 9.71E
-01 7.79E
-01 1.07E+00 2.94E
-01 9.05E
-01 2.97E
-01 8.60E
-01
MIMA
T00028
90 hsa
-miR
-299
-5p 1.08E+00 6.37E
-01 8.94E
-01 3.46E
-01 7.17E
-01 1.22E
-01 6.67E
-01
MIMA
T00000
86 hsa
-miR
-29a
-3p 9.76E
-01 3.20E
-01 9.77E
-01 2.16E
-01 1.02E+00 4.17E
-01 1.84E
-01
MIMA
T00001
00 hsa
-miR
-29b
-3p 8.12E
-01 8.84E
-02 1.04E+00 6.13E
-01 9.12E
-01 3.91E
-01 6.23E
-01
MIMA
T00006
81 hsa
-miR
-29c
-3p 1.03E+00 6.60E
-01 9.81E
-01 6.51E
-01 8.38E
-01 5.37E
-02 2.92E
-01
MIMA
T00049
03 hsa
-miR
-300 9.31E
-01 4.61E
-01 1.11E+00 5.37E
-02 1.01E+00 9.21E
-01 4.56E
-01
MIMA
T00006
88 hsa
-miR
-301a
-3p 1.17E+00 2.34E
-01 9.87E
-01 8.65E
-01 1.45E+00 1.25E
-02 4.30E
-01
MIMA
T00226
96 hsa
-miR
-301a
-5p 9.63E
-01 7.82E
-01 1.16E+00 1.14E
-01 9.49E
-01 6.69E
-01 5.01E
-01
MIMA
T00049
58 hsa
-miR
-301b
-3p 1.02E+00 8.76E
-01 8.36E
-01 8.58E
-02 9.48E
-01 6.17E
-01 2.75E
-01

216
MIMA
T00320
26 hsa
-miR
-301b
-5p 9.41E
-01 7.00E
-01 9.36E
-01 5.37E
-01 7.61E
-01 2.45E
-01 7.73E
-01
MIMA
T00006
84 hsa
-miR
-302a
-3p 9.12E
-01 4.05E
-01 9.37E
-01 3.07E
-01 1.18E+00 7.23E
-02 5.14E
-01
MIMA
T00006
83 hsa
-miR
-302a
-5p 1.15E+00 9.94E
-02 9.89E
-01 8.56E
-01 9.47E
-01 4.65E
-01 9.72E
-01
MIMA
T00007
15 hsa
-miR
-302b
-3p 9.69E
-01 5.98E
-01 1.05E+00 1.05E
-01 9.82E
-01 7.59E
-01 5.74E
-01
MIMA
T00007
17 hsa
-miR
-302c
-3p 1.08E+00 6.29E
-01 7.78E
-01 4.97E
-02 1.05E+00 6.69E
-01 8.76E
-01
MIMA
T00007
18 hsa
-miR
-302d
-3p 8.73E
-01 4.30E
-01 1.00E+00 9.95E
-01 4.26E
-01 7.22E
-03 4.64E
-01
MIMA
T00059
31 hsa
-miR
-302e 1.01E+00 8.59E
-01 1.01E+00 6.19E
-01 1.02E+00 5.03E
-01 8.10E
-01
MIMA
T00059
32 hsa
-miR
-302f 1.14E+00 1.97E
-01 9.99E
-01 9.81E
-01 1.32E+00 3.63E
-02 8.86E
-01
MIMA
T00153
78 hsa
-miR
-3065
-3p 1.06E+00 5.43E
-01 9.29E
-01 2.29E
-01 1.01E+00 9.00E
-01 6.53E
-01
MIMA
T00150
27 hsa
-miR
-3074
-3p 8.72E
-01 2.48E
-01 1.01E+00 8.70E
-01 1.26E+00 3.38E
-02 7.74E
-01
MIMA
T00000
88 hsa
-miR
-30a
-3p 9.94E
-01 7.71E
-01 9.79E
-01 1.78E
-01 1.00E+00 8.82E
-01 9.23E
-02
MIMA
T00004
20 hsa
-miR
-30b
-5p 1.22E+00 2.55E
-01 9.68E
-01 7.29E
-01 1.02E+00 9.22E
-01 4.31E
-01
MIMA
T00002
44 hsa
-miR
-30c
-5p 9.83E
-01 6.79E
-01 9.81E
-01 4.74E
-01 9.41E
-01 1.22E
-01 7.95E
-01
MIMA
T00002
45 hsa
-miR
-30d
-5p 1.03E+00 5.04E
-01 9.94E
-01 8.01E
-01 1.05E+00 1.60E
-01 7.93E
-01
MIMA
T00006
93 hsa
-miR
-30e
-3p 8.77E
-01 3.38E
-01 9.36E
-01 4.64E
-01 9.00E
-01 3.42E
-01 3.64E
-01

217
MIMA
T00006
92 hsa
-miR
-30e
-5p 1.04E+00 3.22E
-01 1.00E+00 9.56E
-01 9.95E
-01 8.75E
-01 2.90E
-01
MIMA
T00149
96 hsa
-miR
-3131 9.99E
-01 9.29E
-01 1.01E+00 5.08E
-01 9.80E
-01 2.19E
-01 3.89E
-01
MIMA
T00150
15 hsa
-miR
-3144
-3p 9.44E
-01 7.31E
-01 9.67E
-01 7.22E
-01 1.15E+00 2.02E
-01 3.89E
-01
MIMA
T00150
14 hsa
-miR
-3144
-5p 9.77E
-01 3.44E
-01 1.00E+00 8.60E
-01 1.02E+00 3.99E
-01 3.08E
-01
MIMA
T00150
19 hsa
-miR
-3147 1.10E+00 5.42E
-01 9.34E
-01 4.65E
-01 8.23E
-01 4.25E
-01 7.29E
-01
MIMA
T00150
24 hsa
-miR
-3151
-5p 9.22E
-01 1.46E
-01 1.05E+00 1.95E
-01 9.72E
-01 5.38E
-01 4.07E
-01
MIMA
T00150
35 hsa
-miR
-3161 1.08E+00 5.78E
-01 1.07E+00 4.39E
-01 9.61E
-01 8.13E
-01 1.09E
-01
MIMA
T00150
43 hsa
-miR
-3168 1.02E+00 7.42E
-01 1.07E+00 4.21E
-02 1.00E+00 9.40E
-01 9.23E
-01
MIMA
T00181
78 hsa
-miR
-3180 9.70E
-01 6.35E
-01 9.17E
-01 2.99E
-02 9.52E
-01 3.57E
-01 3.21E
-01
MIMA
T00150
57 hsa
-miR
-3180
-5p 1.06E+00 6.25E
-01 9.57E
-01 5.65E
-01 1.12E+00 2.13E
-01 4.06E
-01
MIMA
T00150
89 hsa
-miR
-3202 1.13E+00 2.07E
-01 1.05E+00 4.13E
-01 8.95E
-01 3.37E
-01 7.62E
-01
MIMA
T00005
10 hsa
-miR
-320a 9.86E
-01 8.01E
-01 9.49E
-01 1.87E
-01 1.02E+00 6.63E
-01 9.50E
-01
MIMA
T00057
93 hsa
-miR
-320c 9.73E
-01 8.48E
-01 1.02E+00 8.21E
-01 8.57E
-01 3.70E
-01 2.85E
-01
MIMA
T00150
72 hsa
-miR
-320e 1.02E+00 4.72E
-01 9.79E
-01 2.92E
-01 1.02E+00 5.03E
-01 4.47E
-02
MIMA
T00007
55 hsa
-miR
-323a
-3p 1.02E+00 8.60E
-01 9.85E
-01 8.42E
-01 9.78E
-01 8.24E
-01 3.48E
-01

218
MIMA
T00150
50 hsa
-miR
-323b
-3p 9.55E
-01 7.47E
-01 1.00E+00 9.77E
-01 5.11E
-01 2.89E
-02 5.00E
-01
MIMA
T00007
62 hsa
-miR
-324
-3p 1.00E+00 9.94E
-01 9.07E
-01 2.93E
-01 6.10E
-01 1.14E
-02 8.57E
-01
MIMA
T00007
71 hsa
-miR
-325 9.76E
-01 5.41E
-01 1.04E+00 3.77E
-02 9.79E
-01 4.55E
-01 9.40E
-01
MIMA
T00264
86 hsa
-miR
-328
-5p 9.93E
-01 9.26E
-01 9.71E
-01 5.38E
-01 9.00E
-01 1.71E
-01 4.55E
-01
MIMA
T00016
29 hsa
-miR
-329
-3p 9.82E
-01 5.28E
-01 1.02E+00 1.43E
-01 1.01E+00 8.12E
-01 3.75E
-01
MIMA
T00265
55 hsa
-miR
-329
-5p 9.91E
-01 9.46E
-01 8.44E
-01 1.34E
-01 1.04E+00 7.64E
-01 1.60E
-01
MIMA
T00046
93 hsa
-miR
-330
-5p 9.24E
-01 1.52E
-01 9.72E
-01 4.54E
-01 1.03E+00 5.59E
-01 3.06E
-01
MIMA
T00007
65 hsa
-miR
-335
-5p 1.19E+00 1.16E
-01 9.09E
-01 1.75E
-01 8.25E
-01 1.71E
-01 4.86E
-01
MIMA
T00007
54 hsa
-miR
-337
-3p 9.42E
-01 7.02E
-01 9.71E
-01 7.29E
-01 9.62E
-01 8.30E
-01 1.21E
-01
MIMA
T00046
95 hsa
-miR
-337
-5p 1.01E+00 8.28E
-01 9.61E
-01 1.21E
-01 9.84E
-01 5.51E
-01 2.03E
-01
MIMA
T00047
01 hsa
-miR
-338
-5p 9.91E
-01 6.59E
-01 9.90E
-01 4.36E
-01 1.02E+00 3.13E
-01 5.73E
-01
MIMA
T00000
91 hsa
-miR
-33a
-5p 9.94E
-01 9.62E
-01 9.44E
-01 5.35E
-01 9.44E
-01 5.75E
-01 2.12E
-02
MIMA
T00033
01 hsa
-miR
-33b
-5p 9.26E
-01 2.81E
-01 1.07E+00 9.63E
-02 9.51E
-01 4.04E
-01 7.01E
-01
MIMA
T00046
92 hsa
-miR
-340
-5p 9.79E
-01 6.22E
-01 9.89E
-01 7.05E
-01 1.01E+00 6.67E
-01 5.59E
-01
MIMA
T00007
53 hsa
-miR
-342
-3p 1.08E+00 5.57E
-01 9.07E
-01 3.31E
-01 8.44E
-01 2.63E
-01 4.76E
-01

219
MIMA
T00046
94 hsa
-miR
-342
-5p 9.95E
-01 8.45E
-01 1.01E+00 6.08E
-01 9.72E
-01 2.23E
-01 6.74E
-01
MIMA
T00226
98 hsa
-miR
-345
-3p 9.47E
-01 7.09E
-01 8.94E
-01 3.40E
-01 6.97E
-01 4.29E
-02 7.03E
-01
MIMA
T00007
73 hsa
-miR
-346 1.38E+00 3.41E
-02 8.15E
-01 1.07E
-01 6.78E
-01 4.46E
-02 6.56E
-01
MIMA
T00002
55 hsa
-miR
-34a
-5p 1.03E+00 4.53E
-01 1.01E+00 6.35E
-01 1.05E+00 2.23E
-01 3.64E
-01
MIMA
T00046
76 hsa
-miR
-34b
-3p 9.81E
-01 4.16E
-01 1.02E+00 1.02E
-01 9.84E
-01 4.82E
-01 4.92E
-01
MIMA
T00046
77 hsa
-miR
-34c
-3p 1.27E+00 1.01E
-01 1.21E+00 9.37E
-02 8.78E
-01 5.72E
-01 8.89E
-01
MIMA
T00006
86 hsa
-miR
-34c
-5p 9.25E
-01 2.97E
-01 1.17E+00 9.41E
-04 1.00E+00 9.86E
-01 2.05E
-02
MIMA
T00179
81 hsa
-miR
-3605
-5p 1.00E+00 9.54E
-01 9.40E
-01 2.76E
-01 9.90E
-01 9.04E
-01 3.72E
-01
MIMA
T00007
03 hsa
-miR
-361
-5p 9.28E
-01 1.27E
-01 9.88E
-01 6.68E
-01 9.75E
-01 5.46E
-01 5.55E
-01
MIMA
T00179
91 hsa
-miR
-3613
-3p 1.12E+00 3.85E
-01 8.06E
-01 4.83E
-02 8.44E
-01 3.18E
-01 7.45E
-02
MIMA
T00179
92 hsa
-miR
-3614
-5p 9.98E
-01 9.84E
-01 9.55E
-01 3.70E
-01 9.04E
-01 2.49E
-01 1.60E
-01
MIMA
T00179
94 hsa
-miR
-3615 9.51E
-01 4.66E
-01 1.06E+00 2.27E
-01 1.03E+00 6.60E
-01 7.42E
-01
MIMA
T00007
05 hsa
-miR
-362
-5p 9.99E
-01 9.72E
-01 9.94E
-01 8.14E
-01 9.82E
-01 5.25E
-01 6.19E
-01
MIMA
T00007
07 hsa
-miR
-363
-3p 9.99E
-01 9.72E
-01 1.00E+00 9.75E
-01 1.00E+00 8.89E
-01 5.79E
-01
MIMA
T00033
85 hsa
-miR
-363
-5p 9.62E
-01 4.60E
-01 1.02E+00 5.53E
-01 9.97E
-01 9.55E
-01 4.71E
-01

220
MIMA
T00007
10
hsa
-miR
-365a
-3p+hsa
-
miR
-365b
-3p 9.51E
-01 7.49E
-01 9.07E
-01 2.54E
-01 9.77E
-01 8.36E
-01 9.63E
-01
MIMA
T00228
33 hsa
-miR
-365b
-5p 1.04E+00 4.22E
-01 9.90E
-01 7.26E
-01 9.68E
-01 5.19E
-01 9.91E
-01
MIMA
T00007
19 hsa
-miR
-367
-3p 1.01E+00 7.34E
-01 9.84E
-01 5.94E
-01 9.53E
-01 1.76E
-01 3.69E
-01
MIMA
T00007
21 hsa
-miR
-369
-3p 6.55E
-01 4.33E
-02 1.09E+00 3.01E
-01 1.22E+00 1.28E
-01 2.13E
-01
MIMA
T00016
21 hsa
-miR
-369
-5p 1.01E+00 8.41E
-01 1.05E+00 1.41E
-01 9.65E
-01 5.03E
-01 7.05E
-01
MIMA
T00181
19 hsa
-miR
-3690 9.75E
-01 5.30E
-01 1.01E+00 8.04E
-01 9.85E
-01 6.66E
-01 2.38E
-01
MIMA
T00007
22 hsa
-miR
-370
-3p 1.00E+00 9.71E
-01 9.88E
-01 3.31E
-01 9.92E
-01 6.16E
-01 9.42E
-01
MIMA
T00046
87 hsa
-miR
-371a
-5p 1.00E+00 9.69E
-01 1.08E+00 1.99E
-01 7.72E
-01 5.34E
-02 2.94E
-01
MIMA
T00198
92 hsa
-miR
-371b
-5p 1.55E+00 7.61E
-04 1.02E+00 8.53E
-01 3.60E
-01 2.78E
-02 9.30E
-01
MIMA
T00046
88 hsa
-miR
-374a
-3p 9.87E
-01 5.47E
-01 9.65E
-01 1.98E
-02 1.02E+00 4.17E
-01 5.31E
-01
MIMA
T00007
27 hsa
-miR
-374a
-5p 9.88E
-01 6.72E
-01 1.00E+00 9.80E
-01 1.03E+00 2.35E
-01 7.88E
-01
MIMA
T00229
28 hsa
-miR
-376a
-
2
-5p 9.87E
-01 9.19E
-01 1.11E+00 1.17E
-01 1.18E+00 4.56E
-01 8.46E
-01
MIMA
T00007
29 hsa
-miR
-376a
-3p 1.01E+00 8.23E
-01 9.86E
-01 4.63E
-01 1.01E+00 6.59E
-01 2.11E
-01
MIMA
T00007
20 hsa
-miR
-376c
-3p 9.61E
-01 6.23E
-01 1.06E+00 2.46E
-01 8.64E
-01 1.01E
-01 6.54E
-01
MIMA
T00228
61 hsa
-miR
-376c
-5p 1.00E+00 9.31E
-01 9.88E
-01 4.44E
-01 9.79E
-01 3.34E
-01 4.66E
-01

221
MIMA
T00007
30 hsa
-miR
-377
-3p 1.00E+00 9.48E
-01 9.61E
-01 4.07E
-02 9.62E
-01 1.97E
-01 1.42E
-01
MIMA
T00189
26 hsa
-miR
-378d 1.01E+00 5.54E
-01 9.74E
-01 3.58E
-02 1.01E+00 5.63E
-01 1.71E
-01
MIMA
T00189
27 hsa
-miR
-378e 9.88E
-01 7.94E
-01 9.81E
-01 4.42E
-01 1.01E+00 8.50E
-01 9.68E
-01
MIMA
T00189
32 hsa
-miR
-378f 1.02E+00 4.91E
-01 1.00E+00 9.14E
-01 9.99E
-01 9.51E
-01 8.96E
-01
MIMA
T00189
37 hsa
-miR
-378g 8.74E
-01 2.23E
-01 9.86E
-01 7.77E
-01 1.10E+00 3.85E
-01 1.68E
-01
MIMA
T00189
84 hsa
-miR
-378h 8.97E
-01 3.26E
-01 9.92E
-01 8.78E
-01 1.01E+00 9.07E
-01 5.95E
-01
MIMA
T00190
74 hsa
-miR
-378i 1.01E+00 9.43E
-01 9.47E
-01 5.38E
-01 9.35E
-01 6.44E
-01 6.22E
-01
MIMA
T00007
33 hsa
-miR
-379
-5p 9.73E
-01 3.09E
-01 9.94E
-01 7.32E
-01 9.68E
-01 1.95E
-01 9.91E
-01
MIMA
T00007
35 hsa
-miR
-380
-3p 7.86E
-01 5.02E
-03 8.75E
-01 2.31E
-02 1.06E+00 3.73E
-01 7.76E
-01
MIMA
T00007
36 hsa
-miR
-381
-3p 1.04E+00 1.77E
-01 1.04E+00 9.29E
-03 9.82E
-01 5.20E
-01 7.69E
-01
MIMA
T00228
62 hsa
-miR
-381
-5p 1.02E+00 6.31E
-01 9.90E
-01 6.15E
-01 9.41E
-01 1.43E
-01 1.34E
-01
MIMA
T00226
97 hsa
-miR
-382
-3p 9.36E
-01 8.74E
-02 1.01E+00 7.37E
-01 9.61E
-01 2.17E
-01 8.29E
-01
MIMA
T00007
37 hsa
-miR
-382
-5p 1.01E+00 8.49E
-01 1.02E+00 3.03E
-01 9.64E
-01 2.31E
-01 8.99E
-01
MIMA
T00182
05 hsa
-miR
-3928
-3p 9.99E
-01 9.81E
-01 9.72E
-01 4.79E
-01 1.02E+00 7.53E
-01 9.36E
-03
MIMA
T00183
49 hsa
-miR
-3934
-5p 1.31E+00 5.74E
-03 8.84E
-01 9.75E
-02 7.45E
-01 2.13E
-01 3.16E
-01

222
MIMA
T00021
71 hsa
-miR
-410
-3p 1.03E+00 1.92E
-01 1.00E+00 9.58E
-01 9.90E
-01 6.58E
-01 7.75E
-01
MIMA
T00021
70 hsa
-miR
-412
-3p 7.86E
-01 9.23E
-02 9.16E
-01 3.44E
-01 8.40E
-01 2.73E
-01 4.51E
-02
MIMA
T00033
39 hsa
-miR
-421 9.43E
-01 6.38E
-01 1.01E+00 8.74E
-01 1.02E+00 8.07E
-01 8.78E
-01
MIMA
T00013
40 hsa
-miR
-423
-3p 9.54E
-01 2.11E
-01 1.03E+00 1.14E
-01 9.61E
-01 1.90E
-01 9.58E
-01
MIMA
T00047
48 hsa
-miR
-423
-5p 1.01E+00 8.59E
-01 9.98E
-01 9.35E
-01 9.75E
-01 4.51E
-01 9.03E
-01
MIMA
T00169
15 hsa
-miR
-4284 6.72E
-01 3.34E
-02 9.87E
-01 9.04E
-01 7.15E
-01 5.61E
-02 6.13E
-01
MIMA
T00169
16 hsa
-miR
-4286 9.34E
-01 4.45E
-02 1.03E+00 7.48E
-02 1.04E+00 1.28E
-01 1.62E
-01
MIMA
T00016
25 hsa
-miR
-431
-5p 1.05E+00 4.14E
-01 1.00E+00 9.91E
-01 8.75E
-01 9.15E
-02 1.58E
-01
MIMA
T00028
14 hsa
-miR
-432
-5p 1.01E+00 7.80E
-01 1.03E+00 6.00E
-02 9.62E
-01 1.15E
-01 4.60E
-01
MIMA
T00016
27 hsa
-miR
-433
-3p 1.00E+00 8.85E
-01 9.84E
-01 3.41E
-01 1.03E+00 8.00E
-02 3.22E
-01
MIMA
T00265
54 hsa
-miR
-433
-5p 9.90E
-01 6.78E
-01 1.00E+00 9.90E
-01 1.02E+00 3.57E
-01 5.67E
-01
MIMA
T00189
34 hsa
-miR
-4421 9.98E
-01 9.82E
-01 9.98E
-01 9.43E
-01 9.69E
-01 5.94E
-01 1.29E
-01
MIMA
T00189
47 hsa
-miR
-4431 1.14E+00 2.81E
-01 1.10E+00 1.15E
-01 7.87E
-01 1.86E
-01 4.68E
-01
MIMA
T00189
61 hsa
-miR
-4443 1.02E+00 8.97E
-01 1.10E+00 2.82E
-01 1.06E+00 6.93E
-01 9.35E
-01
MIMA
T00189
73 hsa
-miR
-4451 9.58E
-01 7.78E
-01 1.09E+00 3.93E
-01 8.26E
-01 2.91E
-01 4.39E
-01

223
MIMA
T00189
76
hsa
-miR
-4454+hsa
-
miR
-7975 1.04E+00 3.84E
-01 9.81E
-01 5.19E
-01 1.02E+00 4.88E
-01 1.07E
-01
MIMA
T00189
77 hsa
-miR
-4455 9.65E
-01 1.57E
-01 9.90E
-01 3.73E
-01 9.82E
-01 4.06E
-01 8.31E
-01
MIMA
T00189
83 hsa
-miR
-4461 8.99E
-01 2.72E
-01 1.09E+00 1.16E
-01 1.14E+00 1.59E
-01 4.91E
-01
MIMA
T00015
32 hsa
-miR
-448 9.85E
-01 7.01E
-01 9.86E
-01 5.68E
-01 9.94E
-01 8.60E
-01 1.12E
-01
MIMA
T00190
19 hsa
-miR
-4485
-3p 9.47E
-01 2.34E
-01 9.99E
-01 9.71E
-01 9.24E
-01 9.25E
-02 1.29E
-01
MIMA
T00190
22 hsa
-miR
-4488 9.95E
-01 8.46E
-01 9.94E
-01 7.11E
-01 9.78E
-01 2.99E
-01 7.33E
-01
MIMA
T00015
41 hsa
-miR
-449a 1.05E+00 2.22E
-01 1.01E+00 6.61E
-01 1.01E+00 7.26E
-01 4.69E
-01
MIMA
T00033
27 hsa
-miR
-449b
-5p 1.05E+00 5.88E
-01 1.01E+00 8.51E
-01 9.68E
-01 6.98E
-01 9.27E
-01
MIMA
T00102
51 hsa
-miR
-449c
-5p 9.41E
-01 7.28E
-01 8.78E
-01 2.11E
-01 1.09E+00 5.08E
-01 2.11E
-01
MIMA
T00227
00 hsa
-miR
-450a
-
1
-3p 1.10E+00 4.52E
-01 1.00E+00 9.97E
-01 1.00E+00 9.89E
-01 5.94E
-01
MIMA
T00310
74 hsa
-miR
-450a
-
2
-3p 9.76E
-01 4.65E
-01 9.98E
-01 9.35E
-01 1.03E+00 2.81E
-01 8.34E
-01
MIMA
T00015
45 hsa
-miR
-450a
-5p 9.53E
-01 7.21E
-02 9.46E
-01 1.03E
-02 1.03E+00 1.64E
-01 2.95E
-01
MIMA
T00049
10 hsa
-miR
-450b
-3p 9.90E
-01 8.91E
-01 9.86E
-01 7.16E
-01 9.96E
-01 9.38E
-01 2.07E
-01
MIMA
T00190
53 hsa
-miR
-4516 1.01E+00 6.40E
-01 9.92E
-01 6.18E
-01 9.76E
-01 2.72E
-01 8.97E
-01
MIMA
T00016
31 hsa
-miR
-451a 1.03E+00 2.87E
-01 9.93E
-01 7.31E
-01 9.82E
-01 5.62E
-01 8.38E
-01

224
MIMA
T00190
70 hsa
-miR
-4531 9.30E
-01 6.29E
-01 1.10E+00 2.40E
-01 9.24E
-01 5.21E
-01 6.41E
-02
MIMA
T00209
59 hsa
-miR
-4536
-3p 1.05E+00 7.06E
-01 1.03E+00 6.98E
-01 9.80E
-01 9.11E
-01 3.50E
-01
MIMA
T00190
78 hsa
-miR
-4536
-5p 9.82E
-01 6.39E
-01 9.94E
-01 7.95E
-01 9.52E
-01 1.68E
-01 8.05E
-01
MIMA
T00038
85 hsa
-miR
-454
-3p 9.36E
-01 6.06E
-01 8.57E
-01 1.84E
-01 7.51E
-01 9.34E
-02 1.96E
-01
MIMA
T00047
84 hsa
-miR
-455
-3p 9.76E
-01 8.26E
-01 9.55E
-01 5.37E
-01 9.28E
-01 4.97E
-01 3.47E
-01
MIMA
T00031
50 hsa
-miR
-455
-5p 9.80E
-01 8.90E
-01 8.68E
-01 2.33E
-01 8.10E
-01 2.07E
-01 1.46E
-01
MIMA
T00197
09 hsa
-miR
-4647 1.01E+00 8.31E
-01 9.78E
-01 3.92E
-01 9.93E
-01 8.28E
-01 9.07E
-01
MIMA
T00198
08 hsa
-miR
-4707
-3p 9.95E
-01 9.71E
-01 1.01E+00 8.83E
-01 NULL NULL 9.25E
-01
MIMA
T00198
07 hsa
-miR
-4707
-5p 1.27E+00 4.05E
-02 9.23E
-01 4.20E
-01 8.14E
-01 1.12E
-01 5.64E
-02
MIMA
T00198
95 hsa
-miR
-4755
-5p 1.04E+00 3.32E
-01 9.62E
-01 1.23E
-01 1.04E+00 2.24E
-01 4.29E
-01
MIMA
T00199
56 hsa
-miR
-4787
-5p 9.37E
-01 6.82E
-01 1.03E+00 7.63E
-01 1.00E+00 9.92E
-01 6.69E
-01
MIMA
T00199
64 hsa
-miR
-4792 9.21E
-01 5.10E
-01 9.99E
-01 9.90E
-01 1.10E+00 4.25E
-01 4.11E
-01
MIMA
T00021
76 hsa
-miR
-485
-3p 1.05E+00 1.72E
-01 9.61E
-01 7.73E
-02 1.02E+00 3.85E
-01 9.91E
-01
MIMA
T00021
78 hsa
-miR
-487a
-3p 1.03E+00 7.18E
-01 1.06E+00 1.43E
-01 9.17E
-01 3.05E
-01 2.10E
-01
MIMA
T00031
80 hsa
-miR
-487b
-3p 9.35E
-01 9.50E
-02 9.90E
-01 6.72E
-01 9.84E
-01 5.86E
-01 9.27E
-01

225
MIMA
T00266
14 hsa
-miR
-487b
-5p 9.55E
-01 6.57E
-01 1.00E+00 9.92E
-01 9.89E
-01 8.95E
-01 5.20E
-01
MIMA
T00047
63 hsa
-miR
-488
-3p 1.05E+00 7.89E
-01 8.98E
-01 4.16E
-01 8.78E
-01 4.24E
-01 8.45E
-01
MIMA
T00028
06 hsa
-miR
-490
-3p 9.81E
-01 8.79E
-01 9.99E
-01 9.90E
-01 1.01E+00 9.29E
-01 7.80E
-01
MIMA
T00028
07 hsa
-miR
-491
-5p 1.01E+00 6.82E
-01 9.89E
-01 5.41E
-01 9.89E
-01 5.46E
-01 4.14E
-01
MIMA
T00031
61 hsa
-miR
-493
-3p 9.42E
-01 1.38E
-01 9.82E
-01 4.85E
-01 1.00E+00 9.94E
-01 9.54E
-01
MIMA
T00028
16 hsa
-miR
-494
-3p 9.74E
-01 2.23E
-01 1.00E+00 7.11E
-01 9.97E
-01 8.45E
-01 7.18E
-01
MIMA
T00028
17 hsa
-miR
-495
-3p 9.63E
-01 6.41E
-01 1.02E+00 7.37E
-01 1.09E+00 1.99E
-01 9.15E
-01
MIMA
T00229
24 hsa
-miR
-495
-5p 9.77E
-01 8.93E
-01 9.83E
-01 8.80E
-01 6.26E
-01 2.42E
-02 5.85E
-01
MIMA
T00028
20 hsa
-miR
-497
-5p 9.69E
-01 2.37E
-01 1.00E+00 7.52E
-01 9.73E
-01 3.27E
-01 1.90E
-01
MIMA
T00028
24 hsa
-miR
-498 9.91E
-01 8.90E
-01 9.09E
-01 4.81E
-02 1.01E+00 8.58E
-01 4.71E
-01
MIMA
T00047
72 hsa
-miR
-499a
-3p 9.74E
-01 7.40E
-01 9.07E
-01 8.93E
-02 8.93E
-01 8.76E
-02 8.03E
-01
MIMA
T00028
70 hsa
-miR
-499a
-5p 9.72E
-01 4.47E
-01 9.51E
-01 5.61E
-02 9.80E
-01 6.45E
-01 6.13E
-01
MIMA
T00198
97 hsa
-miR
-499b
-5p 1.00E+00 9.81E
-01 9.47E
-01 4.03E
-01 1.04E+00 7.03E
-01 1.52E
-01
MIMA
T00210
21 hsa
-miR
-5001
-5p 1.00E+00 9.79E
-01 1.02E+00 4.53E
-01 9.52E
-01 2.21E
-01 7.11E
-01
MIMA
T00210
44 hsa
-miR
-5010
-3p 9.95E
-01 9.38E
-01 9.74E
-01 5.40E
-01 1.08E+00 1.50E
-01 8.71E
-01

226
MIMA
T00047
75 hsa
-miR
-502
-3p 8.13E
-01 1.17E
-01 9.46E
-01 5.55E
-01 9.51E
-01 6.51E
-01 2.63E
-01
MIMA
T00028
73 hsa
-miR
-502
-5p 9.86E
-01 7.70E
-01 9.91E
-01 7.61E
-01 9.60E
-01 3.89E
-01 4.82E
-01
MIMA
T00229
25 hsa
-miR
-503
-3p 1.09E+00 5.54E
-01 9.03E
-01 3.75E
-01 6.86E
-01 1.45E
-01 7.86E
-01
MIMA
T00028
74 hsa
-miR
-503
-5p 9.98E
-01 9.89E
-01 1.03E+00 7.53E
-01 6.25E
-01 7.59E
-02 4.31E
-01
MIMA
T00028
78 hsa
-miR
-506
-3p 9.96E
-01 9.56E
-01 1.03E+00 5.38E
-01 1.02E+00 6.72E
-01 5.37E
-01
MIMA
T00227
01 hsa
-miR
-506
-5p 1.11E+00 5.02E
-01 9.14E
-01 4.23E
-01 8.34E
-01 3.35E
-01 6.28E
-01
MIMA
T00028
79 hsa
-miR
-507 1.00E+00 8.76E
-01 1.01E+00 4.13E
-01 9.79E
-01 3.94E
-01 9.22E
-01
MIMA
T00047
78 hsa
-miR
-508
-5p 8.91E
-01 4.71E
-01 1.10E+00 2.42E
-01 1.02E+00 8.82E
-01 9.25E
-01
MIMA
T00028
81 hsa
-miR
-509
-3p 1.03E+00 6.82E
-01 9.69E
-01 5.02E
-01 8.57E
-01 6.42E
-02 7.69E
-01
MIMA
T00047
79 hsa
-miR
-509
-5p 1.13E+00 4.70E
-01 9.37E
-01 4.76E
-01 4.04E
-01 2.12E
-01 4.06E
-01
MIMA
T00266
13 hsa
-miR
-510
-3p 1.17E+00 1.41E
-01 8.94E
-01 1.54E
-01 9.27E
-01 4.53E
-01 2.04E
-01
MIMA
T00028
08 hsa
-miR
-511
-5p 9.71E
-01 8.27E
-01 9.84E
-01 8.44E
-01 9.83E
-01 9.04E
-01 3.52E
-01
MIMA
T00028
22 hsa
-miR
-512
-5p 9.73E
-01 2.65E
-01 9.87E
-01 4.45E
-01 9.85E
-01 4.95E
-01 9.07E
-01
MIMA
T00047
77 hsa
-miR
-513a
-3p 1.22E+00 1.57E
-01 1.20E+00 4.70E
-02 9.66E
-01 7.81E
-01 7.21E
-01
MIMA
T00028
77 hsa
-miR
-513a
-5p 9.51E
-01 5.29E
-01 1.03E+00 5.62E
-01 1.06E+00 3.95E
-01 9.42E
-01

227
MIMA
T00057
88 hsa
-miR
-513b
-5p 9.79E
-01 6.58E
-01 9.82E
-01 6.34E
-01 1.11E+00 2.87E
-02 3.09E
-02
MIMA
T00057
89 hsa
-miR
-513c
-5p 9.95E
-01 9.64E
-01 1.03E+00 6.20E
-01 9.40E
-01 4.75E
-01 1.91E
-01
MIMA
T00028
83 hsa
-miR
-514a
-3p 1.05E+00 6.60E
-01 1.05E+00 5.30E
-01 8.05E
-01 3.88E
-02 1.56E
-01
MIMA
T00227
02 hsa
-miR
-514a
-5p 9.96E
-01 9.22E
-01 1.03E+00 4.08E
-01 1.04E+00 3.71E
-01 2.55E
-01
MIMA
T00150
88 hsa
-miR
-514b
-3p 9.72E
-01 8.07E
-01 9.69E
-01 7.22E
-01 1.08E+00 5.38E
-01 6.93E
-01
MIMA
T00150
87 hsa
-miR
-514b
-5p 1.08E+00 4.61E
-01 9.88E
-01 8.51E
-01 1.15E+00 1.10E
-01 7.19E
-01
MIMA
T00028
26 hsa
-miR
-515
-5p 9.58E
-01 7.65E
-01 1.18E+00 7.67E
-02 9.61E
-01 7.92E
-01 5.03E
-01
MIMA
T00028
59 hsa
-miR
-516b
-5p 9.60E
-01 7.21E
-01 1.01E+00 9.02E
-01 9.18E
-01 4.49E
-01 9.31E
-01
MIMA
T00028
52 hsa
-miR
-517a
-3p 9.53E
-01 4.52E
-01 1.01E+00 7.41E
-01 9.42E
-01 3.05E
-01 1.82E
-01
MIMA
T00028
66
hsa
-miR
-517c
-3p+hsa
-
miR
-519a
-3p 9.91E
-01 7.61E
-01 9.80E
-01 3.35E
-01 1.06E+00 3.76E
-02 9.80E
-01
MIMA
T00028
44 hsa
-miR
-518b 1.12E+00 4.91E
-01 9.36E
-01 6.20E
-01 8.74E
-01 6.07E
-01 6.41E
-01
MIMA
T00028
48 hsa
-miR
-518c
-3p 8.79E
-01 3.93E
-01 1.01E+00 9.16E
-01 9.85E
-01 9.15E
-01 8.23E
-01
MIMA
T00028
61 hsa
-miR
-518e
-3p 1.01E+00 8.87E
-01 9.56E
-01 1.23E
-01 1.00E+00 8.74E
-01 6.42E
-01
MIMA
T00028
42 hsa
-miR
-518f-3p 1.00E+00 9.66E
-01 9.40E
-01 3.22E
-01 1.05E+00 4.69E
-01 4.66E
-01
MIMA
T00211
29
hsa
-miR
-5196
-3p+hsa
-
miR
-6732
-3p 9.93E
-01 9.54E
-01 9.92E
-01 9.10E
-01 9.92E
-01 9.28E
-01 6.04E
-01

228
MIMA
T00211
28 hsa
-miR
-5196
-5p 1.06E+00 5.19E
-01 9.90E
-01 8.51E
-01 1.03E+00 6.76E
-01 1.38E
-01
MIMA
T00028
32 hsa
-miR
-519c
-3p 1.01E+00 8.20E
-01 9.85E
-01 5.82E
-01 9.32E
-01 2.06E
-01 8.71E
-01
MIMA
T00028
53 hsa
-miR
-519d
-3p 8.68E
-01 3.86E
-01 1.02E+00 8.61E
-01 1.11E+00 4.24E
-01 9.49E
-01
MIMA
T00028
33 hsa
-miR
-520a
-5p 9.67E
-01 6.58E
-01 9.51E
-01 2.35E
-01 9.70E
-01 6.81E
-01 7.81E
-01
MIMA
T00028
46 hsa
-miR
-520c
-3p 1.10E+00 2.47E
-01 9.70E
-01 5.69E
-01 8.83E
-01 1.63E
-01 8.11E
-01
MIMA
T00028
56 hsa
-miR
-520d
-3p 9.78E
-01 5.09E
-01 1.00E+00 8.16E
-01 9.77E
-01 3.80E
-01 6.92E
-01
MIMA
T00028
30 hsa
-miR
-520f-3p 1.01E+00 7.99E
-01 9.83E
-01 2.74E
-01 9.37E
-01 1.72E
-02 6.56E
-01
MIMA
T00028
58 hsa
-miR
-520g
-3p 1.01E+00 8.04E
-01 1.00E+00 9.87E
-01 9.60E
-01 3.24E
-01 6.79E
-01
MIMA
T00028
67 hsa
-miR
-520h 9.72E
-01 2.52E
-01 9.67E
-01 5.56E
-02 9.99E
-01 9.55E
-01 6.01E
-01
MIMA
T00028
54 hsa
-miR
-521 9.68E
-01 3.41E
-01 1.01E+00 4.80E
-01 9.81E
-01 4.63E
-01 7.27E
-01
MIMA
T00028
68 hsa
-miR
-522
-3p 9.70E
-01 5.70E
-01 9.58E
-01 2.29E
-01 9.82E
-01 6.67E
-01 7.98E
-01
MIMA
T00028
38 hsa
-miR
-525
-5p 1.11E+00 2.38E
-01 1.06E+00 2.32E
-01 9.11E
-01 2.72E
-01 6.51E
-01
MIMA
T00028
45
hsa
-miR
-526a+hsa
-
miR
-518c
-5p+hsa
-
miR
-518d
-5p 1.04E+00 5.57E
-01 9.67E
-01 4.71E
-01 1.04E+00 5.61E
-01 3.29E
-01
MIMA
T00028
35 hsa
-miR
-526b
-5p 1.04E+00 4.89E
-01 1.04E+00 2.10E
-01 1.03E+00 5.31E
-01 8.84E
-01
MIMA
T00047
80 hsa
-miR
-532
-3p 9.98E
-01 9.80E
-01 9.94E
-01 8.93E
-01 8.67E
-01 1.06E
-01 3.56E
-01

229
MIMA
T00033
89 hsa
-miR
-542
-3p 9.09E
-01 6.03E
-01 1.03E+00 7.11E
-01 1.18E+00 1.26E
-01 5.37E
-01
MIMA
T00033
40 hsa
-miR
-542
-5p 1.06E+00 5.84E
-01 1.02E+00 8.01E
-01 8.22E
-01 9.17E
-02 9.21E
-01
MIMA
T00049
54 hsa
-miR
-543 8.17E
-01 1.07E
-01 9.55E
-01 5.63E
-01 9.50E
-01 6.28E
-01 9.68E
-01
MIMA
T00048
03 hsa
-miR
-548a
-5p 9.96E
-01 8.66E
-01 9.71E
-01 4.72E
-02 1.04E+00 1.29E
-02 5.55E
-01
MIMA
T00184
47
hsa
-miR
-548aa+hsa
-
miR
-548t
-3p 1.02E+00 8.43E
-01 9.58E
-01 5.09E
-01 8.86E
-01 2.48E
-01 4.21E
-01
MIMA
T00189
72 hsa
-miR
-548ah
-5p 1.10E+00 3.11E
-01 1.04E+00 4.93E
-01 9.09E
-01 2.06E
-01 7.09E
-01
MIMA
T00190
13 hsa
-miR
-548ak 9.84E
-01 4.71E
-01 9.96E
-01 7.64E
-01 9.96E
-01 8.13E
-01 5.52E
-01
MIMA
T00222
66 hsa
-miR
-548ar
-3p 9.35E
-01 4.61E
-01 1.00E+00 9.67E
-01 9.18E
-01 2.90E
-01 9.35E
-01
MIMA
T00222
65 hsa
-miR
-548ar
-5p 1.19E+00 1.91E
-01 9.95E
-01 9.41E
-01 NULL NULL 8.08E
-01
MIMA
T00048
12 hsa
-miR
-548d
-5p 1.07E+00 4.17E
-01 1.07E+00 2.03E
-01 1.06E+00 5.19E
-01 3.81E
-01
MIMA
T00267
36 hsa
-miR
-548e
-5p 1.00E+00 9.34E
-01 1.03E+00 9.37E
-02 1.01E+00 5.92E
-01 2.20E
-01
MIMA
T00059
12 hsa
-miR
-548g
-3p 7.44E
-01 1.34E
-01 9.81E
-01 8.69E
-01 1.07E+00 6.79E
-01 5.17E
-01
MIMA
T00059
35 hsa
-miR
-548i 9.29E
-01 5.18E
-01 1.02E+00 7.11E
-01 8.92E
-01 2.51E
-01 5.59E
-01
MIMA
T00267
37 hsa
-miR
-548j
-3p 1.16E+00 2.82E
-01 9.38E
-01 5.56E
-01 8.05E
-01 1.41E
-01 4.84E
-01
MIMA
T00058
82 hsa
-miR
-548k 1.08E+00 2.79E
-01 1.02E+00 6.53E
-01 1.06E+00 3.50E
-01 7.95E
-01

230
MIMA
T00059
17 hsa
-miR
-548m 1.10E+00 5.42E
-01 1.06E+00 4.93E
-01 1.18E+00 2.67E
-01 2.05E
-01
MIMA
T00059
16 hsa
-miR
-548n 9.54E
-01 1.49E
-01 9.76E
-01 3.42E
-01 9.66E
-01 2.47E
-01 3.56E
-01
MIMA
T00111
63 hsa
-miR
-548q 1.02E+00 9.16E
-01 1.07E+00 4.83E
-01 6.10E
-01 1.07E
-01 7.79E
-01
MIMA
T00150
20 hsa
-miR
-548v 8.88E
-01 1.54E
-01 9.78E
-01 6.62E
-01 1.01E+00 9.35E
-01 6.59E
-01
MIMA
T00183
54 hsa
-miR
-548y 1.17E+00 2.89E
-01 1.00E+00 9.66E
-01 8.49E
-01 2.13E
-01 2.66E
-01
MIMA
T00184
46
hsa
-miR
-548z+hsa
-
miR
-548h
-3p 9.93E
-01 8.82E
-01 9.94E
-01 8.37E
-01 8.94E
-01 3.48E
-02 5.24E
-01
MIMA
T00033
33 hsa
-miR
-549a 9.49E
-01 3.33E
-01 1.00E+00 9.80E
-01 9.95E
-01 8.91E
-01 5.93E
-01
MIMA
T00032
33 hsa
-miR
-551b
-3p 1.08E+00 4.42E
-01 9.95E
-01 9.38E
-01 9.22E
-01 4.23E
-01 3.41E
-01
MIMA
T00032
15 hsa
-miR
-552
-3p 1.02E+00 8.15E
-01 1.00E+00 9.69E
-01 9.64E
-01 6.36E
-01 2.27E
-01
MIMA
T00032
19 hsa
-miR
-555 9.63E
-01 4.90E
-01 9.39E
-01 1.31E
-01 1.04E+00 4.53E
-01 7.19E
-01
MIMA
T00047
93 hsa
-miR
-556
-3p 1.14E+00 1.51E
-01 9.29E
-01 2.65E
-01 9.51E
-01 5.93E
-01 3.41E
-01
MIMA
T00032
20 hsa
-miR
-556
-5p 9.16E
-01 4.28E
-01 9.45E
-01 4.83E
-01 9.58E
-01 6.36E
-01 6.22E
-01
MIMA
T00227
06 hsa
-miR
-561
-5p 9.83E
-01 8.47E
-01 9.54E
-01 3.88E
-01 9.61E
-01 6.08E
-01 2.34E
-01
MIMA
T00032
27 hsa
-miR
-563 9.89E
-01 7.60E
-01 9.57E
-01 5.09E
-02 9.16E
-01 5.67E
-03 1.51E
-02
MIMA
T00032
28 hsa
-miR
-564 9.98E
-01 9.87E
-01 9.12E
-01 2.21E
-01 8.83E
-01 2.22E
-01 7.51E
-01

231
MIMA
T00032
30 hsa
-miR
-566 9.99E
-01 9.79E
-01 1.01E+00 5.98E
-01 9.84E
-01 5.21E
-01 1.07E
-01
MIMA
T00032
35 hsa
-miR
-570
-3p 1.07E+00 5.89E
-01 1.02E+00 8.27E
-01 1.07E+00 5.85E
-01 9.19E
-01
MIMA
T00032
37 hsa
-miR
-572 9.86E
-01 6.36E
-01 9.64E
-01 9.66E
-02 1.01E+00 7.23E
-01 4.99E
-01
MIMA
T00032
39 hsa
-miR
-574
-3p 9.32E
-01 7.14E
-01 8.69E
-01 3.09E
-01 9.15E
-01 5.93E
-01 4.13E
-01
MIMA
T00047
95 hsa
-miR
-574
-5p 1.01E+00 8.28E
-01 9.82E
-01 2.89E
-01 1.00E+00 9.93E
-01 4.97E
-01
MIMA
T00032
40 hsa
-miR
-575 9.99E
-01 9.73E
-01 9.92E
-01 7.08E
-01 9.37E
-01 2.83E
-02 9.03E
-01
MIMA
T00047
96 hsa
-miR
-576
-3p 1.05E+00 7.37E
-01 9.60E
-01 5.99E
-01 1.06E+00 6.84E
-01 4.90E
-01
MIMA
T00032
41 hsa
-miR
-576
-5p 9.30E
-01 4.30E
-01 1.03E+00 5.70E
-01 1.06E+00 4.24E
-01 7.90E
-04
MIMA
T00032
42 hsa
-miR
-577 1.12E+00 3.31E
-01 1.03E+00 6.63E
-01 1.18E+00 1.30E
-01 4.67E
-01
MIMA
T00266
16 hsa
-miR
-579
-5p 1.03E+00 4.99E
-01 9.86E
-01 4.85E
-01 9.95E
-01 8.34E
-01 5.41E
-01
MIMA
T00047
97 hsa
-miR
-582
-3p 9.21E
-01 4.43E
-01 1.00E+00 9.98E
-01 9.47E
-01 5.93E
-01 5.12E
-01
MIMA
T00032
47 hsa
-miR
-582
-5p 9.56E
-01 6.24E
-01 9.62E
-01 4.27E
-01 9.18E
-01 2.23E
-01 1.88E
-01
MIMA
T00227
08 hsa
-miR
-584
-3p 1.09E+00 3.83E
-01 9.88E
-01 8.55E
-01 9.89E
-01 8.99E
-01 4.56E
-01
MIMA
T00032
49 hsa
-miR
-584
-5p 9.63E
-01 2.95E
-01 1.01E+00 6.70E
-01 9.32E
-01 4.63E
-02 8.37E
-01
MIMA
T00032
50 hsa
-miR
-585
-3p 9.88E
-01 6.59E
-01 9.70E
-01 1.05E
-01 1.04E+00 2.36E
-01 9.51E
-01

232
MIMA
T00032
53 hsa
-miR
-587 1.03E+00 6.59E
-01 1.02E+00 6.23E
-01 8.79E
-01 9.89E
-02 9.87E
-01
MIMA
T00032
58 hsa
-miR
-590
-5p 9.91E
-01 6.66E
-01 9.64E
-01 2.42E
-03 9.89E
-01 5.65E
-01 5.63E
-01
MIMA
T00032
59 hsa
-miR
-591 1.01E+00 8.82E
-01 1.03E+00 6.95E
-01 8.59E
-01 8.92E
-02 1.29E
-01
MIMA
T00032
60 hsa
-miR
-592 9.97E
-01 8.99E
-01 9.93E
-01 5.90E
-01 9.71E
-01 8.79E
-02 9.86E
-01
MIMA
T00048
02 hsa
-miR
-593
-3p 1.03E+00 7.61E
-01 1.02E+00 7.39E
-01 9.40E
-01 5.34E
-01 3.95E
-01
MIMA
T00032
63 hsa
-miR
-595 1.26E+00 1.78E
-01 9.47E
-01 6.58E
-01 9.13E
-01 6.17E
-01 6.92E
-01
MIMA
T00032
65 hsa
-miR
-597
-5p 8.86E
-01 2.50E
-01 9.80E
-01 7.88E
-01 1.13E+00 1.96E
-01 7.14E
-01
MIMA
T00032
66 hsa
-miR
-598
-3p 9.93E
-01 7.57E
-01 1.00E+00 9.90E
-01 9.87E
-01 5.75E
-01 7.58E
-01
MIMA
T00032
71 hsa
-miR
-603 1.08E+00 2.56E
-01 1.01E+00 8.14E
-01 1.06E+00 4.05E
-01 1.17E
-01
MIMA
T00032
73 hsa
-miR
-605
-5p 1.11E+00 3.79E
-01 9.69E
-01 7.03E
-01 1.05E+00 6.69E
-01 6.31E
-01
MIMA
T00032
75 hsa
-miR
-607 1.05E+00 5.77E
-01 9.35E
-01 2.93E
-01 8.84E
-01 1.67E
-01 7.27E
-01
MIMA
T00032
76 hsa
-miR
-608 1.09E+00 5.63E
-01 1.06E+00 5.43E
-01 1.04E+00 7.18E
-01 3.84E
-01
MIMA
T00032
80 hsa
-miR
-612 8.53E
-01 3.13E
-01 1.09E+00 3.11E
-01 9.55E
-01 7.51E
-01 5.34E
-01
MIMA
T00032
83 hsa
-miR
-615
-3p 9.34E
-01 3.83E
-01 1.01E+00 7.87E
-01 8.68E
-01 6.66E
-02 6.70E
-01
MIMA
T00048
05 hsa
-miR
-616
-3p 1.08E+00 5.19E
-01 9.67E
-01 7.08E
-01 8.52E
-01 1.89E
-01 5.47E
-01

233
MIMA
T00032
89 hsa
-miR
-620 1.15E+00 3.74E
-01 9.30E
-01 5.04E
-01 7.37E
-01 1.13E
-01 4.71E
-01
MIMA
T00032
95 hsa
-miR
-626 1.08E+00 2.05E
-01 1.00E+00 9.55E
-01 1.05E+00 3.99E
-01 5.89E
-01
MIMA
T00266
23 hsa
-miR
-627
-3p 9.45E
-01 5.82E
-01 1.03E+00 6.83E
-01 7.13E
-01 4.38E
-02 8.60E
-01
MIMA
T00032
96 hsa
-miR
-627
-5p 9.81E
-01 3.29E
-01 9.76E
-01 9.34E
-02 9.77E
-01 1.67E
-01 6.85E
-01
MIMA
T00032
97 hsa
-miR
-628
-3p 1.02E+00 7.69E
-01 9.81E
-01 5.51E
-01 9.97E
-01 9.57E
-01 2.56E
-02
MIMA
T00032
99 hsa
-miR
-630 1.04E+00 5.21E
-01 9.82E
-01 7.09E
-01 9.21E
-01 2.31E
-01 1.28E
-03
MIMA
T00033
00 hsa
-miR
-631 1.04E+00 7.80E
-01 1.13E+00 1.28E
-01 7.99E
-01 7.19E
-02 1.28E
-03
MIMA
T00033
09 hsa
-miR
-639 9.39E
-01 6.53E
-01 9.96E
-01 9.68E
-01 8.20E
-01 1.98E
-01 9.14E
-02
MIMA
T00033
10 hsa
-miR
-640 9.60E
-01 2.41E
-01 9.72E
-01 2.57E
-01 9.82E
-01 5.41E
-01 7.01E
-01
MIMA
T00033
12 hsa
-miR
-642a
-5p 9.91E
-01 7.52E
-01 9.66E
-01 1.06E
-01 1.02E+00 5.10E
-01 7.27E
-01
MIMA
T00033
13 hsa
-miR
-643 9.77E
-01 3.84E
-01 9.85E
-01 3.97E
-01 1.04E+00 1.04E
-01 7.66E
-01
MIMA
T00033
14 hsa
-miR
-644a 1.03E+00 5.82E
-01 9.93E
-01 8.45E
-01 9.60E
-01 2.83E
-01 6.98E
-01
MIMA
T00033
19 hsa
-miR
-649 9.70E
-01 8.51E
-01 7.21E
-01 8.03E
-03 1.92E+00 6.45E
-05 9.15E
-01
MIMA
T00033
20 hsa
-miR
-650 1.00E+00 9.63E
-01 9.72E
-01 1.27E
-01 1.00E+00 9.68E
-01 7.10E
-01
MIMA
T00254
62 hsa
-miR
-6503
-5p 8.39E
-01 1.36E
-01 1.07E+00 2.71E
-01 1.07E+00 4.10E
-01 3.97E
-01

234
MIMA
T00033
21 hsa
-miR
-651
-5p 1.00E+00 9.87E
-01 9.62E
-01 2.55E
-01 9.51E
-01 3.60E
-01 9.11E
-01
MIMA
T00227
09 hsa
-miR
-652
-5p 7.76E
-01 1.84E
-01 7.79E
-01 5.82E
-02 7.60E
-01 3.02E
-01 9.41E
-01
MIMA
T00033
30 hsa
-miR
-654
-5p 1.03E+00 5.61E
-01 9.71E
-01 3.42E
-01 1.00E+00 9.87E
-01 5.34E
-01
MIMA
T00033
31 hsa
-miR
-655
-3p 9.51E
-01 1.50E
-01 9.89E
-01 6.22E
-01 9.51E
-01 8.50E
-02 6.72E
-01
MIMA
T00033
32 hsa
-miR
-656
-3p 1.03E+00 2.24E
-01 1.01E+00 3.78E
-01 9.85E
-01 4.72E
-01 3.13E
-01
MIMA
T00227
11 hsa
-miR
-660
-3p 9.07E
-01 4.30E
-01 9.06E
-01 2.72E
-01 8.45E
-01 2.02E
-01 8.32E
-01
MIMA
T00033
26 hsa
-miR
-663a 9.90E
-01 9.48E
-01 1.04E+00 6.36E
-01 1.06E+00 7.66E
-01 4.89E
-01
MIMA
T00059
49 hsa
-miR
-664a
-3p 1.04E+00 5.12E
-01 9.97E
-01 9.30E
-01 9.50E
-01 3.97E
-01 3.11E
-01
MIMA
T00222
72 hsa
-miR
-664b
-3p 1.01E+00 8.25E
-01 1.04E+00 3.83E
-02 9.91E
-01 7.85E
-01 2.48E
-01
MIMA
T00049
52 hsa
-miR
-665 9.09E
-01 3.01E
-01 9.69E
-01 6.24E
-01 1.06E+00 5.26E
-01 6.80E
-01
MIMA
T00038
80 hsa
-miR
-671
-5p 1.02E+00 4.50E
-01 9.74E
-01 1.48E
-01 9.79E
-01 4.69E
-01 2.12E
-01
MIMA
T00258
51 hsa
-miR
-6720
-3p 8.97E
-01 4.87E
-01 1.13E+00 1.44E
-01 8.38E
-01 2.82E
-01 7.62E
-01
MIMA
T00258
52 hsa
-miR
-6721
-5p 9.99E
-01 9.72E
-01 1.01E+00 4.67E
-01 9.90E
-01 6.81E
-01 9.04E
-01
MIMA
T00258
56 hsa
-miR
-6724
-5p 9.95E
-01 7.78E
-01 9.66E
-01 2.74E
-03 1.00E+00 7.75E
-01 7.29E
-01
MIMA
T00049
45 hsa
-miR
-744
-5p 1.24E+00 7.31E
-02 1.00E+00 9.97E
-01 1.00E+00 9.73E
-01 9.64E
-01

235
MIMA
T00229
29 hsa
-miR
-758
-5p 1.00E+00 9.89E
-01 9.78E
-01 5.51E
-01 1.00E+00 9.68E
-01 9.14E
-01
MIMA
T00103
64 hsa
-miR
-761 1.00E+00 9.38E
-01 9.89E
-01 5.08E
-01 1.00E+00 8.38E
-01 1.61E
-03
MIMA
T00103
67 hsa
-miR
-764 1.01E+00 7.44E
-01 9.96E
-01 7.80E
-01 9.76E
-01 2.31E
-01 4.62E
-01
MIMA
T00039
45 hsa
-miR
-765 8.35E
-01 1.57E
-01 9.63E
-01 6.43E
-01 9.06E
-01 3.86E
-01 1.94E
-01
MIMA
T00038
82 hsa
-miR
-767
-5p 9.78E
-01 5.22E
-01 1.02E+00 2.84E
-01 1.04E+00 3.19E
-01 7.43E
-01
MIMA
T00038
87 hsa
-miR
-769
-3p 9.90E
-01 7.26E
-01 9.73E
-01 6.07E
-02 9.73E
-01 2.54E
-01 5.86E
-01
MIMA
T00038
86 hsa
-miR
-769
-5p 1.02E+00 5.51E
-01 9.81E
-01 4.27E
-01 1.02E+00 4.63E
-01 7.83E
-01
MIMA
T00039
48 hsa
-miR
-770
-5p 1.00E+00 9.89E
-01 9.87E
-01 5.93E
-01 9.85E
-01 5.98E
-01 5.40E
-01
MIMA
T00041
85 hsa
-miR
-802 6.47E
-01 2.27E
-02 8.17E
-01 1.42E
-01 8.44E
-01 4.14E
-01 6.86E
-01
MIMA
T00227
17 hsa
-miR
-873
-3p 1.01E+00 7.16E
-01 9.82E
-01 3.62E
-01 9.77E
-01 3.89E
-01 4.19E
-01
MIMA
T00049
53 hsa
-miR
-873
-5p 9.97E
-01 8.95E
-01 9.83E
-01 2.77E
-01 9.96E
-01 8.30E
-01 2.61E
-01
MIMA
T00267
18 hsa
-miR
-874
-5p 1.03E+00 6.70E
-01 1.06E+00 1.04E
-01 1.00E+00 9.36E
-01 2.38E
-01
MIMA
T00049
25 hsa
-miR
-876
-3p 1.03E+00 5.38E
-01 9.94E
-01 8.63E
-01 8.89E
-01 1.88E
-02 5.28E
-01
MIMA
T00049
24 hsa
-miR
-876
-5p 9.74E
-01 1.73E
-01 9.62E
-01 8.25E
-03 9.99E
-01 9.58E
-01 8.26E
-01
MIMA
T00049
49 hsa
-miR
-877
-5p 1.15E+00 1.22E
-01 9.79E
-01 7.42E
-01 9.24E
-01 3.67E
-01 1.93E
-01

236
MIMA
T00049
48 hsa
-miR
-885
-3p 9.90E
-01 7.42E
-01 9.88E
-01 6.07E
-01 1.00E+00 8.87E
-01 4.98E
-01
MIMA
T00267
20 hsa
-miR
-887
-5p 9.45E
-01 4.46E
-01 9.24E
-01 1.32E
-01 9.74E
-01 6.81E
-01 3.67E
-01
MIMA
T00049
16 hsa
-miR
-888
-5p 9.76E
-01 6.35E
-01 1.01E+00 8.75E
-01 9.88E
-01 7.60E
-01 2.05E
-01
MIMA
T00049
21 hsa
-miR
-889
-3p 1.01E+00 5.85E
-01 9.77E
-01 1.82E
-01 1.02E+00 5.72E
-01 5.53E
-01
MIMA
T00049
12 hsa
-miR
-890 9.84E
-01 8.26E
-01 8.84E
-01 2.19E
-02 9.42E
-01 3.96E
-01 1.59E
-01
MIMA
T00049
02 hsa
-miR
-891a
-5p 1.05E+00 6.01E
-01 1.05E+00 3.60E
-01 9.39E
-01 3.47E
-01 4.26E
-02
MIMA
T00049
13 hsa
-miR
-891b 9.81E
-01 6.99E
-01 9.84E
-01 5.70E
-01 1.13E+00 1.77E
-02 6.47E
-01
MIMA
T00049
07 hsa
-miR
-892a 1.14E+00 2.41E
-01 1.01E+00 8.37E
-01 1.02E+00 8.74E
-01 5.89E
-01
MIMA
T00049
72 hsa
-miR
-922 9.50E
-01 3.60E
-01 1.06E+00 5.43E
-02 1.01E+00 7.81E
-01 5.06E
-01
MIMA
T00045
07 hsa
-miR
-92a
-
1
-5p 9.98E
-01 9.78E
-01 9.28E
-01 1.42E
-01 1.02E+00 7.49E
-01 2.36E
-01
MIMA
T00000
92 hsa
-miR
-92a
-3p 1.01E+00 6.80E
-01 1.02E+00 1.69E
-01 9.61E
-01 1.02E
-01 6.35E
-01
MIMA
T00032
18 hsa
-miR
-92b
-3p 9.93E
-01 7.84E
-01 9.79E
-01 2.20E
-01 1.01E+00 4.58E
-01 2.57E
-02
MIMA
T00000
93 hsa
-miR
-93
-5p 1.11E+00 3.39E
-01 8.35E
-01 2.62E
-02 1.00E+00 9.71E
-01 9.60E
-01
MIMA
T00049
76 hsa
-miR
-933 1.02E+00 6.03E
-01 9.83E
-01 3.54E
-01 1.01E+00 6.37E
-01 8.50E
-01
MIMA
T00049
77 hsa
-miR
-934 1.08E+00 2.51E
-01 1.18E+00 1.23E
-04 1.03E+00 6.57E
-01 6.21E
-01

237
MIMA
T00049
78 hsa
-miR
-935 9.75E
-01 3.32E
-01 9.84E
-01 3.62E
-01 1.02E+00 2.78E
-01 2.03E
-01
MIMA
T00049
79 hsa
-miR
-936 6.55E
-01 4.41E
-02 8.95E
-01 4.06E
-01 8.16E
-01 1.48E
-01 7.96E
-01
MIMA
T00049
80 hsa
-miR
-937
-3p 9.81E
-01 5.97E
-01 1.02E+00 4.06E
-01 9.82E
-01 5.23E
-01 9.72E
-01
MIMA
T00049
82 hsa
-miR
-939
-5p 1.00E+00 9.99E
-01 1.05E+00 3.19E
-01 1.04E+00 5.93E
-01 7.47E
-01
MIMA
T00049
83 hsa
-miR
-940 9.50E
-01 7.63E
-01 8.78E
-01 2.74E
-01 1.02E+00 9.15E
-01 1.92E
-01
MIMA
T00049
84 hsa
-miR
-941 9.71E
-01 2.76E
-01 9.75E
-01 1.93E
-01 1.04E+00 1.10E
-01 9.06E
-01
MIMA
T00049
85 hsa
-miR
-942
-5p 1.03E+00 5.42E
-01 1.03E+00 2.46E
-01 9.68E
-01 3.65E
-01 5.10E
-01
MIMA
T00000
94 hsa
-miR
-95
-3p 9.25E
-01 5.35E
-01 8.91E
-01 2.27E
-01 8.45E
-01 1.94E
-01 9.73E
-01
MIMA
T00000
95 hsa
-miR
-96
-5p 1.09E+00 2.76E
-01 9.74E
-01 5.73E
-01 9.27E
-01 2.52E
-01 5.98E
-02
MIMA
T00006
89 hsa
-miR
-99b
-5p 1.18E+00 1.65E
-01 1.10E+00 2.28E
-01 1.19E+00 8.17E
-02 9.67E
-01

238
Appendix L. Study characteristics of analytic sample by case-control status
Total (n=917) Cases (n=459) Controls (n=458)
n (%) or mean
(SD)
n (%) or mean
(SD) n (%) or mean (SD)
Study characteristic
Age at biospecimen collection, mean (SD) 69.6 (8.1) 69.7 (8.1) 69.5 (8.1)
Sex, n (%)
Male 416 (45.4) 208 (45.3) 208 (45.4)
Female 501 (54.6) 251 (54.7) 250 (54.6)
Self-identified race and ethnicity, n (%)
African American/Black 171 (18.6) 88 (19.2) 83 (18.1)
Japanese American 330 (36.0) 163 (35.5) 167 (36.5)
Native Hawaiian 94 (10.3) 47 (10.2) 47 (10.3)
Latino 177 (19.3) 89 (19.4) 88 (19.2)
White 145 (15.8) 72 (15.7) 73 (15.9)
Smoking status, n (%)
Never 469 (51.1) 228 (49.7) 241 (52.6)
Former 352 (38.4) 173 (37.7) 179 (39.1)
Current 96 (10.5) 58 (12.6) 38 (8.3)
Alcohol consumption, grams/day, mean (SD) 7.4 (18.8) 7.3 (18.5) 7.5 (19.0)
Alcohol consumption using sex-specific cut-off
points*, n (%)
Nondrinker 480 (52.3) 232 (50.5) 248 (54.1)
Light drinker 340 (37.1) 183 (39.9) 158 (34.5)
Heavy drinker 97 (10.6) 44 (9.6) 52 (11.4)
Body mass index, kg/m2, n (%)
<25 365 (39.8) 175 (38.1) 190 (41.5)
25.0-29.9 373 (40.7) 196 (42.7) 177 (38.6)
≥30 179 (19.5) 88 (19.2) 91 (19.9)
Time between cohort entry and biospecimen
collection, years, mean (SD) 9.0 (2.2) 9.0 (2.2) 9.0 (2.2)

239
Appendix M. Heterogeneity by case-control status for replicating main findings
Accession miRNA Nondrinkers
Cases
Light
drinker
IRR
ethanol
intake
per
drink
Cases
Light
drinker
nominal
p-value
Cases
Heavy
drinker
IRR
ethanol
intake
per
drink
Cases
Heavy
drinker
nominal
p-value
Controls
Light
drinker
IRR
ethanol
intake
per
drink
Controls
Light
drinker
nominal
p-value
Controls
Heavy
drinker
IRR
ethanol
intake
per
drink
Controls
Heavy
drinker
nominal
p-value
P for
heterogeneity
MIMAT0001631
hsamiR451a 1.00 (ref)
6.85E01 1.01E-02
6.27E01 5.78E-02 6.51E-01 5.97E-03 4.02E-01 1.55E-04 1.60E-01
MIMAT0015072
hsamiR320e 1.00 (ref)
5.77E01 1.19E-04
5.73E01 1.99E-02 8.09E-01 1.21E-01 6.93E-01 8.33E-02 7.41E-02

240

241
Appendix N. Association from the replication analysis of alcohol-related liver cirrhosis among MEC participants by the
combined and self-identified race and ethnicity.
rsid
Chromsome
:Position Chromosome Position
Reference
Allele
Alternative
Allele Ethnicity1 Allele Frequency Coefficient Odds Ratio Standard Error P-value
rs738409 22:44324727 22 44324727 C G C 0.369679 0.31 1.37 0.10 <0.01
rs2294915 22:44340904 22 44340904 C T C 0.378821 0.27 1.31 0.10 0.01
rs2294915 22:44340904 22 44340904 C T L 0.482574 0.32 1.38 0.15 0.03
rs738409 22:44324727 22 44324727 C G W 0.228771 0.45 1.56 0.22 0.04
rs3794991 19:19610596 19 19610596 C T H 0.181789 1.25 3.47 0.63 0.048
rs738409 22:44324727 22 44324727 C G L 0.475453 0.30 1.35 0.15 0.05
rs2294915 22:44340904 22 44340904 C T W 0.239912 0.43 1.54 0.22 0.05
rs73004967 19:19717056 19 19717056 A G H 0.016562 2.77 15.98 1.44 0.05
rs738409 22:44324727 22 44324727 C G J 0.489785 0.46 1.58 0.24 0.06
rs1183910 12:121420807 12 1.21E+08 G A W 0.351048 -0.42 0.66 0.23 0.06
rs10401969 19:19407718 19 19407718 T C H 0.132231 1.13 3.11 0.65 0.08
rs626283 19:54677001 19 54677001 G C J 0.221535 0.45 1.57 0.27 0.10
rs148417465 22:24665282 22 24665282 G A J 0.066066 -1.50 0.22 0.91 0.10
rs3794991 19:19610596 19 19610596 C T W 0.071699 -0.81 0.45 0.53 0.13
rs5760491 22:24995134 22 24995134 G T B 0.246578 0.46 1.59 0.32 0.14
rs1183910 12:121420807 12 1.21E+08 G A H 0.37643 0.83 2.29 0.58 0.15
rs626283 19:54677001 19 54677001 G C W 0.407242 -0.30 0.74 0.21 0.15
rs5760491 22:24995134 22 24995134 G T L 0.448759 0.21 1.23 0.16 0.18
rs5760491 22:24995134 22 24995134 G T J 0.337555 -0.36 0.70 0.28 0.20
rs28929474 14:94844947 14 94844947 C T W 0.012773 0.83 2.29 0.67 0.22
rs2006094 22:24997086 22 24997086 G A L 0.478365 0.19 1.21 0.16 0.22
rs626283 19:54677001 19 54677001 G C L 0.355542 0.19 1.21 0.16 0.22
rs2006094 22:24997086 22 24997086 G A J 0.341663 -0.34 0.71 0.28 0.23
rs148417465 22:24665282 22 24665282 G A B 0.005067 6.69 803.69 5.54 0.23
rs2294915 22:44340904 22 44340904 C T J 0.475547 0.28 1.33 0.24 0.23
rs10433937 4:88230100 4 88230100 T G J 0.3439 -0.30 0.74 0.26 0.25
rs73004967 19:19717056 19 19717056 A G W 0.057274 -0.60 0.55 0.53 0.26

242
rs2330805 22:24998619 22 24998619
A
G
J 0.343588
-0.31 0.73 0.28 0.27
rs10433937 4:88230100
4 88230100
T
G
W 0.264711 0.24 1.27 0.22 0.27
rs10024759 4:146797538
4 1.47E+08
A
G
L 0.556973
-0.17 0.84 0.16 0.27
rs28929474 14:94844947 14 94844947
C
T
B 0.004402 1.37 3.95 1.26 0.27
rs10401969 19:19407718 19 19407718
T
C
B 0.195007 0.34 1.40 0.31 0.28
rs5760491 22:24995134 22 24995134
G
T
C 0.383767 0.11 1.12 0.10 0.30
rs1183910 12:121420807 12 1.21E+08
G
A
B 0.120088
-0.49 0.61 0.50 0.33
rs10401969 19:19407718 19 19407718
T
C
W 0.065417
-0.47 0.63 0.48 0.33
rs148417465 22:24665282 22 24665282
G
A
C 0.017733
-0.55 0.57 0.58 0.34
rs2006094 22:24997086 22 24997086
G
A
C 0.43403 0.10 1.10 0.10 0.34
rs148417465 22:24665282 22 24665282
G
A
W 0.006293 1.99 7.32 2.14 0.35
rs5760491 22:24995134 22 24995134
G
T
H 0.380508 0.48 1.61 0.52 0.36
rs10024759 4:146797538
4 1.47E+08
A
G
W 0.467321 0.18 1.20 0.20 0.36
rs2294915 22:44340904 22 44340904
C
T
B 0.194468
-0.35 0.71 0.39 0.37
rs73004967 19:19717056 19 19717056
A
G
C 0.027557
-0.30 0.74 0.34 0.38
rs2330805 22:24998619 22 24998619
A
G
L 0.494873 0.13 1.14 0.16 0.40
rs13147616 4:146791129
4 1.47E+08
C
A
C 0.276438
-0.10 0.91 0.12 0.41
rs2006094 22:24997086 22 24997086
G
A
H 0.39614 0.41 1.51 0.50 0.41
rs13147616 4:146791129
4 1.47E+08
C
A
H 0.437607
-0.47 0.63 0.58 0.42
rs1183910 12:121420807 12 1.21E+08
G
A
J 0.497489 0.19 1.21 0.23 0.42
rs10433937 4:88230100
4 88230100
T
G
L 0.137465
-0.19 0.82 0.24 0.42
rs2330805 22:24998619 22 24998619
A
G
H 0.397335 0.39 1.48 0.49 0.43
rs1183910 12:121420807 12 1.21E+08
G
A
L 0.337195 0.12 1.12 0.15 0.44
rs10433937 4:88230100
4 88230100
T
G
B 0.081471
-0.45 0.64 0.58 0.44
rs2006094 22:24997086 22 24997086
G
A
B 0.49701 0.22 1.25 0.29 0.45
rs10024759 4:146797538
4 1.47E+08
A
G
B 0.401661
-0.22 0.81 0.30 0.48
rs626283 19:54677001 19 54677001
G
C
C 0.347012 0.07 1.07 0.10 0.50
rs73004967 19:19717056 19 19717056
A
G
L 0.022956
-0.39 0.68 0.60 0.52
rs10433937 4:88230100
4 88230100
T
G
C 0.209209
-0.08 0.92 0.13 0.54
rs10433937 4:88230100
4 88230100
T
G
H 0.450541
-0.32 0.73 0.53 0.55
rs10401969 19:19407718 19 19407718
T
C
C 0.083066 0.10 1.11 0.17 0.55

243
rs13147616 4:146791129
4 1.47E+08
C
A
W 0.16683
-0.17 0.84 0.29 0.55
rs10024759 4:146797538
4 1.47E+08
A
G
C 0.481355
-0.06 0.94 0.10 0.55
rs13147616 4:146791129
4 1.47E+08
C
A
L 0.364856
-0.09 0.91 0.16 0.57
rs3794991 19:19610596 19 19610596
C
T
B 0.07315 0.28 1.32 0.50 0.58
rs13147616 4:146791129
4 1.47E+08
C
A
B 0.046971
-0.37 0.69 0.70 0.60
rs10401969 19:19407718 19 19407718
T
C
L 0.048496
-0.17 0.85 0.37 0.65
rs28929474 14:94844947 14 94844947
C
T
L 0.00641
-154.04 0.00 345.49 0.66
rs28929474 14:94844947 14 94844947
C
T
C 0.006679 0.23 1.26 0.54 0.67
rs73004967 19:19717056 19 19717056
A
G
J 0.002906
-5.37 0.00 13.03 0.68
rs2330805 22:24998619 22 24998619
A
G
C 0.474911 0.04 1.04 0.11 0.68
rs73004967 19:19717056 19 19717056
A
G
B 0.023614
-0.43 0.65 1.07 0.69
rs738409 22:44324727 22 44324727
C
G
H 0.305603
-0.21 0.81 0.52 0.69
rs10024759 4:146797538
4 1.47E+08
A
G
J 0.350503
-0.10 0.91 0.24 0.70
rs10401969 19:19407718 19 19407718
T
C
J 0.095226 0.14 1.15 0.41 0.72
rs2006094 22:24997086 22 24997086
G
A
W 0.393349 0.07 1.08 0.21 0.73
rs3794991 19:19610596 19 19610596
C
T
L 0.050578
-0.13 0.88 0.36 0.73
rs2330805 22:24998619 22 24998619
A
G
W 0.402105 0.07 1.07 0.22 0.75
rs10024759 4:146797538
4 1.47E+08
A
G
H 0.560186
-0.15 0.86 0.50 0.76
rs13147616 4:146791129
4 1.47E+08
C
A
J 0.342888
-0.07 0.93 0.25 0.77
rs148417465 22:24665282 22 24665282
G
A
H 0.022029 0.87 2.38 3.14 0.78
rs2330805 22:24998619 22 24998619
A
G
B 0.740723
-0.09 0.91 0.35 0.79
rs148417465 22:24665282 22 24665282
G
A
L 0.008466 0.53 1.70 2.30 0.82
rs626283 19:54677001 19 54677001
G
C
B 0.340078 0.04 1.04 0.30 0.91
rs626283 19:54677001 19 54677001
G
C
H 0.432413 0.05 1.06 0.47 0.91
rs3794991 19:19610596 19 19610596
C
T
C 0.073577
-0.02 0.98 0.19 0.92
rs738409 22:44324727 22 44324727
C
G
B 0.151906
-0.04 0.96 0.39 0.92
rs1183910 12:121420807 12 1.21E+08
G
A
C 0.340956
-0.01 0.99 0.10 0.94
rs5760491 22:24995134 22 24995134
G
T
W 0.376274
-0.01 0.99 0.22 0.97
rs2294915 22:44340904 22 44340904
C
T
H 0.313789 0.01 1.01 0.53 0.99
rs28929474 14:94844947 14 94844947
C
T
H 0.008273
-4363.57 0.00 325229.23 0.99
rs3794991 19:19610596 19 19610596
C
T
J 0.1049 0.00 1.00 0.39 0.99

244
rs28929474 14:94844947 14 94844947 C T J 0 1.00 0.00 1Refers to self-identified race and ethnicity: African American/Black (B), Combined (C), Japanese American (J), Native Hawaiian (H), Latino (L), and White (W).

245
Appendix O. Association from the replication analysis of alcohol-associated liver disease among MEC participants by the
combined and self-identified race and ethnicity adjusting for alcohol intake.
rsid
Chromosome
:Position Chromosome Position
Reference
Allele
Alternative
Allele Ethnicity
Allele
Frequency Coefficient Odds Ratio
Standard
Error P-value
rs10433937 4:88230100 4 88230100 T G C 0.22103 <0.01 1.00 0.11 0.97
rs10433937 4:88230100 4 88230100 T G W 0.268025 0.12 1.13 0.20 0.55
rs10433937 4:88230100 4 88230100 T G B 0.091976 -0.25 0.78 0.53 0.64
rs10433937 4:88230100 4 88230100 T G J 0.339111 -0.09 0.92 0.23 0.70
rs10433937 4:88230100 4 88230100 T G L 0.139742 -0.07 0.93 0.22 0.73
rs10433937 4:88230100 4 88230100 T G H 0.46415 0.12 1.13 0.45 0.79
rs13147616 4:146791129 4 1.47E+08 C A C 0.274029 -0.24 0.79 0.11 0.03
rs13147616 4:146791129 4 1.47E+08 C A W 0.167973 -0.28 0.76 0.27 0.31
rs13147616 4:146791129 4 1.47E+08 C A B 0.050231 -0.10 0.90 0.61 0.87
rs13147616 4:146791129 4 1.47E+08 C A J 0.35479 -0.08 0.92 0.23 0.73
rs13147616 4:146791129 4 1.47E+08 C A L 0.359595 -0.26 0.77 0.16 0.09
rs13147616 4:146791129 4 1.47E+08 C A H 0.394549 -0.45 0.63 0.49 0.35
rs10024759 4:146797538 4 1.47E+08 A G C 0.476159 -0.18 0.84 0.09 0.06
rs10024759 4:146797538 4 1.47E+08 A G W 0.455323 0.05 1.05 0.18 0.78
rs10024759 4:146797538 4 1.47E+08 A G B 0.421792 -0.28 0.75 0.30 0.34
rs10024759 4:146797538 4 1.47E+08 A G J 0.360844 -0.11 0.90 0.22 0.64
rs10024759 4:146797538 4 1.47E+08 A G L 0.558592 -0.33 0.72 0.15 0.02
rs10024759 4:146797538 4 1.47E+08 A G H 0.510047 -0.05 0.95 0.42 0.90
rs1183910 12:121420807 12 1.21E+08 G A C 0.338068 -0.11 0.90 0.10 0.27
rs1183910 12:121420807 12 1.21E+08 G A W 0.342091 -0.35 0.71 0.21 0.10
rs1183910 12:121420807 12 1.21E+08 G A B 0.119141 -0.55 0.57 0.49 0.26
rs1183910 12:121420807 12 1.21E+08 G A J 0.480634 0.12 1.12 0.21 0.58
rs1183910 12:121420807 12 1.21E+08 G A L 0.339794 0.02 1.02 0.15 0.90
rs1183910 12:121420807 12 1.21E+08 G A H 0.344804 -0.20 0.82 0.47 0.67
rs28929474 14:94844947 14 94844947 C T C 0.00662 0.58 1.79 0.47 0.21
rs28929474 14:94844947 14 94844947 C T W 0.013312 1.15 3.17 0.62 0.06
rs28929474 14:94844947 14 94844947 C T B 0.003381 2.22 9.21 1.69 0.19

246
rs28929474 14:94844947 14 94844947
C
T
J 1.42E
-05
-865.52 0.00 219787.80 0.99
rs28929474 14:94844947 14 94844947
C
T
L 0.006559
-0.57 0.56 1.07 0.59
rs28929474 14:94844947 14 94844947
C
T
H 0.007358
-5920.51 0.00 727560.14 0.99
rs10401969 19:19407718 19 19407718
T
C
C 0.089054 0.17 1.18 0.16 0.29
rs10401969 19:19407718 19 19407718
T
C
W 0.070572
-0.34 0.71 0.41 0.40
rs10401969 19:19407718 19 19407718
T
C
B 0.188062 0.36 1.44 0.30 0.23
rs10401969 19:19407718 19 19407718
T
C
J 0.110097 0.08 1.08 0.35 0.82
rs10401969 19:19407718 19 19407718
T
C
L 0.048187 0.11 1.12 0.34 0.74
rs10401969 19:19407718 19 19407718
T
C
H 0.144608 0.85 2.34 0.61 0.16
rs3794991 19:19610596 19 19610596
C
T
C 0.07984
-0.04 0.97 0.18 0.84
rs3794991 19:19610596 19 19610596
C
T
W 0.077724
-0.26 0.77 0.39 0.51
rs3794991 19:19610596 19 19610596
C
T
B 0.075456
-0.36 0.69 0.56 0.52
rs3794991 19:19610596 19 19610596
C
T
J 0.119191 0.13 1.14 0.33 0.70
rs3794991 19:19610596 19 19610596
C
T
L 0.048845
-0.08 0.92 0.35 0.82
rs3794991 19:19610596 19 19610596
C
T
H 0.174002 0.28 1.33 0.57 0.62
rs73004967 19:19717056 19 19717056
A
G
C 0.026767
-0.12 0.88 0.31 0.69
rs73004967 19:19717056 19 19717056
A
G
W 0.05841
-0.30 0.74 0.45 0.50
rs73004967 19:19717056 19 19717056
A
G
B 0.025991
-0.85 0.43 1.12 0.45
rs73004967 19:19717056 19 19717056
A
G
J 0.002369
-5.79 0.00 12.99 0.66
rs73004967 19:19717056 19 19717056
A
G
L 0.020258
-0.38 0.69 0.62 0.54
rs73004967 19:19717056 19 19717056
A
G
H 0.017176 3.74 42.21 1.50 0.01
rs626283 19:54677001 19 54677001
G
C
C 0.344901 0.02 1.02 0.10 0.80
rs626283 19:54677001 19 54677001
G
C
W 0.410265
-0.37 0.69 0.20 0.06
rs626283 19:54677001 19 54677001
G
C
B 0.349687
-0.29 0.75 0.31 0.36
rs626283 19:54677001 19 54677001
G
C
J 0.208009 0.24 1.27 0.26 0.36
rs626283 19:54677001 19 54677001
G
C
L 0.358154 0.26 1.29 0.15 0.08
rs626283 19:54677001 19 54677001
G
C
H 0.408917 0.34 1.40 0.45 0.45
rs148417465 22:24665282 22 24665282
G
A
C 0.018971
-0.84 0.43 0.55 0.13
rs148417465 22:24665282 22 24665282
G
A
W 0.00604 0.74 2.10 2.30 0.75
rs148417465 22:24665282 22 24665282
G
A
B 0.005061 4.01 54.95 2.59 0.12
rs148417465 22:24665282 22 24665282
G
A
J 0.064687
-1.84 0.16 0.85 0.03

247
rs148417465 22:24665282 22 24665282
G
A
L 0.008314 0.01 1.01 2.28 0.99
rs148417465 22:24665282 22 24665282
G
A
H 0.028061
-2.68 0.07 3.86 0.49
rs5760491 22:24995134 22 24995134
G
T
C 0.378753 0.07 1.07 0.10 0.47
rs5760491 22:24995134 22 24995134
G
T
W 0.367703
-0.01 0.99 0.20 0.97
rs5760491 22:24995134 22 24995134
G
T
B 0.246019 0.25 1.29 0.30 0.40
rs5760491 22:24995134 22 24995134
G
T
J 0.336607
-0.24 0.79 0.25 0.33
rs5760491 22:24995134 22 24995134
G
T
L 0.448838 0.16 1.18 0.15 0.28
rs5760491 22:24995134 22 24995134
G
T
H 0.395336 0.67 1.95 0.51 0.19
rs2006094 22:24997086 22 24997086
G
A
C 0.430045 0.03 1.03 0.10 0.75
rs2006094 22:24997086 22 24997086
G
A
W 0.384528 0.02 1.02 0.20 0.91
rs2006094 22:24997086 22 24997086
G
A
B 0.504564
-0.02 0.98 0.29 0.96
rs2006094 22:24997086 22 24997086
G
A
J 0.341247
-0.22 0.80 0.25 0.37
rs2006094 22:24997086 22 24997086
G
A
L 0.479743 0.12 1.13 0.15 0.41
rs2006094 22:24997086 22 24997086
G
A
H 0.410679 0.61 1.85 0.49 0.21
rs2330805 22:24998619 22 24998619
A
G
C 0.469759
-0.03 0.97 0.10 0.74
rs2330805 22:24998619 22 24998619
A
G
W 0.392937 0.00 1.00 0.20 0.99
rs2330805 22:24998619 22 24998619
A
G
B 0.74281
-0.49 0.61 0.34 0.15
rs2330805 22:24998619 22 24998619
A
G
J 0.343363
-0.21 0.81 0.25 0.40
rs2330805 22:24998619 22 24998619
A
G
L 0.496229 0.07 1.08 0.15 0.63
rs2330805 22:24998619 22 24998619
A
G
H 0.410654 0.62 1.86 0.49 0.20
rs738409 22:44324727 22 44324727
C
G
C 0.365631 0.30 1.34 0.10
<0.0
1
rs738409 22:44324727 22 44324727
C
G
W 0.232533 0.52 1.68 0.21 0.01
rs738409 22:44324727 22 44324727
C
G
B 0.143418 0.14 1.15 0.37 0.71
rs738409 22:44324727 22 44324727
C
G
J 0.492815 0.33 1.39 0.22 0.14
rs738409 22:44324727 22 44324727
C
G
L 0.47311 0.29 1.34 0.14 0.04
rs738409 22:44324727 22 44324727
C
G
H 0.308478
-0.31 0.73 0.49 0.52
rs2294915 22:44340904 22 44340904
C
T
C 0.374447 0.28 1.33 0.10
<0.0
1
rs2294915 22:44340904 22 44340904
C
T
W 0.245082 0.49 1.64 0.21 0.02
rs2294915 22:44340904 22 44340904
C
T
B 0.182624
-0.15 0.86 0.35 0.66
rs2294915 22:44340904 22 44340904
C
T
J 0.486949 0.36 1.44 0.22 0.10
rs2294915 22:44340904 22 44340904
C
T
L 0.477382 0.31 1.37 0.15 0.03

248
rs2294915 22:44340904 22 44340904 C T H 0.310586 -0.09 0.91 0.48 0.85

249
Appendix P. Association from the replication analysis of alcohol-associated liver disease among MEC participants with 12 or
more months of continuous FFS coverage by the combined and self-identified race and ethnicity.
rsid
Chromosome
:Position Chromosome Position
Reference
Allele
Alternative
Allele Ethnicity
Allele
Frequency Coefficient Odds Ratio
Standard
Error P-value
rs10433937 4:88230100 4 88230100 T G C 0.228258 0.05 1.05 0.12 0.67
rs10433937 4:88230100 4 88230100 T G W 0.27351 0.23 1.26 0.20 0.26
rs10433937 4:88230100 4 88230100 T G B 0.091183 0.04 1.04 0.45 0.92
rs10433937 4:88230100 4 88230100 T G J 0.344993 -0.01 0.99 0.22 0.98
rs10433937 4:88230100 4 88230100 T G L 0.132874 -0.07 0.94 0.23 0.78
rs10433937 4:88230100 4 88230100 T G H 0.460242 -0.18 0.83 0.42 0.67
rs13147616 4:146791129 4 146791129 C A C 0.276436 -0.23 0.80 0.11 0.04
rs13147616 4:146791129 4 146791129 C A W 0.169066 -0.36 0.69 0.28 0.20
rs13147616 4:146791129 4 146791129 C A B 0.044433 0.15 1.16 0.58 0.80
rs13147616 4:146791129 4 146791129 C A J 0.362172 -0.02 0.98 0.22 0.92
rs13147616 4:146791129 4 146791129 C A L 0.360685 -0.31 0.73 0.17 0.07
rs13147616 4:146791129 4 146791129 C A H 0.404686 -0.48 0.62 0.45 0.29
rs10024759 4:146797538 4 146797538 A G C 0.469798 -0.15 0.86 0.10 0.11
rs10024759 4:146797538 4 146797538 A G W 0.452204 0.04 1.04 0.19 0.82
rs10024759 4:146797538 4 146797538 A G B 0.407299 -0.31 0.73 0.29 0.29
rs10024759 4:146797538 4 146797538 A G J 0.368292 -0.04 0.96 0.22 0.84
rs10024759 4:146797538 4 146797538 A G L 0.557373 -0.27 0.76 0.16 0.08
rs10024759 4:146797538 4 146797538 A G H 0.517389 -0.33 0.72 0.40 0.40
rs1183910 12:121420807 12 121420807 G A C 0.34161 -0.10 0.91 0.10 0.32
rs1183910 12:121420807 12 121420807 G A W 0.33901 -0.42 0.66 0.22 0.05
rs1183910 12:121420807 12 121420807 G A B 0.124769 -0.49 0.62 0.46 0.29
rs1183910 12:121420807 12 121420807 G A J 0.482373 -0.03 0.97 0.20 0.87
rs1183910 12:121420807 12 121420807 G A L 0.33576 0.01 1.01 0.16 0.95
rs1183910 12:121420807 12 121420807 G A H 0.337931 0.44 1.55 0.43 0.31
rs28929474 14:94844947 14 94844947 C T C 0.00661 0.62 1.85 0.48 0.20
rs28929474 14:94844947 14 94844947 C T W 0.013805 1.17 3.22 0.63 0.06
rs28929474 14:94844947 14 94844947 C T B 0.002781 2.21 9.09 1.59 0.16

250
rs28929474 14:94844947 14 94844947
C
T
J 1.46E
-05
-868.45
<0.0
1 219787.80 0.99
rs28929474 14:94844947 14 94844947
C
T
L 0.006505
-0.53 0.59 1.08 0.62
rs28929474 14:94844947 14 94844947
C
T
H 0.008339
-6095.65 0.00 676214.33 0.99
rs10401969 19:19407718 19 19407718
T
C
C 0.094347 0.10 1.11 0.15 0.51
rs10401969 19:19407718 19 19407718
T
C
W 0.076362
-0.62 0.54 0.44 0.16
rs10401969 19:19407718 19 19407718
T
C
B 0.197222 0.27 1.31 0.29 0.35
rs10401969 19:19407718 19 19407718
T
C
J 0.114945 0.08 1.09 0.33 0.80
rs10401969 19:19407718 19 19407718
T
C
L 0.049509 0.06 1.06 0.35 0.86
rs10401969 19:19407718 19 19407718
T
C
H 0.144444 1.14 3.13 0.54 0.04
rs3794991 19:19610596 19 19610596
C
T
C 0.085393 0.01 1.01 0.17 0.96
rs3794991 19:19610596 19 19610596
C
T
W 0.084111
-0.43 0.65 0.39 0.27
rs3794991 19:19610596 19 19610596
C
T
B 0.077378
-0.29 0.75 0.54 0.59
rs3794991 19:19610596 19 19610596
C
T
J 0.121885
-0.08 0.92 0.33 0.81
rs3794991 19:19610596 19 19610596
C
T
L 0.050284 0.11 1.11 0.34 0.75
rs3794991 19:19610596 19 19610596
C
T
H 0.180478 1.14 3.13 0.51 0.02
rs73004967 19:19717056 19 19717056
A
G
C 0.027915
-0.28 0.75 0.32 0.37
rs73004967 19:19717056 19 19717056
A
G
W 0.062506
-0.45 0.64 0.45 0.32
rs73004967 19:19717056 19 19717056
A
G
B 0.023747
-5.61 0.00 10.22 0.58
rs73004967 19:19717056 19 19717056
A
G
J 0.003251
-6.61 0.00 15.08 0.66
rs73004967 19:19717056 19 19717056
A
G
L 0.021056
-0.38 0.68 0.62 0.54
rs73004967 19:19717056 19 19717056
A
G
H 0.019603 3.34 28.35 1.34 0.01
rs626283 19:54677001 19 54677001
G
C
C 0.339612
<0.0
1 1.00 0.10 0.99
rs626283 19:54677001 19 54677001
G
C
W 0.404698
-0.28 0.75 0.19 0.15
rs626283 19:54677001 19 54677001
G
C
B 0.344868
-0.30 0.74 0.31 0.34
rs626283 19:54677001 19 54677001
G
C
J 0.211028 0.30 1.35 0.25 0.23
rs626283 19:54677001 19 54677001
G
C
L 0.35245 0.23 1.26 0.16 0.15
rs626283 19:54677001 19 54677001
G
C
H 0.432939
-0.22 0.80 0.39 0.57
rs148417465 22:24665282 22 24665282
G
A
C 0.02025
-0.39 0.68 0.50 0.44
rs148417465 22:24665282 22 24665282
G
A
W 0.006392 0.06 1.06 2.46 0.98
rs148417465 22:24665282 22 24665282
G
A
B 0.004692 11.52 100493.53 8.25 0.16
rs148417465 22:24665282 22 24665282
G
A
J 0.064989
-0.78 0.46 0.59 0.19

251
rs148417465 22:24665282 22 24665282
G
A
L 0.007367 0.64 1.90 3.35 0.85
rs148417465 22:24665282 22 24665282
G
A
H 0.027333
-0.83 0.43 3.33 0.80
rs5760491 22:24995134 22 24995134
G
T
C 0.382492 0.06 1.07 0.10 0.53
rs5760491 22:24995134 22 24995134
G
T
W 0.374248
-0.17 0.85 0.21 0.43
rs5760491 22:24995134 22 24995134
G
T
B 0.255654 0.32 1.37 0.29 0.27
rs5760491 22:24995134 22 24995134
G
T
J 0.337882
-0.24 0.79 0.25 0.34
rs5760491 22:24995134 22 24995134
G
T
L 0.455222 0.20 1.22 0.16 0.21
rs5760491 22:24995134 22 24995134
G
T
H 0.410561 0.56 1.75 0.47 0.23
rs2006094 22:24997086 22 24997086
G
A
C 0.428706 0.05 1.05 0.10 0.63
rs2006094 22:24997086 22 24997086
G
A
W 0.389685
-0.10 0.91 0.20 0.64
rs2006094 22:24997086 22 24997086
G
A
B 0.504983 0.18 1.19 0.28 0.52
rs2006094 22:24997086 22 24997086
G
A
J 0.342701
-0.22 0.80 0.24 0.37
rs2006094 22:24997086 22 24997086
G
A
L 0.482314 0.15 1.17 0.16 0.33
rs2006094 22:24997086 22 24997086
G
A
H 0.424417 0.51 1.66 0.45 0.26
rs2330805 22:24998619 22 24998619
A
G
C 0.465831
-0.03 0.97 0.10 0.76
rs2330805 22:24998619 22 24998619
A
G
W 0.397851
-0.11 0.89 0.21 0.58
rs2330805 22:24998619 22 24998619
A
G
B 0.733778
-0.28 0.76 0.32 0.38
rs2330805 22:24998619 22 24998619
A
G
J 0.345165
-0.20 0.82 0.24 0.41
rs2330805 22:24998619 22 24998619
A
G
L 0.499891 0.09 1.09 0.16 0.59
rs2330805 22:24998619 22 24998619
A
G
H 0.424147 0.49 1.64 0.44 0.27
rs738409 22:44324727 22 44324727
C
G
C 0.364195 0.26 1.30 0.10 0.01
rs738409 22:44324727 22 44324727
C
G
W 0.232374 0.60 1.82 0.21 0.01
rs738409 22:44324727 22 44324727
C
G
B 0.134431
-0.01 0.99 0.39 0.97
rs738409 22:44324727 22 44324727
C
G
J 0.485266 0.26 1.29 0.22 0.24
rs738409 22:44324727 22 44324727
C
G
L 0.475431 0.18 1.20 0.15 0.23
rs738409 22:44324727 22 44324727
C
G
H 0.313381
-0.05 0.95 0.43 0.90
rs2294915 22:44340904 22 44340904
C
T
C 0.372273 0.27 1.31 0.10 0.01
rs2294915 22:44340904 22 44340904
C
T
W 0.243702 0.56 1.75 0.21 0.01
rs2294915 22:44340904 22 44340904
C
T
B 0.174018
-0.27 0.76 0.37 0.46
rs2294915 22:44340904 22 44340904
C
T
J 0.479816 0.31 1.36 0.22 0.16
rs2294915 22:44340904 22 44340904
C
T
L 0.479699 0.22 1.25 0.15 0.14

252
rs2294915 22:44340904 22 44340904 C T H 0.313075 0.11 1.12 0.42 0.79

253
Appendix Q. Association from the replication analysis of alcohol-associated liver disease among MEC participants without
existing chronic conditions impacting the liver by the combined and self-identified race and ethnicity
rsid
Chromosome
:Position
Chromosom
e Position
Reference
Allele
Alternative
Allele Ethnicity
Allele
Frequency Coefficient Odds Ratio
Standard
Error P-value
rs10433937 4:88230100 4 88230100 T G C 0.221662 0.06 1.06 0.12 0.64
rs10433937 4:88230100 4 88230100 T G W 0.266869 0.21 1.23 0.20 0.31
rs10433937 4:88230100 4 88230100 T G B 0.09147 0.20 1.22 0.46 0.67
rs10433937 4:88230100 4 88230100 T G J 0.340487 0.03 1.03 0.23 0.91
rs10433937 4:88230100 4 88230100 T G L 0.13931 -0.22 0.81 0.27 0.42
rs10433937 4:88230100 4 88230100 T G H 0.458987 -0.08 0.92 0.40 0.84
rs13147616 4:146791129 4 1.47E+08 C A C 0.273949 -0.15 0.86 0.12 0.21
rs13147616 4:146791129 4 1.47E+08 C A W 0.164637 -0.19 0.83 0.27 0.49
rs13147616 4:146791129 4 1.47E+08 C A B 0.048406 -1.01 0.36 0.92 0.27
rs13147616 4:146791129 4 1.47E+08 C A J 0.358044 0.02 1.02 0.23 0.93
rs13147616 4:146791129 4 1.47E+08 C A L 0.361889 -0.14 0.87 0.18 0.41
rs13147616 4:146791129 4 1.47E+08 C A H 0.390475 -0.54 0.59 0.44 0.22
rs10024759 4:146797538 4 1.47E+08 A G C 0.474756 -0.16 0.85 0.10 0.11
rs10024759 4:146797538 4 1.47E+08 A G W 0.451982 0.15 1.16 0.19 0.43
rs10024759 4:146797538 4 1.47E+08 A G B 0.42178 -0.68 0.51 0.32 0.03
rs10024759 4:146797538 4 1.47E+08 A G J 0.364006 <0.01 1.00 0.23 0.99
rs10024759 4:146797538 4 1.47E+08 A G L 0.55923 -0.30 0.74 0.17 0.07
rs10024759 4:146797538 4 1.47E+08 A G H 0.502874 -0.39 0.68 0.39 0.32
rs1183910 12:121420807 12 1.21E+08 G A C 0.339476 -0.17 0.85 0.10 0.11
rs1183910 12:121420807 12 1.21E+08 G A W 0.343719 -0.50 0.61 0.22 0.02
rs1183910 12:121420807 12 1.21E+08 G A B 0.125313 -0.46 0.63 0.47 0.33
rs1183910 12:121420807 12 1.21E+08 G A J 0.479613 0.04 1.04 0.21 0.85
rs1183910 12:121420807 12 1.21E+08 G A L 0.340851 -0.05 0.95 0.17 0.75
rs1183910 12:121420807 12 1.21E+08 G A H 0.333372 0.08 1.08 0.40 0.84
rs28929474 14:94844947 14 94844947 C T C 0.006533 0.67 1.95 0.47 0.16
rs28929474 14:94844947 14 94844947 C T W 0.013591 1.38 3.98 0.58 0.02
rs28929474 14:94844947 14 94844947 C T B 0.00349 1.85 6.33 1.41 0.19

254
rs28929474 14:94844947 14 94844947
C
T
J 1.43E
-05
-862.15 0.00 219787.80 0.99
rs28929474 14:94844947 14 94844947
C
T
L 0.006113
-166.66
<0.0
1 418.44 0.69
rs28929474 14:94844947 14 94844947
C
T
H 0.007543
-6151.03 0.00 631549.37 0.99
rs10401969 19:19407718 19 19407718
T
C
C 0.087807 0.11 1.12 0.16 0.48
rs10401969 19:19407718 19 19407718
T
C
W 0.073295
-0.44 0.65 0.41 0.28
rs10401969 19:19407718 19 19407718
T
C
B 0.182555 0.31 1.37 0.31 0.31
rs10401969 19:19407718 19 19407718
T
C
J 0.108794 0.15 1.17 0.34 0.65
rs10401969 19:19407718 19 19407718
T
C
L 0.046359
<
-0.0
1 1.00 0.40 0.99
rs10401969 19:19407718 19 19407718
T
C
H 0.135678 0.80 2.22 0.52 0.13
rs3794991 19:19610596 19 19610596
C
T
C 0.079259
-0.09 0.91 0.18 0.61
rs3794991 19:19610596 19 19610596
C
T
W 0.079592
-0.36 0.70 0.39 0.35
rs3794991 19:19610596 19 19610596
C
T
B 0.074423
-0.38 0.68 0.61 0.53
rs3794991 19:19610596 19 19610596
C
T
J 0.116973
-0.03 0.97 0.34 0.93
rs3794991 19:19610596 19 19610596
C
T
L 0.047481
-0.27 0.77 0.44 0.55
rs3794991 19:19610596 19 19610596
C
T
H 0.168274 0.68 1.97 0.48 0.16
rs73004967 19:19717056 19 19717056
A
G
C 0.027222
-0.22 0.80 0.32 0.49
rs73004967 19:19717056 19 19717056
A
G
W 0.059014
-0.42 0.66 0.45 0.35
rs73004967 19:19717056 19 19717056
A
G
B 0.026837
-0.94 0.39 1.09 0.39
rs73004967 19:19717056 19 19717056
A
G
J 0.003162
-1984.35
<0.0
1 102933.11 0.98
rs73004967 19:19717056 19 19717056
A
G
L 0.021107
-0.49 0.61 0.74 0.51
rs73004967 19:19717056 19 19717056
A
G
H 0.012706 4.03 56.06 1.43
<0.0
1
rs626283 19:54677001 19 54677001
G
C
C 0.341926
-0.08 0.92 0.11 0.43
rs626283 19:54677001 19 54677001
G
C
W 0.408634
-0.42 0.66 0.20 0.03
rs626283 19:54677001 19 54677001
G
C
B 0.343612
-0.41 0.66 0.33 0.22
rs626283 19:54677001 19 54677001
G
C
J 0.208581 0.20 1.22 0.26 0.44
rs626283 19:54677001 19 54677001
G
C
L 0.354827 0.22 1.25 0.18 0.21
rs626283 19:54677001 19 54677001
G
C
H 0.406731
-0.21 0.81 0.38 0.58
rs148417465 22:24665282 22 24665282
G
A
C 0.019587
-0.26 0.77 0.48 0.59
rs148417465 22:24665282 22 24665282
G
A
W 0.006141 2.99 19.84 2.47 0.23
rs148417465 22:24665282 22 24665282
G
A
B 0.005207 5.84 342.23 3.36 0.08
rs148417465 22:24665282 22 24665282
G
A
J 0.066957
-0.81 0.45 0.60 0.18

255
rs148417465 22:24665282 22 24665282
G
A
L 0.008071 1.20 3.31 2.87 0.68
rs148417465 22:24665282 22 24665282
G
A
H 0.027965
-0.43 0.65 2.51 0.86
rs5760491 22:24995134 22 24995134
G
T
C 0.38061 0.01 1.01 0.10 0.95
rs5760491 22:24995134 22 24995134
G
T
W 0.368341
-0.05 0.95 0.20 0.80
rs5760491 22:24995134 22 24995134
G
T
B 0.247798 0.22 1.25 0.32 0.49
rs5760491 22:24995134 22 24995134
G
T
J 0.339386
-0.19 0.83 0.25 0.46
rs5760491 22:24995134 22 24995134
G
T
L 0.453586 0.02 1.02 0.17 0.90
rs5760491 22:24995134 22 24995134
G
T
H 0.390663 0.49 1.63 0.45 0.27
rs2006094 22:24997086 22 24997086
G
A
C 0.430867
-0.01 0.99 0.10 0.95
rs2006094 22:24997086 22 24997086
G
A
W 0.385495 0.00 1.00 0.20 0.98
rs2006094 22:24997086 22 24997086
G
A
B 0.503516
-0.03 0.97 0.31 0.92
rs2006094 22:24997086 22 24997086
G
A
J 0.344006
-0.17 0.84 0.25 0.50
rs2006094 22:24997086 22 24997086
G
A
L 0.483126 0.01 1.01 0.17 0.93
rs2006094 22:24997086 22 24997086
G
A
H 0.406106 0.42 1.53 0.43 0.33
rs2330805 22:24998619 22 24998619
A
G
C 0.469988
-0.08 0.92 0.11 0.46
rs2330805 22:24998619 22 24998619
A
G
W 0.393327
<
-0.0
1 1.00 0.20 0.99
rs2330805 22:24998619 22 24998619
A
G
B 0.738513
-0.81 0.45 0.36 0.03
rs2330805 22:24998619 22 24998619
A
G
J 0.346109
-0.15 0.86 0.25 0.55
rs2330805 22:24998619 22 24998619
A
G
L 0.499997
-0.03 0.97 0.17 0.87
rs2330805 22:24998619 22 24998619
A
G
H 0.406075 0.42 1.52 0.43 0.32
rs738409 22:44324727 22 44324727
C
G
C 0.365062 0.23 1.26 0.10 0.03
rs738409 22:44324727 22 44324727
C
G
W 0.233714 0.45 1.56 0.21 0.04
rs738409 22:44324727 22 44324727
C
G
B 0.141988
-0.51 0.60 0.46 0.27
rs738409 22:44324727 22 44324727
C
G
J 0.49281 0.10 1.10 0.22 0.66
rs738409 22:44324727 22 44324727
C
G
L 0.47368 0.37 1.45 0.17 0.03
rs738409 22:44324727 22 44324727
C
G
H 0.298606
-0.08 0.92 0.43 0.85
rs2294915 22:44340904 22 44340904
C
T
C 0.374666 0.22 1.25 0.10 0.03
rs2294915 22:44340904 22 44340904
C
T
W 0.245317 0.37 1.44 0.21 0.09
rs2294915 22:44340904 22 44340904
C
T
B 0.183821
-0.63 0.53 0.43 0.14
rs2294915 22:44340904 22 44340904
C
T
J 0.486721 0.15 1.17 0.22 0.49
rs2294915 22:44340904 22 44340904
C
T
L 0.479172 0.39 1.48 0.17 0.02

256
rs2294915 22:44340904 22 44340904 C T H 0.305794 0.05 1.05 0.42 0.91

257
Appendix R. Polygenic risk score, per standard deviation increase, and its association with alcoholrelated liver cirrhosis in the MEC.
Unweighted
Approach
Internal Multiethnic
Weights
Case/Control OR (95% CI) OR (95% CI)
Combined 240/2,400 1.18 (1.03,1.36) 1.30 (1.13,1.49)
White 57/570 1.10 (0.83,1.45) 1.22 (0.94,1.60)
African American/
Black
31/310 1.36 (0.91,2.04) 1.20 (0.83,1.74)
Japanese American 40/400 1.10 (0.79,1.52) 1.48 (1.05,2.07)
Native Hawaiian 11/110 1.16 (0.57,2.35) 1.09 (0.55,2.16)
Latino 101/1,010 1.24 (1.00,1.52) 1.33 (1.08,1.65)
Appendix S. Polygenic risk score, per standard deviation increase, and its association with alcoholassociated liver in the MEC adjusting for alcohol intake.
Unweighted
Approach
Internal Multiethnic
Weights
Case/Control OR (95% CI) OR (95% CI)
Combined 309/3,105 1.18 (1.05,1.33) 1.28 (1.13,1.44)
White 76/753 1.31 (1.03,1.66) 1.38 (1.08,1.75)
African American/
Black
39/405 1.22 (0.86,1.72) 1.30 (0.93,1.83)
Japanese American 56/577 1.02 (0.72,1.34) 1.19 (0.89,1.57)
Native Hawaiian 18/186 1.26 (0.76,2.10) 1.10 (0.66,1.83)
Latino 120/1,184 1.19 (0.98,1.44) 1.32 (1.09,1.60)

258
Appendix T. Polygenic risk score, per standard deviation increase, and its association with alcoholassociated liver in the MEC among those with 12 months or more continuous coverage of Medicare
Fee-For-Service.
Unweighted
Approach
Internal Multiethnic
Weights
Case/Control OR (95% CI) OR (95% CI)
Combined 282/2,618 1.23 (1.08,1.40) 1.29 (1.14,1.47)
White 67/660 1.17 (0.91,1.51) 1.51 (1.16,1.96)
African American/
Black
38/322 1.28 (0.90,1.81) 1.35 (0.94,1.93)
Japanese American 54/561 1.11 (0.83,1.47) 1.17 (0.88,1.56)
Native Hawaiian 17/163 1.26 (0.76,2.10) 1.08 (0.64,1.83)
Latino 106/912 1.34 (1.08,1.65) 1.28 (1.04,1.57)
Appendix U. Polygenic risk score, per standard deviation increase, and its association with alcoholassociated liver in the MEC among those without chronic conditions impacting the liver.
Unweighted
Approach
Internal Multiethnic
Weights
Case/Control OR (95% CI) OR (95% CI)
Combined 256/3,061 1.25 (1.09,1.43) 1.28 (1.12,1.46)
White 69/743 1.42 (1.09,1.85) 1.52 (1.18,1.95)
African American/
Black
32/398 1.94 (1.29,2.92) 1.70 (1.16,2.51)
Japanese American 51/578 1.06 (0.79,1.42) 1.09 (0.81,1.46)
Native Hawaiian 18/181 1.03 (0.61,1.73) 0.97 (0.58,1.64)
Latino 86/1,161 1.17 (0.93,1.47) 1.23 (0.99,1.54)

259
Appendix V. On- and off-premise population-based alcohol outlets in Hawaii (A and B), and Los
Angeles County, California (C and D) by census block group.

Abstract (if available)

Abstract Despite the relative stability of alcohol consumption over time, the harms associated with alcohol use have escalated. Employing a multi-level approach in population health research provides insights into how factors ranging from the proximal (e.g., genetics) to the distal (e.g., neighborhood environments and policy) can influence health outcomes and disparities. This dissertation leverages multi-level data within a multiethnic population, with alcohol consumption serving as the unifying theme across three distinct projects.

The first project examines the relationship between alcohol consumption and the density of on- and oﬀ-premise alcohol outlets—retail locations where alcohol is sold—while exploring potential differences by sex and race/ethnicity. The second project investigates circulating microRNAs at the molecular level to determine their association with alcohol consumption, as well as the potential modification of these effects by various demographic and lifestyle factors. The third project focuses on existing genome-wide association studies (GWAS) related to alcohol-associated liver disease, replicating and validating these findings within a multiethnic cohort. The final chapter synthesizes the main findings from each project, discusses their public health significance, and outlines directions for future research.

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Asset Metadata

Creator Acuna, Nicholas Sebastian (author)

Core Title The role of alcohol and alcohol-related risk factors in population health using a multi-level approach

School Keck School of Medicine

Degree Doctor of Philosophy

Degree Program Epidemiology

Degree Conferral Date 2024-08

Publication Date 09/05/2024

Defense Date 09/04/2024

Publisher Los Angeles, California (original), University of Southern California (original), University of Southern California. Libraries (digital)

Tag alcohol,alcohol liver disease,alcohol outlet,cohort,Epidemiology,microRNA,multi-level,polygenic risk score

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Language English

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Advisor Setiawan, Veronica Wendy (committee chair), Cheng, Iona (committee member), Conti, David V. (committee member), Stern, Mariana C. (committee member), Wu, Anna H. (committee member)

Creator Email acuna.nicholas@gmail.com,nacuna@usc.edu

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