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Synthesis of peptides, peptidomimetics, aminopolyols, and aza -sugars from organoboronic acids, amines and carbonyl compounds
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Atropisomerism In Sterically Hindered Carbocations
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Synthetic studies of chemical probes for i) DNA, ii) RNA polymerases and iii) tropomyosin receptor kinase
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Synthesis of fluorescent conjugates of risedronate and related analogues for bone imaging
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Deoxynucleotide analog probes and model compounds for studying DNA polymerase structure and mechanism: synthesis and evaluation of alkyl-, azido-, and halomethylene bisphosphonate-substituted tri...
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Development of predictive electronic structure methods and their application to atmospheric chemistry, combustion, and biologically relevant systems
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Studies of molecular orientation using iridium phosphors and integration of corannulene into organic light emitting diodes (OLEDs)
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Motions and conformations of nucleic acids studied using site-directed spin labeling
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An organic chemistry approach toward the synthesis of valuable biological compounds: synthetic progress toward the Palmerolide A subunits, expeditious enyne coupling via alkynes, and development ...
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Molecular and computational analysis of spin-labeled nucleic acids and proteins
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Synthesis of multifunctional heterocycles, amino phosphontes using boronic acids
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Fluorinated probes of enzyme mechanisms
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Deoxyribonucleoside triphosphate analogues for inhibition of therapeutically important enzymes
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Synthesis, structural analysis and in vitro antiviral activities of novel cyclic and acyclic (S)-HPMPA and (S)-HPMPC tyrosinamide prodrugs
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Multicomponent reactions of allenyl and alkynyl boron derivatives with amines and aldehydes and their use in the synthesis of novel multifunctional amines and heterocycles
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Progess towards the total synthesis of the antifungal natural product (-)-pramanicin
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New organoboron based multicomponent methodologies for the synthesis of novel heterocycles
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Nucleophilic fluorination of bisphosphonates and its application in PET imaging
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DNA polymerase mechanism and fidelity: using β,γ-bridging oxygen substituted dNTPs to study the mechanism of DNA polymerase β
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Peptidomimetic prodrugs of cidofovir: design, synthesis, transport, mechanism of activation, and antiviral activity
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Sensing sequence-specific DNA micro-environment with nucleotide-independent nitroxides
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Assembling NRPS modules in e. coli to establish a platform for rational design of biologically active compounds
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Computational construction and analysis of DNA and RNA
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