This dissertation focuses on the studies toward total synthesis of palmerolide A, preparation of ligands for rhodium catalyzed C-H activation reaction. Preparation of NHC-Pd (II) catalyst and the application in the conversion of biomass into formic acid.; In chapter 1, different schemes were discussed in the synthesis of subunits of palmerolide A.; In chapter 2, ligands were prepared and used in Rhodium (II) catalyzed C-H desymmetrization reactions. Preparation of intermediates were discussed in the synthesis of kainic acid and allokainic acid.; In chapter 3, Preparation of NHC-Pd catalyst and its application in the conversion of biomass into formic acid was discussed. Oxidative degradation of biomass in presence of cationic palladium was also discussed.; In chapter 4, oxidative degradation of carbohydrates under mild conditions in presence of hydrogen peroxide and ammonium hydroxide was discussed.