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analyses characterizing the cohort, and reported combinations of tumor sites reported for each individual report combinations of sites. We identified AYA cancer survivors cancer based on the reported the age of cancer diagnosis. However, the question about the age of cancer diagnosis in MEPs was asked only on surveys from 2008 to 2012, limiting survey years for which AYA cancers could be identified. In an effort to maintain confidentiality, diagnoses at rare cancer sites were scored as “Other cancer”. Criteria used to score a site as rare differed between survey years, with a frequency count of fewer than four tumors in MEPS used from 2008 to 2011. In 2012, rare cancers were those with a frequency count of fewer than 20 and those clinically rare cancers at any age classified by National Health Institution (NIH): cancers of bone, esophagus, kidney, larynx, liver, mouth, ovary, pancreas, rectum, stomach, testis, and uterus... Consequently 2012, the diagnosis of testis cancer was coded “other cancer” , despite being the most common AYA cancer in males.
Comparison groups
We obtained data on incident cancer diagnosed at AYA ages from the CDC Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) databases. CDC WONDER provides cancer incidence data from selected statewide and metropolitan area cancer registries that meet strict data quality criteria. Cancer case reports in this data set were produced by the Center for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI), and verified by medical doctors ("United States Cancer Statistics: Incidence Public Information Data"). Incidence data are available from 1999 to 2016 and can be accessed by year, state, metropolitan area, age group, race, ethnicity, sex, and classification of cancer sites.
We obtained information on prevalent cancers diagnoses at AYA ages from CANCER TODAY, a part of the project of the World Health Organization (WHO). The cancer cases were collected from cancer registries in forty-six states in the United States ("Cancer today").
Object Description
| Title | A comparison of three different sources of data in assessing the adolescent and young adults cancer survivors |
| Author | Chen, Irene Jiayao |
| Author email | jiayaoch@usc.edu;jiayaoch@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Applied Biostatistics and Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2020-08-07 |
| Date submitted | 2020-08-07 |
| Date approved | 2020-08-08 |
| Restricted until | 2020-08-08 |
| Date published | 2020-08-08 |
| Advisor (committee chair) | Cortessis, Victoria |
| Advisor (committee member) |
Miller, Kimberly Farias, Albert |
| Abstract | Relatively limited data resources are available to study Adolescent and Young Adults (AYA) cancers. We created an AYA cancer survivor cohort by identifying survivors (N=1,142) who were 15 to 39 years of age at the time of their first cancer diagnosis, excluding diagnoses of nonmelanoma skin cancers. We characterized the occurrence of incident cancers in the CDC WONDER, prevalent cancers in the Cancer Today and AYA MEPS according to the absolute number and relative frequency of primary cancers diagnosed at ages 15-39 years of age. We compared the distribution of demographic features and cancer types between the three data resources concerning relative frequency. We found an enormous distortion of the sex ratio of survivors, with female cancer survivors overrepresented. Among females diagnosed in the AYA age range, there was a clear overrepresentation of reproductive cancers, such as cervical, ovarian, and corpus uterus. The numerous limitations of MEPS AYA cohort data, lack of representativeness, inaccuracies in the diagnostic data, and readily anticipated based on methodology, emphasize the need for a nationally representative data resource of AYA cancers. |
| Keyword | adolescent and young adult cancers; diagnostic data; limitations |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Chen, Irene Jiayao |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-ChenIreneJ-8901.pdf |
| Archival file | Volume13/etd-ChenIreneJ-8901.pdf |
Description
| Title | Page 9 |
| Full text | 4 analyses characterizing the cohort, and reported combinations of tumor sites reported for each individual report combinations of sites. We identified AYA cancer survivors cancer based on the reported the age of cancer diagnosis. However, the question about the age of cancer diagnosis in MEPs was asked only on surveys from 2008 to 2012, limiting survey years for which AYA cancers could be identified. In an effort to maintain confidentiality, diagnoses at rare cancer sites were scored as “Other cancer”. Criteria used to score a site as rare differed between survey years, with a frequency count of fewer than four tumors in MEPS used from 2008 to 2011. In 2012, rare cancers were those with a frequency count of fewer than 20 and those clinically rare cancers at any age classified by National Health Institution (NIH): cancers of bone, esophagus, kidney, larynx, liver, mouth, ovary, pancreas, rectum, stomach, testis, and uterus... Consequently 2012, the diagnosis of testis cancer was coded “other cancer” , despite being the most common AYA cancer in males. Comparison groups We obtained data on incident cancer diagnosed at AYA ages from the CDC Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) databases. CDC WONDER provides cancer incidence data from selected statewide and metropolitan area cancer registries that meet strict data quality criteria. Cancer case reports in this data set were produced by the Center for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI), and verified by medical doctors ("United States Cancer Statistics: Incidence Public Information Data"). Incidence data are available from 1999 to 2016 and can be accessed by year, state, metropolitan area, age group, race, ethnicity, sex, and classification of cancer sites. We obtained information on prevalent cancers diagnoses at AYA ages from CANCER TODAY, a part of the project of the World Health Organization (WHO). The cancer cases were collected from cancer registries in forty-six states in the United States ("Cancer today"). |
