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INFLUENCE OF ENDOGENOUS AND EXOGENOUS ESTROGEN
ON SKELETAL MUSCLE DAMAGE AND SYSTEMIC INFLAMMATION
AFTER ELECTRICALLY STIMULATED CONTRACTION
IN YOUNG WOMEN
By
Lindsey Jayne Anderson
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOKINESIOLOGY)
August 2015
Copyright 2015 Lindsey Jayne Anderson
Object Description
| Title | Influence of endogenous and exogenous estrogen on skeletal muscle damage and systemic inflammation after electrically stimulated contraction in young women |
| Author | Anderson, Lindsey Jayne |
| Author email | lindseja@usc.edu;cheerblondie@comcast.net |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biokinesiology and Physical Therapy |
| School | School of Dentistry |
| Date defended/completed | 2015-05-13 |
| Date submitted | 2015-07-06 |
| Date approved | 2015-07-06 |
| Restricted until | 2015-07-06 |
| Date published | 2015-07-06 |
| Advisor (committee chair) | Schroeder, E. Todd |
| Advisor (committee member) |
Baker, Lucinda L. Rice, Judd C. Kutch, Jason J. Dieli-Conwright, Christina |
| Abstract | Exercise is a key regulator of skeletal muscle health as repeated exposure to acute bouts of exercise constitutes muscular adaptation to exercise training. The influence of estrogen on acute exercise-induced muscle damage may provide insight into whether premenopausal estrogen has the potential to influence muscle adaptation over time. This study compared acute contraction-induced muscle damage during exogenous (oral contraceptive; OC, N=9), endogenous (HI, N=9), and low estrogen (LO, N=8) in healthy young women. Participants performed one bout of neuromuscular electrical stimulation (NMES) on the left quadriceps. Soreness was measured with a 100-mm Visual Analog Scale (VAS), a 0-6 point Likert Scale of Muscle Soreness for Lower Limb (LSMSLL), and a 1-10 point LSMSLL at baseline, Follow-up 1 (2 days post-NMES) and Follow-up 2 (4-5 days post-NMES). Strength was measured by maximal voluntary isometric contraction (MVIC) at baseline, immediately post-NMES, and Follow-ups 1 and 2. The NMES bout consisted of a resting blood draw, baseline MVIC, NMES, immediate-post blood draw, and immediate-post MVIC. NMES occurred during the mid-luteal phase for HI, menses for LO, or mid-cycle for OC; measured 17-β estradiol (E2) in LO was not statistically significantly less than HI. Systemic myoglobin (Mb) and lactate dehydrogenase (LDH) were measured to estimate muscle fiber damage and interleukin- (IL)-6, IL-8, and granulocyte-colony stimulating factor (G-CSF) were measured to estimate inflammation. Work performed during NMES was similar across groups. There was a significant effect of Time for Mb and LDH (p≤0.02). E2 was negatively correlated with relative change in Mb (R=-0.52; p<0.05). Effect sizes were greater in LO than OC or HI for change in Mb, IL-8, and G-CSF. There was a significant effect of Time for MVIC (%) (p=0.007), relative strength significantly decreased immediately after NMES compared to Baseline (p<0.001). VAS and LSMSLL scores increased at Follow-up 1 (p<0.001). Mean change score for LSMSLL (0-6) was clinically greater in LO than OC, and trended for being clinically greater than HI (0.9 points), at Follow-up 1. Mean change score for LSMSLL (1-10) at Follow-up 1 was clinically greater in LO than OC or HI. Acute NMES-induced indicators of muscle fiber damage and qualitative muscle soreness may be attenuated during the luteal phase or active OC pill consumption compared to the menstrual phase. |
| Keyword | exercise; skeletal muscle; muscle damage; estrogen; estradiol; oral contraceptives; young women; ethinyl estradiol |
| Language | English |
| Format (imt) | application/pdf |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Anderson, Lindsey Jayne |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-AndersonLi-3540.pdf |
| Archival file | Volume2/etd-AndersonLi-3540.pdf |
Description
| Title | Page 1 |
| Repository email | cisadmin@lib.usc.edu |
| Full text | INFLUENCE OF ENDOGENOUS AND EXOGENOUS ESTROGEN ON SKELETAL MUSCLE DAMAGE AND SYSTEMIC INFLAMMATION AFTER ELECTRICALLY STIMULATED CONTRACTION IN YOUNG WOMEN By Lindsey Jayne Anderson A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOKINESIOLOGY) August 2015 Copyright 2015 Lindsey Jayne Anderson |
