Demethylation and reactivation of growth regulatory genes by 5-Aza-2'-deoxycytidine in human neoplasia. - Page 11 |
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F ig. 3.14 Heritability of 5-Aza-CdR-mediated cell growth 144
suppression.
F ig. 3.15 Analysis of heritability of 5-Aza-CdR-mediated cell 146
growth suppression.
F ig. 3.16 Heritability of 5-Aza-CdR-mediated p16 induction in 147
T24 cells.
Fig. 3.17 Heritability of demethylation by 5-Aza-CdR. 149
Fig. 3.18 Relationship between p16 induction and p16 151
promoter demethylation.
Fig. 3.19 Reactivation of p 16 by 5-Aza-CdR in vivo. 153
Fig. 3.20 Effects of 5-Aza-CdR on tumorigenicity in vivo. 155
Fig. 3.21 p16 expression in tumors induced by T24 cells 157
treated with 5-Aza-CdR.
F ig. 4.1 Cytotoxicity of cytidine analogs. 176
F ig. 4.2 Immediate effects of cytidine analogs on growth 177
suppression in T24 cells.
F ig. 4.3 Effects of 5-Aza-CdR and 'FICR on cell morphology. 179
F ig. 4.4 Kinetics of p16 activation by cytidine analogs. 182
F ig. 4.5 Kinetics of p16 promoter demethylation by 5- 184
Aza-CdR.
Fig. 4.6 Demethylation of the p16 promoter by 5-Aza-CdR. 187
Fig. 4.7 Model for the mechanism of DNA demethylation by 190
5-Aza-CdR.
Fig. 4.8 Timing of p16 promoter demethylation by cytidine 193
analogs.
F ig. 4.9 CpG distributions in the p16, PAX6, c-Abl, and 197
Myf3 exonic sequences.
ix
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| Title | Demethylation and reactivation of growth regulatory genes by 5-Aza-2'-deoxycytidine in human neoplasia. - Page 11 |
| Repository email | cisadmin@lib.usc.edu |
| Full text | F ig. 3.14 Heritability of 5-Aza-CdR-mediated cell growth 144 suppression. F ig. 3.15 Analysis of heritability of 5-Aza-CdR-mediated cell 146 growth suppression. F ig. 3.16 Heritability of 5-Aza-CdR-mediated p16 induction in 147 T24 cells. Fig. 3.17 Heritability of demethylation by 5-Aza-CdR. 149 Fig. 3.18 Relationship between p16 induction and p16 151 promoter demethylation. Fig. 3.19 Reactivation of p 16 by 5-Aza-CdR in vivo. 153 Fig. 3.20 Effects of 5-Aza-CdR on tumorigenicity in vivo. 155 Fig. 3.21 p16 expression in tumors induced by T24 cells 157 treated with 5-Aza-CdR. F ig. 4.1 Cytotoxicity of cytidine analogs. 176 F ig. 4.2 Immediate effects of cytidine analogs on growth 177 suppression in T24 cells. F ig. 4.3 Effects of 5-Aza-CdR and 'FICR on cell morphology. 179 F ig. 4.4 Kinetics of p16 activation by cytidine analogs. 182 F ig. 4.5 Kinetics of p16 promoter demethylation by 5- 184 Aza-CdR. Fig. 4.6 Demethylation of the p16 promoter by 5-Aza-CdR. 187 Fig. 4.7 Model for the mechanism of DNA demethylation by 190 5-Aza-CdR. Fig. 4.8 Timing of p16 promoter demethylation by cytidine 193 analogs. F ig. 4.9 CpG distributions in the p16, PAX6, c-Abl, and 197 Myf3 exonic sequences. ix |
