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63 Song, Z., et al., Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum. Chembiochem, 2004. 5(9): p. 1196-1203. Tsai, S.-C., et al., Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel. Proceedings of the National Academy of Sciences of the United States of America, 2001. 98(26): p. 14808-14813. Tsai, S.-C., et al., Insights into Channel Architecture and Substrate Specificity from Crystal Structures of Two Macrocycle-Forming Thioesterases of Modular Polyketide Synthases†,‡. Biochemistry, 2002. 41(42): p. 12598-12606. Xie, X., et al., Acyltransferase Mediated Polyketide Release from a Fungal Megasynthase. Journal of the American Chemical Society, 2009. 131(24): p. 8388-8389. Wang, M., et al., A Thioesterase from an Iterative Fungal Polyketide Synthase Shows Macrocyclization and Cross Coupling Activity and May Play a Role in Controlling Iterative Cycling through Product Offloading. Biochemistry, 2009. 48(27): p. 6288-6290. Watanabe, C.M.H. and C.A. Townsend, Initial Characterization of a Type I Fatty Acid Synthase and Polyketide Synthase Multienzyme Complex NorS in the Biosynthesis of Aflatoxin B1. Chemistry & biology, 2002. 9(9): p. 981-988. Watanabe, A. and Y. Ebizuka, Unprecedented Mechanism of Chain Length Determination in Fungal Aromatic Polyketide Synthases. Chemistry & biology, 2004. 11(8): p. 1101-1106. Weissman, K.J., Peering into the Black Box of Fungal Polyketide Biosynthesis. Chembiochem, 2010. 11(4): p. 485-488. Yadav, G., R.S. Gokhale, and D. Mohanty, Towards Prediction of Metabolic Products of Polyketide Synthases: An <italic>In Silico</italic> Analysis. PLoS Comput Biol, 2009. 5(4): p. e1000351. Zhou, H., et al., A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences, 2008. 105(17): p. 6249-6254. Zhu, X., et al., Production of Dihydroisocoumarins in Fusarium verticillioides by Swapping Ketosynthase Domain of the Fungal Iterative Polyketide Synthase Fum1p with That of Lovastatin Diketide Synthase. Journal of the American Chemical Society, 2006. 129(1): p. 36-37.
Object Description
Title | Fungal polyketides -- Review of recent findings |
Author | Jain, Sofina M. |
Author email | sofinaja@usc.edu; sofinajain27@gmail.com |
Degree | Master of Science |
Document type | Thesis |
Degree program | Pharmacy / Pharmaceutical Sciences |
School | School of Pharmacy |
Date defended/completed | 2011-05-04 |
Date submitted | 2011 |
Restricted until | Unrestricted |
Date published | 2011-05-05 |
Advisor (committee chair) | Wang, Clay C. C. |
Advisor (committee member) |
Okamoto, Curtis Toshio Shen, Wei-Chiang |
Abstract | Fungal polyketides are a group of bioactive compounds which have found use in humans as anti-cholesterol, anti-cancer and antibiotic agents. These are synthesized by a group of enzymes called the polyketide synthases (PKSs) which are found in fungi as well as bacteria. PKSs are classified as type I, II and III. All fungal PKSs are type I iterative polyketide synthases which means they use a set of catalytic functions by a group of active domains in repetitive cycles to give the end product. Type I enzymes contain multidomains that catalyze a set of reactions.; The minimal PKS contains the domains ketosynthase (KS), acyltransferase (AT) and acyl carrier protein (ACP). The three types of PKSs are non-reduced polyketide synthases (NR-PKSs), highly-reduced polyketide synthases (HR-PKSs) and partially-reduced polyketide synthases (PR-PKSs). This classification is another form separate from type I, II and III. This paper discusses the recent research into further details of the SAT, PT and TE domain of the NR-PKSs and also recent advances in the HR-PKSs. This paper will also discuss the role of NADPH, SAM and CON domain in the HR-PKSs. We will also discuss the two off-loading mechanism of HR-PKSs that were seen in recent papers. While little research is done on PR-PKSs, NR-PKS and HR-PKS are extensively being worked on.Recent findings have brought us a step closer to the domains of the PKSs and promise us a better clearer understanding of this complex multidomain entity. |
Keyword | fungal polyketides; HR-PKS; NR-PKS; PT domain; SAT domain; TE domain |
Language | English |
Part of collection | University of Southern California dissertations and theses |
Publisher (of the original version) | University of Southern California |
Place of publication (of the original version) | Los Angeles, California |
Publisher (of the digital version) | University of Southern California. Libraries |
Provenance | Electronically uploaded by the author |
Type | texts |
Legacy record ID | usctheses-m3914 |
Contributing entity | University of Southern California |
Rights | Jain, Sofina M. |
Repository name | Libraries, University of Southern California |
Repository address | Los Angeles, California |
Repository email | cisadmin@lib.usc.edu |
Filename | etd-jain-4552 |
Archival file | uscthesesreloadpub_Volume40/etd-jain-4552.pdf |
Description
Title | Page 69 |
Contributing entity | University of Southern California |
Repository email | cisadmin@lib.usc.edu |
Full text |
63
Song, Z., et al., Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium
venenatum. Chembiochem, 2004. 5(9): p. 1196-1203.
Tsai, S.-C., et al., Crystal structure of the macrocycle-forming thioesterase
domain of the erythromycin polyketide synthase: Versatility from a unique
substrate channel. Proceedings of the National Academy of Sciences of the
United States of America, 2001. 98(26): p. 14808-14813.
Tsai, S.-C., et al., Insights into Channel Architecture and Substrate Specificity
from Crystal Structures of Two Macrocycle-Forming Thioesterases of Modular
Polyketide Synthases†,‡. Biochemistry, 2002. 41(42): p. 12598-12606.
Xie, X., et al., Acyltransferase Mediated Polyketide Release from a Fungal
Megasynthase. Journal of the American Chemical Society, 2009. 131(24): p.
8388-8389.
Wang, M., et al., A Thioesterase from an Iterative Fungal Polyketide Synthase
Shows Macrocyclization and Cross Coupling Activity and May Play a Role in
Controlling Iterative Cycling through Product Offloading. Biochemistry, 2009.
48(27): p. 6288-6290.
Watanabe, C.M.H. and C.A. Townsend, Initial Characterization of a Type I Fatty
Acid Synthase and Polyketide Synthase Multienzyme Complex NorS in the
Biosynthesis of Aflatoxin B1. Chemistry & biology, 2002. 9(9): p. 981-988.
Watanabe, A. and Y. Ebizuka, Unprecedented Mechanism of Chain Length
Determination in Fungal Aromatic Polyketide Synthases. Chemistry & biology,
2004. 11(8): p. 1101-1106.
Weissman, K.J., Peering into the Black Box of Fungal Polyketide Biosynthesis.
Chembiochem, 2010. 11(4): p. 485-488.
Yadav, G., R.S. Gokhale, and D. Mohanty, Towards Prediction of Metabolic
Products of Polyketide Synthases: An |