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59
21. Bruner, S.D., et al., Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE. Structure (London, England : 1993), 2002. 10(3): p. 301-310.
22. Tsai, S.-C., et al., Insights into Channel Architecture and Substrate Specificity from Crystal Structures of Two Macrocycle-Forming Thioesterases of Modular Polyketide Synthases†,‡. Biochemistry, 2002. 41(42): p. 12598-12606.
23. Campbell, C.D. and J.C. Vederas, Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers, 2010. 93(9): p. 755-763.
24. Xie, X., et al., Acyltransferase Mediated Polyketide Release from a Fungal Megasynthase. Journal of the American Chemical Society, 2009. 131(24): p. 8388-8389.
25. Kennedy, J., et al., Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis. Science, 1999. 284(5418): p. 1368-1372.
26. Zhou, H., et al., A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences, 2008. 105(17): p. 6249-6254.
27. Tsai, S.-C., et al., Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel. Proceedings of the National Academy of Sciences of the United States of America, 2001. 98(26): p. 14808-14813.
28. Song, Z., et al., Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum. Chembiochem, 2004. 5(9): p. 1196-1203.
29. Gerber, R., L. Lou, and L. Du, A PLP-Dependent Polyketide Chain Releasing Mechanism in the Biosynthesis of Mycotoxin Fumonisins in Fusarium verticillioides. Journal of the American Chemical Society, 2009. 131(9): p. 3148-3149.
30. Cox, R.J., Polyketides, Proteins and Genes in Fungi: Programmed Nano-Machines Begin to Reveal Their Genes. ChemInform, 2007. 38(40): p. no-no.
Object Description
| Title | Fungal polyketides -- Review of recent findings |
| Author | Jain, Sofina M. |
| Author email | sofinaja@usc.edu; sofinajain27@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Pharmacy / Pharmaceutical Sciences |
| School | School of Pharmacy |
| Date defended/completed | 2011-05-04 |
| Date submitted | 2011 |
| Restricted until | Unrestricted |
| Date published | 2011-05-05 |
| Advisor (committee chair) | Wang, Clay C. C. |
| Advisor (committee member) |
Okamoto, Curtis Toshio Shen, Wei-Chiang |
| Abstract | Fungal polyketides are a group of bioactive compounds which have found use in humans as anti-cholesterol, anti-cancer and antibiotic agents. These are synthesized by a group of enzymes called the polyketide synthases (PKSs) which are found in fungi as well as bacteria. PKSs are classified as type I, II and III. All fungal PKSs are type I iterative polyketide synthases which means they use a set of catalytic functions by a group of active domains in repetitive cycles to give the end product. Type I enzymes contain multidomains that catalyze a set of reactions.; The minimal PKS contains the domains ketosynthase (KS), acyltransferase (AT) and acyl carrier protein (ACP). The three types of PKSs are non-reduced polyketide synthases (NR-PKSs), highly-reduced polyketide synthases (HR-PKSs) and partially-reduced polyketide synthases (PR-PKSs). This classification is another form separate from type I, II and III. This paper discusses the recent research into further details of the SAT, PT and TE domain of the NR-PKSs and also recent advances in the HR-PKSs. This paper will also discuss the role of NADPH, SAM and CON domain in the HR-PKSs. We will also discuss the two off-loading mechanism of HR-PKSs that were seen in recent papers. While little research is done on PR-PKSs, NR-PKS and HR-PKS are extensively being worked on.Recent findings have brought us a step closer to the domains of the PKSs and promise us a better clearer understanding of this complex multidomain entity. |
| Keyword | fungal polyketides; HR-PKS; NR-PKS; PT domain; SAT domain; TE domain |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3914 |
| Contributing entity | University of Southern California |
| Rights | Jain, Sofina M. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-jain-4552 |
| Archival file | uscthesesreloadpub_Volume40/etd-jain-4552.pdf |
Description
| Title | Page 65 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | 59 21. Bruner, S.D., et al., Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE. Structure (London, England : 1993), 2002. 10(3): p. 301-310. 22. Tsai, S.-C., et al., Insights into Channel Architecture and Substrate Specificity from Crystal Structures of Two Macrocycle-Forming Thioesterases of Modular Polyketide Synthases†,‡. Biochemistry, 2002. 41(42): p. 12598-12606. 23. Campbell, C.D. and J.C. Vederas, Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers, 2010. 93(9): p. 755-763. 24. Xie, X., et al., Acyltransferase Mediated Polyketide Release from a Fungal Megasynthase. Journal of the American Chemical Society, 2009. 131(24): p. 8388-8389. 25. Kennedy, J., et al., Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis. Science, 1999. 284(5418): p. 1368-1372. 26. Zhou, H., et al., A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences, 2008. 105(17): p. 6249-6254. 27. Tsai, S.-C., et al., Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel. Proceedings of the National Academy of Sciences of the United States of America, 2001. 98(26): p. 14808-14813. 28. Song, Z., et al., Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum. Chembiochem, 2004. 5(9): p. 1196-1203. 29. Gerber, R., L. Lou, and L. Du, A PLP-Dependent Polyketide Chain Releasing Mechanism in the Biosynthesis of Mycotoxin Fumonisins in Fusarium verticillioides. Journal of the American Chemical Society, 2009. 131(9): p. 3148-3149. 30. Cox, R.J., Polyketides, Proteins and Genes in Fungi: Programmed Nano-Machines Begin to Reveal Their Genes. ChemInform, 2007. 38(40): p. no-no. |
