Page 63 |
Save page Remove page | Previous | 63 of 69 | Next |
|
small (250x250 max)
medium (500x500 max)
Large (1000x1000 max)
Extra Large
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
|
57
REFERENCES
1. Crawford, J.M. and C.A. Townsend, New insights into the formation of fungal aromatic polyketides. Nature Reviews Microbiology, 2010. 8(12): p. 879-889.
2. Chiang, Y.M., et al., Unraveling polyketide synthesis in members of the genus Aspergillus. Applied Microbiology and Biotechnology, 2010. 86(6): p. 1719-1736.
3. Yadav, G., R.S. Gokhale, and D. Mohanty, Towards Prediction of Metabolic Products of Polyketide Synthases: An <italic>In Silico</italic> Analysis. PLoS Comput Biol, 2009. 5(4): p. e1000351.
4. Moffitt, M.C. and B.A. Neilan, Evolutionary Affiliations Within the Superfamily of Ketosynthases Reflect Complex Pathway Associations. Journal of Molecular Evolution, 2003. 56(4): p. 446-457.
5. Graziani, S., C. Vasnier, and M.-J. Daboussi, Novel Polyketide Synthase from Nectria haematococca. Appl. Environ. Microbiol., 2004. 70(5): p. 2984-2988.
6. Zhu, X., et al., Production of Dihydroisocoumarins in Fusarium verticillioides by Swapping Ketosynthase Domain of the Fungal Iterative Polyketide Synthase Fum1p with That of Lovastatin Diketide Synthase. Journal of the American Chemical Society, 2006. 129(1): p. 36-37.
7. Watanabe, A. and Y. Ebizuka, Unprecedented Mechanism of Chain Length Determination in Fungal Aromatic Polyketide Synthases. Chemistry & biology, 2004. 11(8): p. 1101-1106.
8. Wang, M., et al., A Thioesterase from an Iterative Fungal Polyketide Synthase Shows Macrocyclization and Cross Coupling Activity and May Play a Role in Controlling Iterative Cycling through Product Offloading. Biochemistry, 2009. 48(27): p. 6288-6290.
9. Watanabe, C.M.H. and C.A. Townsend, Initial Characterization of a Type I Fatty Acid Synthase and Polyketide Synthase Multienzyme Complex NorS in the Biosynthesis of Aflatoxin B1. Chemistry & biology, 2002. 9(9): p. 981-988.
Object Description
| Title | Fungal polyketides -- Review of recent findings |
| Author | Jain, Sofina M. |
| Author email | sofinaja@usc.edu; sofinajain27@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Pharmacy / Pharmaceutical Sciences |
| School | School of Pharmacy |
| Date defended/completed | 2011-05-04 |
| Date submitted | 2011 |
| Restricted until | Unrestricted |
| Date published | 2011-05-05 |
| Advisor (committee chair) | Wang, Clay C. C. |
| Advisor (committee member) |
Okamoto, Curtis Toshio Shen, Wei-Chiang |
| Abstract | Fungal polyketides are a group of bioactive compounds which have found use in humans as anti-cholesterol, anti-cancer and antibiotic agents. These are synthesized by a group of enzymes called the polyketide synthases (PKSs) which are found in fungi as well as bacteria. PKSs are classified as type I, II and III. All fungal PKSs are type I iterative polyketide synthases which means they use a set of catalytic functions by a group of active domains in repetitive cycles to give the end product. Type I enzymes contain multidomains that catalyze a set of reactions.; The minimal PKS contains the domains ketosynthase (KS), acyltransferase (AT) and acyl carrier protein (ACP). The three types of PKSs are non-reduced polyketide synthases (NR-PKSs), highly-reduced polyketide synthases (HR-PKSs) and partially-reduced polyketide synthases (PR-PKSs). This classification is another form separate from type I, II and III. This paper discusses the recent research into further details of the SAT, PT and TE domain of the NR-PKSs and also recent advances in the HR-PKSs. This paper will also discuss the role of NADPH, SAM and CON domain in the HR-PKSs. We will also discuss the two off-loading mechanism of HR-PKSs that were seen in recent papers. While little research is done on PR-PKSs, NR-PKS and HR-PKS are extensively being worked on.Recent findings have brought us a step closer to the domains of the PKSs and promise us a better clearer understanding of this complex multidomain entity. |
| Keyword | fungal polyketides; HR-PKS; NR-PKS; PT domain; SAT domain; TE domain |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m3914 |
| Contributing entity | University of Southern California |
| Rights | Jain, Sofina M. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-jain-4552 |
| Archival file | uscthesesreloadpub_Volume40/etd-jain-4552.pdf |
Description
| Title | Page 63 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text |
57
REFERENCES
1. Crawford, J.M. and C.A. Townsend, New insights into the formation of fungal aromatic polyketides. Nature Reviews Microbiology, 2010. 8(12): p. 879-889.
2. Chiang, Y.M., et al., Unraveling polyketide synthesis in members of the genus Aspergillus. Applied Microbiology and Biotechnology, 2010. 86(6): p. 1719-1736.
3. Yadav, G., R.S. Gokhale, and D. Mohanty, Towards Prediction of Metabolic Products of Polyketide Synthases: An |
