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134
Mills, K., T. Daish, et al. (2006). "The Drosophila melanogaster Apaf-1 homologue
ARK is required for most, but not all, programmed cell death." J Cell Biol 172(6): 809-
15.
Min, K. J., Tatar, M., et al. (2008). "Drosophila lifespan control by dietary restriction
independent of insulin-like signaling." Aging Cell 7(2): 199-206.
Moffat, J., J. H. Reiling, et al. (2007). "Off-target effects associated with long dsRNAs
in Drosophila RNAi screens." Trends Pharmacol Sci 28(4): 149-51.
Montgomery, M. K. and A. Fire (1998). "Double-stranded RNA as a mediator in
sequence-specific genetic silencing and co-suppression." Trends Genet 14(7): 255-8.
Morrow, G., M. Samson, et al. (2004). "Overexpression of the small mitochondrial
Hsp22 extends Drosophila lifespan and increases resistance to oxidative stress." FASEB
J 18(3): 598-9.
Moshitzky, P., I. Fleischmann, et al. (1996). "Sex-peptide activates juvenile hormone
biosynthesis in the Drosophila melanogaster corpus allatum." Arch Insect Biochem
Physiol 32(3-4): 363-74.
Mukae, N., H. Yokoyama, et al. (2002). "Activation of the innate immunity in
Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation."
Genes Dev 16(20): 2662-71.
Mulder, N. J., R. Apweiler, et al. (2007). "New developments in the InterPro database."
Nucleic Acids Res 35(Database issue): D224-8.
Mullins, M. C., D. C. Rio, et al. (1989). "cis-acting DNA sequence requirements for P-element
transposition." Genes Dev 3(5): 729-38.
Muro, I., J. C. Means, et al. (2005). "Cleavage of the apoptosis inhibitor DIAP1 by the
apical caspase DRONC in both normal and apoptotic Drosophila cells." J Biol Chem
280(19): 18683-8.
Murphy, C. T., S. A. McCarroll, et al. (2003). "Genes that act downstream of DAF-16 to
influence the lifespan of Caenorhabditis elegans." Nature 424(6946): 277-83.
Nezis, I. P., D. J. Stravopodis, et al. (2002). "Dynamics of apoptosis in the ovarian
follicle cells during the late stages of Drosophila oogenesis." Cell Tissue Res 307(3):
401-9.
Nishikura, K. (2001). "A short primer on RNAi: RNA-directed RNA polymerase acts as
a key catalyst." Cell 107(4): 415-8.
Object Description
| Title | Characterization of Drosophila longevity and fecundity regulating genes |
| Author | Li, Yishi |
| Author email | yishili@usc.edu; yishili@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Molecular & Computational Biology |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2008-08-19 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-10-31 |
| Advisor (committee chair) | Tower, John |
| Advisor (committee member) |
Finkel, Steven E. Aparicio, Oscar Martin Longo, Valter D Comai, Lucio |
| Abstract | The regulation of Drosophila melanogaster longevity and fecundity involves many factors. Longevity is governed by oxidative stress, stem cell loss, dietary restriction, the insulin/IGF-1 pathway, and other factors. Fecundity is also regulated by multiple tissues and factors, including the germline stem cells and stem cell niche, the fat body, yolk proteins, and sex peptides. The fecundity of wild type female Drosophila gradually declines during aging, suggesting a common pathway regulating longevity and fecundity machinery. Since both mechanisms involve multiple factors, sorting through the Gordian’s knot is a formidable task. Using a PdL mutagenesis approach, I screened for a specific phenotype in thousands of independent mutant strains to examine both regulatory networks simultaneously. Two novel genes, magu and hebe, were identified and characterized to regulate longevity and fecundity. While Drosophila lifespan was extended upon the induction of these genes, fecundity increase requires that the gene induction be in an ideal range to show the expected phenotypic change. I also performed several other projects, including studying the lifespan extension effect of dIAP2, characterization of a Drosophila gut driver strain, and intra-abdominal RNAi injection in adult Drosophila. These projects provided us insight on longevity, fecundity, anti-apoptosis, stem cell biology, RNAi and other aspects of Drosophila research. In sum, Drosophila melanogaster, as a model organism for molecular biology and genetics study, will continue to contribute to the scientific community. |
| Keyword | Drosophila; longevity; fecundity |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1735 |
| Contributing entity | University of Southern California |
| Rights | Li, Yishi |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-Li-2382 |
| Archival file | uscthesesreloadpub_Volume44/etd-Li-2382.pdf |
Description
| Title | Page 144 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | 134 Mills, K., T. Daish, et al. (2006). "The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death." J Cell Biol 172(6): 809- 15. Min, K. J., Tatar, M., et al. (2008). "Drosophila lifespan control by dietary restriction independent of insulin-like signaling." Aging Cell 7(2): 199-206. Moffat, J., J. H. Reiling, et al. (2007). "Off-target effects associated with long dsRNAs in Drosophila RNAi screens." Trends Pharmacol Sci 28(4): 149-51. Montgomery, M. K. and A. Fire (1998). "Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression." Trends Genet 14(7): 255-8. Morrow, G., M. Samson, et al. (2004). "Overexpression of the small mitochondrial Hsp22 extends Drosophila lifespan and increases resistance to oxidative stress." FASEB J 18(3): 598-9. Moshitzky, P., I. Fleischmann, et al. (1996). "Sex-peptide activates juvenile hormone biosynthesis in the Drosophila melanogaster corpus allatum." Arch Insect Biochem Physiol 32(3-4): 363-74. Mukae, N., H. Yokoyama, et al. (2002). "Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation." Genes Dev 16(20): 2662-71. Mulder, N. J., R. Apweiler, et al. (2007). "New developments in the InterPro database." Nucleic Acids Res 35(Database issue): D224-8. Mullins, M. C., D. C. Rio, et al. (1989). "cis-acting DNA sequence requirements for P-element transposition." Genes Dev 3(5): 729-38. Muro, I., J. C. Means, et al. (2005). "Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells." J Biol Chem 280(19): 18683-8. Murphy, C. T., S. A. McCarroll, et al. (2003). "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans." Nature 424(6946): 277-83. Nezis, I. P., D. J. Stravopodis, et al. (2002). "Dynamics of apoptosis in the ovarian follicle cells during the late stages of Drosophila oogenesis." Cell Tissue Res 307(3): 401-9. Nishikura, K. (2001). "A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst." Cell 107(4): 415-8. |
