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Hawkins, C. J., S. L. Wang, et al. (1999). "A cloning method to identify caspases and
their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the
Drosophila caspase DCP-1." Proc Natl Acad Sci U S A 96(6): 2885-90.
Hawkins, C. J., S. J. Yoo, et al. (2000). "The Drosophila caspase DRONC cleaves
following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM." J Biol
Chem 275(35): 27084-93.
Hay, B. A. and M. Guo (2006). "Caspase-dependent cell death in Drosophila." Annu
Rev Cell Dev Biol 22: 623-50.
Hay, B. A., J. R. Huh, et al. (2004). "The genetics of cell death: approaches, insights and
opportunities in Drosophila." Nat Rev Genet 5(12): 911-22.
Hay, B. A., D. A. Wassarman, et al. (1995). "Drosophila homologs of baculovirus
inhibitor of apoptosis proteins function to block cell death." Cell 83(7): 1253-62.
Hipfner, D. R., K. Weigmann, et al. (2002). "The bantam gene regulates Drosophila
growth." Genetics 161(4): 1527-37.
Huh, J. R., I. Foe, et al. (2007). "The Drosophila inhibitor of apoptosis (IAP) DIAP2 is
dispensable for cell survival, required for the innate immune response to gram-negative
bacterial infection, and can be negatively regulated by the reaper/hid/grim family of
IAP-binding apoptosis inducers." J Biol Chem 282(3): 2056-68.
Hunter, C. P. (1999). "Genetics: a touch of elegance with RNAi." Curr Biol 9(12):
R440-2.
Hwangbo, D. S., B. Gershman, et al. (2004). "Drosophila dFOXO controls lifespan and
regulates insulin signalling in brain and fat body." Nature 429(6991): 562-6.
Jaklevic, B., L. Uyetake, et al. (2008). "Modulation of ionizing radiation-induced
apoptosis by bantam microRNA in Drosophila." Dev Biol.
Kaiser, W. J., D. Vucic, et al. (1998). "The Drosophila inhibitor of apoptosis D-IAP1
suppresses cell death induced by the caspase drICE." FEBS Lett 440(1-2): 243-8.
Kaliss, N. and M.A.Graubard (1936). "The effect of temperature on oviposition in
Drosophila melanogaster." Biology Bulletin 70: 385-391.
Kanehisa, M., S. Goto, et al. (2002). "The KEGG databases at GenomeNet." Nucleic
Acids Res 30(1): 42-6.
Kanuka, H., K. Sawamoto, et al. (1999). "Control of the cell death pathway by Dapaf-1,
a Drosophila Apaf-1/CED-4-related caspase activator." Mol Cell 4(5): 757-69.
Object Description
| Title | Characterization of Drosophila longevity and fecundity regulating genes |
| Author | Li, Yishi |
| Author email | yishili@usc.edu; yishili@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Molecular & Computational Biology |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2008-08-19 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-10-31 |
| Advisor (committee chair) | Tower, John |
| Advisor (committee member) |
Finkel, Steven E. Aparicio, Oscar Martin Longo, Valter D Comai, Lucio |
| Abstract | The regulation of Drosophila melanogaster longevity and fecundity involves many factors. Longevity is governed by oxidative stress, stem cell loss, dietary restriction, the insulin/IGF-1 pathway, and other factors. Fecundity is also regulated by multiple tissues and factors, including the germline stem cells and stem cell niche, the fat body, yolk proteins, and sex peptides. The fecundity of wild type female Drosophila gradually declines during aging, suggesting a common pathway regulating longevity and fecundity machinery. Since both mechanisms involve multiple factors, sorting through the Gordian’s knot is a formidable task. Using a PdL mutagenesis approach, I screened for a specific phenotype in thousands of independent mutant strains to examine both regulatory networks simultaneously. Two novel genes, magu and hebe, were identified and characterized to regulate longevity and fecundity. While Drosophila lifespan was extended upon the induction of these genes, fecundity increase requires that the gene induction be in an ideal range to show the expected phenotypic change. I also performed several other projects, including studying the lifespan extension effect of dIAP2, characterization of a Drosophila gut driver strain, and intra-abdominal RNAi injection in adult Drosophila. These projects provided us insight on longevity, fecundity, anti-apoptosis, stem cell biology, RNAi and other aspects of Drosophila research. In sum, Drosophila melanogaster, as a model organism for molecular biology and genetics study, will continue to contribute to the scientific community. |
| Keyword | Drosophila; longevity; fecundity |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1735 |
| Contributing entity | University of Southern California |
| Rights | Li, Yishi |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-Li-2382 |
| Archival file | uscthesesreloadpub_Volume44/etd-Li-2382.pdf |
Description
| Title | Page 140 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | 130 Hawkins, C. J., S. L. Wang, et al. (1999). "A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1." Proc Natl Acad Sci U S A 96(6): 2885-90. Hawkins, C. J., S. J. Yoo, et al. (2000). "The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM." J Biol Chem 275(35): 27084-93. Hay, B. A. and M. Guo (2006). "Caspase-dependent cell death in Drosophila." Annu Rev Cell Dev Biol 22: 623-50. Hay, B. A., J. R. Huh, et al. (2004). "The genetics of cell death: approaches, insights and opportunities in Drosophila." Nat Rev Genet 5(12): 911-22. Hay, B. A., D. A. Wassarman, et al. (1995). "Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death." Cell 83(7): 1253-62. Hipfner, D. R., K. Weigmann, et al. (2002). "The bantam gene regulates Drosophila growth." Genetics 161(4): 1527-37. Huh, J. R., I. Foe, et al. (2007). "The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers." J Biol Chem 282(3): 2056-68. Hunter, C. P. (1999). "Genetics: a touch of elegance with RNAi." Curr Biol 9(12): R440-2. Hwangbo, D. S., B. Gershman, et al. (2004). "Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body." Nature 429(6991): 562-6. Jaklevic, B., L. Uyetake, et al. (2008). "Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila." Dev Biol. Kaiser, W. J., D. Vucic, et al. (1998). "The Drosophila inhibitor of apoptosis D-IAP1 suppresses cell death induced by the caspase drICE." FEBS Lett 440(1-2): 243-8. Kaliss, N. and M.A.Graubard (1936). "The effect of temperature on oviposition in Drosophila melanogaster." Biology Bulletin 70: 385-391. Kanehisa, M., S. Goto, et al. (2002). "The KEGG databases at GenomeNet." Nucleic Acids Res 30(1): 42-6. Kanuka, H., K. Sawamoto, et al. (1999). "Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator." Mol Cell 4(5): 757-69. |
