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Bibliography
Adams, M. D. and J. J. Sekelsky (2002). "From sequence to phenotype: reverse genetics
in Drosophila melanogaster." Nat Rev Genet 3(3): 189-98.
Akdemir, F., R. Farkas, et al. (2006). "Autophagy occurs upstream or parallel to the
apoptosome during histolytic cell death." Development 133(8): 1457-65.
Allikian, M. J., D. Deckert-Cruz, et al. (2002). "Doxycycline-induced expression of
sense and inverted-repeat constructs modulates phosphogluconate mutase (Pgm) gene
expression in adult Drosophila melanogaster." Genome Biol 3(5): research0021.
Alpatov, W. W. (1932). "Egg production in Drosophila melanogaster and some factors
which influence it." Journal of Experimental Zoology 63: 85-111.
Anderson, R. M., K. J. Bitterman, et al. (2003). "Nicotinamide and PNC1 govern
lifespan extension by calorie restriction in Saccharomyces cerevisiae." Nature
423(6936): 181-5.
Arbeitman, M. N., E. E. Furlong, et al. (2002). "Gene expression during the life cycle of
Drosophila melanogaster." Science 297(5590): 2270-5.
Ashburner, M., K. G. Golic, et al. (1989). Drosophila A Laboratory Handbook, Cold
Spring Harbor Laboratory Press.
Baeg, G. H., R. Zhou, et al. (2005). "Genome-wide RNAi analysis of JAK/STAT
signaling components in Drosophila." Genes Dev 19(16): 1861-70.
Bello, B. C., N. Izergina, et al. (2008). "Amplification of neural stem cell proliferation
by intermediate progenitor cells in Drosophila brain development." Neural Develop 3: 5.
Bernstein, E., A. A. Caudy, et al. (2001). "Role for a bidentate ribonuclease in the
initiation step of RNA interference." Nature 409(6818): 363-6.
Bhat, K. M. and P. Schedl (1997). "Establishment of stem cell identity in the Drosophila
germline." Dev Dyn 210(4): 371-82.
Bieschke, E. T., J. C. Wheeler, et al. (1998). "Doxycycline-induced transgene expression
during Drosophila development and aging." Mol Gen Genet 258(6): 571-9.
Birnbaum, M. J., R. J. Clem, et al. (1994). "An apoptosis-inhibiting gene from a nuclear
polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs." J Virol 68(4):
2521-8.
Object Description
| Title | Characterization of Drosophila longevity and fecundity regulating genes |
| Author | Li, Yishi |
| Author email | yishili@usc.edu; yishili@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Molecular & Computational Biology |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2008-08-19 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-10-31 |
| Advisor (committee chair) | Tower, John |
| Advisor (committee member) |
Finkel, Steven E. Aparicio, Oscar Martin Longo, Valter D Comai, Lucio |
| Abstract | The regulation of Drosophila melanogaster longevity and fecundity involves many factors. Longevity is governed by oxidative stress, stem cell loss, dietary restriction, the insulin/IGF-1 pathway, and other factors. Fecundity is also regulated by multiple tissues and factors, including the germline stem cells and stem cell niche, the fat body, yolk proteins, and sex peptides. The fecundity of wild type female Drosophila gradually declines during aging, suggesting a common pathway regulating longevity and fecundity machinery. Since both mechanisms involve multiple factors, sorting through the Gordian’s knot is a formidable task. Using a PdL mutagenesis approach, I screened for a specific phenotype in thousands of independent mutant strains to examine both regulatory networks simultaneously. Two novel genes, magu and hebe, were identified and characterized to regulate longevity and fecundity. While Drosophila lifespan was extended upon the induction of these genes, fecundity increase requires that the gene induction be in an ideal range to show the expected phenotypic change. I also performed several other projects, including studying the lifespan extension effect of dIAP2, characterization of a Drosophila gut driver strain, and intra-abdominal RNAi injection in adult Drosophila. These projects provided us insight on longevity, fecundity, anti-apoptosis, stem cell biology, RNAi and other aspects of Drosophila research. In sum, Drosophila melanogaster, as a model organism for molecular biology and genetics study, will continue to contribute to the scientific community. |
| Keyword | Drosophila; longevity; fecundity |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1735 |
| Contributing entity | University of Southern California |
| Rights | Li, Yishi |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-Li-2382 |
| Archival file | uscthesesreloadpub_Volume44/etd-Li-2382.pdf |
Description
| Title | Page 135 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | 125 Bibliography Adams, M. D. and J. J. Sekelsky (2002). "From sequence to phenotype: reverse genetics in Drosophila melanogaster." Nat Rev Genet 3(3): 189-98. Akdemir, F., R. Farkas, et al. (2006). "Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death." Development 133(8): 1457-65. Allikian, M. J., D. Deckert-Cruz, et al. (2002). "Doxycycline-induced expression of sense and inverted-repeat constructs modulates phosphogluconate mutase (Pgm) gene expression in adult Drosophila melanogaster." Genome Biol 3(5): research0021. Alpatov, W. W. (1932). "Egg production in Drosophila melanogaster and some factors which influence it." Journal of Experimental Zoology 63: 85-111. Anderson, R. M., K. J. Bitterman, et al. (2003). "Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae." Nature 423(6936): 181-5. Arbeitman, M. N., E. E. Furlong, et al. (2002). "Gene expression during the life cycle of Drosophila melanogaster." Science 297(5590): 2270-5. Ashburner, M., K. G. Golic, et al. (1989). Drosophila A Laboratory Handbook, Cold Spring Harbor Laboratory Press. Baeg, G. H., R. Zhou, et al. (2005). "Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila." Genes Dev 19(16): 1861-70. Bello, B. C., N. Izergina, et al. (2008). "Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development." Neural Develop 3: 5. Bernstein, E., A. A. Caudy, et al. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference." Nature 409(6818): 363-6. Bhat, K. M. and P. Schedl (1997). "Establishment of stem cell identity in the Drosophila germline." Dev Dyn 210(4): 371-82. Bieschke, E. T., J. C. Wheeler, et al. (1998). "Doxycycline-induced transgene expression during Drosophila development and aging." Mol Gen Genet 258(6): 571-9. Birnbaum, M. J., R. J. Clem, et al. (1994). "An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs." J Virol 68(4): 2521-8. |
