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THE RELATIONSHIP OF RESISTIN, LEPTIN,
ADIPONECTIN, AND GHRELIN WITH BONE MINERAL
DENSITY IN HEALTHY POSTMENOPAUSAL WOMEN:
LONGITUDINAL ANALYSIS
by
Song Wang
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
August 2012
Copyright 2012 Song Wang
Object Description
| Title | The relationship of resistin, leptin, adiponectin, and ghrelin with bone mineral density in healthy postmenopausal women: longitudinal analysis |
| Author | Wang, Song |
| Author email | songwang@usc.edu;wangsong05@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2012-07-02 |
| Date submitted | 2012-07-30 |
| Date approved | 2012-07-31 |
| Restricted until | 2012-07-31 |
| Date published | 2012-07-31 |
| Advisor (committee chair) | Mack, Wendy |
| Advisor (committee member) |
Hodis, Howard N. Azen, Stanley |
| Abstract | Purpose: We investigated the relationship between annualized rates of change in bone mineral density (BMD) and serum resistin, leptin, adiponectin, and ghrelin in healthy postmenopausal women. ❧ Methods: Adipocytokines (resistin, leptin, adiponectin), ghrelin, and BMD (lumbar spine, femoral neck, and total hip) were collected from 350 healthy postmenopausal women in the Women’s Isoflavone Soy Health (WISH) trial at 0, 6, 12, 18, 24 and 30 months (adipocytokines and ghrelin) and at 0, 12 and 30 months (BMD). For the statistical analysis, we used mixed multiple linear regression models to investigate the impact of serum levels of adipocytokines and ghrelin on annualized rates of change in BMD. ❧ Results: Resistin, adiponectin, leptin and ghrelin were not significantly related to annualized rates of change in BMD (all p-values > 0.05). Leptin had a positive impact on annualized change rates in femoral neck BMD. Resistin, ghrelin, and adiponectin were inversely but not significantly associated with rates of change in BMD of the femoral neck in the multivariable analysis (all p-values > 0.1). After adjusting for treatment group, race, BMI, DBP, weekly hours in vigorous activity and weekly hours in vigorous activity interaction with time, leptin and ghrelin were marginally associated with rates of change in total hip BMD (p=0.06 and p=0.09 separately); resistin and adiponectin were not significantly associated with change in total hip BMD. Leptin, resistin, ghrelin and adiponectin were not significantly associated with annualized change rates in lumbar spine BMD after controlling for treatment group, age, race, BMI and age interaction with time (all p-values > 0.10). ❧ Conclusion: Resistin, leptin, adiponectin, and ghrelin do not significantly relate to annualized rates of change in BMD in healthy postmenopausal women. |
| Keyword | adipocytokines; resistin; adiponectin; leptin; ghrelin; bone mineral density; postmenopausal women |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Wang, Song |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume4/etd-WangSong-1074.pdf |
Description
| Title | Page 1 |
| Full text | THE RELATIONSHIP OF RESISTIN, LEPTIN, ADIPONECTIN, AND GHRELIN WITH BONE MINERAL DENSITY IN HEALTHY POSTMENOPAUSAL WOMEN: LONGITUDINAL ANALYSIS by Song Wang A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) August 2012 Copyright 2012 Song Wang |
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