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INTEGRATION OF PRACTICAL HIGH SENSITIVITY
WHISPERING GALLERY MODE RESONATOR SENSORS
by
Thanh M. Le
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(ELECTRICAL ENGINEERING)
May 2012
Copyright 2012 Thanh M. Le
Object Description
| Title | Integration of practical high sensitivity whispering gallery mode resonator sensors |
| Author | Le, Thanh M. |
| Author email | thanh.m.le@jpl.nasa.gov;tml@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Electrical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2012-03-09 |
| Date submitted | 2012-03-28 |
| Date approved | 2012-03-29 |
| Restricted until | 2012-03-29 |
| Date published | 2012-03-29 |
| Advisor (committee chair) | Steier, William H. |
| Advisor (committee member) |
Sawchuk, Alexander A. Armani, Andrea |
| Abstract | This work is a study of a practical Whispering Gallery Mode based sensing device that consists of optical polymer waveguides integrated with high Q Whispering Gallery Mode (WGM) resonators that is incorporated with microfluidics technology. We proposed, developed and experimental demonstrated a method that solves the issue of integrating high Q WGM resonators into practical sensors for real time and portable on field detection. ❧ We demonstrated a novel implementation of a polymer optical waveguide coupled to the whispering gallery modes of a fused silica resonator disk. This is the first step in bringing high Q WGM disks closer to the integrated optics technology. We obtained near-critical coupling and a loaded Q = 1.2 x 10⁷. ❧ The use of a WGM resonator with an ultra-high quality factor Q is promising in highly sensitive, label-free, lab-on-a-chip sensor applications. However, one issue that causes the reduction of sensitivity and detection limits of the resonant sensor class is the fluctuation of temperature in the surrounding medium. We investigated a novel method of using the differential frequency of TE and TM modes to reduce the thermal noise baseline. Then, we studied the temperature dependence of the WGM based sensors and experimentally demonstrated the reduction of temperature fluctuation; and, thus, there was a significant improvement in the practical sensor detection limit. Consequently, the United States Patent 8,111,402 was granted for our novel invention. ❧ In additional, the optical sensors are desirable to analyze small volumes or extremely dilute concentrations of analyte, thus we need an efficient method of delivering target molecules to the sensor's surface. Microfluidics and the concept of micro total analysis systems (μTAS) is a new and promising technology expected to revolutionize chemical and medical analysis systems. We theoretical analyzed and experimental demonstrated an integrating prototype of polymer waveguide-high Q WGM based sensor with the microfluidics technology. It is the critical step to bringing the prototype into a practical biosensor, which will lead to the ability to form a so-called lab-on-a-chip system. |
| Keyword | optical sensors; whispering gallery mode resonator |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Le, Thanh M. |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume3/etd-LeThanhM-559.pdf |
Description
| Title | Page 1 |
| Full text | INTEGRATION OF PRACTICAL HIGH SENSITIVITY WHISPERING GALLERY MODE RESONATOR SENSORS by Thanh M. Le A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (ELECTRICAL ENGINEERING) May 2012 Copyright 2012 Thanh M. Le |
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