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DEVELOPMENT OF INTERLIMB STEPPING FOR LOCOMOTION IN THE CHICK:
IMPACT OF LIGHT EXPOSURE DURING EMBRYOGENESIS
by
Anil Sindhurakar
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(SYSTEMS BIOLOGY AND DISEASE)
August 2012
Copyright 2012 Anil Sindhurakar
Object Description
| Title | Development of interlimb stepping for locomotion in the chick: impact of light exposure during embryogenesis |
| Author | Sindhurakar, Anil |
| Author email | sindhura@usc.edu;mailit2anil@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Systems Biology and Disease |
| School | Keck School of Medicine |
| Date defended/completed | 2012-06-11 |
| Date submitted | 2012-07-24 |
| Date approved | 2012-07-25 |
| Restricted until | 2012-07-25 |
| Date published | 2012-07-25 |
| Advisor (committee chair) | Bradley, Nina S. |
| Advisor (committee member) |
Powers, Christopher M. Fetters, Linda Sampath, Alapakkam P. |
| Abstract | Previous studies on locomotor development in chicks have exclusively focused on within limb activity mostly due to technical difficulties in accessing bilateral limb activity in the embryo. This has led to a gap in understanding interlimb circuitry development in the chick. The major undertaking of this dissertation is to bridge this gap. Here, I first summarize a study that light exposure during embryogenesis can accelerate locomotor performance in neonatal chicks. In my second study, I provide evidence indicating interlimb circuitry is present during embryonic stages in chicks before hatching and that light can accelerate its development as well. Through this study, I also extend our previous findings of flexor bias during limb activity before hatching during bilateral limb activity. Finally, in my third study I describe the findings that light during embryogenesis impacts postural control in addition to locomotor control in neonatal chicks. Through the synthesis of these studies, first I assert that light is a significantly important environmental factor capable of influencing the development of multiple systems. In addition, my studies also provide evidence in support of two longstanding conceptual frameworks. First, I provide evidence in support of the view point that there is developmental continuum between prenatal and postnatal development within the context of locomotor development. Secondly, I provide evidence in support of a previous developmental framework that interlimb neural circuitry develops in a sequential order with intralimb control preceding interlimb control. Finally, I provide evidence that alternating interlimb stepping emerges as the default pattern from a disorganized bilateral activity. |
| Keyword | chick; embryogenesis; interlimb; locomotion; motor behavior; photoacceleration |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Sindhurakar, Anil |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@dots.usc.edu |
| Archival file | uscthesesreloadpub_Volume4/etd-Sindhuraka-978.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | DEVELOPMENT OF INTERLIMB STEPPING FOR LOCOMOTION IN THE CHICK: IMPACT OF LIGHT EXPOSURE DURING EMBRYOGENESIS by Anil Sindhurakar A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (SYSTEMS BIOLOGY AND DISEASE) August 2012 Copyright 2012 Anil Sindhurakar |
