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Running head: COGNITIVE FUNCTIONING FOLLOWING OVARIAN REMOVAL
Cognitive Functioning Following Ovarian Removal
Before or After Natural Menopause
By
Keiko Kurita
University of Southern California
Degree Conferral Date: August 2014
This research was supported by the National Institutes of Health Grant Numbers R01 AG08724, R01AG-17160, and F31AG040937 from the National Institute on Aging, U01-AT001653 from the National Center for Complementary and Alternative Medicine, the Office of Dietary Supplements, and the Office of Research on Women’s Health, and R01AG024154, P01 AG026572, P30 CA-71789, and 5-T32-AG00037. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or the National Institutes of Health.
Object Description
| Title | Cognitive functioning following ovarian removal before or after natural menopause |
| Author | Kurita, Keiko |
| Author email | kkurita@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Psychology / Public Health |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2014-05-21 |
| Date submitted | 2014-08-10 |
| Date approved | 2014-08-11 |
| Restricted until | 2015-08-10 |
| Date published | 2015-08-10 |
| Advisor (committee chair) | Meyerowitz, Beth E. |
| Advisor (committee member) |
Gatz, Margaret Mack, Wendy Jean Pike, Christian J. Wood, Wendy |
| Abstract | Estrogen has been associated with cognitive function, and cognitive difficulties become more prevalent in older age when estrogen is reduced. However, the long‐term cognitive function of older women who had reductions in estrogen through having their ovaries removed is not well understood. This dissertation examined the extent to which bilateral oophorectomy and its timing relative to natural menopause are associated with cognitive functioning through two complementary studies. Depressive symptoms as a mediator and hormone therapy as a protective factor were also examined. In Study I, twins over 65 years of age in the Swedish Twin Registry with linkages to the national Inpatient Discharge Registry were used in classic, case‐control (154 women with bilateral oophorectomy and 7,600 women with ovaries intact) and discordant co‐twin (n = 63 pairs) analyses to examine associations between oophorectomy and both cognitive impairment and scores on a cognitive screening test. In Study II, oophorectomy status and performance on global cognitive function and five cognitive domains among healthy postmenopausal women in 3 clinical trials conducted in Los Angeles County were analyzed in linear regression models both cross‐sectionally (n = 1,149) and on repeat cognitive assessment 2.5 years after baseline (n = 463). In both studies, covariates included age, education, and health factors. In Study I, neither oophorectomy nor its timing was associated with cognitive impairment. In Study II, oophorectomy after age 45 compared to no history of oophorectomy was a risk factor for poorer performance in verbal learning (p = .03) in the cross‐sectional design and with a decrease in visual memory (p < .01) performance over time. Oophorectomy status was associated with a decrease in visual memory (p < .05) over time. Neither study showed a significant interaction of oophorectomy and hormone treatment. However, in Study I, hormone treatment was protective against cognitive impairment (p < .02 for length of time on hormone treatment, p < .01 for history of any hormone treatment). In both studies, depressive symptoms were not found to be a mediator but were found to be associated with poorer cognitive function. The dissertation findings suggest that ovarian removal may be associated with poorer performance in specific cognitive domains but not with longer‐term cognitive impairment. |
| Keyword | oophorectomy; cognitive function; menopause |
| Language | English |
| Format (imt) | application/pdf |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Kurita, Keiko |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-KuritaKeik-2804.pdf |
| Archival file | uscthesesreloadpub_Volume14/etd-KuritaKeik-2804.pdf |
Description
| Title | Page 1 |
| Repository email | cisadmin@lib.usc.edu |
| Full text | Running head: COGNITIVE FUNCTIONING FOLLOWING OVARIAN REMOVAL Cognitive Functioning Following Ovarian Removal Before or After Natural Menopause By Keiko Kurita University of Southern California Degree Conferral Date: August 2014 This research was supported by the National Institutes of Health Grant Numbers R01 AG08724, R01AG-17160, and F31AG040937 from the National Institute on Aging, U01-AT001653 from the National Center for Complementary and Alternative Medicine, the Office of Dietary Supplements, and the Office of Research on Women’s Health, and R01AG024154, P01 AG026572, P30 CA-71789, and 5-T32-AG00037. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or the National Institutes of Health. |
