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CTC: CAPTURE AND ANALYSIS OF CIRCULATING TUMOR CELLS IN PATIENTS
WITH HEPATOCELLULAR CARCINOMA – ANALYSIS OF A PILOT STUDY
Capture and Analysis of Circulating Tumor Cells in Patients with
Hepatocellular Carcinoma – Analysis of a Pilot Study
Cheng Dong
University of Southern California
Author Note
Cheng Dong, Department of Preventive Medicine, Keck School of Medicine
Object Description
| Title | Capture and analysis of circulating tumor cells in patients with hepatocellular carcinoma: analysis of a pilot study |
| Author | Dong, Cheng |
| Author email | veran.dc@gmail.com;chengdon@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2014-07-17 |
| Date submitted | 2014-07-17 |
| Date approved | 2014-07-17 |
| Restricted until | 2014-07-17 |
| Date published | 2014-07-17 |
| Advisor (committee chair) | Gauderman, William James |
| Advisor (committee member) |
Groshen, Susan L. Stram, Daniel O. |
| Abstract | Hepatocellular carcinoma (HCC), which we can also call malignant hepatoma, is a primary liver cancer and a major cause of cancer morbidity and mortality all over the world. According to Zhang Y, Li J, Cao L, Xu W, and Yin Z (2012), circulating tumor cells (CTCs) reflect the information of HCC metastasis or recurrence. This makes CTC as a useful biomarker of HCC. The popular standard method based on immunomagnetic binding of epithelial cell adhesion molecules (EpCAMs) cannot be used to collect CTC of HCC because HCC cells rarely express EpCAM. However, Dr. Amir Goldkorn solved this problem by developing a parylene–C slot microfilter platform. So a total of 170 HCC patients are planned to be recruited to analyze CTC in HCC. For now, only 93 patients are enrolled to this program and the study is still in process. The hypothesis in this study to be tested are (1) Patients with advanced disease stage will have more CTCs. (2) The numbers of CTC are decreased after treatment. |
| Keyword | HCC; CTC |
| Language | English |
| Format (imt) | application/pdf |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Dong, Cheng |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-DongCheng-2715.pdf |
| Archival file | uscthesesreloadpub_Volume14/etd-DongCheng-2715.pdf |
Description
| Title | Page 1 |
| Repository email | cisadmin@lib.usc.edu |
| Full text | CTC: CAPTURE AND ANALYSIS OF CIRCULATING TUMOR CELLS IN PATIENTS WITH HEPATOCELLULAR CARCINOMA – ANALYSIS OF A PILOT STUDY Capture and Analysis of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma – Analysis of a Pilot Study Cheng Dong University of Southern California Author Note Cheng Dong, Department of Preventive Medicine, Keck School of Medicine |
