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Running head: GENES, LIFE STYLES, AND COGNITIVE DECLINE 1
Identifying Diverse Pathways to Cognitive Decline in Later Life Using Genetic and Environmental Factors
Yusuke Kuroki
University of Southern California
Object Description
| Title | Identifying diverse pathways to cognitive decline in later life using genetic and environmental factors |
| Author | Kuroki, Yusuke |
| Author email | yusukekuroki@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Psychology |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2014-05-20 |
| Date submitted | 2014-07-14 |
| Date approved | 2014-07-14 |
| Restricted until | 2014-07-14 |
| Date published | 2014-07-14 |
| Advisor (committee chair) | McArdle, John J. |
| Advisor (committee member) |
John, Richard S. Zelinski, Elizabeth M. Gauderman, William James |
| Abstract | The ε4 allele of the apolipoprotein E is associated with dementia. However, ε4 is neither necessary nor sufficient to cause dementia and leaves much of variability in dementia unexplained. One possible reason for unexplained variability is gene‐environment (G × E) interactions. Are there lifestyle factors that can moderate the effect of APOE ε4 on memory? To address this question, two analytical approaches were proposed. First, the gene‐environment interaction on episodic memory was examined using the structural equation modeling (SEM). Specifically, the present study asked, “Does the effect of the ε4 on memory vary by education, job authority, or physical activity?” Second, an innovative exploratory technique called structural equation model tree (SEM Trees; Brandmaier, von Oertzen, McArdle, & Lindenberger, 2013) was used. Data from the Wisconsin Longitudinal Study were used. Memory was assessed with immediate recall, delayed recall and digit ordering. Results of SEM (n = 10,317) showed that APOE ε4, education, job authority and physical activity affected memory; however, education, job authority or physical activity did not moderate the effect of APOE ε4 on memory. Results of SEM Trees (n = 4569) showed that gender, IQ, literacy use at work, personality, smoking, and four genetic polymorphisms in APOC3, DRD2, CH25H, and SSADH produced complex interactions and influenced memory decline in late life. However, the influences of genetic variants on memory were subtle. This study also demonstrates the utility of SEM Trees as a powerful technique for exploring the data within a theoretical context. |
| Keyword | structural equation models; gene‐environment interaction; data‐mining; aging; episodic memory |
| Language | English |
| Format (imt) | application/pdf |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Kuroki, Yusuke |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-KurokiYusu-2671.pdf |
| Archival file | uscthesesreloadpub_Volume14/etd-KurokiYusu-2671.pdf |
Description
| Title | Page 1 |
| Repository email | cisadmin@lib.usc.edu |
| Full text | Running head: GENES, LIFE STYLES, AND COGNITIVE DECLINE 1 Identifying Diverse Pathways to Cognitive Decline in Later Life Using Genetic and Environmental Factors Yusuke Kuroki University of Southern California |
