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TISSUE INTERACTIONS & MOLECULAR PATHWAYS IN SPECIFICATION OF THE ECTOMESENCHYME FROM CRANIAL NEURAL CREST
by
Ankita Das
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(GENETIC, MOLECULAR AND CELLULAR BIOLOGY)
May 2012
Copyright 2012 Ankita Das
Object Description
| Title | Tissue interactions & molecular pathways in specification of the ectomesenchyme from cranial neural crest |
| Author | Das, Ankita |
| Author email | ankitada@usc.edu;ankita23@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Genetic, Molecular and Cellular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2012-01-27 |
| Date submitted | 2012-05-15 |
| Date approved | 2012-05-15 |
| Restricted until | 2012-05-15 |
| Date published | 2012-05-15 |
| Advisor (committee chair) | Maxson, Robert |
| Advisor (committee member) |
Lien, Ellen Sucov, Henry Lu, Wange |
| Abstract | Vertebrate cranial neural crest cells (CNCCs) contribute not only to ectodermal lineages like neurons, glia and pigment but also to “ectomesenchymal” lineages like cartilage and bone. Whereas studies have established that in zebrafish the CNCCs are lineage restricted at the neural tube, the molecular bases for regulation of the cell lineage remains unknown. In this thesis work, I will discuss my studies on the role of Bmp signaling from the ectoderm in restricting the ectomesenchyme potential of the CNCC. I will provide evidence for functions of Id2a and Twist1 proteins in specification of the ectomesenchyme. We show that although twist1 genes are expressed in the CNCC starting at pre-migratory stages, presence of Id2a in these cells prevents Twist1 from functioning, and that a loss of Id2a in the migratory CNCCs over time in development facilitates specification of the ectomesenchyme lineage. Furthermore, I will discuss a detailed characterization of the roles of Twist1 in specification of the ectomesenchyme lineage in zebrafish. We propose that Twist1 functions as a master-regulator in specification of the ectomesenchyme lineage via regulating induction of early ectomesenchyme genes and repressing the non-ectomesenchyme. |
| Keyword | ectomesenchyme; neural crest |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Das, Ankita |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume4/etd-DasAnkita-852.pdf |
Description
| Title | Page 1 |
| Full text | TISSUE INTERACTIONS & MOLECULAR PATHWAYS IN SPECIFICATION OF THE ECTOMESENCHYME FROM CRANIAL NEURAL CREST by Ankita Das A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (GENETIC, MOLECULAR AND CELLULAR BIOLOGY) May 2012 Copyright 2012 Ankita Das |
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