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DNA METHYLATION CHANGES IN THE
DEVELOPMENT OF LUNG ADENOCARCINOMA
by
Suhaida Adura Selamat
________________________________________________
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(GENETIC, MOLECULAR AND CELLULAR BIOLOGY)
May 2012
Copyright 2012 Suhaida Adura Selamat
Object Description
| Title | DNA methylation changes in the development of lung adenocarcinoma |
| Author | Selamat, Suhaida Adura |
| Author email | selamat@usc.edu;suhaidaadura@yahoo.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Genetic, Molecular and Cellular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2012-04-05 |
| Date submitted | 2012-04-05 |
| Date approved | 2012-04-05 |
| Restricted until | 2012-04-05 |
| Date published | 2012-04-05 |
| Advisor (committee chair) | Laird-Offringa, Ite A. |
| Advisor (committee member) |
Siegmund, Kimberly Borok, Zea |
| Abstract | Lung cancer accounted for 13% of total cancer cases and 18% of cancer deaths globally in 2008. The combination of increasing smoking prevalence in many developing countries and a long latency period predicts that lung cancer will remain a major world health problem for decades to come. This work focuses on DNA methylation in lung adenocarcinoma, a subtype of lung cancer that is the most prevalent in the United States, as well as the most common amongst women and non-smokers. We built on previously identified DNA methylation early detection markers by delineating the timing of these changes in preneoplastic lesions. We then used genome-scale DNA methylation profiling to identify novel potential blood-based non-small cell lung cancer biomarkers, and integrated DNA methylation information with gene expression data to identify DNA methylation changes that may lead to functional consequences in the development of cancer. Additionally, we identified a DNA methylation based subgroup of lung adenocarcinoma that is associated with KRAS mutations and smoking status, as well as explored the use of paraffin-embedded tissues to facilitate larger genome-scale DNA methylation studies. Our findings provide insights into the roles that DNA methylation may play in the development of lung adenocarcinoma, as well as potential DNA methylation markers for the early detection or risk assessment of the disease. |
| Keyword | DNA methylation; lung adenocarcinoma; lung cancer; epigenetics |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Selamat, Suhaida Adura |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@dots.usc.edu |
| Archival file | uscthesesreloadpub_Volume3/etd-SelamatSuh-569.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | DNA METHYLATION CHANGES IN THE DEVELOPMENT OF LUNG ADENOCARCINOMA by Suhaida Adura Selamat ________________________________________________ A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (GENETIC, MOLECULAR AND CELLULAR BIOLOGY) May 2012 Copyright 2012 Suhaida Adura Selamat |
