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REWARD IMMEDIACY AND SUBJECTIVE STRESS MODULATE ANTICIPATION
OF PRIMARY AND SECONDARY REWARDS IN TEMPORARILY-ABSTINENT
CIGARETTE SMOKERS
by
Louise Debs Cosand
_________________________________________________________
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PSYCHOLOGY)
May 2013
Copyright 2013 Louise Debs Cosand
Object Description
| Title | Reward immediacy and subjective stress modulate anticipation of primary and secondary rewards in temporarily-abstinent cigarette smokers |
| Author | Cosand, Louise Debs |
| Author email | lcosand@gmail.com;lcosand@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Psychology |
| School | College of Letters, Arts And Sciences |
| Date defended/completed | 2013-03-14 |
| Date submitted | 2013-05-08 |
| Date approved | 2013-05-08 |
| Restricted until | 2013-05-08 |
| Date published | 2013-05-08 |
| Advisor (committee chair) | Monterosso, John R. |
| Advisor (committee member) |
Bechara, Antoine Kutch, Jason J. Saxbe, Darby E. |
| Abstract | The majority of cessation attempts in nicotine-dependent individuals result in relapse. It is unknown if cessation failure is related to a change in a reward’s motivational value (incentive salience), a change in inhibitory ability, or is attributable to other factors. To test for stress effects on incentive salience, and specifically assessing a potential differential effect on immediate versus delayed reward, neuroimaging and behavioral data were collected while 17 overnight-abstinent male cigarette smokers engaged in a reward anticipation task. During the task, which was an adaptation of the monetary incentive delay paradigm (MID; Knutson, Westdorp, Kaiser, & Hommer, 2000), participants attempted to win prizes varying in immediacy (now or in seven days) and type (money or nicotine vapor). When a participant won immediately-available nicotine vapor, he was allowed draw one puff of nicotine vapor before the subsequent trial began. Participants were scanned twice; once after stress induction using the cold pressor task (Lovallo, 1975) and once after a control task. Reward immediacy was associated with faster reaction times (RT) and stronger blood oxygen level-dependent (BOLD) signals in the bilateral insula and anterior cingulate cortices. Under greater stress, however, the immediacy-related anterior cingulate BOLD signal was significantly lower than in the control condition. Furthermore, slower RTs in the stress condition suggested that stress decreases incentive salience of anticipated rewards. These results were unexpected, and may be related to anhedonia associated with acute withdrawal. |
| Keyword | addiction; fMRI; neuroimaging; functional magnetic resonance imaging; delay discounting; stress; reward; motivation; anhedonia; incentive salience; anticipation; human; smoking; nicotine; money; cortisol; cigarette |
| Language | English |
| Format (imt) | application/pdf |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Cosand, Louise Debs |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-CosandLoui-1672.pdf |
| Archival file | uscthesesreloadpub_Volume7/etd-CosandLoui-1672.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | REWARD IMMEDIACY AND SUBJECTIVE STRESS MODULATE ANTICIPATION OF PRIMARY AND SECONDARY REWARDS IN TEMPORARILY-ABSTINENT CIGARETTE SMOKERS by Louise Debs Cosand _________________________________________________________ A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PSYCHOLOGY) May 2013 Copyright 2013 Louise Debs Cosand |
