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DEVELOPMENT OF POSITRON EMISSION TOMOGRAPHY (PET) LABELED POLYPEPTIDE NANOPARTICLES FOR TUMOR IMAGING AND TARGETING
by
Siti Najila Mohd Janib
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PHARMACEUTICAL SCIENCES)
May 2013
Copyright 2013 Siti Najila Mohd Janib
Object Description
| Title | Development of positron emission tomography (PET) labeled polypeptide nanoparticles for tumor imaging and targeting |
| Author | Janib, Siti Najila Mohd |
| Author email | mohdjani@usc.edu;ceetee41@yahoo.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Pharmacy / Pharmaceutical Sciences |
| School | School of Pharmacy |
| Date defended/completed | 2013-01-29 |
| Date submitted | 2013-04-26 |
| Date approved | 2013-04-26 |
| Restricted until | 2013-04-26 |
| Date published | 2013-04-26 |
| Advisor (committee chair) | MacKay, J. Andrew |
| Advisor (committee member) |
Wolf, Walter Conti, Peter Markland, Frank |
| Abstract | The two main problems currently stalling the efficient treatment of cancer has been detecting cancer early enough in the disease process for successful treatment, and treating cancer cells while avoiding excessive toxicity to normal tissues. Arguably the most important factor in the fight against cancer, besides prevention is early detection because the cancer will be easier to treat and less likely to have drug resistance. ❧ The work highlighted in this thesis attempts to address the issues related to the effective treatment and management of cancer. The objective of this work is to develop new materials and methods for co-assembly of drugs and imaging agents that permit quantitative imaging of drug delivery and disease progression. By using molecular imaging technique to non-invasively study and detect various molecular markers of diseases can allow for much earlier diagnosis, earlier treatment, and better prognosis that will eventually lead to personalized medicine. Exploration of particulates and polymeric carriers is gaining momentum in diagnostic imaging, initiated by successful therapies using long circulating liposomes. However, liposomes are challenging pharmaceuticals, which include many chemical components, require complex drug encapsulation strategies, and must be physically sheared to control their particle diameter and polydispersity. Polymeric nanocarriers have emerged as an alternative to liposomes as carriers of drugs and imaging agents. Co-inclusion of therapeutic and imaging agents, into these carriers might be advantageous because they increase solubility of hydrophobic agents, may enhance permeability across physiological barriers, alter drug biodistribution, increase local bioavailability and reduce of side effects. |
| Keyword | elastin like polypeptides (ELP); vicrostatin (VCN); positron emission tomography (PET); block copolymer; thermal self-assembly; nanoparticle; micelles |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Janib, Siti Najila Mohd |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Filename | etd-JanibSitiN-1608.pdf |
| Archival file | uscthesesreloadpub_Volume3/etd-JanibSitiN-1608.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Full text | DEVELOPMENT OF POSITRON EMISSION TOMOGRAPHY (PET) LABELED POLYPEPTIDE NANOPARTICLES FOR TUMOR IMAGING AND TARGETING by Siti Najila Mohd Janib A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PHARMACEUTICAL SCIENCES) May 2013 Copyright 2013 Siti Najila Mohd Janib |
