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PROSTHETIC VISION IN BLIND HUMAN PATIENTS: PREDICTING THE
PERCEPTS OF EPIRETINAL STIMULATION
by
Devyani Nanduri
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
December 2011
Copyright 2011 Devyani Nanduri
Object Description
| Title | Prosthetic vision in blind human patients: predicting the percepts of epiretinal stimulation |
| Author | Nanduri, Devyani |
| Author email | nanduri@usc.edu;devyani.nanduri@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2011-08-24 |
| Date submitted | 2011-12-06 |
| Date approved | 2011-12-07 |
| Restricted until | 2012-12-06 |
| Date published | 2012-12-06 |
| Advisor (committee chair) | Weiland, James D. |
| Advisor (committee member) |
Fine, Ione Loeb, Gerald E. Humayun, Mark S. Medioni, Gerard G. Medioni, Gérard G. |
| Abstract | Over the last 8 years it has been shown that an implantable retinal prosthesis can partially restore visual capabilities to blind humans. With current electrode arrays it is only possible to stimulate groups of cells rather than individual single cells with spatio-temporal precision. While artificial vision from a retinal prosthesis is unable to completely replicate the neural response patterns of normal vision, by stimulating groups of cells with electrodes patients see electrically elicited visual percepts. Thus this work will focus mainly on the form of percepts created with single electrodes in a prosthesis given certain varying stimulation parameters, and the development of a model to predict how stimuli applied produce certain percepts with single and paired prosthesis electrodes. ❧ Ideally we would want this model to resemble a digital display with independent pixels in order to individually control each percept seen by the subject in relation to the stimuli. We find however that the model that best fits the data does not resemble a digital display but instead the nerve fiber bundle trajectories in the human retina. ❧ The work presented here gives insight into the factors affecting form perception with a microelectronic retinal prosthesis. Specifically, by directly measuring the shapes of visual percepts from single and paired electrodes at different stimulation parameters, the building blocks of prosthetic vision are understood. The incentive is that we can use this information to develop a strategy that can control the percepts from each individual prosthesis electrode and piece them together in an organized way to best represent the visual world. |
| Keyword | artificial vision; neural prostheses; retinal prosthesis; form vision; retintis pigmentosa; psychophysics |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Nanduri, Devyani |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@dots.usc.edu |
| Archival file | uscthesesreloadpub_Volume7/etd-NanduriDev-452.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | PROSTHETIC VISION IN BLIND HUMAN PATIENTS: PREDICTING THE PERCEPTS OF EPIRETINAL STIMULATION by Devyani Nanduri A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) December 2011 Copyright 2011 Devyani Nanduri |
