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AN ULTRASOUND LOCALIZATION SYSTEM
FOR ENDOVASCULAR AORTIC ANEURYSM REPAIR
by
Jay C. Mung
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Ful llment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
May 2012
Copyright 2012 Jay C. Mung
Object Description
| Title | An ultrasound localization system for endovascular aortic aneurysm repair |
| Author | Mung, Jay C. |
| Author email | jmung@usc.edu;jay.mung@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2012-03-20 |
| Date submitted | 2012-04-30 |
| Date approved | 2012-05-01 |
| Restricted until | 2012-05-01 |
| Date published | 2012-05-01 |
| Advisor (committee chair) | Yen, Jesse T. |
| Advisor (committee member) |
Weaver, Fred A. Shung, K. Kirk Hsiai, Tzung Nayak, Krishna |
| Abstract | Image guidance is crucial to minimally invasive surgery. This dissertation describes a novel ultrasound-based localization system to guide catheter based repair of abdominal aortic aneurysm. Chapter 1 provides background on the clinical significance of abdominal aortic aneurysm, the state of the art for interventional tool tracking and summarizes the technical contributions of this work. Chapter 2 describes the Ultrasound Localization System (ULS) in detail; it covers the real-time signal pathway from raw ultrasound data to location coordinates. The in vitro experiments show that the ULS is capable of tracking in water with 1.05 mm accuracy and with a layer of intervening pork tissue with 3.23 mm accuracy. Chapter 3 describes a pilot in vivo study using the ULS in conjunction with pre-operative CT imaging data to deploy a stent-graft in a live pig. The results showed tracking was feasible but pig bowel gas reduced system SNR. Chapter 4 describes a design revision to the ULS based on the pilot in vivo study and follows with further in vitro validation of the new design, presenting various filtering strategies to smooth motion in the presence of noise. Chapter 5 describes the second in vivo pig study, using the revised ULS described in the previous chapter as well as the third pig study, using a yet further refined version of the ULS and an intuitive "virtual endoluminal" view. The results show that the ULS system is accurate to within 1 mm of fluoroscopy and capable of delivering aortic stent-grafts within 1 cm of the intended target. Chapter 6 concludes this dissertation and suggests future work, which is required to address ultrasound tool miniaturization and image registration. |
| Keyword | biomedical engineering; image guided interventions; abdominal aortic aneurysm; stent; ultrasound; time of flight; in vivo |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Mung, Jay C. |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume4/etd-MungJayC-691-1.pdf |
Description
| Title | Page 1 |
| Full text | AN ULTRASOUND LOCALIZATION SYSTEM FOR ENDOVASCULAR AORTIC ANEURYSM REPAIR by Jay C. Mung A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Ful llment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) May 2012 Copyright 2012 Jay C. Mung |
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