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ASYMMETRIC CELL DIVISION DURING NEUROGENESIS, AND THE MECHANISMS
BEHIND GABAERGIC CORTICAL INTERNEURON DEVELOPMENT AND
SPECIFICATION
by
Corey Sayuri Kauai Kelsom
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
DECEMBER 2012
Copyright 2012 Corey Sayuri Kauai Kelsom
Object Description
| Title | Asymmetric cell division during neurogenesis, and the mechanisms behind GABAergic cortical interneuron development and specification |
| Author | Kelsom, Corey Sayuri Kauai |
| Author email | ckelsom@gmail.com;kelsom@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry and Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2012-09-20 |
| Date submitted | 2012-11-19 |
| Date approved | 2012-11-19 |
| Restricted until | 2012-11-19 |
| Date published | 2012-11-19 |
| Advisor (committee chair) | Tokes, Zoltan |
| Advisor (committee member) |
Lu, Wange Hacia, Joseph |
| Abstract | On the most basic level, an asymmetric division is a developmental process that produces two daughter cells, each possessing a different identity or fate. Progenitor cells known as neuroblasts undergo asymmetric division to produce a daughter neuroblast and another cell known as a ganglion mother cell. There are several features of asymmetric division in Drosophila melanogaster that make it a very complex process. The cell fate determinants that play a role in specifying daughter cell fate, as well as the mechanisms behind setting up cortical polarity within neuroblasts, have proved to be essential to ensuring that neurogenesis occurs properly. The role of mitotic spindle orientation, as well as how cell cycle regulators influence asymmetric division machinery, will also be addressed. Most significantly, malfunctions during asymmetric cell division have shown to be causally linked with neoplastic growth and tumor formation. A number of neuronal types and subtypes develop upon the completion of neurogenesis. One type of neuron that will be discussed at length is the GABAergic interneuron of the cerebral cortex. GABAergic interneurons are inhibitory neurons of the nervous system that are so named due to their release of the neurotransmitter gamma-aminobutyric acid (GABA). The developmental origins of GABAergic interneurons will be discussed, as well as factors that influence the migration routes that these interneurons must take in order to ultimately localize in the cerebral cortex. A number of recent findings concerning the transcriptional network of genes and candidate genes that play a role in the specification and maintenance of GABAergic interneuron fate will be discussed. Gaining an understanding of the different aspects of cortical interneuron development and specification, especially in humans, has useful clinical applications that may serve to treat various neurological disorders linked to alterations in interneuron populations. |
| Keyword | neuroblast; asymmetric; GABA; cortical; interneuron |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Kelsom, Corey Sayuri Kauai |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume6/etd-KelsomCore-1312.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Full text | ASYMMETRIC CELL DIVISION DURING NEUROGENESIS, AND THE MECHANISMS BEHIND GABAERGIC CORTICAL INTERNEURON DEVELOPMENT AND SPECIFICATION by Corey Sayuri Kauai Kelsom A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) DECEMBER 2012 Copyright 2012 Corey Sayuri Kauai Kelsom |
