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DIFFUSION TENSOR TRACTOGRAPHY:
VISUALIZATION AND QUANTITATION WITH APPLICATIONS TO
ALZHEIMER DISEASE AND TRAUMATIC BRAIN INJURY
by
Darryl Hwa Hwang
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
December 2012
Copyright 2012 Darryl Hwa Hwang
Object Description
| Title | Diffusion tensor tractography: visualization and quantitation with applications to Alzheimer disease and traumatic brain injury |
| Author | Hwang, Darryl Hwa |
| Author email | darrylhw@usc.edu;darrylhw@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2012-10-19 |
| Date submitted | 2012-11-15 |
| Date approved | 2012-11-16 |
| Restricted until | 2012-11-16 |
| Date published | 2012-11-16 |
| Advisor (committee chair) | D'Argenio, David Z. |
| Advisor (committee member) |
Yen, Jesse T. Wolf, Walter Lepore, Natasha Leporé, Natasha |
| Abstract | With the advent of diffusion tensor imaging (DTI) came insight into the organization of the most complex organic computer in existence—the human brain. Diffusion Tensor Tractography (DTT) introduced the ability to visualize, in vivo, axonal fiber bundles, the brain’s internal wiring structures. ❧ Rendering tractography in three dimensions aids in the understanding of how the axonal connections of the brain are organized, and is an important tool in illustrating the complex geometry of fiber bundles. To better facilitate the use of 3D visualization for tractography, we wrote flexible custom software targeted at researchers. ❧ The use of tractography need not be limited to visualization; quantitation allows for tractography to be used for clinical applications. In order to create objective metrics of tractography for group analysis, we have created new algorithms to register diffusion data to a single space for comparison, introduced new metrics such as tract count and tract-length histograms to quantify tractography, and developed methods to properly distribute seed points for tractography, a necessary step for quantitation. Finally, we have provided the ability to conduct tractography in the original, and most accurate, acquisition space, and then bring the tracts into a common space for comparison. ❧ Validation of theses metrics and techniques required application to conditions that affect axonal integrity. We examined data from subjects with Alzheimer Disease (AD) and traumatic brain injury (TBI), two afflictions believed to compromise axons of the brain. These studies and others indicate that our understanding of both conditions can be greatly enhanced by the application of DTI and DTT. |
| Keyword | DTI; DTT; diffusion tensor imaging; diffusion tensor tractography; tractography; MRI |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Hwang, Darryl Hwa |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@lib.usc.edu |
| Archival file | uscthesesreloadpub_Volume4/etd-HwangDarry-1294.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | DIFFUSION TENSOR TRACTOGRAPHY: VISUALIZATION AND QUANTITATION WITH APPLICATIONS TO ALZHEIMER DISEASE AND TRAUMATIC BRAIN INJURY by Darryl Hwa Hwang A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) December 2012 Copyright 2012 Darryl Hwa Hwang |
