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THE INTEGRATION OF PERIPHERAL AND CENTRAL GLUCOSE
SENSING WITH THE RATE OF FALL IN GLYCEMIA
By
Anne Jokiaho
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOLOGICAL SCIENCES)
December 2012
Copyright 2012 Anne Jokiaho
Object Description
| Title | The integration of peripheral and central glucose sensing with the rate of fall in glycemia |
| Author | Jokiaho, Anne |
| Author email | jokiaho@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Integrative and Evolutionary Biology |
| School | College of Letters, Arts And Sciences |
| Date defended/completed | 2012-09-27 |
| Date submitted | 2012-11-16 |
| Date approved | 2012-11-16 |
| Restricted until | 2012-11-16 |
| Date published | 2012-11-16 |
| Advisor (committee chair) | Donovan, Casey D. |
| Abstract | Iatrogenic hypoglycemia is the limiting factor to glycemic control in type I diabetes and in the course of late stages of type II diabetes. Profound, prolonged hypoglycemia, if unchecked, can cause brain death. When glucose levels fall, an elaborate and redundant feedback loop involving counterregulatory endocrine responses operates synchronously to prevent or correct hypoglycemia in humans. Glucose sensing elements located in the hypothalamus, hindbrain, and portal-mesenteric veins are responsible mediating this homeostatic mechanism. Individuals with diabetes are unable to maintain blood glucose within a narrow healthy physiologic range because of therapeutic insulin excess and compromised glycemic defenses. Understanding the functional organization and how glucose sensing information is integrated between these networks should provide insight into the pathogenic mechanisms underlying impaired hypoglycemic detection. ❧ Therefore, the overall goal was to 1) investigate the interaction between the peripheral glucose sensors and those of the central nervous system (CNS) when hypoglycemia develops at different rates and 2) whether catecholaminergic projections from the hindbrain to forebrain are required linkage for the control of counterregulation during insulin induced hypoglycemia and to 3) examine the role of portal-mesenteric glucagon-like peptide-1 (GLP-1) receptors in hypoglycemic sensing. |
| Keyword | hypoglycemia; portal-mesenteric glucose sensors; catecholaminergic neurons; glucagon-like peptide 1 |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Jokiaho, Anne |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@dots.usc.edu |
| Archival file | uscthesesreloadpub_Volume4/etd-JokiahoAnn-1296.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | THE INTEGRATION OF PERIPHERAL AND CENTRAL GLUCOSE SENSING WITH THE RATE OF FALL IN GLYCEMIA By Anne Jokiaho A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOLOGICAL SCIENCES) December 2012 Copyright 2012 Anne Jokiaho |
