Page 1 |
Save page Remove page | Previous | 1 of 127 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
THE EFFECTS OF THE VITREOUS STATE ON THE OCULAR PHARMACOKINETICS FOLLOWING INTRAVITREAL DRUG DELIVERY:
AN EVALUATION WITH QUANTITATIVE MAGNETIC RESONANCE IMAGING
by
Susan Shu-Hsun Lee
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
December 2012
Copyright 2012 Susan Shu-Hsun Lee
Object Description
| Title | The effects of the vitreous state on the ocular pharmacokinetics following intravitreal drug delivery: an evaluation with quantitative magnetic resonance imaging |
| Author | Lee, Susan Shu-Hsun |
| Author email | susan.sh.lee@gmail.com;susansle@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2012-09-11 |
| Date submitted | 2012-10-29 |
| Date approved | 2012-10-30 |
| Restricted until | 2012-10-30 |
| Date published | 2012-10-30 |
| Advisor (committee chair) | D'Argenio, David Z. |
| Advisor (committee member) |
Moats, Rex A. Wolf, Walter Khoo, Michael C.K. |
| Abstract | The current most effective drug delivery route for retinal diseases is via intravitreal injection, although it is unclear why there is substantial variation of dosing frequency requirements among patients to achieve visual recovery. There are a number of factors in the vitreous that could affect drug distribution, including changes in vitreous composition as a result of aging or vitrectomy. The initial hypothesis was that the state of the vitreous may be an important determinant in drug distribution in the eye, and to be able to study the effects of vitreous changes on pharmacokinetics, a number of methods were developed. |
| Keyword | MRI; ocular; pharmacokinetics; vitreous |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Lee, Susan Shu-Hsun |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume4/etd-LeeSusanSh-1260.pdf |
Description
| Title | Page 1 |
| Full text | THE EFFECTS OF THE VITREOUS STATE ON THE OCULAR PHARMACOKINETICS FOLLOWING INTRAVITREAL DRUG DELIVERY: AN EVALUATION WITH QUANTITATIVE MAGNETIC RESONANCE IMAGING by Susan Shu-Hsun Lee A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) December 2012 Copyright 2012 Susan Shu-Hsun Lee |
Comments
Post a Comment for Page 1
