Page 1 |
Save page Remove page | Previous | 1 of 38 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
VARIATION IN INSULIN-LIKE GROWTH FACTOR-2 BINDING PROTEIN 2 INTERACTS WITH ADIPOSITY TO ALTER INSULIN SENSITIVITY IN MEXICAN AMERICANS by Xia Li ________________________________________________________________________ A Thesis Presented to the FALCULTY OF THE KECK SCHOOL OF MEDICINE UNIVERSITY OF SOUTHERN CAILFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATISTICS AND EPIDEMIOLOGY) December 2008
Copyright 2008 Xia Li
Object Description
| Title | Variation in insulin-like growth factor-2 binding protein 2 interacts with adiposity to alter insulin sensitivity in Mexican Americans |
| Author | Li, Xia |
| Author email | xial@usc.edu; ionalee@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Applied Biostatistics & Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-11-02 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-11-14 |
| Advisor (committee chair) | Watanabe, Richard M. |
| Advisor (committee member) |
Mack, Wendy Allayee, Hooman |
| Abstract | GWA studies have shown that variation in IGF2BP2 is associated with T2DM. We examined a 20 kb region of IGF2BP2 for association with T2DM-related quantitative traits in Mexican American families from the BetaGene study. We genotyped 14 SNPs in 783 individuals from 146 families phenotyped by OGTT, IVGTT, and DEXA scan for percent body fat. Three SNPs and one SNP combination were tested for association with T2DM-related quantitative traits using a variance components framework. rs11705701 showed association with adiposity (P_ACT=0.041), whereby body fat decreased ~1.5-2% per copy of the A allele. We next tested whether rs11705701 interacted with body fat to affect T2DM-related quantitative traits. The joint effect of rs11705701 and its interaction with percent body fat was significantly associated with S_I (Bonferroni p=0.028). We conclude that rs11705701 is associated with body fat and this effect on body fat influences insulin resistance which may contribute to T2DM. |
| Keyword | adiposity; genetics; IGF2BP2; insulin resistance; Mexican American; type 2 diabetes |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1766 |
| Rights | Li, Xia |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Li-2522 |
| Archival file | uscthesesreloadpub_Volume23/etd-Li-2522.pdf |
Description
| Title | Page 1 |
| Full text | VARIATION IN INSULIN-LIKE GROWTH FACTOR-2 BINDING PROTEIN 2 INTERACTS WITH ADIPOSITY TO ALTER INSULIN SENSITIVITY IN MEXICAN AMERICANS by Xia Li ________________________________________________________________________ A Thesis Presented to the FALCULTY OF THE KECK SCHOOL OF MEDICINE UNIVERSITY OF SOUTHERN CAILFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (APPLIED BIOSTATISTICS AND EPIDEMIOLOGY) December 2008 Copyright 2008 Xia Li |
Comments
Post a Comment for Page 1
