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ADOPTIVE CELL-BASED IMMUNOTHERAPY OF CANCER
by
Hae Jung Won
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(PHYSIOLOGY AND BIOPHYSICS)
August 2008
Copyright 2008 Hae Jung Won
Object Description
| Title | Adoptive cell-based immunotherapy of cancer |
| Author | Won, Hae Jung |
| Author email | haejungw@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Physiology & Biophysics |
| School | Keck School of Medicine |
| Date defended/completed | 2008-06-10 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-07-31 |
| Advisor (committee chair) | Kaslow, Harvey |
| Advisor (committee member) |
Peti-Peterdi, Janos Epstein, Alan |
| Abstract | Background: Pertussis toxin (PT) is used to promote autoimmune response. Evidence suggests this effect arises by improving T cell function. We hypothesized PT or PTtreated spleen cells (PT-SPC) can improve the efficacy of adoptively transferred T cells in tumor immunotherapy.; Purpose: Establish experimental systems to test the hypothesis.; Approach: Pmel-1 spleen cells were cultured with various cytokines for different periods of time to find optimal condition to activate the T cells. The cells were administrated to mice bearing B16 melanoma. We examined combining immunotherapy with DC101, anti-VEGF receptor 2 antibody.; Result: Tumor associated T cell primed with antigen in the presence of IL-12 was effective in rejecting the tumor prophylactically and therapeutically whereas IL-2 and IL-15 failed. DC101 synergized efficacy. PT and PT-SPC resulted in death of mice.; Conclusion: Culturing T cells with IL-12 for 3 days generated effective effector T cells and their anti-tumor function was enhanced by co-administration of DC101. PT holds potential to improve efficacy. |
| Keyword | immunotherapy; pretussis toxin; T cell; angiogenesis |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1473 |
| Rights | Won, Hae Jung |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Won-20080731 |
| Archival file | uscthesesreloadpub_Volume44/etd-Won-20080731.pdf |
Description
| Title | Page 1 |
| Full text | ADOPTIVE CELL-BASED IMMUNOTHERAPY OF CANCER by Hae Jung Won A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (PHYSIOLOGY AND BIOPHYSICS) August 2008 Copyright 2008 Hae Jung Won |
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