Page 1 |
Save page Remove page | Previous | 1 of 46 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
ROLE OF NOTCH AND HYALURONAN IN MODULATING THE EXPRESSION
OF
LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR1 (LYVE1)
by
Sathish Kumar Ganesan
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(MOLECULAR MICROBIOLOGY AND IMMUNOLOGY)
August 2008
Copyright 2008 Sathish Kumar Ganesan
Object Description
| Title | Role of Notch and hyaluronan in modulating the expression of lymphatic vessel endothelial hyaluronan receptor1 (LYVE1) |
| Author | Ganesan, Sathish Kumar |
| Author email | g.sathish.k@gmail.com; sathish158@yahoo.co.in |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Molecular Microbiology & Immunology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-06-23 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-08-04 |
| Advisor (committee chair) | Schonthal, Alex |
| Advisor (committee member) |
Landolph, Joseph, Jr. Hong, Young Kwon |
| Abstract | Lymphatic Hyaluronan receptor (LYVE1) is a lymphatic endothelial cell marker and is implicated in the embryonic development of the lymphatic system. Notch plays a major role in development of the blood vascular system. Previous studies at our lab found that Notch activates LYVE1. The aim of this project was to investigate this new finding. We have studied activation of LYVE1 by Notch at transcriptional and translational levels by overexpression of Notch and also by using Notch inhibitors. Hyaluronic acid (HA) is ligand of LYVE1. We have studied the influence of HA with respect to Notch activation of LYVE1. We show that Notch activates LYVE1, and the soluble form of Notch ligand can inhibit Notch-mediated activation of LYVE1. We have analyzed the effect of Notch inhibitors on the binding of HA to LYVE1 and also LEC proliferation. We also found that HA influences cell migration when notch activity is inhibited. |
| Keyword | LYVE1; hyaluronan; Notch1 |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1522 |
| Rights | Ganesan, Sathish Kumar |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Ganesan-2260 |
| Archival file | uscthesesreloadpub_Volume40/etd-Ganesan-2260.pdf |
Description
| Title | Page 1 |
| Full text | ROLE OF NOTCH AND HYALURONAN IN MODULATING THE EXPRESSION OF LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR1 (LYVE1) by Sathish Kumar Ganesan A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (MOLECULAR MICROBIOLOGY AND IMMUNOLOGY) August 2008 Copyright 2008 Sathish Kumar Ganesan |
Comments
Post a Comment for Page 1
