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IDENTIFICATION AND CHARACTERIZATION OF IMMUNE-ESCAPE MECHANISMS IN SOLID TUMORS
by
Scott Anthony Bergfeld
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(EXPERIMENTAL AND MOLECULAR PATHOLOGY)
August 2008
Copyright 2008 Scott Anthony Bergfeld
Object Description
| Title | Identification and characterization of immune-escape mechanisms in solid tumors |
| Author | Bergfeld, Scott Anthony |
| Author email | bergfeld@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Experimental & Molecular Pathology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-06-24 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-07-31 |
| Advisor (committee chair) | Epstein, Alan L. |
| Advisor (committee member) |
Taylor, Clive R. Kaslow, Harvey R. |
| Abstract | Tumor development depends on immunomodulatory signals produced by multiple cells within the microenvironment, resulting in the recruitment of suppressive cell populations which limit anti-tumor immunity. Expression markers for suppressive cells can indicate their relative contribution to tumor immunoregulation and highlight potential treatments to limit proliferation and spread. With this goal in mind, Rt-PCR analysis was carried out on murine tumor cell lines grown in vivo and in vitro, along with immunohistochemical analysis of expression markers. In vivo, murine tumors of lung, breast and colorectal origin were found to upregulate the Treg marker FoxP3, the suppressive DC marker B7-H3, and the MSC marker arginase I. IHC studies were inconclusive, but in vitro coculturing lung or breast tumor with myeloid cells induced production of arginase I by myeloid cells. Chemokines found to recruit myeloid cells were also upregulated. MSC recruitment pathways may provide a novel target for future combination therapies. |
| Keyword | myeloid suppressor cell; arginase I; monocyte chemoattractant protein-2; platelet factor 4 |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1475 |
| Rights | Bergfeld, Scott Anthony |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Bergfeld-20080731 |
| Archival file | uscthesesreloadpub_Volume44/etd-Bergfeld-20080731.pdf |
Description
| Title | Page 1 |
| Full text | IDENTIFICATION AND CHARACTERIZATION OF IMMUNE-ESCAPE MECHANISMS IN SOLID TUMORS by Scott Anthony Bergfeld A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (EXPERIMENTAL AND MOLECULAR PATHOLOGY) August 2008 Copyright 2008 Scott Anthony Bergfeld |
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