Page 1 |
Save page Remove page | Previous | 1 of 36 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
APPLICATION OF RANDOM EFFECTS MODELS TO A CLINICAL
RETROSPECTIVE HIERARCHICAL DATABASE
by
Choo Phei Wee
A Thesis Presented to the
FACULTY OF THE KECK SCHOOL OF MEDICINE
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
August 2008
Copyright 2008 Choo Phei Wee
Object Description
| Title | Application of random effects models to a clinical retrospective hierarchical database |
| Author | Wee, Choo Phei |
| Author email | cwee@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2008 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-07-21 |
| Advisor (committee chair) |
Conti, David Dorey, Frederick |
| Advisor (committee member) | Mack, Wendy |
| Abstract | The NEC study is a retrospective study exploring factors related to mortality and evaluating if surgical treatment for NEC results in less mortality in at-risk neonates after adjusting for all risk factors. Based on OSHPD inpatient hospital discharge data from the NEC study, we initially found that the surgery did not decrease the risk of mortality before any adjustment (OR=3.37, 95%CI=2.85-4.88, p<0.001). NEC surgery remained a significant risk factor after adjusting for NICU levels and other risk factors while using hospitals as a random effect (OR=2.40, 95%CI=1.72-3.36, p<0.001). Thus, after adjusting for all available risk factors, surgery was association with a doubling in the likelihood of death. Due to the variation of mortality amongst the hospitals, and the correlation of outcomes within the hospitals, it is preferable to use a random effects model to adjust for NICU levels with hospitals treated as a random effect. |
| Keyword | random effects models |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1362 |
| Rights | Wee, Choo Phei |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Wee-20080721 |
| Archival file | uscthesesreloadpub_Volume14/etd-Wee-20080721.pdf |
Description
| Title | Page 1 |
| Full text | APPLICATION OF RANDOM EFFECTS MODELS TO A CLINICAL RETROSPECTIVE HIERARCHICAL DATABASE by Choo Phei Wee A Thesis Presented to the FACULTY OF THE KECK SCHOOL OF MEDICINE UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) August 2008 Copyright 2008 Choo Phei Wee |
Comments
Post a Comment for Page 1
