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STRUCTURAL CHARACTERIZATION
OF PSEUDOREPEAT SHUFFLED ALPHA-SYNUCLEIN
by
Leena S. Park
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
August 2008
Copyright 2008 Leena S. Park
Object Description
| Title | Structural characterization of pseudorepeat shuffled alpha-synuclein |
| Author | Park, Leena S. |
| Author email | psy3572@hotmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-03-25 |
| Date submitted | 2008 |
| Restricted until | Restricted until 27 June 2010. |
| Date published | 2010-06-27 |
| Advisor (committee chair) | Tokes, Zoltal |
| Advisor (committee member) |
Ulmer, Tobias Langen, Ralf |
| Abstract | The 140-residue alpha-synuclein plays a central role in the molecular chain of events leading to Parkinson' s disease. Alpha-synuclein is dynamically unstructured in aqueous solution, but readily binds to negatively charged membranes and micelles. Seven degenerate 11-residue repeats located within the first 89 amino acid residues confer membrane binding in an alpha-helical conformation. In this research, the structure of a pseudorepeat shuffled alpha-synuclein variant is characterized by NMR spectroscopy and is compared to the wild-type protein. It is shown that residues 30 to 40 become more rigid than the corresponding wild-type segment. Moreover, in contrast to the wild type, which prefers to adopt two anti-parallel helices, the shuffled variant prefers to adopt a single helix. |
| Keyword | alpha-synuclein |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1299 |
| Rights | Park, Leena S. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Park-20080627 |
| Archival file | uscthesesreloadpub_Volume17/etd-Park-20080627.pdf |
Description
| Title | Page 1 |
| Full text | STRUCTURAL CHARACTERIZATION OF PSEUDOREPEAT SHUFFLED ALPHA-SYNUCLEIN by Leena S. Park A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) August 2008 Copyright 2008 Leena S. Park |
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