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ROLES OF KLF4 IN EMBRYONIC STEM CELLS
by
Rosemary G. Andrianakos
_____________________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY)
May 2008
Copyright 2008 Rosemary G. Andrianakos
Object Description
| Title | Roles of Klf4 in embryonic stem cells |
| Author | Andrianakos, Rosemary G. |
| Author email | roseandrianakos@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-03-15 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-04-29 |
| Advisor (committee chair) | Lu, Wange |
| Advisor (committee member) |
Tokes, Zoltan Stellwagen, Robert |
| Abstract | Human and mouse ES cells are defined by their ability to confer self-renewal and differentiate into various cell types, making them an invaluable tool for investigation of Stem cell maintenance, differentiation, and reprogramming. Human ES cells have infinite potential for therapeutic applications. Unfortunately, acquiring ES cells is problematic, and reprogramming somatic cells to Induced Pluripotent Stem Cells occurs by an unknown mechanism.; This thesis establishes Klf4' s role in ES cell maintenance. Klf4 interacts with core ES cell maintenance transcription factors, Oct-4 and Sox-2, which bind to Klf4 's C-terminal domain zinc fingers, and this binding is essential for the collective function of the ES-Cell maintenance network. Moreover, this study contributes to the knowledge of dose dependant cross-regulation of various factors in the stem cell maintenance network, and provides a model for understanding how these factors may confer ES cell stability, self renewal, and reprogramming. |
| Keyword | stem cells; reprogramming somatic cells; Klf4; Oct-4; Sox-2; differentiation of Es cells; pluripotency; ES cell maintenance and self renewal |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1210 |
| Rights | Andrianakos, Rosemary G. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Andrianakos-20080429 |
| Archival file | uscthesesreloadpub_Volume14/etd-Andrianakos-20080429.pdf |
Description
| Title | Page 1 |
| Full text | ROLES OF KLF4 IN EMBRYONIC STEM CELLS by Rosemary G. Andrianakos _____________________________________________________________ A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY) May 2008 Copyright 2008 Rosemary G. Andrianakos |
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