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A NEW APPROACH FOR ASSESSING EARLY OSTEOARTHRITIS IN THE
RAT
by
Mark Joseph Roberts
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CLINICAL AND BIOMEDICAL INVESTIGATIONS)
August 2008
Copyright 2008 Mark Joseph Roberts
Object Description
| Title | A new approach for assessing early osteoarthritis in the rat |
| Author | Roberts, Mark Joseph |
| Author email | mark@griffints.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Clinical & Biomedical Investigations |
| School | Keck School of Medicine |
| Date defended/completed | 2008-05-01 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-06-10 |
| Advisor (committee chair) | Azen, Stanley |
| Advisor (committee member) |
Schechter, Joel Frenkel, Baruch |
| Abstract | Several animal models have been developed to investigate osteoarthritis and potential disease modifying therapeutics. However, early disease data from these models are limited by the resolution of current imaging modalities. In this in vitro study, an optical coherence tomography (OCT) system, with an axial resolution of 15 µm, was used to track sequential changes in osteoarthritic rat knees. Osteoarthritis was induced via transection of the medial collateral ligament and an artificial full thickness meniscal tear. Imaging occurred at one, two, and three weeks after surgery.; OCT successfully detected early signs of osteoarthritic change, including alteration of the cartilage surface and disruption of the bone-cartilage interface. This study demonstrates that OCT, along with the induction of mechanical injury, provides an excellent model for monitoring the sequential changes of osteoarthritis. |
| Keyword | osteoarthritis; optical coherence tomography |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1260 |
| Rights | Roberts, Mark Joseph |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Roberts-20080610 |
| Archival file | uscthesesreloadpub_Volume26/etd-Roberts-20080610.pdf |
Description
| Title | Page 1 |
| Full text | A NEW APPROACH FOR ASSESSING EARLY OSTEOARTHRITIS IN THE RAT by Mark Joseph Roberts A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CLINICAL AND BIOMEDICAL INVESTIGATIONS) August 2008 Copyright 2008 Mark Joseph Roberts |
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