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THE ROLE OF BMP SIGNALING IN THE REGULATION
OF HAIR FOLLICLE PROGENITORS
by
Leila Sheikholeslam
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(EXPERIMENTAL AND MOLECULAR PATHOLOGY)
December 2011
Copyright 2011 Leila Sheikholeslam
Object Description
| Title | The role of BMP signaling in the regulation of hair follicle progenitor cells |
| Author | Sheikholeslam, Leila |
| Author email | leilas29@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Experimental and Molecular Pathology |
| School | Keck School of Medicine |
| Date defended/completed | 2011-10-25 |
| Date submitted | 2011-11-16 |
| Date approved | 2011-11-16 |
| Restricted until | 2011-11-16 |
| Date published | 2011-11-16 |
| Advisor (committee chair) | Kobielak, Kris |
| Advisor (committee member) |
Widelitz, Randall B. Kobielak, Agnieszka Ouellette, Andre J. |
| Abstract | The spatially defined differentiation programs of the hair follicle provide a significant model to study the underlying mechanisms of stem cell lineage determination. The biochemical signals that govern these biological mechanisms continue to be unraveled. Bone Morphogenetic Proteins (BMP) play an integral role in the homeostasis and differentiation of the hair follicle. ❧ To further study the role of BMP signaling in regulation of hair follicle progenitors, we labeled hair follicle progenitor cells in conditional K14-Cre-mediated-BMPR1A mice using a green fluorescent protein (GFP) reporter gene to investigate the target genes of BMP signaling involved in the differentiation of progenitor cells into the inner root sheath and hair shaft. Without BMPR1A activation, BMP signaling responsive genes are downregulated and the differentiation program is compromised. ❧ Our studies indicate the important role of Wnt signaling in the differentiation program of hair follicle progenitors and an elusive crosstalk between the Wnt and BMP pathway that further define the differentiation of the hair shaft cortical layer. |
| Keyword | BMP signaling; hair follicle progenitors; differentiation |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Sheikholeslam, Leila |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@lib.usc.edu |
| Archival file | uscthesesreloadpub_Volume71/etd-Sheikholes-410.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | THE ROLE OF BMP SIGNALING IN THE REGULATION OF HAIR FOLLICLE PROGENITORS by Leila Sheikholeslam A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (EXPERIMENTAL AND MOLECULAR PATHOLOGY) December 2011 Copyright 2011 Leila Sheikholeslam |
