Page 1 |
Save page Remove page | Previous | 1 of 182 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
COMMON GENETIC VARIATION AND OBESITY:
A MULTI-ETHNIC AND PEDIATRIC PERSPECTIVE
by
Mohamed T. Hassanein
A Dissertation Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(SYSTEMS BIOLOGY AND DISEASE)
December 2011
Copyright 2011 Mohamed T. Hassanein
Object Description
| Title | Common genetic variation and obesity: a multi-ethnic and pediatric perspective |
| Author | Hassanein, Mohamed T. |
| Author email | hassanei@usc.edu;mthassanein@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Systems Biology and Disease |
| School | Keck School of Medicine |
| Date defended/completed | 2011-07-26 |
| Date submitted | 2011-11-02 |
| Date approved | 2011-11-02 |
| Restricted until | 2012-11-02 |
| Date published | 2012-11-02 |
| Advisor (committee chair) | Schumacher , Fredrick |
| Advisor (committee member) |
Haiman, Christopher Berhane, Kiros Mittelman , Steven |
| Abstract | This dissertation work assesses the influence of genetic variation on measures of obesity in ancestrally diverse populations and in both adults and pediatrics. Quantifying how genetic variation influences such measures elucidates the genetic architecture of body mass index (BMI). The research presented in this work has been instrumental in generalizing established genetic findings as well as implicating a new set of potential variants important in influencing longitudinal BMI change in pediatrics. ❧ Chapter two entitled ""Fine-mapping of the Association with Obesity at the FTO Locus in African-derived Populations"" examines whether variants in the FTO locus associated with BMI identified in European populations also show similar association in African derived populations. This analysis was conducted in conjunction across five large studies that in total had nearly 10,000 subjects with African ancestry. The SNPs selected for analysis were correlated with the index signal of association in individuals of European ancestry but that have varying degrees of correlation in African-derived individuals. The work was published in 2010 in the journal Human Molecular Genetics (Human Molecular Genetics. vol. 19, no. 14, pp. 2907-2916, 2010.). ❧ Chapter three entitled ""Genetic Determinants of Longitudinal BMI Change in Both Hispanics and Non-Hispanic White Pediatrics From the Children's Health Study"" is focused on testing whether BMI genetic variants identified in adult cross-sectional studies associate with cross-sectional as well as longitudinal BMI measures among pediatrics. The most recent genome-wide association (GWA) study on BMI identified thirty-two variants in nearly a quarter million subjects of European ancestry. Generalizing these established variants in pediatrics is important in order to assess whether the same genetic determinants that influence BMI in adults have an impact children. This work utilized data from the Children's Health Study, which is a longitudinal study of health outcomes in children throughout southern California. Given the longitudinal structure of the data, in addition to assessing cross-sectional genetic effects, we were able to capture the longitudinal genetic effects which had yet to be analyzed in such a manner in the literature. This work is currently under further review at the journal Human Molecular Genetics. ❧ Chapter four entitled ""Genome-Wide Association Study of Longitudinal BMI and BMI-Z Change in the Children's Health Study"" examined whether additional variants across the genome influence BMI and BMI-Z change during childhood in pediatrics. Utilizing subjects for the Children's Health Study, we conducted a GWA study on longitudinal BMI and BMI-Z change over a fourteen year period. We identified many novel SNPs and further assessed their effects in published studies in adult populations of European ancestry. Given the nature of GWA studies, future replication in independent samples will be required to verify our initial findings. |
| Keyword | genomics; obesity; African-American; Hispanic; pediatrics |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Hassanein, Mohamed T. |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume71/etd-HassaneinM-388.pdf |
Description
| Title | Page 1 |
| Full text | COMMON GENETIC VARIATION AND OBESITY: A MULTI-ETHNIC AND PEDIATRIC PERSPECTIVE by Mohamed T. Hassanein A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (SYSTEMS BIOLOGY AND DISEASE) December 2011 Copyright 2011 Mohamed T. Hassanein |
Comments
Post a Comment for Page 1
