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ONE-DIMENSIONAL NANOSTRUCTURES FOR NOVEL BIOSENSOR AND TRANSPARENT ELECTRONICS APPLICATIONS
by
Hsiao-Kang Chang
A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (ELECTRICAL ENGINEERING)
December 2011
Copyright 2011 Hsiao-Kang Chang
Object Description
| Title | One-dimensional nanostructures for novel biosensor and transparent electronics applications |
| Author | Chang, Hsiao-Kang |
| Author email | hsiaokac@usc.edu;hsiaokang@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Electrical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2011-10-24 |
| Date submitted | 2011-10-27 |
| Date approved | 2011-10-27 |
| Restricted until | 2011-10-27 |
| Date published | 2011-10-27 |
| Advisor (committee chair) | Zhou, Chongwu |
| Advisor (committee member) |
Thompson, Mark E. Cronin, Stephen B. |
| Abstract | This dissertation presents one-dimensional nanostructures for novel biosensors and transparent electronics applications. In chapter 1, background information regarding nanomaterials studied in this dissertation is described. ❧ In chapter 2, I describe the first application of antibody mimic proteins (AMPs) in the field of nanobiosensors. In2O3 nanowire based biosensors have been configured with an AMP (Fibronectin, Fn) to detect nucleocapsid (N) protein, a biomarker for severe acute respiratory syndrome (SARS). Using these devices, N protein was detected at sub-nanomolar concentration in the presence of 44 µM bovine serum albumin as a background. Furthermore, the binding constant of the AMP to Fn was determined from the concentration dependence of the response of our biosensors. ❧ In chapter 3, I demonstrate an In2O3 nanowire-based biosensing system that is capable of performing rapid, label-free, electrical detection of cancer biomarkers directly from human whole blood collected by a finger prick. Detection of multiple cancer biomarkers with high reliability at clinically meaningful concentrations from whole blood collected by a finger prick using this sensing system is demonstrated. ❧ In chapter 4, I introduce a top-down nanobiosensor based on polysilicon nanoribbon with enhanced yield and device uniformity. The polysilicon nanoribbon devices can be fabricated by conventional photolithography with only easily available materials and equipments required, thus results in great time and cost efficiency as well as scalability. The devices show great response to pH changes with a wide dynamic range and high sensitivity. Biomarker detection is also demonstrated with clinically relevant sensitivity. Such results suggest that polysilicon nanoribbon devices exhibit great potential toward a highly efficient, reliable and sensitive biosensing platform. ❧ In chapter 5, I demonstrate the first printed nanobiosensor application based on separated semiconducting single-walled carbon nanotubes. The printed nanosensors exhibit reliable sensing to pH variation. We have successfully achieved the detection of Estradial, a commonly used hormone biomarker, as a proof of concept for using printed nanobiosensors on disease diagnosis. ❧ High-performance fully transparent thin-film transistors (TTFTs) on both rigid and flexible substrates with transfer printed aligned nanotubes as the active channel and indium-tin oxide as the source, drain and gate electrodes is reported in chapter 6. Such transistors are fabricated through low temperature processing, which allows device fabrication even on flexible substrates. Transparent transistors with high effective mobilities (~1,300 cm2V-1s-1) were first demonstrated on glass substrates via engineering of the source and drain contacts, and high on/off ratio (3 × 104) was achieved using electrical breakdown. In addition, flexible TTFTs with good transparency were also fabricated and successfully operated under bending up to 120˚. All of the devices showed good transparency (~80% on average). The transparent transistors were further utilized to construct a fully transparent and flexible logic inverter on a plastic substrate, and also used to control commercial GaN light–emitting diodes (LEDs) with light intensity modulation of 103. Our results suggest that aligned nanotubes have great potential to work as building blocks for future transparent electronics. ❧ In chapter 7, a summary of all topics in this dissertation is described. Future work regarding the nanobiosensor project is also proposed. |
| Keyword | nanotechnology; nanobiosensor; transparent electronics; metal oxide nanowire; carbon nanotube; polysilicon nanoribbon |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Contributing entity | University of Southern California |
| Rights | Chang, Hsiao-Kang |
| Physical access | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@dots.usc.edu |
| Archival file | uscthesesreloadpub_Volume71/etd-ChangHsiao-368.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | ONE-DIMENSIONAL NANOSTRUCTURES FOR NOVEL BIOSENSOR AND TRANSPARENT ELECTRONICS APPLICATIONS by Hsiao-Kang Chang A Dissertation Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (ELECTRICAL ENGINEERING) December 2011 Copyright 2011 Hsiao-Kang Chang |
