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DEFINING FUNCTION OF AN AUTISM PATHWAY IN HUMAN NEURONAL CELLS
by
Anita Ramanathan
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
August 2011
Copyright 2011 Anita Ramanathan
Object Description
| Title | Defining function of an autism pathway in human neuronal cells |
| Author | Ramanathan, Anita |
| Author email | anitaram@usc.edu;anita.rrn@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry and Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2011-05-18 |
| Date submitted | 2011-07-14 |
| Date approved | 2011-07-15 |
| Restricted until | 2011-07-15 |
| Date published | 2011-07-15 |
| Advisor (committee chair) | Tokes, Zoltan |
| Advisor (committee member) |
Campbell, Daniel Laird, Ite |
| Abstract | Autism is a neurodevelopmental disorder that affects 1% of the population and causes deficits in social interaction, communication and behavioral flexibility. Autism is highly heritable, but multiple genes appear to contribute to the disorder. Recent research indicates that several genes in the phosphoinositide‐3‐kinase (PI3K) signaling pathway contribute to autism risk (Levitt & Campbell, 2009, Journal of Clinical Investigation, 119: 747). Moreover, many neurodevelopmental syndromes like neurofibromatosis, tuberous sclerosis and Fragile X, having significant rates of co-occurring autism, show evident disruption in the signaling of the PI3K pathway. ❧ Dysfunction of the PI3K pathway signaling has been described extensively in cancer cells, and although it has received substantial implications in ASD, it has not been studied in brain cells. To begin to understand how PI3K signaling is disrupted in autism, we propose experiments in human neuronal cell lines that use the tools developed by years of cancer research. The cancer literature indicates this pathway can be manipulated by the use of pharmacological inhibitors of PI3K. We plan to study the effect of an array of inhibitors of PI3K as well as its individual subunits on the cellular signaling pathway of these neuronal cell lines. |
| Keyword | autism; luminex; PI3K signaling; PI3K Akt pathway |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Ramanathan, Anita |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume71/etd-Ramanathan-95.pdf |
Description
| Title | Page 1 |
| Full text | DEFINING FUNCTION OF AN AUTISM PATHWAY IN HUMAN NEURONAL CELLS by Anita Ramanathan A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) August 2011 Copyright 2011 Anita Ramanathan |
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