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RISK OF PRION DISEASE TRANSMISSION THROUGH BOVINE-DERIVED BONE SUBSTITUTES
by
Yeoungsug Kim
_________________________________________________________
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CRANIOFACIAL BIOLOGY)
August 2011
Copyright 2011 Yeoungsug Kim
Object Description
| Title | Risk of prion disease transmission through bovine-derived bone substitutes |
| Author | Kim, Yeoungsug |
| Author email | yeoungki@usc.edu;yeongsgkim@yahoo.co.kr |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Cranio-Facial Biology |
| School | School of Dentistry |
| Date defended/completed | 2011-06-16 |
| Date submitted | 2011-07-13 |
| Date approved | 2011-07-13 |
| Restricted until | 2011-07-13 |
| Date published | 2011-07-13 |
| Advisor (committee chair) | Nowzari, Hessam |
| Advisor (committee member) |
Rich, Sandra Navazesh, Mahvash |
| Abstract | Background: Despite epidemiological and laboratory evidence for the causal association between variant Creutzfeldt-Jakob disease and Bovine Spongiform Encephalopathy (BSE), bovine origin graft materials are widely used during dental surgical procedures. The aim of this study is to assess the risk of BSE transmission through bovine bone substitutes by a systematic literature review. ❧ Methods: A systematic review was performed on studies in MEDLINE published in English between 1998 and 2010 to evaluate the risk of BSE transmission from bovine-derived bone graft materials. ❧ Results: Search strategy identified 1912 potentially relevant studies, and 25 studies were included in the final analysis. Wide distribution of PrPSc and BSE infectivity was detected in peripheral nerve system and other tissues including bone marrow and serum samples. Low levels of prion infectivity in non-central nervous system (CNS) tissues appeared increased with contamination by CNS tissues with potentially high prion infectivity during bovine slaughtering and carcass handling process, and washing facilities could not eliminate the CNS tissue contamination occurred on bovine carcasses, operatives, and abattoir machinery. Proteins were detected in some deproteinized anorganic bovine bone substitutes, and inactivation of BSE prion infectivity by biomaterial manufacturing processes has not been proven. Additionally, PrPSc , a current surrogate marker for transmissible spongiform encephalopathies (TSE) infectivity including BSE, was not always detected in tissues containing BSE infectivity, and inconsistent results among different PrPSc detection methods was not uncommon. ❧ Conclusion: This review indicates that bovine-derived graft biomaterials carry a risk of prion transmission to patients. |
| Keyword | prion; bovine spongiform encephalopathy; bovine-derived bone substitutes; PrPSc; BSE prion inactivation; prion infectivity; protein |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Kim, Yeoungsug |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume71/etd-KimYeoungs-86.pdf |
Description
| Title | Page 1 |
| Full text | RISK OF PRION DISEASE TRANSMISSION THROUGH BOVINE-DERIVED BONE SUBSTITUTES by Yeoungsug Kim _________________________________________________________ A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CRANIOFACIAL BIOLOGY) August 2011 Copyright 2011 Yeoungsug Kim |
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