Page 1 |
Save page Remove page | Previous | 1 of 56 | Next |
|
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
All (PDF)
|
This page
All
Subset |
EXPOSURE TO FREEWAY AIR POLLUTION AND
DEVELOPMENTAL DELAYS
by
Nitya Mary Mathew
A Thesis Presented to the
FACULTY OF THE USC GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
August 2011
Copyright 2011 Nitya Mary Mathew
Object Description
| Title | Exposure to freeway air pollution and developmental delays |
| Author | Mathew, Nitya Mary |
| Author email | nmathew@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2011-07-08 |
| Date submitted | 2011-07-10 |
| Date approved | 2011-07-11 |
| Restricted until | 2011-07-11 |
| Date published | 2011-07-11 |
| Advisor (committee chair) | Azen, Stanley |
| Advisor (committee member) |
Gauderman, Jim Chen, J.C. Volk, Heather |
| Abstract | Background: Traffic related air pollution, using measurements of specific pollutants such as PAH or NO₂, highly associated with traffic exhaust, have been found to significantly decrease cognitive ability in children. However, freeway proximity models are a better proxy for a global measurement of ambient pollutants associated with freeway traffic. ❧ Objectives: Using distance to nearest freeway as a proxy, determine whether traffic related air pollution is associated with developmental delays, evaluated using cognitive and adaptive assessments. Further analyze the association between freeway air pollution and cognitive and adaptive ability among cases and controls. ❧ Methods: Data from the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study was utilized to obtain freeway distance and information on pertinent covariates. The Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) were used to diagnose 132 children with a developmental delay and 259 children as typically developing controls. Birth certificate residence was geocoded using ArcGIS software to obtain distance measures, categorized four different ways according to previous research and distribution. Logistic regression was used to compare cases and controls for each method of categorization as well as continuously. Linear regression was used to analyze assessment scores among controls, and logistic regression was used to analyze assessment scores among cases, for each method of freeway distance categorization. ❧ Results: Close proximity to a freeway around time of birth, characterized as living within 300 m relative to greater than 1400 m, is significantly associated with developmental delays (Adjusted OR = 2.38, 95% Confidence Interval (CI) = (1.12, 5.11), p = 0.024). Even among typically developing controls, freeway air pollution significantly decreases cognitive ability, with no significant effects on adaptive ability. ❧ Conclusions: Results suggest a significant effect of a wide range of air pollutants associated with freeway exhaust on a child’s neurodevelopment early in life. |
| Keyword | air pollution, developmental delays, freeway distance, Mullens Scale of Early Learning, Vineland Adaptive Behavior Scale |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m |
| Rights | Mathew, Nitya Mary |
| Access conditions | The author retains rights to his/her dissertation, thesis or other graduate work according to U.S. copyright law. Electronic access is being provided by the USC Libraries in agreement with the author, as the original true and official version of the work, but does not grant the reader permission to use the work if the desired use is covered by copyright. It is the author, as rights holder, who must provide use permission if such use is covered by copyright. The original signature page accompanying the original submission of the work to the USC Libraries is retained by the USC Libraries and a copy of it may be obtained by authorized requesters contacting the repository e-mail address given. |
| Repository name | University of Southern California Digital Library |
| Repository address | USC Digital Library, University of Southern California, University Park Campus MC 7002, 106 University Village, Los Angeles, California 90089-7002, USA |
| Repository email | cisadmin@usc.edu |
| Archival file | uscthesesreloadpub_Volume71/etd-MathewNity-69.pdf |
Description
| Title | Page 1 |
| Full text | EXPOSURE TO FREEWAY AIR POLLUTION AND DEVELOPMENTAL DELAYS by Nitya Mary Mathew A Thesis Presented to the FACULTY OF THE USC GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) August 2011 Copyright 2011 Nitya Mary Mathew |
Comments
Post a Comment for Page 1
