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SKIN APPENDAGE GROWTH CONTROL BY HORMONES AND
MORPHOGENS
by
Julie Ann Mayer
____________________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PATHOBIOLOGY)
December 2007
Copyright 2007 Julie Ann Mayer
Object Description
| Title | Skin appendage growth control by hormones and morphogens |
| Author | Mayer, Julie Ann |
| Author email | juliemay@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Pathobiology |
| School | Keck School of Medicine |
| Date defended/completed | 2007-07-17 |
| Date submitted | 2007 |
| Restricted until | Restricted until 8 Dec. 2009. |
| Date published | 2009-12-08 |
| Advisor (committee chair) | Widelitz, Randall |
| Advisor (committee member) |
Chuong, Cheng-Ming Press, Michael Pike, Malcolm |
| Abstract | The mammary gland, hairs, feathers, etc. are all skin appendages derived from epidermis as a result of epithelial - mesenchymal interactions. The growth of these epithelial organs shares fundamental morphogens including BMP, SHH, Wnt/beta catenin, etc. Mutation or de-regulation of these morphogens have been identified in many human diseases including tumors and genetic diseases. Sex hormones also play a major role in regulating the growth and phenotypes of these epithelial organs (sexual dimorphism). How the sex hormones are coupled to the morphogens is mostly unknown. In this thesis I utilized two distinct epithelial appendage models, a chicken tail feather (between rooster and hen), and the mouse mammary gland model. In the chicken tail feather model, we were able to show that the female feather phenotype is dependent on the local conversion of estrogen. We also utilized the transgenic KRT14-Noggin (BMP antagonist) mouse that shows abnormal mammary gland stroma formation and delayed involution. Imbalance of BMP pathway lead to increased collagen I deposition surrounding the ducts and hair formation within the nipple of these transgenic mice. Taken together, this opens the possibility that the sex hormone pathway may be involved with the BMP pathway. We offer novel experimental models that may contribute to further understanding of the hormone dependent growth of breast and prostate cancer, which are clinically more important but less susceptible to experimental analyses. |
| Keyword | feather; hair; BMP pathway; estrogen; androgen; receptor; mammary gland; nipple; noggin |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m972 |
| Rights | Mayer, Julie Ann |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Mayer-20071208 |
| Archival file | uscthesesreloadpub_Volume44/etd-Mayer-20071208.pdf |
Description
| Title | Page 1 |
| Full text | SKIN APPENDAGE GROWTH CONTROL BY HORMONES AND MORPHOGENS by Julie Ann Mayer ____________________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PATHOBIOLOGY) December 2007 Copyright 2007 Julie Ann Mayer |
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