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ULTRADIAN RHYTHMICITY OF AUTONOMIC FUNCTION
IN SLEEP-DISORDERED BREATHING
by
Suradej Tretriluxana
______________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
May 2008
Copyright 2008 Suradej Tretriluxana
Object Description
| Title | Ultradian rhythmicity of autonomic function in sleep-disordered breathing |
| Author | Tretriluxana, Suradej |
| Author email | stretril@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2007-10-05 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-01-28 |
| Advisor (committee chair) | Khoo, Michael C. K. |
| Advisor (committee member) |
Singh, Manbir Keens, Thomas G. |
| Abstract | This dissertation was designed to examine the different characteristics during sleep of autonomic function in normal and sleep-disordered breathing (SDB) groups. By establishing the mathematical model, we were able to control for the self oscillation sleep depth, random arousal events and respiration patterns, which were the three major influences to the variation of sympathovagal function. Seven models from seven autonomic indices were investigated on three compartments; input, overall gain and output. All the parameters in those three compartments were compared to determine whether the differences exist between normal and SDB groups.; Forty six polysomnograms were selected from multi-center the Sleep Heart Health Study. The data were divided equally into 2 groups (normal and SDB) according to their Respiratory Disturbance Index. Applying the model with the dual input (sleep depth and arousal intensity), single output (changes in autonomic index), our results showed that the output prediction performance was better when a non-stationary form of model was assumed. This suggests that the underlying dynamics of ultradian rhythmicity of the cardiac autonomic modulation are time-varying.; Five statistical analyses were performed on seventeen parameters in three model compartments. They revealed that there was no significant difference between two groups on the input (delta activity representing sleep depth) but there were significant effects of sleep stage, time of night on this parameter. All analyses reported that the delta-to-MeanRR5 gain in SDB was almost half as large as the corresponding gain in normal. Additionally, there was a tendency of lower parasympathetic modulation, represented by delta-to-NHFPra gain in SDB. Three of five analyses showed lower only in MeanRR5 (temporal autonomic index) in SDB than normal. However there was a strong effect of sleep stage on all autonomic indices.; In conclusion, by employing a model-based approach, we have demonstrated four key findings: (1) the ultradian rhythm of autonomic control is time-varying system, (2) the gain might be an alternative measure used to characterize sleep breathing disorder. (3) ultradian modulation of autonomic heart rate control is impaired in subject with sleep disorder breathing primarily in vagal control and (4) sleep stage and time of night are essential factors for sleep data analysis. |
| Keyword | ultradian rhythm; autonomic nervours system; heart rate variability; sleep apnea; physiological modeling; sleep research |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m997 |
| Rights | Tretriluxana, Suradej |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-TretriluxanaS-20080128 |
| Archival file | uscthesesreloadpub_Volume26/etd-TretriluxanaS-20080128.pdf |
Description
| Title | Page 1 |
| Full text | ULTRADIAN RHYTHMICITY OF AUTONOMIC FUNCTION IN SLEEP-DISORDERED BREATHING by Suradej Tretriluxana ______________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) May 2008 Copyright 2008 Suradej Tretriluxana |
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