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THE PATTERN AND DISTRIBUTION OF SYMPATHETIC NERVE ACTIVITY IN
PATIENTS WITH HIGH CARDIOVASCULAR RISK
by
Jeanie Park
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOMEDICAL AND CLINICAL INVESTIGATIONS)
May 2008
Copyright 2008 Jeanie Park
Object Description
| Title | The pattern and distribution of sympathetic nerve activity in patients with high cardiovascular risk |
| Author | Park, Jeanie |
| Author email | jeaniep@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Clinical & Biomedical Investigations |
| School | Keck School of Medicine |
| Date defended/completed | 2008-03-25 |
| Date submitted | 2008 |
| Restricted until | Restricted until 17 Apr. 2010. |
| Date published | 2010-04-17 |
| Advisor (committee chair) | Campese, Vito |
| Advisor (committee member) |
Azen, Stanley Yu, Alan |
| Abstract | End-stage renal disease (ESRD) patients and chronic smokers are two populations characterized by sympathetic overactivity and high cardiovascular risk. These studies examine the distribution of sympathetic activity in ESRD patients, and the pattern of sympathetic activity with the ovarian cycle in female smokers. Simultaneous measurements of sympathetic activity to the muscle and skin were made in ESRD patients and compared to healthy controls. In premenopausal female smokers, sympathetic activity was measured during both the follicular and midluteal phases of the ovarian cycle. Sympathetic activity directed to muscle was significantly higher in ESRD compared to controls; however, skin activity was not elevated. This suggests that sympathetic overactivity in ESRD is not widespread, and reflects independent regulatory patterns. Female smokers exhibited an abnormal pattern of sympathetic outflow with failure to decline sympathetic activity during the follicular phase. This abnormal pattern may increase the total burden of sympathetic activity, contributing to cardiovascular risk. |
| Keyword | end-stage renal disease; sympathetic activity; smokers |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1143 |
| Rights | Park, Jeanie |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Park-20080417 |
| Archival file | uscthesesreloadpub_Volume14/etd-Park-20080417.pdf |
Description
| Title | Page 1 |
| Full text | THE PATTERN AND DISTRIBUTION OF SYMPATHETIC NERVE ACTIVITY IN PATIENTS WITH HIGH CARDIOVASCULAR RISK by Jeanie Park A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOMEDICAL AND CLINICAL INVESTIGATIONS) May 2008 Copyright 2008 Jeanie Park |
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