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MAPPING ARENAVIRUS GLYCOPROTEIN DETERMINANTS THAT
CORRELATE TO CELL ENTRY CHARACTERISTICS AND VIRUS
PATHOGENECITY
by
Vanessa Kimiko Martin
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fullfillment of the
Requirements of the Degree
MASTER OF SCIENCE
(MOLECULAR MICROBIOLOGY AND IMMUNOLOGY)
May 2008
Copyright 2008 Vanessa Kimiko Martin
Object Description
| Title | Mapping arenavirus glycoprotein determinants that correlate to cell entry and virus pathogenicity |
| Author | Martin, Vanessa Kimiko |
| Author email | vkmartin@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Molecular Microbiology & Immunology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-03-13 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-04-16 |
| Advisor (committee chair) | Cannon, Paula |
| Advisor (committee member) |
Landolph, Joseph McMillan, Minnie |
| Abstract | Five arenaviruses can cause hemorrhagic fever in humans. They are classified by the CDC as category A pathogens because of the possibility to be manipulated into biological weapons. Of interest, the New World clade B group of the arenaviruses contains both pathogenic and non-pathogenic members, including the closely related Amapari (AMAV) and Guanarito (GTOV) viruses. In our recent study, we determined that pathogenic viruses have a specific tropism and are able to transduce human T-lymphocytes and use the human transferrin receptor 1 for cell entry. By dividing the GP1 protein, the subunit that promotes cell binding and entry, into five domains based upon conserved cysteine residues, we generated a series of AMAV and GTOV chimeras to map the region of the GP1 subunit that correlates to pathogenic tropism. We have found a valine in the domain five of the GTOV GP1 that is necessary for pathogenic tropism in arenavirus. |
| Keyword | arenavirus; glycoprotein; human transferrin |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1133 |
| Rights | Martin, Vanessa Kimiko |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Martin-20080416 |
| Archival file | uscthesesreloadpub_Volume44/etd-Martin-20080416.pdf |
Description
| Title | Page 1 |
| Full text | MAPPING ARENAVIRUS GLYCOPROTEIN DETERMINANTS THAT CORRELATE TO CELL ENTRY CHARACTERISTICS AND VIRUS PATHOGENECITY by Vanessa Kimiko Martin A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fullfillment of the Requirements of the Degree MASTER OF SCIENCE (MOLECULAR MICROBIOLOGY AND IMMUNOLOGY) May 2008 Copyright 2008 Vanessa Kimiko Martin |
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