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EARLY LIFE RISK FACTORS FOR CHILDHOOD ASTHMA
by
Md. Towhid Salam
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(EPIDEMIOLOGY)
August 2009
Copyright 2009 Md. Towhid Salam
Object Description
| Title | Early life risk factors for childhood asthma |
| Author | Salam, Md. Towhid |
| Author email | msalam@usc.edu; towhids@yahoo.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Epidemiology |
| School | Keck School of Medicine |
| Date defended/completed | 2009-06-18 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-07-28 |
| Advisor (committee chair) | Gilliland, Frank D. |
| Advisor (committee member) |
McConnell, Robert Langholz, Bryan Ingles, Sue A. Dubeau, Louis |
| Abstract | Asthma is the most common chronic inflammatory disease in childhood. The disease often starts early in life with significant burden to children and their families and the healthcare system. An accumulating body of evidence indicates that both prenatal and early life exposures play uniquely important roles in asthma occurrence by modulating airway and immune functions. In addition, timing of such exposures during these periods is likely to modulate the growth and development of airways and immune functions. Extensive literature reviews were done to critically evaluate earlier work and to understand the mechanisms of the underlying associations. The findings of the analyses are encouraging. Using data from the southern California Children's Health study, both prenatal and early life exposures were found to be associated with asthma occurrence in children. Additionally, timing of exposure in infancy and family history of asthma modified some of these associations. Some of the associations were stronger for particular asthma phenotypes. Given the enormous burden from childhood asthma, further research is needed to assess the role of these and other genetic, epigenetic and environmental factors during critical windows of development across distinct asthma phenotypes. These findings also indicate that any intervention strategy to reduce the burden of asthma in young children should target prenatal and early life as a critical time point to modulate exposures to prevent disease occurrence. |
| Keyword | asthma; cesarean section; environmental exposures; life course epidemiology; pregnancy; prenatal exposures |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2393 |
| Contributing entity | University of Southern California |
| Rights | Salam, Md. Towhid |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Salam-3090 |
| Archival file | uscthesesreloadpub_Volume40/etd-Salam-3090.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | EARLY LIFE RISK FACTORS FOR CHILDHOOD ASTHMA by Md. Towhid Salam A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (EPIDEMIOLOGY) August 2009 Copyright 2009 Md. Towhid Salam |
